{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T13:59:52Z","timestamp":1784210392509,"version":"3.55.0"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31472267"],"award-info":[{"award-number":["31472267"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFD0900205"],"award-info":[{"award-number":["2018YFD0900205"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1016\/j.ijbiomac.2023.123794","type":"journal-article","created":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T02:48:00Z","timestamp":1677120480000},"page":"123794","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["DNA methylation mediates gonadal development via regulating the expression levels of cyp19a1a in loach Misgurnus anguillicaudatus"],"prefix":"10.1016","volume":"235","author":[{"given":"Junxiao","family":"Su","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaokui","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zexia","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalid","family":"Abbas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijbiomac.2023.123794_bb0005","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.steroids.2008.01.017","article-title":"Aromatase expression in the ovary: hormonal and molecular regulation","volume":"73","author":"Stocco","year":"2008","journal-title":"Steroids"},{"key":"10.1016\/j.ijbiomac.2023.123794_bb0010","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1002\/dvdy.22507","article-title":"Role of estrogen in spermatogenesis in initial phase males of the three-spot wrasse (Halichoeres trimaculatus): effect of aromatase inhibitor on the testis","volume":"240","author":"Kobayashi","year":"2011","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.ijbiomac.2023.123794_bb0015","doi-asserted-by":"crossref","first-page":"3030","DOI":"10.1210\/en.2016-1865","article-title":"Targeted disruption of aromatase reveals dual functions of cyp19a1a during sex differentiation in zebrafish","volume":"158","author":"Yin","year":"2017","journal-title":"Endocrinology"},{"key":"10.1016\/j.ijbiomac.2023.123794_bb0020","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1210\/endo-103-6-2283","article-title":"Phylogenetic distribution of aromatase and other androgen-converting enzymes in the central nervous system","volume":"103","author":"Callard","year":"1978","journal-title":"Endocrinology"},{"key":"10.1016\/j.ijbiomac.2023.123794_bb0025","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1002447","article-title":"DNA methylation of the gonadal aromatase (cyp19a) promoter is involved in temperature-dependent sex ratio shifts in the european sea bass","volume":"7","author":"Navarro-Mart\u00edn","year":"2011","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ijbiomac.2023.123794_bb0030","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1530\/rep.0.1210685","article-title":"Mammalian aromatases","volume":"121","author":"Conley","year":"2001","journal-title":"Reproduction"},{"key":"10.1016\/j.ijbiomac.2023.123794_bb0035","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.ygcen.2008.05.016","article-title":"Tissue and sexually dimorphic expression of ovarian and brain aromatase mRNA in the japanese medaka (Oryzias latipes): implications for their preferential roles in ovarian and neural differentiation and development","volume":"158","author":"Patil","year":"2008","journal-title":"Gen. Comp. Endocr."},{"key":"10.1016\/j.ijbiomac.2023.123794_bb0040","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.ygcen.2009.03.002","article-title":"Ovarian aromatase and estrogens: a pivotal role for gonadal sex differentiation and sex change in fish","volume":"165","author":"Guiguen","year":"2010","journal-title":"Gen. Comp. Endocr."},{"key":"10.1016\/j.ijbiomac.2023.123794_bb0045","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ygcen.2007.03.005","article-title":"Interference of endocrine disrupting chemicals with aromatase CYP19 expression or activity, and consequences for reproduction of teleost fish","volume":"155","author":"Cheshenko","year":"2008","journal-title":"Gen. Comp. Endocr."},{"key":"10.1016\/j.ijbiomac.2023.123794_bb0050","doi-asserted-by":"crossref","first-page":"3900","DOI":"10.1210\/en.2010-0228","article-title":"Cortisol is involved in temperature dependent sex determination in the japanese flounder","volume":"151","author":"Yamaguchi","year":"2010","journal-title":"Endocrinology"},{"key":"10.1016\/j.ijbiomac.2023.123794_bb0055","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.bbrc.2012.02.012","article-title":"High temperature induces cyp26b1 mRNA expression and delays meiotic initiation of germ cells by increasing cortisol levels during gonadal sex differentiation in Japanese flounder","volume":"419","author":"Yamaguchi","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ijbiomac.2023.123794_bb0060","doi-asserted-by":"crossref","first-page":"2881","DOI":"10.1210\/en.2012-2220","article-title":"Epigenetic modifications during sex change repress gonadotropin stimulation of cyp19a1a in a teleost ricefield eel (Monopterus albus)","volume":"154","author":"Zhang","year":"2013","journal-title":"Endocrinology"},{"key":"10.1016\/j.ijbiomac.2023.123794_bb0065","doi-asserted-by":"crossref","first-page":"37357","DOI":"10.1038\/srep37357","article-title":"Knockout of zebrafish ovarian aromatase gene (cyp19a1a) by TALEN and CRISPR\/Cas9 leads to all-male offspring due to failed ovarian differentiation","volume":"6","author":"Lau","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ijbiomac.2023.123794_bb0070","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1111\/j.1742-4658.2008.06330.x","article-title":"Epigenetics: differential DNA methylation in mammalian somatic tissues","volume":"275","author":"Nagase","year":"2008","journal-title":"FEBS J."},{"key":"10.1016\/j.ijbiomac.2023.123794_bb0075","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.steroids.2010.02.004","article-title":"Epigenetic regulation of the expression of genes involved in steroid hormone biosynthesis and action","volume":"75","author":"Martinez-Arguelles","year":"2010","journal-title":"Steroids"},{"key":"10.1016\/j.ijbiomac.2023.123794_bb0080","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1677\/JME-10-0053","article-title":"Epigenetics meets endocrinology","volume":"46","author":"Zhang","year":"2011","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.ijbiomac.2023.123794_bb0085","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.gene.2013.05.037","article-title":"DNA methylation status of cyp17-II gene correlated with its expression pattern and reproductive endocrinology during ovarian development stages of japanese flounder (Paralichthys olivaceus)","volume":"527","author":"Ding","year":"2017","journal-title":"Gene"},{"key":"10.1016\/j.ijbiomac.2023.123794_bb0090","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1002\/dvdy.23924","article-title":"Epigenetics of sex determination and gonadogenesis","volume":"242","author":"Piferrer","year":"2013","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.ijbiomac.2023.123794_bb0095","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.gene.2015.09.006","article-title":"DNA methylation level of cyp19a1a and Foxl2 gene related to their expression patterns and reproduction traits during ovary development stages of japanese flounder (Paralichthys olivaceus)","volume":"575","author":"Si","year":"2016","journal-title":"Gene"},{"key":"10.1016\/j.ijbiomac.2023.123794_bb0100","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.mce.2010.02.035","article-title":"Epigenetic mechanisms regulating CYP19 transcription in human breast adipose fibroblasts","volume":"321","author":"Knower","year":"2010","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.ijbiomac.2023.123794_bb0105","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.ygcen.2010.07.012","article-title":"Tissue-specific promoter methylation coincides with Cyp19 gene expression in buffalo (Bubalus bubalis) placenta of different stages of gestation","volume":"169","author":"Ghai","year":"2010","journal-title":"Gen. Comp. Endocr."},{"key":"10.1016\/j.ijbiomac.2023.123794_bb0110","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.ygcen.2011.05.016","article-title":"Tissue-specific promoter methylation and histone modification regulate CYP19 gene expression during folliculogenesis and luteinization in buffalo ovary","volume":"173","author":"Monga","year":"2011","journal-title":"Gen. Comp. Endocr."},{"key":"10.1016\/j.ijbiomac.2023.123794_bb0115","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.rvsc.2010.10.008","article-title":"Term placenta shows methylation independent down regulation of Cyp19 gene in animals with retained fetal membranes","volume":"92","author":"Ghai","year":"2012","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.ijbiomac.2023.123794_bb0120","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1210\/en.2012-1610","article-title":"Changes in histone modification and DNA methylation of the StAR and Cyp19a1 promoter regions in granulosa cells undergoing luteinization during ovulation in rats","volume":"154","author":"Lee","year":"2013","journal-title":"Endocrinology"},{"key":"10.1016\/j.ijbiomac.2023.123794_bb0125","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0063599","article-title":"Epigenetic control of gonadal aromatase (cyp19a1) in temperature-dependent sex determination of redeared slider turtles","volume":"8","author":"Matsumoto","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ijbiomac.2023.123794_bb0130","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1095\/biolreprod.115.137463","article-title":"The testis is a primary factor that contributes to epigenetic modifications in the ovaries of the protandrous black porgy, Acanthopagrus schlegelii","volume":"94","author":"Wu","year":"2016","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.ijbiomac.2023.123794_bb0135","doi-asserted-by":"crossref","first-page":"522","DOI":"10.3389\/fgene.2019.00522","article-title":"Transcriptome profiling insights the feature of sex reversal induced by high temperature in tongue sole Cynoglossus semilaevis","volume":"10","author":"Liu","year":"2019","journal-title":"Front. Genet."},{"key":"10.1016\/j.ijbiomac.2023.123794_bb0140","doi-asserted-by":"crossref","first-page":"11699","DOI":"10.1038\/s41598-018-29991-6","article-title":"Full-length transcriptome of Misgurnus anguillicaudatus provides insights into evolution of genus misgurnus","volume":"8","author":"Yi","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ijbiomac.2023.123794_bb0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10641-017-0608-z","article-title":"Comparison of age and growth performance of diploid and tetraploid loach Misgurnus anguillicaudatus in the Yangtze River basin, China","volume":"100","author":"Feng","year":"2017","journal-title":"Environ. Biol. Fish"},{"key":"10.1016\/j.ijbiomac.2023.123794_bb0150","first-page":"107","article-title":"Genetics of the loach, Misgurnus anguillicaudatus, recent progress and perspective","volume":"51","author":"Arai","year":"2003","journal-title":"Folia Biol. (Krak\u00f3w)"},{"key":"10.1016\/j.ijbiomac.2023.123794_bb0155","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s10499-009-9248-4","article-title":"Comparative studies on survival and growth performance among diploid, triploid and tetraploid dojo loach Misgurnus anguillicaudatus","volume":"18","author":"Zhou","year":"2010","journal-title":"Aquacult. Int."},{"key":"10.1016\/j.ijbiomac.2023.123794_bb0160","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1111\/j.0022-1112.2004.00293.x","article-title":"Spawning dynamics of common carp in the river Murray, South Australia, shown by macroscopic and histological staging of gonads","volume":"64","author":"Smith","year":"2004","journal-title":"J. Fish Biol."},{"key":"10.1016\/j.ijbiomac.2023.123794_bb0165","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.aquaculture.2011.02.017","article-title":"Developmental expression pattern of the fc-vasa-like gene, gonadogenesis and development of germ cell in chinese shrimp, Fenneropenaeus chinensis","volume":"314","author":"Feng","year":"2011","journal-title":"Aquaculture"},{"key":"10.1016\/j.ijbiomac.2023.123794_bb0170","series-title":"Molecular Cloning: A Laboratory Manual","author":"Sambrook","year":"2001"},{"key":"10.1016\/j.ijbiomac.2023.123794_bb0175","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.ygcen.2004.07.003","article-title":"Localization and expression of aromatase mRNA in adult zebrafish","volume":"139","author":"Goto-Kazeto","year":"2004","journal-title":"Gen. Comp. Endocr."},{"key":"10.1016\/j.ijbiomac.2023.123794_bb0180","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1002\/mrd.21335","article-title":"Aromatase is expressed and active in the rainbow trout","volume":"78","author":"Gohin","year":"2011","journal-title":"Mol. Reprod. Dev."},{"key":"10.1016\/j.ijbiomac.2023.123794_bb0185","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.cbpc.2005.01.009","article-title":"Molecular cloning of cytochrome P450 aromatases in the protogynous wrasse, Halichoeres tenuispinis","volume":"141","author":"Choi","year":"2005","journal-title":"Comp. Biochem. Physiol. B"},{"key":"10.1016\/j.ijbiomac.2023.123794_bb0190","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1095\/biolreprod29.2.310","article-title":"Evidence for a decrease in aromatase activity in the ovarian granulosa cells of amago salmon (Oncorhynchus rhodurus) associated with final oocyte maturation","volume":"29","author":"Young","year":"1983","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.ijbiomac.2023.123794_bb0195","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s13293-015-0044-8","article-title":"Large-scale transcriptome sequencing reveals novel expression patterns for key sex-related genes in a sex-changing fish","volume":"6","author":"Liu","year":"2015","journal-title":"Biol. Sex Differ."},{"key":"10.1016\/j.ijbiomac.2023.123794_bb0200","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.ygcen.2009.05.022","article-title":"Oogenesis in teleosts: how eggs are formed","volume":"165","author":"Lubzens","year":"2010","journal-title":"Gen. Comp. Endocr."},{"key":"10.1016\/j.ijbiomac.2023.123794_bb0205","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.ygcen.2009.02.013","article-title":"Spermatogenesis in fish","volume":"165","author":"Schulz","year":"2010","journal-title":"Gen. Comp. Endocr."},{"key":"10.1016\/j.ijbiomac.2023.123794_bb0210","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1677\/jme.0.0230167","article-title":"Suppression of P450 aromatase gene expression in sex-reversed males produced by rearing genetically female larvae at a high water temperature during a period of sex differentiation in the Japanese flounder (Paralichthys olivaceus)","volume":"23","author":"Kitano","year":"1999","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.ijbiomac.2023.123794_bb0215","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1210\/endo-122-4-1349","article-title":"Changes in brain aromatase and 5 alpha-reductase activities correlate significantly with seasonal reproductive cycles in goldfish (Carassius auratus)","volume":"122","author":"Pasmanik","year":"1988","journal-title":"Endocrinology"},{"key":"10.1016\/j.ijbiomac.2023.123794_bb0220","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/0016-6480(91)90299-L","article-title":"Effects of castration and androgen treatment on aromatase activity in the brain of mature male Atlantic salmon (Salmo salar L.) parr","volume":"82","author":"Mayer","year":"1991","journal-title":"Gen. Comp. Endocr."},{"key":"10.1016\/j.ijbiomac.2023.123794_bb0225","doi-asserted-by":"crossref","first-page":"4133","DOI":"10.1210\/endo.140.9.6951","article-title":"Dual regulation of promoter II- and promoter 1f-derived cytochrome P450 aromatase transcripts in equine granulosa cells during human chorionic gonadotropin-induced ovulation: a novel model for the study of aromatase promoter switching","volume":"140","author":"Boerboom","year":"1999","journal-title":"Endocrinology"},{"key":"10.1016\/j.ijbiomac.2023.123794_bb0230","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1210\/endo-129-3-1452","article-title":"Regulation of cytochrome P450 aromatase messenger ribonucleic acid and activity by steroids and gonadotropins in rat granulosa cells","volume":"129","author":"Fitzpatrick","year":"1991","journal-title":"Endocrinology"},{"key":"10.1016\/j.ijbiomac.2023.123794_bb0235","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1046\/j.1432-1327.2001.01988.x","article-title":"Chromatin structure of the bovine Cyp19 promoter 1.1: DNaseI hypersensitive sites and DNA hypomethylation correlate with placental expression","volume":"268","author":"F\u00fcrbass","year":"2001","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.ijbiomac.2023.123794_bb0240","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1006\/bbrc.2001.5796","article-title":"The 5\u2019-flanking regions of CYP19A1 and CYP19A2 in zebrafish","volume":"288","author":"Kazeto","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ijbiomac.2023.123794_bb0245","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1210\/endo.142.2.7928","article-title":"Distinct cytochrome P450 aromatase isoforms in zebrafish (Danio rerio) brain and ovary are differentially programmed and estrogen regulated during early development","volume":"142","author":"Kishida","year":"2001","journal-title":"Endocrinology"},{"key":"10.1016\/j.ijbiomac.2023.123794_bb0250","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.aquatox.2004.04.008","article-title":"Effects of endocrine disrupting chemicals on the expression of CYP19 genes in zebrafish (Danio rerio) juveniles","volume":"69","author":"Kazeto","year":"2004","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ijbiomac.2023.123794_bb0255","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S1096-4959(01)00319-0","article-title":"Estrogen and xenoestrogens upregulate the brain aromatase isoform (P450aromB) and perturb markers of early development in zebrafish (Danio rerio)","volume":"129","author":"Kishida","year":"2001","journal-title":"Comp. Biochem. Physiol. B"},{"key":"10.1016\/j.ijbiomac.2023.123794_bb0260","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S0960-0760(01)00120-0","article-title":"Callard, promoter characteristics of two cyp19 genes differentially expressed in the brain and ovary of teleost fish","volume":"5","author":"Tchoudakova","year":"2001","journal-title":"J. Steroid. Biochem."},{"key":"10.1016\/j.ijbiomac.2023.123794_bb0265","doi-asserted-by":"crossref","DOI":"10.1016\/j.ygcen.2020.113538","article-title":"Epigenetic regulation of gonadal and brain aromatase expression in a cichlid fish with environmental sex determination","volume":"296","author":"Driscoll","year":"2020","journal-title":"Gen. Comp. Endocr."},{"key":"10.1016\/j.ijbiomac.2023.123794_bb0270","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0166-2236(97)01221-6","article-title":"New insights into the regulation and function of brain estrogen synthase (aromatase)","volume":"21","author":"Balthazart","year":"1998","journal-title":"Trends Neurosci."}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813023006888?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813023006888?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T08:24:07Z","timestamp":1749716647000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0141813023006888"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":54,"alternative-id":["S0141813023006888"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2023.123794","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"DNA methylation mediates gonadal development via regulating the expression levels of cyp19a1a in loach Misgurnus anguillicaudatus","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2023.123794","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"123794"}}