{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T12:11:00Z","timestamp":1791807060928,"version":"4.3.4"},"reference-count":74,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100008109","name":"Wuxi City Department of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008109","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.ijbiomac.2023.124208","type":"journal-article","created":{"date-parts":[[2023,3,25]],"date-time":"2023-03-25T18:46:30Z","timestamp":1679769990000},"page":"124208","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Synthesis, characterization, and in vitro anti-tumor activity studies of the hyaluronic acid-mangiferin-methotrexate nanodrug targeted delivery system"],"prefix":"10.1016","volume":"239","author":[{"given":"Haojue","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanfei","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianyi","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxia","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peizhi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ijbiomac.2023.124208_bb0005","first-page":"7","article-title":"Cancer statistics, 2022","volume":"72","author":"Siegel","year":"2022","journal-title":"CA Cancer J. Clin."},{"issue":"1","key":"10.1016\/j.ijbiomac.2023.124208_bb0010","doi-asserted-by":"crossref","first-page":"188643","DOI":"10.1016\/j.bbcan.2021.188643","article-title":"The evolution and ecology of benign tumors","volume":"1877","author":"Boutry","year":"2022","journal-title":"Biochim. Biophys. Acta, Rev. Cancer"},{"key":"10.1016\/j.ijbiomac.2023.124208_bb0015","doi-asserted-by":"crossref","first-page":"102301","DOI":"10.1016\/j.ctrv.2021.102301","article-title":"Triplet chemotherapy in combination with anti-EGFR agents for the treatment of metastatic colorectal cancer: current evidence, advances, and future perspectives","volume":"102","author":"Folprecht","year":"2022","journal-title":"Cancer Treat. Rev."},{"key":"10.1016\/j.ijbiomac.2023.124208_bb0020","doi-asserted-by":"crossref","first-page":"101676","DOI":"10.1016\/j.suronc.2021.101676","article-title":"The many faces of intraperitoneal chemotherapy","volume":"40","author":"Mageed","year":"2022","journal-title":"Surg. Oncol"},{"issue":"6","key":"10.1016\/j.ijbiomac.2023.124208_bb0025","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1080\/10611860600888843","article-title":"Special issue in honour of Professor Helmut Ringsdorf, recipient of the Journal of Drug Targeting's Life-time Achievement Award for 2006","volume":"14","year":"2006","journal-title":"J Drug Target"},{"key":"10.1016\/j.ijbiomac.2023.124208_bb0030","doi-asserted-by":"crossref","first-page":"3433","DOI":"10.3390\/nano11123433","article-title":"Development and in vitro\/in vivo evaluation of pH-sensitive polymeric nanoparticles loaded hydrogel for the management of psoriasis","volume":"11","author":"Asad","year":"2021","journal-title":"Nanomaterials"},{"issue":"6","key":"10.1016\/j.ijbiomac.2023.124208_bb0035","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1080\/10611860600833856","article-title":"Polymer therapeutics - polymers as drugs, drug and protein conjugates and gene delivery systems: past, present and future opportunities (Reprinted from advances in polymer science, vol 192, pg 1\u20138, 2005)","volume":"14","author":"Duncan","year":"2006","journal-title":"J. Drug Target."},{"key":"10.1016\/j.ijbiomac.2023.124208_bb0040","doi-asserted-by":"crossref","first-page":"860","DOI":"10.3390\/nano9060860","article-title":"A photocleavable amphiphilic prodrug self-assembled nanoparticles with effective anticancer activity in vitro","volume":"9","author":"Chen","year":"2019","journal-title":"Nanomaterials"},{"key":"10.1016\/j.ijbiomac.2023.124208_bb0045","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.3390\/nano10101899","article-title":"pH-sensitive dendrimersomes of hybrid triazine-carbosilane dendritic amphiphiles-smart vehicles for drug delivery","volume":"10","author":"Apartsin","year":"2020","journal-title":"Nanomaterials"},{"key":"10.1016\/j.ijbiomac.2023.124208_bb0050","doi-asserted-by":"crossref","first-page":"126166","DOI":"10.1016\/j.colsurfa.2021.126166","article-title":"Double flow focusing microfluidic-assisted based preparation of methotrexate-loaded liposomal nanoparticles: encapsulation efficacy, drug release and stability","volume":"614","author":"Aghaei","year":"2021","journal-title":"Colloid Surf. A"},{"key":"10.1016\/j.ijbiomac.2023.124208_bb0055","doi-asserted-by":"crossref","first-page":"0589","DOI":"10.1016\/j.ijpharm.2021.120589","article-title":"Is hyaluronic acid the perfect excipient for the pharmaceutical need?","volume":"601","author":"Harrer","year":"2021","journal-title":"Int. J. Pharm."},{"issue":"18","key":"10.1016\/j.ijbiomac.2023.124208_bb0060","doi-asserted-by":"crossref","first-page":"4035","DOI":"10.3390\/molecules25184035","article-title":"Hyaluronic acid as a component of natural polymer blends for biomedical applications: a review","volume":"25","author":"Sionkowska","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.ijbiomac.2023.124208_bb0065","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.3390\/nano11092334","article-title":"Hyaluronic acid\/collagen nanofiber tubular scaffolds support endothelial cell proliferation, phenotypic shape and endothelialization","volume":"11","author":"Niu","year":"2021","journal-title":"Nanomaterials"},{"key":"10.1016\/j.ijbiomac.2023.124208_bb0070","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.3390\/nano11051086","article-title":"A hyaluronic acid functionalized self-Nano-emulsifying drug delivery system (SNEDDS) for enhancement in ciprofloxacin targeted delivery against intracellular infection","volume":"11","author":"Arshad","year":"2021","journal-title":"Nanomaterials"},{"key":"10.1016\/j.ijbiomac.2023.124208_bb0075","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.3390\/nano11051354","article-title":"Hyaluronic acid-based nanocapsules as efficient delivery systems of garlic oil active components with anticancer activity","volume":"11","author":"Janik-Hazuka","year":"2021","journal-title":"Nanomaterials"},{"issue":"1","key":"10.1016\/j.ijbiomac.2023.124208_bb0080","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s40164-020-00192-0","article-title":"CD44 as a tumor biomarker and therapeutic target","volume":"9","author":"Xu","year":"2020","journal-title":"Exp. Hematol. Oncol."},{"issue":"1","key":"10.1016\/j.ijbiomac.2023.124208_bb0085","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s13045-018-0605-5","article-title":"The biology and role of CD44 in cancer progression: therapeutic implications","volume":"11","author":"Chen","year":"2018","journal-title":"J. Hematol. Oncol."},{"issue":"3","key":"10.1016\/j.ijbiomac.2023.124208_bb0090","doi-asserted-by":"crossref","first-page":"426","DOI":"10.34172\/apb.2021.050","article-title":"Understanding hyaluronan receptor (CD44) interaction, HA-CD44 activated potential targets in cancer therapeutics","volume":"11","author":"Chaudhry","year":"2021","journal-title":"Adv. Pharm. Bull."},{"key":"10.1016\/j.ijbiomac.2023.124208_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2020.117103","article-title":"Drug delivery systems based on CD44-targeted glycosaminoglycans for cancer therapy","volume":"251","author":"Li","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2023.124208_bb0100","first-page":"1","article-title":"Mangiferin: a review of dietary sources, absorption, metabolism, bioavailability, and safety","volume":"10","author":"Mei","year":"2021","journal-title":"Crit. Rev. Food Sci."},{"issue":"1","key":"10.1016\/j.ijbiomac.2023.124208_bb0105","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3390\/biom11010079","article-title":"Mangiferin as new potential anti-cancer agent and mangiferin-integrated polymer systems-a novel research direction","volume":"11","author":"Morozkina","year":"2021","journal-title":"Biomolecules"},{"issue":"1","key":"10.1016\/j.ijbiomac.2023.124208_bb0110","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.sjbs.2020.11.037","article-title":"Protective effect of mangiferin on memory impairment: a systematic review","volume":"28","author":"Lum","year":"2021","journal-title":"Saudi J. Biol. Sci."},{"issue":"4","key":"10.1016\/j.ijbiomac.2023.124208_bb0115","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s13596-020-00471-5","article-title":"The multifaceted role of mangiferin in health and diseases: a review","volume":"21","author":"Jangra","year":"2021","journal-title":"Adv. Tradit. Med."},{"key":"10.1016\/j.ijbiomac.2023.124208_bb0120","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1016\/j.fct.2021.111997","article-title":"Anticancer and anti-inflammatory properties of mangiferin: a review of its molecular mechanisms","volume":"149","author":"Mei","year":"2021","journal-title":"Food Chem. Toxicol."},{"issue":"2","key":"10.1016\/j.ijbiomac.2023.124208_bb0125","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.3892\/mmr.2017.6752","article-title":"Mangiferin positively regulates osteoblast differentiation and suppresses osteoclast differentiation","volume":"16","author":"Sekiguchi","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.ijbiomac.2023.124208_bb0130","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jff.2018.04.048","article-title":"Effect of long-term administration of mangiferin from Belamcanda chinensis on bone metabolism in ovariectomized rats","volume":"46","author":"Nowak","year":"2018","journal-title":"J. Funct. Foods"},{"issue":"9","key":"10.1016\/j.ijbiomac.2023.124208_bb0135","doi-asserted-by":"crossref","first-page":"16025","DOI":"10.3390\/ijms150916025","article-title":"Mangiferin reduces the inhibition of chondrogenic differentiation by IL-1 beta in mesenchymal stem cells from subchondral bone and targets multiple aspects of the smad and SOX9 pathways","volume":"15","author":"Huh","year":"2014","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.ijbiomac.2023.124208_bb0140","doi-asserted-by":"crossref","first-page":"167","DOI":"10.4274\/BMJ.galenos.2021.55265","article-title":"Evaluation of protective effects of folinic acid and gonadotropin-releasing hormone agonist and antagonist against methotrexate toxicity in rats","volume":"17","author":"Atakul","year":"2021","journal-title":"Med. J. Bakirkoy"},{"issue":"14","key":"10.1016\/j.ijbiomac.2023.124208_bb0145","doi-asserted-by":"crossref","first-page":"4652","DOI":"10.1039\/D1MA00188D","article-title":"A slow and sustained release of methotrexate (MTX) from a new polymeric dicalcium phosphate dehydrate cement (P-DCPD)","volume":"2","author":"Vaidya","year":"2021","journal-title":"Mater. Adv."},{"issue":"2","key":"10.1016\/j.ijbiomac.2023.124208_bb0150","first-page":"163","article-title":"Cutaneous methotrexate-related T-cell lymphoproliferative disorder with CD4, CD30, CD56, EBV-positive tumor cell infiltration: a case illustration and a brief review","volume":"11","author":"Omori","year":"2021","journal-title":"Am. J. Blood Res."},{"key":"10.1016\/j.ijbiomac.2023.124208_bb0155","doi-asserted-by":"crossref","first-page":"636","DOI":"10.3390\/nano9040636","article-title":"Lipidic liquid crystalline cubic phases and magnetocubosomes as methotrexate carriers","volume":"9","author":"Mierzwa","year":"2019","journal-title":"Nanomaterials"},{"issue":"4","key":"10.1016\/j.ijbiomac.2023.124208_bb0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0250339","article-title":"A dose-dependent beneficial effect of methotrexate on the risk of interstitial lung disease in rheumatoid arthritis patients","volume":"16","author":"Kur-Zalewska","year":"2021","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.ijbiomac.2023.124208_bb0165","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1007\/s12185-020-03071-w","article-title":"Risk factors for delayed elimination of high-dose methotrexate in childhood acute lymphoblastic leukemia and lymphoma","volume":"113","author":"Nakano","year":"2021","journal-title":"Int. J. Hematol."},{"key":"10.1016\/j.ijbiomac.2023.124208_bb0170","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3390\/nano8010024","article-title":"Enhanced and selective antiproliferative activity of methotrexate-functionalized-nanocapsules to human breast cancer cells (MCF-7)","volume":"8","author":"De Oliveira","year":"2018","journal-title":"Nanomaterials"},{"key":"10.1016\/j.ijbiomac.2023.124208_bb0175","doi-asserted-by":"crossref","first-page":"985","DOI":"10.3390\/nano8120985","article-title":"Photothermally controlled methotrexate release system using \u03b2-cyclodextrin and gold nanoparticles","volume":"8","author":"Silva","year":"2018","journal-title":"Nanomaterials"},{"key":"10.1016\/j.ijbiomac.2023.124208_bb0180","first-page":"1","article-title":"The state of CD44 activation in cancer progression and therapeutic targeting","volume":"9","author":"Guo","year":"2021","journal-title":"FEBS J."},{"key":"10.1016\/j.ijbiomac.2023.124208_bb0185","doi-asserted-by":"crossref","first-page":"0078","DOI":"10.1016\/j.biomaterials.2020.120078","article-title":"Synthetic macromolecules as therapeutics that overcome resistance in cancer and microbial infection","volume":"252","author":"Tan","year":"2020","journal-title":"Biomaterials"},{"key":"10.1016\/j.ijbiomac.2023.124208_bb0190","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jddst.2019.04.014","article-title":"Smart dendrimers: synergizing the targeting of anticancer bioactives","volume":"52","author":"Saluja","year":"2019","journal-title":"J. Drug Deliv. Sci. Technol."},{"issue":"8","key":"10.1016\/j.ijbiomac.2023.124208_bb0195","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.3390\/pharmaceutics13081151","article-title":"Advanced and innovative nano-systems for anticancer targeted drug delivery","volume":"13","author":"Tang","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ijbiomac.2023.124208_bb0200","doi-asserted-by":"crossref","first-page":"4907","DOI":"10.1021\/acsabm.1c00199","article-title":"Alendronate-decorated nanoparticles as bone-targeted alendronate carriers for potential osteoporosis treatment","volume":"4","author":"Jing","year":"2021","journal-title":"ACS Appl. Bio Mater."},{"key":"10.1016\/j.ijbiomac.2023.124208_bb0205","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1080\/21691401.2017.1416390","article-title":"Multifunctional redox-responsive and CD44 receptor targeting polymer-drug nanomedicine based curcumin and alendronate: synthesis, characterization and in vitro evaluation","volume":"46","author":"Dong","year":"2018","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"10.1016\/j.ijbiomac.2023.124208_bb0210","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.colsurfb.2017.01.050","article-title":"Fabrication and functional attributes of lipidic nanoconstructs of lycopene: an innovative Endeavour for enhanced cytotoxicity in MCF-7 breast cancer cells","volume":"152","author":"Jain","year":"2017","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.ijbiomac.2023.124208_bb0215","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.colsurfb.2017.01.050","article-title":"Methotrexate and beta-carotene loaded- lipid polymer hybrid nanoparticles:a preclinical study for breast cancer","volume":"152","author":"Jain","year":"2017","journal-title":"Colloids Surf. B: Biointerfaces"},{"issue":"1","key":"10.1016\/j.ijbiomac.2023.124208_bb0220","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.jconrel.2007.06.003","article-title":"Design of surface-modified poly(D, L-lactide-co-glycolide) nanoparticles for targeted drug delivery to bone","volume":"122","author":"Choi","year":"2007","journal-title":"J. Control. Release"},{"issue":"5","key":"10.1016\/j.ijbiomac.2023.124208_bb0225","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0097358","article-title":"Cellular uptake and antitumor activity of DOX-hyd-PEG-FA nanoparticles","volume":"9","author":"Ye","year":"2014","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.ijbiomac.2023.124208_bb0230","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1021\/acs.molpharmaceut.7b01091","article-title":"Bile acid-based drug delivery Systems for Enhanced Doxorubicin Encapsulation: comparing hydrophobic and ionic interactions in drug loading and release","volume":"15","author":"Cunningham","year":"2018","journal-title":"Mol. Pharm."},{"issue":"6","key":"10.1016\/j.ijbiomac.2023.124208_bb0235","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1021\/acs.molpharmaceut.6b01167","article-title":"Tat-tagged and folate-modified N-succinyl-chitosan (Tat-suc-FA) self-assembly nanoparticle for therapeutic delivery OGX-011 to A549 cells","volume":"14","author":"Yan","year":"2017","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ijbiomac.2023.124208_bb0240","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1021\/bc010098m","article-title":"Polyethylene glycol conjugates of methotrexate varying in their molecular weight from MW 750 to MW 40000: synthesis, characterization, and structure-activity relationships in vitro and in vivo","volume":"13","author":"Riebeseel","year":"2002","journal-title":"Bioconjug. Chem."},{"issue":"4","key":"10.1016\/j.ijbiomac.2023.124208_bb0245","doi-asserted-by":"crossref","first-page":"4662","DOI":"10.1021\/acsnano.0c00364","article-title":"Surfactant-free, self-assembled nanomicelles-based transdermal hydrogel for safe and targeted delivery of methotrexate against rheumatoid arthritis","volume":"14","author":"Qindeel","year":"2020","journal-title":"ACS Nano"},{"issue":"12","key":"10.1016\/j.ijbiomac.2023.124208_bb0250","doi-asserted-by":"crossref","first-page":"8786","DOI":"10.1021\/acsabm.0c01151","article-title":"Ligusticum striatum-derived carbon dots as nanocarriers to deliver methotrexate for effective therapy of cancer cells","volume":"3","author":"Hsin","year":"2020","journal-title":"ACS Appl. Bio Mater."},{"issue":"sup1","key":"10.1016\/j.ijbiomac.2023.124208_bb0255","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1080\/21691401.2017.1416390","article-title":"Multifunctional redox-responsive and CD44 receptor targeting polymer-drug nanomedicine based curcumin and alendronate: synthesis, characterization and in vitro evaluation","volume":"46","author":"Dong","year":"2018","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"issue":"5","key":"10.1016\/j.ijbiomac.2023.124208_bb0260","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1021\/acs.molpharmaceut.8b01335","article-title":"Multifunctional nanosystem based on graphene oxide for synergistic multistage tumor-targeting and combined chemo-photothermal therapy","volume":"16","author":"Zhang","year":"2019","journal-title":"Mol. Pharm."},{"issue":"9","key":"10.1016\/j.ijbiomac.2023.124208_bb0265","doi-asserted-by":"crossref","first-page":"4049","DOI":"10.1021\/acs.molpharmaceut.8b00473","article-title":"Hyaluronic acid-methotrexate conjugates coated magnetic polydopamine nanoparticles for multimodal imaging-guided multistage targeted chemo-photothermal therapy","volume":"15","author":"Li","year":"2018","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ijbiomac.2023.124208_bb0270","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.ijbiomac.2020.10.088","article-title":"Preparation, characterization and in vitro antitumor activity evaluation of hyaluronic acid-alendronate-methotrexate nanoparticles","volume":"166","author":"Gao","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2023.124208_bb0275","doi-asserted-by":"crossref","first-page":"42683","DOI":"10.1038\/srep42683","article-title":"Mangiferin from Pueraria tuberosa reduces inflammation via inactivation of NLRP3 inflammasome","volume":"7","author":"Bulugonda","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ijbiomac.2023.124208_bb0280","first-page":"313","article-title":"Mangiferin attenuates oxidative stress induced renal cell damage through activation of PI3K induced Akt and Nrf-2 mediated signaling pathways","volume":"5","author":"Sukanya","year":"2016","journal-title":"Biochem. Biophys. Rep"},{"key":"10.1016\/j.ijbiomac.2023.124208_bb0285","first-page":"313","article-title":"Mangiferin attenuates oxidative stress induced renal cell damage through activation of PI3K induced akt and Nrf-2 mediated signaling pathways","volume":"5","author":"Saha","year":"2016","journal-title":"Biochem. Biophys. Rep."},{"issue":"51","key":"10.1016\/j.ijbiomac.2023.124208_bb0290","doi-asserted-by":"crossref","first-page":"56692","DOI":"10.1021\/acsami.0c13453","article-title":"A logic AND-gated sonogene nanosystem for precisely regulating the apoptosis of tumor cells","volume":"12","author":"Wang","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"9","key":"10.1016\/j.ijbiomac.2023.124208_bb0295","doi-asserted-by":"crossref","first-page":"10499","DOI":"10.1021\/acsnano.9b04480","article-title":"Mapping subpopulations of cancer cell-derived extracellular vesicles and particles by Nano-flow cytometry","volume":"13","author":"Choi","year":"2019","journal-title":"ACS Nano"},{"key":"10.1016\/j.ijbiomac.2023.124208_bb0300","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.3390\/nano11082048","article-title":"Assessing suitability of Co@Au Core\/Shell nanoparticle geometry for improved theranostics in colon carcinoma","volume":"11","author":"Dhawan","year":"2021","journal-title":"Nanomaterials"},{"issue":"12","key":"10.1016\/j.ijbiomac.2023.124208_bb0305","doi-asserted-by":"crossref","first-page":"4209","DOI":"10.1021\/acs.molpharmaceut.6b00870","article-title":"CD44 receptor targeting and endosomal pH-sensitive dual functional hyaluronic acid micelles for intracellular paclitaxel delivery","volume":"13","author":"Liu","year":"2016","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ijbiomac.2023.124208_bb0310","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.3390\/nano12081299","article-title":"Development of a novel methotrexate-loaded nanoemulsion for rheumatoid arthritis treatment with site-specific targeting subcutaneous delivery","volume":"12","author":"Suresh","year":"2022","journal-title":"Nanomaterials"},{"key":"10.1016\/j.ijbiomac.2023.124208_bb0315","doi-asserted-by":"crossref","first-page":"2812","DOI":"10.3390\/nano11112812","article-title":"Construction of a Nano-controlled release methotrexate delivery system for the treatment of rheumatoid arthritis by local percutaneous administration","volume":"11","author":"Guo","year":"2021","journal-title":"Nanomaterials"},{"issue":"12","key":"10.1016\/j.ijbiomac.2023.124208_bb0320","doi-asserted-by":"crossref","first-page":"8786","DOI":"10.1021\/acsabm.0c01151","article-title":"Ligusticum striatum-derived carbon dots as nanocarriers to deliver methotrexate for effective therapy of cancer cells","volume":"3","author":"Hsin","year":"2020","journal-title":"ACS Appl Bio Mater"},{"key":"10.1016\/j.ijbiomac.2023.124208_bb0325","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.colsurfb.2017.01.050","article-title":"Fabrication and functional attributes of lipidic nanoconstructs of lycopene: an innovative Endeavour for enhanced cytotoxicity in MCF-7 breast cancer cells","volume":"152","author":"Jain","year":"2017","journal-title":"Colloids Surf B Biointerfaces"},{"key":"10.1016\/j.ijbiomac.2023.124208_bb0330","doi-asserted-by":"crossref","first-page":"14614","DOI":"10.1038\/srep14614","article-title":"Doxorubicin-poly (ethylene glycol)-alendronate self-assembled micelles for targeted therapy of bone metastatic cancer","volume":"5","author":"Ye","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ijbiomac.2023.124208_bb0335","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.colsurfb.2015.09.043","article-title":"Hyaluronic acid-conjugated polyamidoamine dendrimers for targeted delivery of 3,4-difluorobenzylidene curcumin to CD44 overexpressing pancreatic cancer cells","volume":"136","author":"Kesharwani","year":"2015","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.ijbiomac.2023.124208_bb0340","doi-asserted-by":"crossref","first-page":"144","DOI":"10.3390\/nano11010144","article-title":"Development of a new hyaluronic acid based redox-responsive nanohydrogel for the encapsulation of oncolytic viruses for cancer immunotherapy","volume":"11","author":"Deng","year":"2021","journal-title":"Nanomaterials"},{"key":"10.1016\/j.ijbiomac.2023.124208_bb0345","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3390\/biom11010079","article-title":"Mangiferin as new potential anti-cancer agent and mangiferin-integrated polymer systems\u2014a novel research direction","volume":"11","author":"Morozkina","year":"2021","journal-title":"Biomolecules"},{"issue":"1","key":"10.1016\/j.ijbiomac.2023.124208_bb0350","first-page":"6","article-title":"Design of potential vitamin-drug conjugate for enhanced anticancer activity","volume":"105","author":"Bhole","year":"2022","journal-title":"Bull. Karaganda Univ."},{"issue":"10","key":"10.1016\/j.ijbiomac.2023.124208_bb0355","doi-asserted-by":"crossref","first-page":"4812","DOI":"10.1021\/acsapm.0c01323","article-title":"Conjugated bio-polymer anchored surfaces to mitigate stain and bacterial colonization for Oral hygiene application","volume":"3","author":"Pathan","year":"2021","journal-title":"ACS Applied Polymer Materials."},{"issue":"6","key":"10.1016\/j.ijbiomac.2023.124208_bb0360","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1021\/acs.molpharmaceut.6b01167","article-title":"Tat-tagged and folate-modified N-succinyl-chitosan (Tat-suc-FA) self-assembly nanoparticle for therapeutic delivery OGX-011 to A549 cells","volume":"14","author":"Yan","year":"2017","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ijbiomac.2023.124208_bb0365","doi-asserted-by":"crossref","first-page":"771","DOI":"10.3390\/jpm11080771","article-title":"The enhanced permeability and retention (EPR) effect: the significance of the concept and methods to enhance its application","volume":"11","author":"Wu","year":"2021","journal-title":"J. Pers. Med."},{"key":"10.1016\/j.ijbiomac.2023.124208_bb0370","doi-asserted-by":"crossref","first-page":"124","DOI":"10.3390\/jpm11020124","article-title":"Nanodrug delivery systems modulate tumor vessels to increase the enhanced permeability and retention effect","volume":"11","author":"Huang","year":"2021","journal-title":"J. Pers. Med."}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813023011029?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813023011029?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T10:10:34Z","timestamp":1758881434000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0141813023011029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":74,"alternative-id":["S0141813023011029"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2023.124208","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis, characterization, and in vitro anti-tumor activity studies of the hyaluronic acid-mangiferin-methotrexate nanodrug targeted delivery system","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2023.124208","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"124208"}}