{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T22:51:40Z","timestamp":1793832700312,"version":"4.6.1"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072476"],"award-info":[{"award-number":["82072476"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20220046"],"award-info":[{"award-number":["BK20220046"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.ijbiomac.2023.126166","type":"journal-article","created":{"date-parts":[[2023,8,6]],"date-time":"2023-08-06T17:33:28Z","timestamp":1691343208000},"page":"126166","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Fucoidan-functionalized gelatin methacryloyl microspheres ameliorate intervertebral disc degeneration by restoring redox and matrix homeostasis of nucleus pulposus"],"prefix":"10.1016","volume":"250","author":[{"given":"Yangfeng","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyang","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunju","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zejun","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huilin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10137","key":"10.1016\/j.ijbiomac.2023.126166_bb0005","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1016\/S0140-6736(18)30480-X","article-title":"What low back pain is and why we need to pay attention","volume":"391","author":"Hartvigsen","year":"2018","journal-title":"Lancet"},{"issue":"18","key":"10.1016\/j.ijbiomac.2023.126166_bb0010","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1056\/NEJMcp1512658","article-title":"Clinical practice. Herniated lumbar intervertebral disk","volume":"374","author":"Deyo","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijbiomac.2023.126166_bb0015","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.matbio.2018.02.025","article-title":"Glycosaminoglycan synthesis in the nucleus pulposus: dysregulation and the pathogenesis of disc degeneration","volume":"71-72","author":"Silagi","year":"2018","journal-title":"Matrix Biol."},{"issue":"3","key":"10.1016\/j.ijbiomac.2023.126166_bb0020","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/s41584-020-00568-w","article-title":"Cell-based strategies for IVD repair: clinical progress and translational obstacles","volume":"17","author":"Binch","year":"2021","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.ijbiomac.2023.126166_bb0025","doi-asserted-by":"crossref","first-page":"2166817","DOI":"10.1155\/2022\/2166817","article-title":"The role of oxidative stress in Intervertebral disc degeneration","volume":"2022","author":"Cao","year":"2022","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.ijbiomac.2023.126166_bb0030","doi-asserted-by":"crossref","first-page":"5601593","DOI":"10.1155\/2017\/5601593","article-title":"ROS: crucial intermediators in the pathogenesis of Intervertebral disc degeneration","volume":"2017","author":"Feng","year":"2017","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.ijbiomac.2023.126166_bb0035","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.ijbiomac.2021.01.072","article-title":"Interaction of artemisinin protects the activity of antioxidant enzyme catalase: a biophysical study","volume":"172","author":"Samal","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2023.126166_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.124509","article-title":"The thioredoxin expression of Cristaria plicata is regulated by Nrf2\/ARE pathway under microcystin stimulation","volume":"242","author":"Feng","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"issue":"22","key":"10.1016\/j.ijbiomac.2023.126166_bb0045","doi-asserted-by":"crossref","first-page":"5474","DOI":"10.3390\/molecules25225474","article-title":"An overview of Nrf2 signaling pathway and its role in inflammation","volume":"25","author":"Saha","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.ijbiomac.2023.126166_bb0050","doi-asserted-by":"crossref","first-page":"5558687","DOI":"10.1155\/2021\/5558687","article-title":"Ulinastatin ameliorates IL-1\u03b2-induced cell dysfunction in human nucleus pulposus cells via Nrf2\/NF-\u03baB pathway","volume":"2021","author":"Luo","year":"2021","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.ijbiomac.2023.126166_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2019.115381","article-title":"Composition, isolation, purification and biological activities of Sargassum fusiforme polysaccharides: a review","volume":"228","author":"Zhang","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2023.126166_bb0060","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.ijbiomac.2022.07.068","article-title":"Fucoidan-based nanoparticles: preparations and applications","volume":"217","author":"Venkatesan","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"issue":"4","key":"10.1016\/j.ijbiomac.2023.126166_bb0065","doi-asserted-by":"crossref","first-page":"212","DOI":"10.3390\/md18040212","article-title":"Antioxidant potential of sulfated polysaccharides from Padina boryana; protective effect against oxidative stress in in vitro and in vivo zebrafish model","volume":"18","author":"Jayawardena","year":"2020","journal-title":"Mar. Drugs."},{"key":"10.1016\/j.ijbiomac.2023.126166_bb0070","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.ijbiomac.2022.04.083","article-title":"Fucoidan isolated from fermented Sargassum fusiforme suppresses oxidative stress through stimulating the expression of superoxidase dismutase and catalase by regulating Nrf2 signaling pathway","volume":"209","author":"Wang","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"issue":"12","key":"10.1016\/j.ijbiomac.2023.126166_bb0075","doi-asserted-by":"crossref","first-page":"4050","DOI":"10.3390\/ijms19124050","article-title":"Fucoidan alleviates acetaminophen-induced hepatotoxicity via oxidative stress inhibition and Nrf2 translocation","volume":"19","author":"Wang","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ijbiomac.2023.126166_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2021.117692","article-title":"Study of fucoidans as natural biomolecules for therapeutical applications in osteoarthritis","volume":"258","author":"Vaamonde-Garc\u00eda","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2023.126166_bb0085","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.ijbiomac.2022.01.060","article-title":"Novel ROS-responsive marine biomaterial fucoidan nanocarriers with AIE effect and chemodynamic therapy","volume":"202","author":"Guo","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"issue":"3","key":"10.1016\/j.ijbiomac.2023.126166_bb0090","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1080\/09205063.2017.1413759","article-title":"Biocompatibility of subcutaneously implanted marine macromolecules cross-linked bio-composite scaffold for cartilage tissue engineering applications","volume":"29","author":"Sumayya","year":"2018","journal-title":"J. Biomater. Sci. Polym. Ed."},{"issue":"40","key":"10.1016\/j.ijbiomac.2023.126166_bb0095","doi-asserted-by":"crossref","first-page":"8181","DOI":"10.1039\/D2TB01146H","article-title":"A dynamic nano-coordination protein hydrogel for photothermal treatment and repair of infected skin injury","volume":"10","author":"Yin","year":"2022","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.ijbiomac.2023.126166_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2021.111949","article-title":"Progress of gelatin-based microspheres (GMSs) as delivery vehicles of drug and cell","volume":"122","author":"Dong","year":"2021","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"10.1016\/j.ijbiomac.2023.126166_bb0105","first-page":"304","article-title":"Synergistic antibiosis with spatiotemporal controllability based on multiple-responsive hydrogel for infectious cutaneous wound healing","volume":"3","author":"Tian","year":"2022","journal-title":"Smart Mater. Med."},{"issue":"1","key":"10.1016\/j.ijbiomac.2023.126166_bb0110","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.ijpharm.2018.06.015","article-title":"Porous microspheres: synthesis, characterisation and applications in pharmaceutical & medical fields","volume":"548","author":"Ghosh Dastidar","year":"2018","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ijbiomac.2023.126166_bb0115","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.jconrel.2018.08.019","article-title":"Intradiscal delivery of celecoxib-loaded microspheres restores intervertebral disc integrity in a preclinical canine model","volume":"286","author":"Tellegen","year":"2018","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ijbiomac.2023.126166_bb0120","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ijbiomac.2022.08.171","article-title":"Recent advances on gelatin methacrylate hydrogels with controlled microstructures for tissue engineering","volume":"221","author":"Zhang","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2023.126166_bb0125","article-title":"Vascularized pulp regeneration via injecting simvastatin functionalized GelMA cryogel microspheres loaded with stem cells from human exfoliated deciduous teeth","volume":"13","author":"Yuan","year":"2022","journal-title":"Mater. Today Bio."},{"key":"10.1016\/j.ijbiomac.2023.126166_bb0130","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.ijbiomac.2020.12.158","article-title":"Intra-articular injection of anti-inflammatory peptide-loaded glycol chitosan\/fucoidan nanogels to inhibit inflammation and attenuate osteoarthritis progression","volume":"170","author":"Li","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2023.126166_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.124510","article-title":"Marine collagen-chitosan-fucoidan\/chondroitin sulfate cryo-biomaterials loaded with primary human cells envisaging cartilage tissue engineering","volume":"241","author":"Carvalho","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2023.126166_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2021.118493","article-title":"Preparation of triamcinolone acetonide-loaded chitosan\/fucoidan hydrogel and its potential application as an oral mucosa patch","volume":"272","author":"Zheng","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2023.126166_bb0145","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.carbpol.2016.03.102","article-title":"Three dimensional alginate-fucoidan composite hydrogel augments the chondrogenic differentiation of mesenchymal stromal cells","volume":"147","author":"Karunanithi","year":"2016","journal-title":"Carbohydr. Polym."},{"issue":"6","key":"10.1016\/j.ijbiomac.2023.126166_bb0150","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/s41584-022-00783-7","article-title":"Mechanisms and clinical implications of intervertebral disc calcification","volume":"18","author":"Zehra","year":"2022","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.ijbiomac.2023.126166_bb0155","doi-asserted-by":"crossref","first-page":"227","DOI":"10.22203\/eCM.v039a15","article-title":"Intervertebral disc and endplate cells response to IL-1\u03b2 inflammatory cell priming and identification of molecular targets of tissue degeneration","volume":"39","author":"De Luca","year":"2020","journal-title":"Eur. Cell. Mater."},{"key":"10.1016\/j.ijbiomac.2023.126166_bb0160","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.ijbiomac.2022.10.255","article-title":"Fucoidan-gelatin wound dressing accelerates wound healing by enhancing antibacterial and anti-inflammatory activities","volume":"223","author":"Lu","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"issue":"6","key":"10.1016\/j.ijbiomac.2023.126166_bb0165","doi-asserted-by":"crossref","first-page":"328","DOI":"10.3390\/md18060328","article-title":"Fucoidan isolated from Saccharina japonica inhibits LPS-induced inflammation in macrophages via blocking NF-\u03baB, MAPK and JAK-STAT pathways","volume":"18","author":"Ye","year":"2020","journal-title":"Mar. Drugs."},{"issue":"9","key":"10.1016\/j.ijbiomac.2023.126166_bb0170","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1089\/jmf.2014.3334","article-title":"Fucoidan prevents the progression of osteoarthritis in rats","volume":"18","author":"Lee","year":"2015","journal-title":"J. Med. Food"},{"key":"10.1016\/j.ijbiomac.2023.126166_bb0175","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.actbio.2022.05.054","article-title":"Fucoidan-loaded nanofibrous scaffolds promote annulus fibrosus repair by ameliorating the inflammatory and oxidative microenvironments in degenerative intervertebral discs","volume":"148","author":"Yu","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.ijbiomac.2023.126166_bb0180","doi-asserted-by":"crossref","first-page":"1984742","DOI":"10.1155\/2022\/1984742","article-title":"Oxidative stress and Intervertebral disc degeneration: pathophysiology, signaling pathway, and therapy","volume":"2022","author":"Li","year":"2022","journal-title":"Oxidative Med. Cell. Longev."},{"issue":"2","key":"10.1016\/j.ijbiomac.2023.126166_bb0185","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/ni.1831","article-title":"Thioredoxin-interacting protein links oxidative stress to inflammasome activation","volume":"11","author":"Zhou","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.ijbiomac.2023.126166_bb0190","doi-asserted-by":"crossref","first-page":"6681815","DOI":"10.1155\/2021\/6681815","article-title":"Reactive oxygen species mediate low Back pain by upregulating substance P in Intervertebral disc degeneration","volume":"2021","author":"Zheng","year":"2021","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.ijbiomac.2023.126166_bb0195","doi-asserted-by":"crossref","first-page":"5608133","DOI":"10.1155\/2021\/5608133","article-title":"Programmed NP cell death induced by mitochondrial ROS in a one-strike loading disc degeneration organ culture model","volume":"2021","author":"Li","year":"2021","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.ijbiomac.2023.126166_bb0200","doi-asserted-by":"crossref","first-page":"89","DOI":"10.22203\/eCM.v030a07","article-title":"Oxidative stress inhibits the proliferation, induces premature senescence and promotes a catabolic phenotype in human nucleus pulposus intervertebral disc cells","volume":"30","author":"Dimozi","year":"2015","journal-title":"Eur. Cell. Mater."},{"issue":"7","key":"10.1016\/j.ijbiomac.2023.126166_bb0205","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1038\/s41419-019-1701-3","article-title":"Nrf2 drives oxidative stress-induced autophagy in nucleus pulposus cells via a Keap1\/Nrf2\/p62 feedback loop to protect intervertebral disc from degeneration","volume":"10","author":"Tang","year":"2019","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.ijbiomac.2023.126166_bb0210","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1186\/s13075-022-02876-w","article-title":"Targeting clock-controlled gene Nrf2 ameliorates inflammation-induced intervertebral disc degeneration","volume":"24","author":"Peng","year":"2022","journal-title":"Arthritis. Res. Ther."},{"issue":"Pt A","key":"10.1016\/j.ijbiomac.2023.126166_bb0215","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.ijbiomac.2022.04.083","article-title":"Fucoidan isolated from fermented Sargassum fusiforme suppresses oxidative stress through stimulating the expression of superoxidase dismutase and catalase by regulating Nrf2 signaling pathway","volume":"209","author":"Wang","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"issue":"3","key":"10.1016\/j.ijbiomac.2023.126166_bb0220","doi-asserted-by":"crossref","first-page":"568","DOI":"10.3390\/nu15030568","article-title":"Molecular mechanism of Fucoidan nanoparticles as protector on endothelial cell dysfunction in diabetic Rats\u2019 aortas","volume":"15","author":"Wardani","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.ijbiomac.2023.126166_bb0225","article-title":"Precision medicine strategies for spinal degenerative diseases: injectable biomaterials with in situ repair and regeneration","volume":"16","author":"Zhao","year":"2022","journal-title":"Mater. Today Bio."},{"key":"10.1016\/j.ijbiomac.2023.126166_bb0230","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.ijbiomac.2022.11.133","article-title":"Sustain release of loaded insulin within biomimetic hydrogel microsphere for sciatic tissue engineering in vivo","volume":"225","author":"Zolfagharzadeh","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2023.126166_bb0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.121102","article-title":"Fucoidan-functionalized polysaccharide submicroparticles loaded with alteplase for efficient targeted thrombolytic therapy","volume":"277","author":"Zenych","year":"2021","journal-title":"Biomaterials"},{"issue":"534","key":"10.1016\/j.ijbiomac.2023.126166_bb0240","doi-asserted-by":"crossref","first-page":"eaay2380","DOI":"10.1126\/scitranslmed.aay2380","article-title":"Combined nucleus pulposus augmentation and annulus fibrosus repair prevents acute intervertebral disc degeneration after discectomy","volume":"12","author":"Sloan","year":"2020","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.ijbiomac.2023.126166_bb0245","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.ijbiomac.2022.12.046","article-title":"Tomato based gelatin methacryloyl hydrogel as an effective natural and low-cost scaffold for accelerative wound healing","volume":"229","author":"Fang","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2023.126166_bb0250","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.biomaterials.2015.08.045","article-title":"Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels","volume":"73","author":"Yue","year":"2015","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.ijbiomac.2023.126166_bb0255","doi-asserted-by":"crossref","DOI":"10.1088\/1758-5090\/abc4d3","article-title":"Growth differentiation factor-5-gelatin methacryloyl injectable microspheres laden with adipose-derived stem cells for repair of disc degeneration","volume":"13","author":"Xu","year":"2020","journal-title":"Biofabrication"},{"key":"10.1016\/j.ijbiomac.2023.126166_bb0260","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/j.ijbiomac.2022.12.308","article-title":"Injectable carboxymethyl chitosan\/nanosphere-based hydrogel with dynamic crosslinking network for efficient lubrication and sustained drug release","volume":"229","author":"Yang","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2023.126166_bb0265","first-page":"535","article-title":"Fucoidan and topography modification improved in situ endothelialization on acellular synthetic vascular grafts","volume":"22","author":"Yao","year":"2023","journal-title":"Bioact. Mater."},{"issue":"1","key":"10.1016\/j.ijbiomac.2023.126166_bb0270","first-page":"179","article-title":"A 3D-bioprinted dual growth factor-releasing intervertebral disc scaffold induces nucleus pulposus and annulus fibrosus reconstruction","volume":"6","author":"Sun","year":"2020","journal-title":"Bioact. Mater."}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813023030623?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813023030623?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T20:47:47Z","timestamp":1785790067000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0141813023030623"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":54,"alternative-id":["S0141813023030623"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2023.126166","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fucoidan-functionalized gelatin methacryloyl microspheres ameliorate intervertebral disc degeneration by restoring redox and matrix homeostasis of nucleus pulposus","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2023.126166","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"126166"}}