{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T07:27:33Z","timestamp":1790148453659,"version":"4.0.1"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81903723"],"award-info":[{"award-number":["81903723"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81974509"],"award-info":[{"award-number":["81974509"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82074111"],"award-info":[{"award-number":["82074111"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.ijbiomac.2023.128016","type":"journal-article","created":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T11:32:21Z","timestamp":1699875141000},"page":"128016","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"P2","title":["Protective effect of Angelica sinensis polysaccharide on pregnant rats suffering from iron deficiency anemia via regulation of the hepcidin-FPN1 axis"],"prefix":"10.1016","volume":"256","author":[{"given":"Yu","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihao","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinglin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Mei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.ijbiomac.2023.128016_bb0005","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.mcna.2016.09.004","article-title":"Iron deficiency anemia","volume":"101","author":"Deloughery","year":"2017","journal-title":"Med. Clin. North Am."},{"issue":"14","key":"10.1016\/j.ijbiomac.2023.128016_bb0010","doi-asserted-by":"crossref","first-page":"2976","DOI":"10.3390\/nu14142976","article-title":"Iron deficiency anemia: efficacy and limitations of nutritional and comprehensive mitigation strategies","volume":"14","author":"Kumar","year":"2022","journal-title":"Nutrients"},{"issue":"11","key":"10.1016\/j.ijbiomac.2023.128016_bb0015","doi-asserted-by":"crossref","DOI":"10.1172\/JCI148671","article-title":"Ironing out mechanisms of iron homeostasis and disorders of iron deficiency","volume":"131","author":"Koleini","year":"2021","journal-title":"J. Clin. Invest."},{"issue":"4","key":"10.1016\/j.ijbiomac.2023.128016_bb0020","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.fertnstert.2022.08.850","article-title":"Iron deficiency anemia: impact on women\u2019s reproductive health","volume":"118","author":"Petraglia","year":"2022","journal-title":"Fertil. Steril."},{"issue":"Suppl. 6","key":"10.1016\/j.ijbiomac.2023.128016_bb0025","doi-asserted-by":"crossref","first-page":"1655S","DOI":"10.3945\/ajcn.117.156000","article-title":"Iron status in pregnant women and women of reproductive age in Europe","volume":"106","author":"Milman","year":"2017","journal-title":"Am. J. Clin. Nutr."},{"issue":"1","key":"10.1016\/j.ijbiomac.2023.128016_bb0030","doi-asserted-by":"crossref","first-page":"e16","DOI":"10.1016\/S2214-109X(13)70001-9","article-title":"Global, regional, and national trends in hemoglobin concentration and prevalence of total and severe anemia in children and pregnant and non-pregnant women for 1995\u20132011: a systematic analysis of population-representative data","volume":"1","author":"Stevens","year":"2013","journal-title":"Lancet Glob. Health"},{"issue":"4","key":"10.1016\/j.ijbiomac.2023.128016_bb0035","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.ajog.2020.03.006","article-title":"Iron deficiency in pregnancy","volume":"223","author":"Georgieff","year":"2020","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"2","key":"10.1016\/j.ijbiomac.2023.128016_bb0040","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1002\/ajh.25341","article-title":"Iron homeostasis in pregnancy and spontaneous abortion","volume":"94","author":"Guo","year":"2019","journal-title":"Am. J. Hematol."},{"issue":"3","key":"10.1016\/j.ijbiomac.2023.128016_bb0045","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1159\/000495978","article-title":"Perinatal iron deficiency: implications for mothers and infants","volume":"115","author":"Juul","year":"2019","journal-title":"Neonatology"},{"issue":"1\u20132","key":"10.1016\/j.ijbiomac.2023.128016_bb0050","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.mrfmmm.2006.06.013","article-title":"Lymphocyte DNA damage and oxidative stress in patients with iron deficiency anemia","volume":"601","author":"Aslan","year":"2006","journal-title":"Mutat. Res. Fundam. Mol. Mech. Mutagen."},{"issue":"3","key":"10.1016\/j.ijbiomac.2023.128016_bb0055","doi-asserted-by":"crossref","first-page":"543","DOI":"10.3390\/nu14030543","article-title":"Comparative effects between oral lactoferrin and ferrous sulfate supplementation on iron-deficiency anemia: a comprehensive review and meta-analysis of clinical trials","volume":"14","author":"Zhao","year":"2022","journal-title":"Nutrients"},{"issue":"4","key":"10.1016\/j.ijbiomac.2023.128016_bb0060","first-page":"CD4905","article-title":"Multiple-micronutrient supplementation for women during pregnancy","volume":"4","author":"Haider","year":"2017","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.ijbiomac.2023.128016_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.mam.2020.100865","article-title":"Oral iron supplementation in iron-deficient women: how much and how often?","volume":"75","author":"Stoffel","year":"2020","journal-title":"Mol. Asp. Med."},{"issue":"3","key":"10.1016\/j.ijbiomac.2023.128016_bb0070","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.jtemb.2007.06.002","article-title":"On risks and benefits of iron supplementation recommendations for iron intake revisited","volume":"21","author":"Sch\u00fcmann","year":"2007","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.ijbiomac.2023.128016_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115446","article-title":"The comparison of preliminary structure and intestinal anti-inflammatory and anti-oxidative activities of polysaccharides from different root parts of Angelica sinensis (oliv.) Diels","volume":"295","author":"Zou","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.ijbiomac.2023.128016_bb0080","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1016\/j.ijbiomac.2021.05.213","article-title":"Extraction, structure, pharmacological activities and drug carrier applications of Angelica sinensis polysaccharide","volume":"183","author":"Nai","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"issue":"1","key":"10.1016\/j.ijbiomac.2023.128016_bb0085","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1080\/13880209.2023.2207592","article-title":"Angelica sinensis polysaccharides alleviate the oxidative burden on hematopoietic cells by restoring 5-fluorouracil-induced oxidative damage in perivascular mesenchymal progenitor cells","volume":"61","author":"Niu","year":"2023","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.ijbiomac.2023.128016_bb0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2017\/7601592","article-title":"Acidic polysaccharide from Angelica sinensis reverses anemia of chronic disease involving the suppression of inflammatory hepcidin and NF-\u03baB activation","volume":"2017","author":"Wang","year":"2017","journal-title":"Oxidative Med. Cell. Longev."},{"issue":"3","key":"10.1016\/j.ijbiomac.2023.128016_bb0095","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1016\/j.jep.2011.02.015","article-title":"Inhibitory effect of polysaccharides isolated from Angelica sinensis on hepcidin expression","volume":"134","author":"Wang","year":"2011","journal-title":"J. Ethnopharmacol."},{"issue":"7","key":"10.1016\/j.ijbiomac.2023.128016_bb0100","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1039\/c4fo00006d","article-title":"The action of JAK, SMAD and ERK signal pathways on hepcidin suppression by polysaccharides from Angelica sinensis in rats with iron deficiency anemia","volume":"5","author":"Zhang","year":"2014","journal-title":"Food Funct."},{"issue":"1","key":"10.1016\/j.ijbiomac.2023.128016_bb0105","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.cell.2010.06.028","article-title":"Two to tango: regulation of mammalian iron metabolism","volume":"142","author":"Hentze","year":"2010","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.ijbiomac.2023.128016_bb0110","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1002\/ajh.26152","article-title":"Marginally reduced maternal hepatic and splenic ferroportin under severe nutritional iron deficiency in pregnancy maintains systemic iron supply","volume":"96","author":"Mazgaj","year":"2021","journal-title":"Am. J. Hematol."},{"issue":"1","key":"10.1016\/j.ijbiomac.2023.128016_bb0115","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1002\/ajh.26001","article-title":"Cell-type-specific insights into iron regulatory processes","volume":"96","author":"Mleczko-Sanecka","year":"2021","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.ijbiomac.2023.128016_bb0120","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.pharmthera.2014.09.004","article-title":"The iron-regulatory hormone hepcidin: a possible therapeutic target?","volume":"146","author":"Rochette","year":"2015","journal-title":"Pharmacol. Ther."},{"issue":"8","key":"10.1016\/j.ijbiomac.2023.128016_bb0125","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1182\/blood.2020008986","article-title":"RNF217 regulates iron homeostasis through its E3 ubiquitin ligase activity by modulating ferroportin degradation","volume":"138","author":"Jiang","year":"2021","journal-title":"Blood"},{"issue":"10","key":"10.1016\/j.ijbiomac.2023.128016_bb0130","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1089\/jmf.2012.2231","article-title":"Polysaccharide isolated from Angelica sinensis inhibits hepcidin expression in rats with iron deficiency anemia","volume":"15","author":"Liu","year":"2012","journal-title":"J. Med. Food"},{"key":"10.1016\/j.ijbiomac.2023.128016_bb0135","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.ijbiomac.2020.06.166","article-title":"Angelica sinensis polysaccharide attenuates CCl4-induced liver fibrosis via the IL-22\/STAT3 pathway","volume":"162","author":"Wang","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"issue":"79","key":"10.1016\/j.ijbiomac.2023.128016_bb0140","doi-asserted-by":"crossref","first-page":"50378","DOI":"10.1039\/C7RA09576G","article-title":"Silkworm feces extract improves iron deficiency anemia via suppressing hepcidin expression and promoting iron-regulatory proteins expression","volume":"7","author":"Huang","year":"2017","journal-title":"RSC Adv."},{"issue":"2","key":"10.1016\/j.ijbiomac.2023.128016_bb0145","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s12011-015-0412-6","article-title":"Effects of a tripeptide iron on iron-deficiency anemia in rats","volume":"169","author":"Xiao","year":"2016","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.ijbiomac.2023.128016_bb0150","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.carbpol.2016.09.011","article-title":"Bioactive potential and structural chracterization of sulfated polysaccharide from seaweed (Gracilaria corticata)","volume":"155","author":"Seedevi","year":"2017","journal-title":"Carbohydr. Polym."},{"issue":"1","key":"10.1016\/j.ijbiomac.2023.128016_bb0155","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.carbpol.2011.07.011","article-title":"Determination of the structural changes by FT-IR, Raman, and CP\/MAS 13C NMR spectroscopy on retrograded starch of maize tortillas","volume":"87","author":"Flores-Morales","year":"2012","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2023.128016_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2022.119457","article-title":"Extraction, isolation, structural characterization and prebiotic activity of cell wall polysaccharide from Kluyveromyces marxianus","volume":"289","author":"Tang","year":"2022","journal-title":"Carbohydr. Polym."},{"issue":"11\u221212","key":"10.1016\/j.ijbiomac.2023.128016_bb0165","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/j.nut.2008.05.012","article-title":"Influence of nutritional iron deficiency anemia on DNA stability and lipid peroxidation in rats","volume":"24","author":"D\u00edaz-Castro","year":"2008","journal-title":"Nutrition"},{"issue":"18","key":"10.1016\/j.ijbiomac.2023.128016_bb0170","doi-asserted-by":"crossref","first-page":"3627","DOI":"10.1182\/blood-2010-03-271791","article-title":"Down-regulation of hepcidin resulting from long-term treatment with an anti-IL-6 receptor antibody (tocilizumab) improves anemia of inflammation in multicentric Castleman disease","volume":"116","author":"Song","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.ijbiomac.2023.128016_bb0175","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2022.997006","article-title":"Food-derived bioactive oligopeptide iron complexes ameliorate iron deficiency anemia and offspring development in pregnant rats","volume":"9","author":"Pan","year":"2022","journal-title":"Front. Nutr."},{"issue":"3","key":"10.1016\/j.ijbiomac.2023.128016_bb0180","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.carbpol.2012.04.049","article-title":"Isolation, structure and bioactivities of the polysaccharides from Angelica sinensis (oliv.) Diels: a review","volume":"89","author":"Jin","year":"2012","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2023.128016_bb0190","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.ijbiomac.2017.12.033","article-title":"A novel low molecular weight Enteromorpha polysaccharide-iron (III) complex and its effect on rats with iron deficiency anemia (IDA)","volume":"108","author":"Cui","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"issue":"3","key":"10.1016\/j.ijbiomac.2023.128016_bb0195","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1017\/S0029665121001944","article-title":"Iron, iodine and vitamin D deficiencies during pregnancy: epidemiology, risk factors and developmental impacts","volume":"80","author":"Kiely","year":"2021","journal-title":"Proc. Nutr. Soc."},{"issue":"12","key":"10.1016\/j.ijbiomac.2023.128016_bb0200","doi-asserted-by":"crossref","DOI":"10.1210\/endocr\/bqab215","article-title":"Maternal iron deficiency alters trophoblast differentiation and placental development in rat pregnancy","volume":"162","author":"Roberts","year":"2021","journal-title":"Endocrinology"},{"issue":"9","key":"10.1016\/j.ijbiomac.2023.128016_bb0205","doi-asserted-by":"crossref","first-page":"4591","DOI":"10.3390\/ijms22094591","article-title":"On iron metabolism and its regulation","volume":"22","author":"Vogt","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.ijbiomac.2023.128016_bb0210","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.3390\/nu12051336","article-title":"Role of fermented goat milk on liver gene and protein profiles related to iron metabolism during anemia recovery","volume":"12","author":"Moreno-Fernandez","year":"2020","journal-title":"Nutrients"},{"issue":"9","key":"10.1016\/j.ijbiomac.2023.128016_bb0215","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1039\/C8RA08451C","article-title":"Effectiveness of AOS-iron on iron deficiency anemia in rats","volume":"9","author":"He","year":"2019","journal-title":"RSC Adv."},{"issue":"5704","key":"10.1016\/j.ijbiomac.2023.128016_bb0220","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1126\/science.1104742","article-title":"Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization","volume":"306","author":"Nemeth","year":"2004","journal-title":"Science"},{"issue":"8","key":"10.1016\/j.ijbiomac.2023.128016_bb0225","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1182\/blood-2017-05-786590","article-title":"Structure-function analysis of ferroportin defines the binding site and an alternative mechanism of action of hepcidin","volume":"131","author":"Aschemeyer","year":"2018","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.ijbiomac.2023.128016_bb0230","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1136\/gut.2007.131722","article-title":"Evidence for differential effects of hepcidin in macrophages and intestinal epithelial cells","volume":"57","author":"Chaston","year":"2008","journal-title":"Gut"},{"issue":"3","key":"10.1016\/j.ijbiomac.2023.128016_bb0235","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.tips.2014.01.004","article-title":"The pathophysiology and pharmacology of hepcidin","volume":"35","author":"Ruchala","year":"2014","journal-title":"Trends Pharmacol. Sci."},{"issue":"9B","key":"10.1016\/j.ijbiomac.2023.128016_bb0240","doi-asserted-by":"crossref","first-page":"3091","DOI":"10.1111\/j.1582-4934.2008.00494.x","article-title":"Hepcidin suppression and defective iron recycling account for dysregulation of iron homeostasis in heme oxygenase-1 deficiency","volume":"13","author":"Kartikasari","year":"2009","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.ijbiomac.2023.128016_bb0245","article-title":"The cardinal roles of ferroportin and its partners in controlling cellular iron in and out","volume":"258","author":"Yang","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.ijbiomac.2023.128016_bb0250","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1146\/annurev.nutr.012809.104801","article-title":"Iron-sensing proteins that regulate hepcidin and enteric iron absorption","volume":"30","author":"Knutson","year":"2010","journal-title":"Annu. Rev. Nutr."},{"issue":"4","key":"10.1016\/j.ijbiomac.2023.128016_bb0255","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.jcmgh.2018.06.006","article-title":"Severe iron metabolism defects in mice with double knockout of the multicopper ferroxidases hephaestin and ceruloplasmin","volume":"6","author":"Fuqua","year":"2018","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.ijbiomac.2023.128016_bb0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101209","article-title":"IL-1 beta-mediated macrophage-hepatocyte crosstalk upregulates hepcidin under physiological low oxygen levels","volume":"24","author":"Silva","year":"2019","journal-title":"Redox Biol."},{"issue":"6","key":"10.1016\/j.ijbiomac.2023.128016_bb0265","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/j.jhep.2005.10.025","article-title":"Hepcidin generated by hepatoma cells inhibits iron export from co-cultured THP1 monocytes","volume":"44","author":"Andriopoulos","year":"2006","journal-title":"J. Hepatol."},{"issue":"8","key":"10.1016\/j.ijbiomac.2023.128016_bb0270","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.3945\/jn.108.102905","article-title":"Hepcidin decreases iron transporter expression in vivo in mouse duodenum and spleen and in vitro in THP-1 macrophages and intestinal Caco-2 cells","volume":"139","author":"Chung","year":"2009","journal-title":"J. Nutr."},{"issue":"1","key":"10.1016\/j.ijbiomac.2023.128016_bb0275","doi-asserted-by":"crossref","first-page":"G192","DOI":"10.1152\/ajpgi.00122.2007","article-title":"Hepcidin inhibits apical iron uptake in intestinal cells","volume":"294","author":"Mena","year":"2008","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"issue":"4","key":"10.1016\/j.ijbiomac.2023.128016_bb0280","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1053\/j.gastro.2010.12.037","article-title":"Intestinal DMT1 cotransporter is down-regulated by hepcidin via proteasome internalization and degradation","volume":"140","author":"Brasse Lagnel","year":"2011","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.ijbiomac.2023.128016_bb0285","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1172\/JCI122359","article-title":"Hepatic hepcidin\/intestinal HIF-2\u03b1 axis maintains iron absorption during iron deficiency and overload","volume":"129","author":"Schwartz","year":"2019","journal-title":"J. Clin. Invest."}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813023049152?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813023049152?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T11:05:09Z","timestamp":1758884709000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0141813023049152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":56,"alternative-id":["S0141813023049152"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2023.128016","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protective effect of Angelica sinensis polysaccharide on pregnant rats suffering from iron deficiency anemia via regulation of the hepcidin-FPN1 axis","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2023.128016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"128016"}}