{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T01:40:30Z","timestamp":1794447630029,"version":"4.9.1"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100012021","name":"Iran University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012021","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.ijbiomac.2024.130141","type":"journal-article","created":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T04:43:00Z","timestamp":1707885780000},"page":"130141","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"special_numbering":"P2","title":["Alginate hydrogel-PCL\/gelatin nanofibers composite scaffold containing mesenchymal stem cells-derived exosomes sustain release for regeneration of tympanic membrane perforation"],"prefix":"10.1016","volume":"262","author":[{"given":"Hadi","family":"Chahsetareh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Yazdian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad","family":"Pezeshki-Modaress","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Aleemardani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sajad","family":"Hassanzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roghayeh","family":"Najafi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Simorgh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vajihe","family":"Taghdiri Nooshabadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zohreh","family":"Bagher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Mohammad","family":"Davachi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijbiomac.2024.130141_bb0005","series-title":"Anatomy, Head and Neck, Ear Tympanic Membrane","author":"Szymanski","year":"2023"},{"key":"10.1016\/j.ijbiomac.2024.130141_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.127128","article-title":"Fabrication and optimization of multilayered composite scaffold made of sulfated alginate-based nanofiber\/decellularized Wharton\u2019s jelly ECM for tympanic membrane tissue engineering","volume":"253","author":"Najafi","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2024.130141_bb0015","first-page":"1","article-title":"Can tissue engineering bring hope to the development of human tympanic membrane?","author":"Aleemardani","year":"2021","journal-title":"Tissue Eng. Part B Rev."},{"issue":"5","key":"10.1016\/j.ijbiomac.2024.130141_bb0020","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1097\/01.mlg.0000208549.44462.fa","article-title":"Tissue-engineered calcium alginate patches in the repair of chronic chinchilla tympanic membrane perforations","volume":"116","author":"Weber","year":"2006","journal-title":"Laryngoscope"},{"key":"10.1016\/j.ijbiomac.2024.130141_bb0025","series-title":"Tissue Engineering Made Easy","author":"Akter","year":"2016"},{"issue":"1","key":"10.1016\/j.ijbiomac.2024.130141_bb0030","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0144-8617(02)00258-8","article-title":"Preparation and in vitro anticoagulant activities of alginate sulfate and its quaterized derivatives","volume":"52","author":"Ronghua","year":"2003","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2024.130141_bb0035","doi-asserted-by":"crossref","unstructured":"B. Pishva, J. Nourmohammadi, and S. Hesaraki, \u201cGallic acid-grafted hybrid strontium fluoride\/ polycaprolactone nanocomposite fibers for bone regeneration,\u201d Prog. Org. Coatings, vol. 170, p. 106976, Sep. 2022, doi:https:\/\/doi.org\/10.1016\/j.porgcoat.2022.106976.","DOI":"10.1016\/j.porgcoat.2022.106976"},{"issue":"34","key":"10.1016\/j.ijbiomac.2024.130141_bb0040","doi-asserted-by":"crossref","first-page":"4532","DOI":"10.1016\/j.biomaterials.2008.08.007","article-title":"Electrospun poly(\u03b5-caprolactone)\/gelatin nanofibrous scaffolds for nerve tissue engineering","volume":"29","author":"Ghasemi-Mobarakeh","year":"2008","journal-title":"Biomaterials"},{"key":"10.1016\/j.ijbiomac.2024.130141_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.127227","article-title":"Modeling and optimization of poly(lactic acid)\/poly(\u2107-caprolactone)\/Nigella sativa extract nanofibers production for skin wounds healing by artificial neural network and response surface methodology models","volume":"253","author":"Sharifi","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"issue":"5","key":"10.1016\/j.ijbiomac.2024.130141_bb0050","article-title":"Protein-based hydrogels: promising materials for","volume":"14","author":"Davari","year":"2022","journal-title":"Tissue Eng."},{"key":"10.1016\/j.ijbiomac.2024.130141_bb0055","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.msec.2017.04.084","article-title":"Electrospun PCL\/gelatin composite nanofiber structures for effective guided bone regeneration membranes","volume":"78","author":"Ren","year":"2017","journal-title":"Mater. Sci. Eng. C"},{"issue":"6","key":"10.1016\/j.ijbiomac.2024.130141_bb0060","first-page":"1","article-title":"Synthesis of nanobentonite\u2013poly(vinyl alcohol)\u2013bacterial cellulose nanocomposite by electrospinning for wound healing applications","volume":"217","author":"Zeaiean Firouzabadi","year":"2020","journal-title":"Phys. Status Solidi Appl. Mater. Sci."},{"issue":"April","key":"10.1016\/j.ijbiomac.2024.130141_bb0065","article-title":"Silk-derived oxygen-generating electrospun patches for enhancing tissue regeneration: investigation of calcium peroxide role and its effects on controlled oxygen delivery","volume":"14","author":"Aleemardani","year":"2020","journal-title":"Materialia"},{"key":"10.1016\/j.ijbiomac.2024.130141_bb0070","doi-asserted-by":"crossref","unstructured":"I. Ullah, R. B. Subbarao, and G. J. Rho, \u201cHuman mesenchymal stem cells - current trends and future prospective,\u201d Bioscience Reports, vol. 35.2015, doi:https:\/\/doi.org\/10.1042\/BSR20150025.","DOI":"10.1042\/BSR20150025"},{"issue":"21","key":"10.1016\/j.ijbiomac.2024.130141_bb0075","doi-asserted-by":"crossref","first-page":"3558","DOI":"10.1039\/C7LC00592J","article-title":"Microfluidics for exosome isolation and analysis: enabling liquid biopsy for personalized medicine","volume":"17","author":"Contreras-Naranjo","year":"2017","journal-title":"Lab Chip"},{"issue":"6","key":"10.1016\/j.ijbiomac.2024.130141_bb0080","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/ncb1596","article-title":"Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells","volume":"9","author":"Valadi","year":"2007","journal-title":"Nat. Cell Biol."},{"issue":"12","key":"10.1016\/j.ijbiomac.2024.130141_bb0085","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1016\/j.joca.2016.06.022","article-title":"Exosomes derived from human embryonic mesenchymal stem cells promote osteochondral regeneration","volume":"24","author":"Zhang","year":"2016","journal-title":"Osteoarthr. Cartil."},{"issue":"1","key":"10.1016\/j.ijbiomac.2024.130141_bb0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-020-14887-9","article-title":"Fiber reinforced GelMA hydrogel to induce the regeneration of corneal stroma","volume":"11","author":"Kong","year":"2020","journal-title":"Nat. Commun."},{"issue":"7","key":"10.1016\/j.ijbiomac.2024.130141_bb0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/nano8070551","article-title":"Nanostructured hydrogels by blend electrospinning of polycaprolactone\/gelatin nanofibers","volume":"8","author":"Daelemans","year":"2018","journal-title":"Nanomaterials"},{"key":"10.1016\/j.ijbiomac.2024.130141_bb0100","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.ijbiomac.2020.11.199","article-title":"Alginate-magnetic short nanofibers 3D composite hydrogel enhances the encapsulated human olfactory mucosa stem cells bioactivity for potential nerve regeneration application","volume":"167","author":"Karimi","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2024.130141_bb0105","doi-asserted-by":"crossref","unstructured":"P. Zare et al., \u201cAlginate sulfate-based hydrogel\/nanofiber composite scaffold with controlled Kartogenin delivery for tissue engineering,\u201d Carbohydr. Polym., vol. 266, p. 118123, Apr. 2021, doi:https:\/\/doi.org\/10.1016\/j.carbpol.2021.118123.","DOI":"10.1016\/j.carbpol.2021.118123"},{"key":"10.1016\/j.ijbiomac.2024.130141_bb0110","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.procbio.2023.11.018","article-title":"Nanofiber\/hydrogel composite scaffolds based on alginate sulfate and extra- cellular matrix for cartilage tissue engineering applications","volume":"136","author":"Azarsa","year":"2024","journal-title":"Process Biochem."},{"issue":"31","key":"10.1016\/j.ijbiomac.2024.130141_bb0115","doi-asserted-by":"crossref","first-page":"2203096","DOI":"10.1002\/advs.202203096","article-title":"Structural color medical patch with surface dual-properties of wet bioadhesion and slipperiness","volume":"9","author":"Kong","year":"2022","journal-title":"Adv. Sci."},{"issue":"2","key":"10.1016\/j.ijbiomac.2024.130141_bb0120","doi-asserted-by":"crossref","first-page":"2798","DOI":"10.1007\/s12274-022-4936-8","article-title":"Natural biopolymers derived hydrogels with injectable, self-healing, and tissue adhesive abilities for wound healing","volume":"16","author":"Kong","year":"2023","journal-title":"Nano Res."},{"key":"10.1016\/j.ijbiomac.2024.130141_bb0125","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.ijbiomac.2019.03.208","article-title":"Tough, hybrid chondroitin sulfate nanofibers as a promising scaffold for skin tissue engineering","volume":"132","author":"Sadeghi","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"issue":"11","key":"10.1016\/j.ijbiomac.2024.130141_bb0130","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1002\/jbm.a.36959","article-title":"Impact of exosome-loaded chitosan hydrogel in wound repair and layered dermal reconstitution in mice animal model","volume":"108","author":"Nooshabadi","year":"2020","journal-title":"J. Biomed. Mater. Res. - Part A"},{"issue":"3","key":"10.1016\/j.ijbiomac.2024.130141_bb0135","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1002\/jbm.a.36835","article-title":"Exosome loaded alginate hydrogel promotes tissue regeneration in full-thickness skin wounds: an in vivo study","volume":"108","author":"Shafei","year":"2020","journal-title":"J. Biomed. Mater. Res. Part A"},{"issue":"1","key":"10.1016\/j.ijbiomac.2024.130141_bb0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-022-13002-w","article-title":"Nanofibrous materials affect the reaction of cyto- toxicity assays","volume":"12","author":"Podg\u00f3rski","year":"2022","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.ijbiomac.2024.130141_bb0145","doi-asserted-by":"crossref","DOI":"10.3390\/bioengineering10040394","article-title":"Investigation of the in vitro and in vivo biocompatibility of a three-dimensional printed thermoplastic polyurethane\/Polylactic acid blend for the development of tracheal scaffolds","volume":"10","author":"Abdul Samat","year":"2023","journal-title":"Bioengineering"},{"issue":"7","key":"10.1016\/j.ijbiomac.2024.130141_bb0150","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1080\/00914037.2014.945208","article-title":"Electrospinning and structure of bicomponent poly- caprolactone\/gelatin nanofibers obtained using alternative solvent system","volume":"64","author":"Denis","year":"2015","journal-title":"Int. J. Polym. Mater. Polym. Biomater."},{"key":"10.1016\/j.ijbiomac.2024.130141_bb0155","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.polymdegradstab.2016.05.022","article-title":"Biodegradation of bicomponent PCL\/gelatin and PCL\/collagen nanofibers electrospun from alternative solvent system","volume":"130","author":"Dulnik","year":"2016","journal-title":"Polym. Degrad. Stab."},{"issue":"7","key":"10.1016\/j.ijbiomac.2024.130141_bb0160","doi-asserted-by":"crossref","DOI":"10.3390\/polym14071311","article-title":"Gelatin blends enhance performance of electrospun polymeric scaffolds in comparison to coating protocols","volume":"14","author":"Bikuna-Izagirre","year":"2022","journal-title":"Polymers (Basel)."},{"issue":"1","key":"10.1016\/j.ijbiomac.2024.130141_bb0165","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1080\/00914037.2017.1297939","article-title":"Fabrication and characterization of poly(\u03b5-caprolactone)\/gelatin nanofibrous scaffolds for retinal tissue engineering","volume":"67","author":"Rahmani","year":"2018","journal-title":"Int. J. Polym. Mater. Polym. Biomater."},{"key":"10.1016\/j.ijbiomac.2024.130141_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2017.04.095","article-title":"Fabrication, optimization and characteri- zation of electrospun poly(caprolactone)\/gelatin\/graphene nanofibrous mats","author":"Heidari","year":"2017","journal-title":"Mater. Sci. Eng. C"},{"issue":"3","key":"10.1016\/j.ijbiomac.2024.130141_bb0175","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1016\/j.msec.2012.12.015","article-title":"Fabrication and characterization of PCL\/gelatin composite nano fi brous scaffold for tissue engineering applications by electrospinning method","volume":"33","author":"Gautam","year":"2013","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.ijbiomac.2024.130141_bb0180","doi-asserted-by":"crossref","first-page":"3323","DOI":"10.1016\/j.ijbiomac.2020.08.233","article-title":"Alginate hydrogel containing hydrogen sulfide as the functional wound dressing material: in vitro and in vivo study","volume":"164","author":"Nazarnezhada","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"issue":"4","key":"10.1016\/j.ijbiomac.2024.130141_bb0185","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1080\/09205063.2013.859872","article-title":"PCL-gelatin composite nanofibers electrospun using diluted acetic acid-ethyl acetate solvent system for stem cell-based bone tissue engineering","volume":"25","author":"Binulal","year":"2014","journal-title":"J. Biomater. Sci. Polym. Ed."},{"issue":"6","key":"10.1016\/j.ijbiomac.2024.130141_bb0190","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/pharmaceutics12060504","article-title":"Mucoadhesive electrospun fibre-based technologies for oral medicine","volume":"12","author":"Edmans","year":"2020","journal-title":"Pharmaceutics"},{"issue":"34","key":"10.1016\/j.ijbiomac.2024.130141_bb0195","doi-asserted-by":"crossref","first-page":"4532","DOI":"10.1016\/j.biomaterials.2008.08.007","article-title":"Electrospun poly (\u025b-caprolactone)\/gelatin nanofibrous scaffolds for nerve tissue engineering","volume":"29","author":"Ghasemi-Mobarakeh","year":"2008","journal-title":"Biomaterials"},{"issue":"August","key":"10.1016\/j.ijbiomac.2024.130141_bb0200","first-page":"281","article-title":"Effect of outdoor exposure on the moisture diffusion and mechanical properties of epoxy polymers","volume":"65","author":"Startsev","year":"2017","journal-title":"Polym. Test."},{"issue":"5","key":"10.1016\/j.ijbiomac.2024.130141_bb0205","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1089\/ten.tec.2013.0252","article-title":"Swelling and mechanical properties of alginate hydrogels with respect to promotion of neural growth","volume":"20","author":"Matyash","year":"2014","journal-title":"Tissue Eng. - Part C Methods"},{"issue":"9","key":"10.1016\/j.ijbiomac.2024.130141_bb0210","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1002\/pi.1517","article-title":"The effect of crystallinity and water absorption on the dynamic mechanical relaxation behaviour of polycaprolactone","volume":"53","author":"Harrison","year":"2004","journal-title":"Polym. Int."},{"key":"10.1016\/j.ijbiomac.2024.130141_bb0215","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.jcis.2017.08.092","article-title":"Long-acting and broad-spectrum antimicrobial electrospun poly (\u03b5-caprolactone)\/ gelatin micro\/nanofibers for wound dressing","volume":"509","author":"Shi","year":"2018","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.ijbiomac.2024.130141_bb0220","doi-asserted-by":"crossref","unstructured":"D. Kai, M. P. Prabhakaran, G. Jin, L. Tian, and S. Ramakrishna, \u201cPotential of VEGF-encapsulated electrospun nanofibers for in vitro cardiomyogenic differentiation of human mesenchymal stem cells,\u201d J. Tissue Eng. Regen. Med., vol. 11, no. 4, pp. 1002\u20131010, 2017, doi:https:\/\/doi.org\/10.1002\/term. 1999.","DOI":"10.1002\/term.1999"},{"issue":"9","key":"10.1016\/j.ijbiomac.2024.130141_bb0225","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1166\/jbn.2013.1653","article-title":"PCL and PCL-gelatin nanofibers as esophageal tissue scaffolds: optimization, characterization and cell-matrix interactions","volume":"9","author":"Kuppan","year":"2013","journal-title":"J. Biomed. Nanotechnol."},{"issue":"7","key":"10.1016\/j.ijbiomac.2024.130141_bb0230","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1016\/j.actbio.2009.01.039","article-title":"Aligned and random nanofibrous substrate for the in vitro culture of Schwann cells for neural tissue engineering","volume":"5","author":"Gupta","year":"2009","journal-title":"Acta Biomater."},{"key":"10.1016\/j.ijbiomac.2024.130141_bb0235","doi-asserted-by":"crossref","first-page":"8891","DOI":"10.2147\/IJN.S210329","article-title":"Regulating preparation of functional alginate-chitosan three-dimensional scaffold for skin tissue engineering","volume":"14","author":"Zhu","year":"2019","journal-title":"Int. J. Nanomedicine"},{"issue":"December","key":"10.1016\/j.ijbiomac.2024.130141_bb0240","article-title":"Potentials of sandwich-like chitosan\/polycaprolactone\/gelatin scaffolds for guided tissue regeneration membrane","volume":"109","author":"Zhang","year":"2020","journal-title":"Mater. Sci. Eng. C"},{"issue":"1","key":"10.1016\/j.ijbiomac.2024.130141_bb0245","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s40870-015-0041-3","article-title":"Mechanical properties of a human eardrum at high strain rates after exposure to blast waves","volume":"2","author":"Luo","year":"2016","journal-title":"J. Dyn. Behav. Mater."},{"issue":"1","key":"10.1016\/j.ijbiomac.2024.130141_bb0250","doi-asserted-by":"crossref","first-page":"81","DOI":"10.7150\/thno.16803","article-title":"Exosomes derived from platelet-rich plasma promote the re-epithelization of chronic cutaneous wounds via activation of YAP in a diabetic rat model","volume":"7","author":"Guo","year":"2017","journal-title":"Theranostics"},{"issue":"42","key":"10.1016\/j.ijbiomac.2024.130141_bb0255","doi-asserted-by":"crossref","first-page":"6830","DOI":"10.1039\/C6TB01560C","article-title":"Fabrication of hydroxyapatite\/ chitosan composite hydrogels loaded with exosomes derived from miR-126-3p overexpressed synovial mesenchymal stem cells for diabetic chronic wound healing","volume":"4","author":"Li","year":"2016","journal-title":"J. Mater. Chem. B"},{"issue":"7","key":"10.1016\/j.ijbiomac.2024.130141_bb0260","doi-asserted-by":"crossref","first-page":"2920","DOI":"10.1039\/C9BM00101H","article-title":"Human umbilical cord mesenchymal stem cell derived exosomes encapsulated in functional peptide hydrogels promote cardiac repair","volume":"7","author":"Han","year":"2019","journal-title":"Biomater. Sci."},{"issue":"4","key":"10.1016\/j.ijbiomac.2024.130141_bb0265","article-title":"Endometrial mesenchymal stem cell-derived exosome promote endothelial cell angiogenesis in a dose dependent manner: a new perspective on regenerative medicine and cell-free therapy","volume":"6","author":"Nooshabadi","year":"2019","journal-title":"Arch. Neurosci."},{"issue":"3","key":"10.1016\/j.ijbiomac.2024.130141_bb0270","first-page":"217","article-title":"Kinetic modeling on drug release from controlled drug delivery systems","volume":"67","author":"Dash","year":"2010","journal-title":"Acta Poloniae Pharmaceutica-Drug Research"},{"issue":"1","key":"10.1016\/j.ijbiomac.2024.130141_bb0275","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13287-016-0391-3","article-title":"Exosomes\/tricalcium phosphate combination scaffolds can enhance bone regeneration by activating the PI3K\/Akt signaling pathway","volume":"7","author":"Zhang","year":"2016","journal-title":"Stem Cell Res Ther"},{"issue":"6","key":"10.1016\/j.ijbiomac.2024.130141_bb0280","doi-asserted-by":"crossref","first-page":"554","DOI":"10.14639\/0392-100X-1839","article-title":"Surgical outcomes of tympanoplasty using a sterile acellular dermal allograft: a prospective randomised controlled study","volume":"38","author":"Lee","year":"2018","journal-title":"Acta Otorhinolaryngol. Ital."}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813024009449?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813024009449?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T00:16:11Z","timestamp":1739924171000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0141813024009449"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":56,"alternative-id":["S0141813024009449"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2024.130141","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Alginate hydrogel-PCL\/gelatin nanofibers composite scaffold containing mesenchymal stem cells-derived exosomes sustain release for regeneration of tympanic membrane perforation","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2024.130141","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"130141"}}