{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T01:00:22Z","timestamp":1785805222036,"version":"3.56.0"},"reference-count":71,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Chongqing Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013290","name":"National Key Research and Development Program of China Stem Cell and Translational Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013290","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.ijbiomac.2024.130660","type":"journal-article","created":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T08:23:39Z","timestamp":1709799819000},"page":"130660","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"P2","title":["pGM-CSF as an adjuvant in DNA vaccination against SARS-CoV-2"],"prefix":"10.1016","volume":"264","author":[{"given":"Chang","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruo-Yi","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Cheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Yi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Yi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rang","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Li","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan-Ming","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Bo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijbiomac.2024.130660_bb0005","author":"World Health Organization"},{"issue":"7","key":"10.1016\/j.ijbiomac.2024.130660_bb0010","doi-asserted-by":"crossref","first-page":"A450","DOI":"10.1016\/j.jval.2014.08.1211","article-title":"The economic value of vaccination: why prevention is wealth","volume":"17","author":"Remy","year":"2014","journal-title":"Value Health"},{"issue":"14","key":"10.1016\/j.ijbiomac.2024.130660_bb0015","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1056\/NEJMc2202542","article-title":"Efficacy of a fourth dose of Covid-19 mRNA vaccine against omicron","volume":"386","author":"Regev-Yochay","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijbiomac.2024.130660_bb0020","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1146\/annurev-med-012621-102252","article-title":"COVID-19 vaccines: adenoviral vectors","volume":"73","author":"Jacob-Dolan","year":"2022","journal-title":"Annu. Rev. Med."},{"issue":"7862","key":"10.1016\/j.ijbiomac.2024.130660_bb0025","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/s41586-021-03530-2","article-title":"Adjuvanting a subunit COVID-19 vaccine to induce protective immunity","volume":"594","author":"Arunachalam","year":"2021","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.ijbiomac.2024.130660_bb0030","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1001\/jama.2021.8565","article-title":"Effect of 2 inactivated SARS-CoV-2 vaccines on symptomatic COVID-19 infection in adults: a randomized clinical trial","volume":"326","author":"Al Kaabi","year":"2021","journal-title":"JAMA"},{"key":"10.1016\/j.ijbiomac.2024.130660_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118919","article-title":"DNA vaccines against COVID-19: perspectives and challenges","volume":"267","author":"Silveira","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.ijbiomac.2024.130660_bb0040","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1146\/annurev.immunol.18.1.927","article-title":"DNA vaccines: immunology, application, and optimization*","volume":"18","author":"Gurunathan","year":"2000","journal-title":"Annu. Rev. Immunol."},{"issue":"10332","key":"10.1016\/j.ijbiomac.2024.130660_bb0045","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1016\/S0140-6736(22)00151-9","article-title":"ZyCoV-D phase 3 Study Investigator Group, Efficacy, safety, and immunogenicity of the DNA SARS-CoV-2 vaccine (ZyCoV-D): the interim efficacy results of a phase 3, randomised, double-blind, placebo-controlled study in India","volume":"399","author":"Khobragade","year":"2022","journal-title":"Lancet"},{"key":"10.1016\/j.ijbiomac.2024.130660_bb0050","doi-asserted-by":"crossref","first-page":"101020","DOI":"10.1016\/j.eclinm.2021.101020","article-title":"Safety and immunogenicity of a DNA SARS-CoV-2 vaccine (ZyCoV-D): results of an open-label, non-randomized phase I part of phase I\/II clinical study by intradermal route in healthy subjects in India","volume":"38","author":"Momin","year":"2021","journal-title":"EClinicalMedicine"},{"issue":"1","key":"10.1016\/j.ijbiomac.2024.130660_bb0055","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1038\/s41467-020-16505-0","article-title":"Immunogenicity of a DNA vaccine candidate for COVID-19","volume":"11","author":"Smith","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ijbiomac.2024.130660_bb0060","series-title":"Phase I Study to Assess the Safety and Immunogenicity of an Intradermal COVID-19 DNA Vaccine Administered Using a Pyro-Drive Jet Injector in Healthy Adults, Vaccines (Basel)","volume":"10(9)","author":"Nakagami","year":"2022"},{"issue":"2","key":"10.1016\/j.ijbiomac.2024.130660_bb0065","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1586\/14760584.6.2.227","article-title":"Enhancing DNA vaccine potency by modifying the properties of antigen-presenting cells","volume":"6","author":"Tsen","year":"2007","journal-title":"Expert Rev. Vaccines"},{"issue":"1744\u20138395 (Electronic)","key":"10.1016\/j.ijbiomac.2024.130660_bb0070","article-title":"Molecular mechanisms for enhanced DNA vaccine immunogenicity","volume":"15","author":"Li","year":"2016","journal-title":"Expert Rev. Vaccines"},{"issue":"2","key":"10.1016\/j.ijbiomac.2024.130660_bb0075","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1006\/excr.1999.4716","article-title":"Sequence requirements for plasmid nuclear import","volume":"253","author":"Dean","year":"1999","journal-title":"Exp. Cell Res."},{"issue":"6","key":"10.1016\/j.ijbiomac.2024.130660_bb0080","doi-asserted-by":"crossref","first-page":"479","DOI":"10.2174\/156652311798192815","article-title":"Novel strategies to improve DNA vaccine immunogenicity","volume":"11","author":"Coban","year":"2011","journal-title":"Curr. Gene Ther."},{"key":"10.1016\/j.ijbiomac.2024.130660_bb0085","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/308732","article-title":"Fusion-expressed CTB improves both systemic and mucosal T-cell responses elicited by an intranasal DNA priming\/intramuscular recombinant vaccinia boosting regimen","volume":"2014","author":"Qiu","year":"2014","journal-title":"J. Immunol. Res."},{"issue":"4","key":"10.1016\/j.ijbiomac.2024.130660_bb0090","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.dsx.2020.04.020","article-title":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): an overview of viral structure and host response","volume":"14","author":"Astuti","year":"2020","journal-title":"Diabetes Metab. Syndr."},{"issue":"2","key":"10.1016\/j.ijbiomac.2024.130660_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.jksus.2020.101297","article-title":"Evaluating the potency of Sulawesi propolis compounds as ACE-2 inhibitors through molecular docking for COVID-19 drug discovery preliminary study","volume":"33","author":"Khayrani","year":"2021","journal-title":"J King Saud Univ Sci"},{"issue":"22","key":"10.1016\/j.ijbiomac.2024.130660_bb0100","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1056\/NEJMoa2202261","article-title":"Efficacy and safety of the RBD-dimer-based Covid-19 vaccine ZF2001 in adults","volume":"386","author":"Dai","year":"2022","journal-title":"N. Engl. J. Med."},{"issue":"3","key":"10.1016\/j.ijbiomac.2024.130660_bb0105","article-title":"A universal design of betacoronavirus vaccines against COVID-19","volume":"182","author":"Dai","year":"2020","journal-title":"MERS, and SARS, Cell"},{"issue":"1","key":"10.1016\/j.ijbiomac.2024.130660_bb0110","doi-asserted-by":"crossref","first-page":"99","DOI":"10.4142\/jvs.2014.15.1.99","article-title":"Positive effects of porcine IL-2 and IL-4 on virus-specific immune responses induced by the porcine reproductive and respiratory syndrome virus (PRRSV) ORF5 DNA vaccine in swine","volume":"15","author":"Tang","year":"2014","journal-title":"J. Vet. Sci."},{"issue":"2","key":"10.1016\/j.ijbiomac.2024.130660_bb0115","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1348-0421.2006.tb03773.x","article-title":"Cytokine GM-CSF genetic adjuvant facilitates prophylactic DNA vaccine against pseudorabies virus through enhanced immune responses","volume":"50","author":"Yoon","year":"2006","journal-title":"Microbiol. Immunol."},{"issue":"2","key":"10.1016\/j.ijbiomac.2024.130660_bb0120","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0378-1135(00)00238-8","article-title":"Co-administration of IL-2 enhances antigen-specific immune responses following vaccination with DNA encoding the glycoprotein E2 of bovine viral diarrhoea virus","volume":"76","author":"Nobiron","year":"2000","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.ijbiomac.2024.130660_bb0125","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2020.581812","article-title":"IL-12 DNA displays efficient adjuvant effects improving immunogenicity of Ag85A in DNA prime\/MVA boost immunizations","volume":"10","author":"Morelli","year":"2020","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"3","key":"10.1016\/j.ijbiomac.2024.130660_bb0130","article-title":"Cytokine adjuvants IL-7 and IL-15 improve humoral responses of a SHIV LentiDNA vaccine in animal models","volume":"10","author":"Leroy","year":"2022","journal-title":"Vaccines (Basel)"},{"key":"10.1016\/j.ijbiomac.2024.130660_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2019.154814","article-title":"Interleukin-21 enhances the antibody avidity elicited by DNA prime and MVA boost vaccine","volume":"125","author":"Fan","year":"2020","journal-title":"Cytokine"},{"key":"10.1016\/j.ijbiomac.2024.130660_bb0140","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1051\/parasite\/2020021","article-title":"Adjuvantic cytokine IL-33 improves the protective immunity of cocktailed DNA vaccine of ROP5 and ROP18 against toxoplasma gondii infection in mice","volume":"27","author":"Zhu","year":"2020","journal-title":"Parasite"},{"issue":"6","key":"10.1016\/j.ijbiomac.2024.130660_bb0145","doi-asserted-by":"crossref","first-page":"3044","DOI":"10.4049\/jimmunol.1100402","article-title":"Mucosa-associated epithelial chemokine\/CCL28 expression in the uterus attracts CCR10+ IgA plasma cells following mucosal vaccination via estrogen control","volume":"187","author":"Cha","year":"2011","journal-title":"J. Immunol."},{"issue":"29","key":"10.1016\/j.ijbiomac.2024.130660_bb0150","doi-asserted-by":"crossref","first-page":"22313","DOI":"10.1074\/jbc.M001461200","article-title":"Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2)*","volume":"275","author":"Wang","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.ijbiomac.2024.130660_bb0155","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.vaccine.2005.08.093","article-title":"Anti-HBV immune responses in rhesus macaques elicited by electroporation mediated DNA vaccination","volume":"24","author":"Zhao","year":"2006","journal-title":"Vaccine"},{"issue":"8","key":"10.1016\/j.ijbiomac.2024.130660_bb0160","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.vaccine.2018.12.066","article-title":"The mucosal adjuvant effect of plant polysaccharides for induction of protective immunity against Helicobacter pylori infection","volume":"37","author":"Liu","year":"2019","journal-title":"Vaccine"},{"key":"10.1016\/j.ijbiomac.2024.130660_bb0165","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.833418","article-title":"Novel synthetic lipopeptides as potential mucosal adjuvants enhanced SARS-CoV-2 rRBD-induced immune response","volume":"13","author":"Mao","year":"2022","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.ijbiomac.2024.130660_bb0170","doi-asserted-by":"crossref","first-page":"1930636","DOI":"10.1080\/19420862.2021.1930636","article-title":"A human antibody of potent efficacy against SARS-CoV-2 in rhesus macaques showed strong blocking activity to B.1.351","volume":"13","author":"Gu","year":"2021","journal-title":"MAbs"},{"issue":"1","key":"10.1016\/j.ijbiomac.2024.130660_bb0175","doi-asserted-by":"crossref","first-page":"4831","DOI":"10.1038\/s41467-022-32547-y","article-title":"Promotion of neutralizing antibody-independent immunity to wild-type and SARS-CoV-2 variants of concern using an RBD-Nucleocapsid fusion protein","volume":"13","author":"Castro","year":"2022","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.ijbiomac.2024.130660_bb0180","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s00428-020-02926-1","article-title":"Increased number of pulmonary megakaryocytes in COVID-19 patients with diffuse alveolar damage: an autopsy study with clinical correlation and review of the literature","volume":"478","author":"Valdivia-Mazeyra","year":"2021","journal-title":"Virchows Arch."},{"issue":"4","key":"10.1016\/j.ijbiomac.2024.130660_bb0185","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1038\/s41385-018-0003-x","article-title":"Pulmonary antigen encounter regulates the establishment of tissue-resident CD8 memory T cells in the lung airways and parenchyma","volume":"11","author":"McMaster","year":"2018","journal-title":"Mucosal Immunol."},{"issue":"6","key":"10.1016\/j.ijbiomac.2024.130660_bb0190","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1084\/jem.20090283","article-title":"The route of priming influences the ability of respiratory virus-specific memory CD8+ T cells to be activated by residual antigen","volume":"207","author":"Takamura","year":"2010","journal-title":"J. Exp. Med."},{"issue":"1","key":"10.1016\/j.ijbiomac.2024.130660_bb0195","doi-asserted-by":"crossref","first-page":"203","DOI":"10.4049\/jimmunol.1402975","article-title":"Airway-resident memory CD8 T cells provide antigen-specific protection against respiratory virus challenge through rapid IFN-\u03b3 production","volume":"195","author":"McMaster","year":"2015","journal-title":"J. Immunol."},{"issue":"12","key":"10.1016\/j.ijbiomac.2024.130660_bb0200","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1038\/nm.3409","article-title":"Key roles of adjuvants in modern vaccines","volume":"19","author":"Reed","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.ijbiomac.2024.130660_bb0205","doi-asserted-by":"crossref","first-page":"429","DOI":"10.3389\/fimmu.2019.00429","article-title":"Toll-like receptor 7 enhances rabies virus-induced humoral immunity by facilitating the formation of germinal centers","volume":"10","author":"Luo","year":"2019","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.ijbiomac.2024.130660_bb0210","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/j.immuni.2020.11.009","article-title":"SARS-CoV-2 mRNA vaccines foster potent antigen-specific germinal center responses associated with neutralizing antibody generation","volume":"53","author":"Lederer","year":"2020","journal-title":"Immunity"},{"issue":"9","key":"10.1016\/j.ijbiomac.2024.130660_bb0215","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1008887","article-title":"Luteolin-mediated Kv1.3 K+ channel inhibition augments BCG vaccine efficacy against tuberculosis by promoting central memory T cell responses in mice","volume":"16","author":"Singh","year":"2020","journal-title":"PLoS Pathog."},{"issue":"12","key":"10.1016\/j.ijbiomac.2024.130660_bb0220","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1080\/21645515.2017.1330236","article-title":"Advancements in DNA vaccine vectors, non-mechanical delivery methods, and molecular adjuvants to increase immunogenicity","volume":"13","author":"Suschak","year":"2017","journal-title":"Hum. Vaccin. Immunother."},{"issue":"1","key":"10.1016\/j.ijbiomac.2024.130660_bb0225","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s13567-019-0698-z","article-title":"Recent advances in delivery of veterinary DNA vaccines against avian pathogens","volume":"50","author":"Jazayeri","year":"2019","journal-title":"Vet. Res."},{"key":"10.1016\/j.ijbiomac.2024.130660_bb0230","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.actbio.2018.08.033","article-title":"Engineering DNA vaccines against infectious diseases","volume":"80","author":"Lee","year":"2018","journal-title":"Acta Biomater."},{"issue":"1","key":"10.1016\/j.ijbiomac.2024.130660_bb0235","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s12929-019-0536-7","article-title":"Endoplasmic reticulum stress enhances the antigen-specific T cell immune responses and therapeutic antitumor effects generated by therapeutic HPV vaccines","volume":"26","author":"Lee","year":"2019","journal-title":"J. Biomed. Sci."},{"issue":"11","key":"10.1016\/j.ijbiomac.2024.130660_bb0240","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/nri2868","article-title":"Vaccine delivery: a matter of size, geometry, kinetics and molecular patterns","volume":"10","author":"Bachmann","year":"2010","journal-title":"Nat. Rev. Immunol."},{"issue":"1\u20133","key":"10.1016\/j.ijbiomac.2024.130660_bb0245","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0168-3659(01)00549-1","article-title":"Targeting to macrophages: role of physicochemical properties of particulate carriers\u2014liposomes and microspheres\u2014on the phagocytosis by macrophages","volume":"79","author":"Ahsan","year":"2002","journal-title":"J. Control. Release"},{"issue":"1","key":"10.1016\/j.ijbiomac.2024.130660_bb0250","article-title":"Molecular adjuvants for DNA vaccines","volume":"22","author":"Li","year":"2017","journal-title":"Curr. Issues Mol. Biol."},{"issue":"4","key":"10.1016\/j.ijbiomac.2024.130660_bb0255","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1089\/jir.2018.0099","article-title":"CCL28 is involved in mucosal IgA responses, olfaction, and resistance to enteric infections","volume":"39","author":"Burkhardt","year":"2019","journal-title":"J. Interferon Cytokine Res."},{"key":"10.1016\/j.ijbiomac.2024.130660_bb0260","series-title":"CCL19 and CCL28 Assist Herpes Simplex Virus 2 Glycoprotein D to Induce Protective Systemic Immunity against Genital Viral Challenge, mSphere 6(2)","author":"Yan","year":"2021"},{"issue":"1","key":"10.1016\/j.ijbiomac.2024.130660_bb0265","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/gt.2009.112","article-title":"Plasmids encoding the mucosal chemokines CCL27 and CCL28 are effective adjuvants in eliciting antigen-specific immunity in vivo","volume":"17","author":"Kutzler","year":"2010","journal-title":"Gene Ther."},{"issue":"4","key":"10.1016\/j.ijbiomac.2024.130660_bb0270","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.vaccine.2010.11.014","article-title":"Evaluation of a DNA vaccine candidate expressing prM-E-NS1 antigens of dengue virus serotype 1 with or without granulocyte-macrophage colony-stimulating factor (GM-CSF) in immunogenicity and protection","volume":"29","author":"Zheng","year":"2011","journal-title":"Vaccine"},{"issue":"7","key":"10.1016\/j.ijbiomac.2024.130660_bb0275","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1016\/j.vaccine.2006.09.089","article-title":"Intramuscular immunization with a monogenic plasmid DNA tuberculosis vaccine: enhanced immunogenicity by electroporation and co-expression of GM-CSF transgene","volume":"25","author":"Zhang","year":"2007","journal-title":"Vaccine"},{"issue":"7","key":"10.1016\/j.ijbiomac.2024.130660_bb0280","doi-asserted-by":"crossref","first-page":"3638","DOI":"10.4049\/jimmunol.159.7.3638","article-title":"Intranasal immunization of a DNA vaccine with IL-12- and granulocyte-macrophage colony-stimulating factor (GM-CSF)-expressing plasmids in liposomes induces strong mucosal and cell-mediated immune responses against HIV-1 antigens","volume":"159","author":"Okada","year":"1997","journal-title":"J. Immunol."},{"issue":"6","key":"10.1016\/j.ijbiomac.2024.130660_bb0285","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0011021","article-title":"GM-CSF increases mucosal and systemic immunogenicity of an H1N1 influenza DNA vaccine administered into the epidermis of non-human primates","volume":"5","author":"Loudon","year":"2010","journal-title":"PloS One"},{"issue":"1","key":"10.1016\/j.ijbiomac.2024.130660_bb0290","doi-asserted-by":"crossref","first-page":"211","DOI":"10.3109\/08923971003782327","article-title":"Enhancement of the immunogenicity of DNA replicon vaccine of Clostridium botulinum neurotoxin serotype A by GM-CSF gene adjuvant","volume":"33","author":"Li","year":"2011","journal-title":"Immunopharmacol. Immunotoxicol."},{"issue":"12","key":"10.1016\/j.ijbiomac.2024.130660_bb0295","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1038\/mt.2008.196","article-title":"Phase I\/II study of GM-CSF DNA as an adjuvant for a multipeptide cancer vaccine in patients with advanced melanoma","volume":"16","author":"Perales","year":"2008","journal-title":"Mol. Ther."},{"issue":"3","key":"10.1016\/j.ijbiomac.2024.130660_bb0300","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.immuni.2007.09.002","article-title":"Antibodies and B cell memory in viral immunity","volume":"27","author":"Dorner","year":"2007","journal-title":"Immunity"},{"issue":"30","key":"10.1016\/j.ijbiomac.2024.130660_bb0305","doi-asserted-by":"crossref","first-page":"4108","DOI":"10.1016\/j.vaccine.2021.05.098","article-title":"Immunogenic potential of DNA vaccine candidate, ZyCoV-D against SARS-CoV-2 in animal models","volume":"39","author":"Dey","year":"2021","journal-title":"Vaccine"},{"issue":"7830","key":"10.1016\/j.ijbiomac.2024.130660_bb0310","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/s41586-020-2622-0","article-title":"SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness","volume":"586","author":"Corbett","year":"2020","journal-title":"Nature"},{"issue":"7853","key":"10.1016\/j.ijbiomac.2024.130660_bb0315","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/s41586-021-03275-y","article-title":"BNT162b vaccines protect rhesus macaques from SARS-CoV-2","volume":"592","author":"Vogel","year":"2021","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.ijbiomac.2024.130660_bb0320","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1038\/s41423-020-00550-2","article-title":"A compromised specific humoral immune response against the SARS-CoV-2 receptor-binding domain is related to viral persistence and periodic shedding in the gastrointestinal tract","volume":"17","author":"Hu","year":"2020","journal-title":"Cell. Mol. Immunol."},{"issue":"6496","key":"10.1016\/j.ijbiomac.2024.130660_bb0325","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1126\/science.abc2241","article-title":"A noncompeting pair of human neutralizing antibodies block COVID-19 virus binding to its receptor ACE2","volume":"368","author":"Wu","year":"2020","journal-title":"Science"},{"issue":"42","key":"10.1016\/j.ijbiomac.2024.130660_bb0330","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2107249118","article-title":"Highly active engineered IgG3 antibodies against SARS-CoV-2","volume":"118","author":"Kallolimath","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7","key":"10.1016\/j.ijbiomac.2024.130660_bb0335","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1038\/s41590-022-01248-5","article-title":"The humoral response and antibodies against SARS-CoV-2 infection","volume":"23","author":"Qi","year":"2022","journal-title":"Nat. Immunol."},{"issue":"5","key":"10.1016\/j.ijbiomac.2024.130660_bb0340","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/j.immuni.2019.04.011","article-title":"T follicular helper cell biology: A decade of discovery and diseases","volume":"50","author":"Crotty","year":"2019","journal-title":"Immunity"},{"issue":"6","key":"10.1016\/j.ijbiomac.2024.130660_bb0345","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/s41577-020-0311-8","article-title":"The trinity of COVID-19: immunity, inflammation and intervention","volume":"20","author":"Tay","year":"2020","journal-title":"Nat. Rev. Immunol."},{"issue":"2","key":"10.1016\/j.ijbiomac.2024.130660_bb0350","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/s41590-021-01122-w","article-title":"The T cell immune response against SARS-CoV-2","volume":"23","author":"Moss","year":"2022","journal-title":"Nat. Immunol."},{"issue":"12","key":"10.1016\/j.ijbiomac.2024.130660_bb0355","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1016\/j.celrep.2017.08.078","article-title":"Human tissue-resident memory T cells are defined by core transcriptional and functional signatures in lymphoid and mucosal sites","volume":"20","author":"Kumar","year":"2017","journal-title":"Cell Rep."}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813024014636?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813024014636?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T10:02:03Z","timestamp":1719309723000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0141813024014636"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":71,"alternative-id":["S0141813024014636"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2024.130660","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"pGM-CSF as an adjuvant in DNA vaccination against SARS-CoV-2","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2024.130660","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"130660"}}