{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T19:24:26Z","timestamp":1794338666499,"version":"4.9.0"},"reference-count":80,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100014738","name":"Vision Group on Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["EEQ-282\/2013"],"award-info":[{"award-number":["EEQ-282\/2013"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.ijbiomac.2024.133147","type":"journal-article","created":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T08:39:44Z","timestamp":1718267984000},"page":"133147","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"P2","title":["Effect of \u2018Procumbenase\u2019 a serine protease from Tridax procumbens aqueous extract on wound healing: A scar free healing of full thickness wounds"],"prefix":"10.1016","volume":"273","author":[{"given":"Vinod","family":"Gubbiveeranna","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.T.","family":"Megha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.G.","family":"Kusuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Ravikumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.S.","family":"Thoyajakshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Vijayakumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.N.","family":"Mathad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5541-939X","authenticated-orcid":false,"given":"S.","family":"Nagaraju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huda","family":"Wazzan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anish","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalid A.","family":"Alzahrani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asmaa M.","family":"Malash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijbiomac.2024.133147_bb0005","doi-asserted-by":"crossref","first-page":"148","DOI":"10.3109\/17453054.2010.525439","article-title":"Editorial","volume":"33","author":"Swann","year":"2010","journal-title":"J. Vis. Commun. Med."},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0010","first-page":"1","article-title":"Skin acute wound healing: a comprehensive review","volume":"2019","author":"Ca\u00f1edo-Dorantes","year":"2019","journal-title":"Int. J. Inflamm."},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0015","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1152\/physrev.00067.2017","article-title":"Wound healing: a cellular perspective","volume":"99","author":"Rodrigues","year":"2019","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0020","doi-asserted-by":"crossref","DOI":"10.1098\/rsob.200223","article-title":"Wound healing: cellular mechanisms and pathological outcomes","volume":"10","author":"Wilkinson","year":"2020","journal-title":"Open Biol."},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0025","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/s13287-019-1212-2","article-title":"Skin tissue engineering: wound healing based on stem-cell-based therapeutic strategies","volume":"10","author":"NourianDehkordi","year":"2019","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0030","doi-asserted-by":"crossref","first-page":"655","DOI":"10.3390\/cells10030655","article-title":"Chronic diabetic wounds and their treatment with skin substitutes","volume":"10","author":"Holl","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0035","doi-asserted-by":"crossref","first-page":"3861","DOI":"10.1007\/s00018-016-2268-0","article-title":"Transition from inflammation to proliferation: a critical step during wound healing","volume":"73","author":"Land\u00e9n","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0040","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1111\/j.1346-8138.2001.tb00025.x","article-title":"Cutaneous wound healing: an update","volume":"28","author":"Yamaguchi","year":"2001","journal-title":"J. Dermatol."},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0045","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/j.bbadis.2012.12.013","article-title":"Coagulation and coagulation signalling in fibrosis","volume":"1832","author":"Mercer","year":"2013","journal-title":"Biochim. Biophys. Acta (BBA) - Mol. Basis Dis."},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0050","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2021.716184","article-title":"Platelets in wound healing: what happens in space?","volume":"9","author":"Locatelli","year":"2021","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0055","doi-asserted-by":"crossref","first-page":"12772","DOI":"10.3390\/ijms232112772","article-title":"Platelets and their role in hemostasis and thrombosis\u2014from physiology to pathophysiology and therapeutic implications","volume":"23","author":"Scridon","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0060","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1016\/S0002-9610(01)00773-5","article-title":"The role of fibrin sealants in hemostasis","volume":"182","author":"Mankad","year":"2001","journal-title":"Am. J. Surg."},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0065","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.3390\/ijms17122085","article-title":"Inflammation in chronic wounds","volume":"17","author":"Zhao","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0070","series-title":"Wound Healing Biomaterials","first-page":"117","article-title":"Manipulating inflammation to improve healing","author":"Urao","year":"2016"},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0075","doi-asserted-by":"crossref","DOI":"10.1017\/S1462399411001943","article-title":"Inflammation and wound healing: the role of the macrophage","volume":"13","author":"Koh","year":"2011","journal-title":"Expert Rev. Mol. Med."},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0080","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.603187","article-title":"The roles of inflammation in keloid and hypertrophic scars","volume":"11","author":"Wang","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0085","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1089\/wound.2012.0383","article-title":"Neutrophils and wound repair: positive actions and negative reactions","volume":"2","author":"Wilgus","year":"2013","journal-title":"Adv. Wound Care"},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0090","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/s41572-022-00377-3","article-title":"Chronic wounds","volume":"8","author":"Falanga","year":"2022","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0095","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1042\/ETLS20200346","article-title":"Wound dressings: curbing inflammation in chronic wound healing","volume":"5","author":"Verdolino","year":"2021","journal-title":"Emerg. Top. Life Sci."},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0100","doi-asserted-by":"crossref","first-page":"641","DOI":"10.3390\/ijms24010641","article-title":"Acute inflammation in tissue healing","volume":"24","author":"Soliman","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0105","doi-asserted-by":"crossref","first-page":"301","DOI":"10.2147\/CCID.S50046","article-title":"Fibroblasts and myofibroblasts in wound healing","author":"Desmouliere","year":"2014","journal-title":"Clin. Cosmet. Investig. Dermatol."},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0110","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1159\/000339613","article-title":"Wound repair and regeneration","volume":"49","author":"Reinke","year":"2012","journal-title":"Eur. Surg. Res."},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0115","doi-asserted-by":"crossref","DOI":"10.7759\/cureus.24856","article-title":"Collagen structure, synthesis, and its applications: a systematic review","author":"Shenoy","year":"2022","journal-title":"Cureus"},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0120","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.719922","article-title":"Regulation of extracellular matrix production in activated fibroblasts: roles of amino acid metabolism in collagen synthesis","volume":"11","author":"Kay","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0125","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3390\/bioengineering8050063","article-title":"Collagen in wound healing","volume":"8","author":"Mathew-Steiner","year":"2021","journal-title":"Bioengineering"},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0130","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3390\/biomimetics7030087","article-title":"The role of the extracellular matrix (ECM) in wound healing: a review","volume":"7","author":"Diller","year":"2022","journal-title":"Biomimetics"},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0135","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1089\/wound.2021.0026","article-title":"Human wound and its burden: updated 2020 compendium of estimates","volume":"10","author":"Sen","year":"2021","journal-title":"Adv. Wound Care"},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0140","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1089\/wound.2015.0635","article-title":"Challenges in the treatment of chronic wounds","volume":"4","author":"Frykberg","year":"2015","journal-title":"Adv. Wound Care"},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0145","article-title":"Economic implications of health care burden for elderly population","volume":"59","author":"Tang","year":"2022","journal-title":"Inquiry"},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0150","doi-asserted-by":"crossref","first-page":"124","DOI":"10.4103\/0975-9476.100171","article-title":"Traditional healing practice and folk medicines used by Mishing community of North East India","volume":"3","author":"Shankar","year":"2012","journal-title":"J. Ayurveda Integr. Med."},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0155","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/1440-1681.13743","article-title":"A comprehensive review on medicinal plants possessing antioxidant potential","volume":"50","author":"Zafar","year":"2023","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0160","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1093\/ecam\/nem127","article-title":"Evaluation of the wound-healing activity of ethanolic extract of Morinda citrifolia L. leaf","volume":"6","author":"Nayak","year":"2009","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0165","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1186\/s12906-017-1930-x","article-title":"Wound healing effect of Euphorbia hirta Linn. (Euphorbiaceae) in alloxan induced diabetic rats","volume":"17","author":"Tuhin","year":"2017","journal-title":"BMC Complement. Altern. Med."},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0170","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/6474706","article-title":"Development and evaluation of the wound healing effect of a novel topical cream formula based on Ginkgo biloba extract on wounds in diabetic rats","volume":"2021","author":"Bardaa","year":"2021","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0175","article-title":"Aloe vera for treating acute and chronic wounds","volume":"2012","author":"Dat","year":"2012","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0180","doi-asserted-by":"crossref","first-page":"3566","DOI":"10.3390\/molecules27113566","article-title":"Phytochemistry and biological activity of medicinal plants in wound healing: an overview of current research","volume":"27","author":"Vitale","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0185","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1007\/s40200-021-00868-2","article-title":"The current and advanced therapeutic modalities for wound healing management","volume":"20","author":"Fallah","year":"2021","journal-title":"J. Diabetes Metab. Disord."},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0190","first-page":"363","article-title":"Potent procoagulant and platelet aggregation inducing serine protease from Tridax procumbens extract","volume":"11","author":"Gubbiveeranna","year":"2019","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0195","first-page":"705","article-title":"A protease isolated from the latex of Plumeria rubra Linn (Apocynaceae) 1: purification and characterization","volume":"10","author":"Chanda","year":"2011","journal-title":"Trop. J. Pharm. Res."},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0200","series-title":"Proteolytic Signaling in Health and Disease","first-page":"131","article-title":"Proteolytic signaling in cutaneous wound healing","author":"Kalogeropoulos","year":"2022"},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0205","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/ncpgasthep0846","article-title":"Mechanisms of disease: protease functions in intestinal mucosal pathobiology","volume":"4","author":"Antalis","year":"2007","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0210","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.matbio.2017.04.003","article-title":"The provisional matrix: setting the stage for tissue repair outcomes","volume":"60\u201361","author":"Barker","year":"2017","journal-title":"Matrix Biol."},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0215","first-page":"1","article-title":"Ethnomedicinal, phytochemical constituents and pharmacological activities of Tridax procumbens: a review","volume":"8","author":"Gubbiveeranna","year":"2016","journal-title":"Int J Pharm Pharm Sci"},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.phyplu.2021.100199","article-title":"Phytochemistry and pharmacological aspects of Tridax procumbens (L.): a systematic and comprehensive review","volume":"2","author":"Ingole","year":"2022","journal-title":"Phytomed. Plus"},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0225","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4103\/jpbs.JPBS_175_19","article-title":"Preparation of medicinal plants: basic extraction and fractionation procedures for experimental purposes","volume":"12","author":"Abubakar","year":"2020","journal-title":"J. Pharm. Bioallied Sci."},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0230","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s12896-015-0129-9","article-title":"Isolation, production, purification and characterization of an organic-solvent-thermo stable alkalophilic cellulase from Bacillus vallismortis RG-07","volume":"15","author":"Gaur","year":"2015","journal-title":"BMC Biotechnol."},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0235","doi-asserted-by":"crossref","first-page":"275","DOI":"10.5483\/BMBRep.2004.37.3.275","article-title":"Presence of rhodanese in the cytosolic fraction of the fruit bat (Eidolon helvum) liver","volume":"37","author":"Agboola","year":"2004","journal-title":"BMB Rep."},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0240","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1093\/oxfordjournals.jbchem.a127107","article-title":"The spectrophotometric determination of amine, amino acid and peptide with 2,4,6- trinitrobenzene 1-sulfonic acid*","volume":"47","author":"Satake","year":"1960","journal-title":"J. Biochem."},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0245","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1016\/j.biochi.2012.02.027","article-title":"Bafibrinase: a non-toxic, non-hemorrhagic, direct-acting fibrinolytic serine protease from Bacillus sp. strain AS-S20-I exhibits in vivo anticoagulant activity and thrombolytic potency","volume":"94","author":"Mukherjee","year":"2012","journal-title":"Biochimie"},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0250","doi-asserted-by":"crossref","DOI":"10.21769\/BioProtoc.3899","article-title":"Reverse phase-high-performance liquid chromatography (RP-HPLC) analysis of globin chains from human erythroid cells","volume":"11","author":"Chalumeau","year":"2021","journal-title":"Bio-Protoc."},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0255","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0260","doi-asserted-by":"crossref","first-page":"5734","DOI":"10.1021\/bi00566a011","article-title":"Behavior of glycopolypeptides with empirical molecular weight estimation methods. 1. In sodium dodecyl sulfate","volume":"19","author":"Leach","year":"1980","journal-title":"Biochemistry"},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0265","series-title":"Chemical Genomics and Proteomics","first-page":"227","article-title":"Protein identification by MALDI-TOF mass spectrometry","author":"Webster","year":"2012"},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0270","doi-asserted-by":"crossref","first-page":"8400","DOI":"10.1039\/D0CS00558D","article-title":"Tools and methods for circular dichroism spectroscopy of proteins: a tutorial review","volume":"50","author":"Miles","year":"2021","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0275","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.bcab.2017.04.004","article-title":"Catalytic properties and thermal stability of a crude protease from the keratinolytic Bacillus sp. CL33A","volume":"10","author":"De Oliveira","year":"2017","journal-title":"Biocatal. Agric. Biotechnol."},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0280","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1111\/j.1550-7408.1992.tb04856.x","article-title":"Plasmodium falciparum: differential sensitivity in vitro to E-64 (cysteine protease inhibitor) and pepstatin A (aspartyl protease inhibitor)","volume":"39","author":"Bailly","year":"1992","journal-title":"J. Protozool."},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0285","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.jep.2012.10.006","article-title":"Wound healing activity of latex of Euphorbia caducifolia","volume":"144","author":"Goyal","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0290","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2011\/438056","article-title":"Practices in wound healing studies of plants","volume":"2011","author":"Thakur","year":"2011","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0295","first-page":"32","article-title":"Excision and incision wound healing activity of flower head alcoholic extract of Sphaeranthus indicus Linn. in albino rats","volume":"3","author":"Jha","year":"2009","journal-title":"Glob. J. Pharmacol."},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0300","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.jep.2012.06.049","article-title":"Evaluation of in vivo wound healing activity of methanol extract of Achyranthes aspera L","volume":"143","author":"Fikru","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0305","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1186\/s12906-015-0878-y","article-title":"Evaluation of wound healing and anti-inflammatory activity of the rhizomes of Rumex abyssinicus J. (Polygonaceae) in mice","volume":"15","author":"Mulisa","year":"2015","journal-title":"BMC Complement. Altern. Med."},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0310","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/iep.12346","article-title":"Experimental models and methods for cutaneous wound healing assessment","volume":"101","author":"Masson-Meyers","year":"2020","journal-title":"Int. J. Exp. Pathol."},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0315","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.jep.2009.04.038","article-title":"Evaluation of wound healing activity of root of Mimosa pudica","volume":"124","author":"Kokane","year":"2009","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0320","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.jep.2011.02.010","article-title":"In vitro and in vivo evaluation of the wound healing properties of Siegesbeckia pubescens","volume":"134","author":"Wang","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0325","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/0003-9861(61)90291-0","article-title":"The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid","volume":"93","author":"Woessner","year":"1961","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0330","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nprot.2007.30","article-title":"In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro","volume":"2","author":"Liang","year":"2007","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0335","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.ijbiomac.2015.02.041","article-title":"Effect of different chitosan derivatives on in vitro scratch wound assay: a comparative study","volume":"76","author":"Felice","year":"2015","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0340","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1089\/wound.2012.0370","article-title":"Proteases and delayed wound healing","volume":"2","author":"McCarty","year":"2013","journal-title":"Adv. Wound Care"},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0345","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1007\/s00726-010-0715-z","article-title":"Proline and hydroxyproline metabolism: implications for animal and human nutrition","volume":"40","author":"Wu","year":"2011","journal-title":"Amino Acids"},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0350","doi-asserted-by":"crossref","first-page":"4645","DOI":"10.1093\/emboj\/18.17.4645","article-title":"Functional overlap between two classes of matrix-degrading proteases in wound healing","volume":"18","author":"Lund","year":"1999","journal-title":"EMBO J."},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0355","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1146\/annurev.cellbio.17.1.463","article-title":"How matrix metalloproteinases regulate cell behavior","volume":"17","author":"Sternlicht","year":"2001","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0360","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.biochi.2007.07.024","article-title":"Cysteine cathepsins: cellular roadmap to different functions","volume":"90","author":"Brix","year":"2008","journal-title":"Biochimie"},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0365","series-title":"Wound Healing, Tissue Repair, and Regeneration in Diabetes","first-page":"357","article-title":"Protease technology in wound repair","author":"Herman","year":"2020"},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0370","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1080\/10826068.2017.1373289","article-title":"Extraction, purification, and biochemical characterization of serine protease from leaves of Abrus precatorius","volume":"47","author":"Serge","year":"2017","journal-title":"Prep. Biochem. Biotechnol."},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0375","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1097\/01.WON.0000319125.21854.78","article-title":"Enzymatic wound debridement","volume":"35","author":"Ramundo","year":"2008","journal-title":"J. Wound Ostomy Continence Nurs."},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0380","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1046\/j.1524-475X.2003.11404.x","article-title":"Comparison of inflammatory and systemic sources of growth factors in acute and chronic human wounds","volume":"11","author":"Wagner","year":"2003","journal-title":"Wound Repair Regen."},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0385","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1002\/ptr.2599","article-title":"Evaluation of wound healing activity of Lantana camara L. \u2013 a preclinical study","volume":"23","author":"Nayak","year":"2009","journal-title":"Phytother. Res."},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0390","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.ijbiomac.2020.09.215","article-title":"Drupin, a cysteine protease from Ficus drupacea latex accelerates excision wound healing in mice","volume":"165","author":"Manjuprasanna","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0395","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.jep.2009.10.011","article-title":"Investigations on the in vivo wound healing potential of Hypericum perforatum L","volume":"127","author":"S\u00fcntar","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.ijbiomac.2024.133147_bb0400","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jep.2013.06.056","article-title":"Topical application of serine proteases from Wrightia tinctoria R. Br. (Apocyanaceae) latex augments healing of experimentally induced excision wound in mice","volume":"149","author":"Yariswamy","year":"2013","journal-title":"J. Ethnopharmacol."}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813024039527?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813024039527?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T18:59:15Z","timestamp":1794337155000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0141813024039527"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":80,"alternative-id":["S0141813024039527"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2024.133147","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of \u2018Procumbenase\u2019 a serine protease from Tridax procumbens aqueous extract on wound healing: A scar free healing of full thickness wounds","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2024.133147","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"133147"}}