{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T22:27:32Z","timestamp":1790893652593,"version":"4.1.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82074283"],"award-info":[{"award-number":["82074283"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.ijbiomac.2024.133459","type":"journal-article","created":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T14:09:11Z","timestamp":1719583751000},"page":"133459","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"P1","title":["Chemical structure and immunomodulatory activity of a polysaccharide from Saposhnikoviae Radix"],"prefix":"10.1016","volume":"276","author":[{"given":"Xinyang","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haitao","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijbiomac.2024.133459_bb0005","doi-asserted-by":"crossref","first-page":"3005","DOI":"10.1016\/j.ijbiomac.2020.08.110","article-title":"Structural characterization and proliferation activity of chondroitin sulfate from the sturgeon, Acipenser schrenckii","volume":"164","author":"Wang","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2024.133459_bb0010","doi-asserted-by":"crossref","DOI":"10.3389\/fmars.2023.1326516","article-title":"Editorial: biological macromolecules from marine organisms: isolation, characterization and pharmacological activities","volume":"10","author":"Wang","year":"2023","journal-title":"Front. Mar. Sci."},{"key":"10.1016\/j.ijbiomac.2024.133459_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2020.116020","article-title":"Purification, structural characterization, and antioxidant activity of the COP-W1 polysaccharide from Codonopsis tangshen Oliv","volume":"236","author":"Wu","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2024.133459_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2021.736677","article-title":"The effect of Astragalus polysaccharide on growth, gut and liver health, and anti-viral immunity of zebrafish","volume":"540","author":"Li","year":"2021","journal-title":"Aquaculture"},{"key":"10.1016\/j.ijbiomac.2024.133459_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2020.116567","article-title":"Isolation, structural eluci- dation, and immunoregulation properties of an arabinofuranan from the rinds of Garcinia mangostana","volume":"246","author":"Zhang","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2024.133459_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2020.117521","article-title":"Structural properties and in vitro and in vivo immunomodulatory activity of an arabinofuranan from the fruits of Akebia quinate","volume":"256","author":"Wang","year":"2021","journal-title":"Carbohydr. Polym."},{"issue":"3","key":"10.1016\/j.ijbiomac.2024.133459_bb0035","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.reval.2021.02.001","article-title":"Mechanism of modified Yupingfeng naristillae in protecting the nasal mucosal epithelial barrier during allergic rhinitis","volume":"61","author":"Wang","year":"2021","journal-title":"Rev. Fr. Allergol."},{"key":"10.1016\/j.ijbiomac.2024.133459_bb0040","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/1263053","article-title":"Yupingfeng granule improves Th2-biased immune state in microenvironment of hepatocellular carcinoma through TSLP-DC-OX40L pathway","volume":"2020","author":"Yao","year":"2020","journal-title":"Evid. Based Complement. Altern. Med."},{"issue":"7","key":"10.1016\/j.ijbiomac.2024.133459_bb0045","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.reval.2019.03.007","article-title":"Intranasal concentration gradient of yupingfeng promotes induction of microRNA-21 by PTEN to reverse activation of OVA mimicking allergic rhinitis","volume":"59","author":"Huang","year":"2019","journal-title":"Rev. Fr. Allergol."},{"issue":"17","key":"10.1016\/j.ijbiomac.2024.133459_bb0050","doi-asserted-by":"crossref","first-page":"8155","DOI":"10.3390\/app11178155","article-title":"Metabolomic investigation of synergistic mechanism for Fangfeng extract preventing LPS induced Neuroinflammation in BV-2 microglia cells","volume":"11","author":"Zhu","year":"2021","journal-title":"Appl. Sci."},{"key":"10.1016\/j.ijbiomac.2024.133459_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2019.153076","article-title":"Huangqi-Fangfeng protects against allergic airway remodeling through inhibiting epithelial-mesenchymal transition process in mice via regulating epithelial derived TGF-\u03b21","volume":"64","author":"Yao","year":"2019","journal-title":"Phytomedicine"},{"issue":"20","key":"10.1016\/j.ijbiomac.2024.133459_bb0060","first-page":"1755","article-title":"Effect of Saposhnikovan sulphate on the recruitment and re-education of macrophages by MCF-7 cells In vitro through CCL3","volume":"53","author":"Lin","year":"2018","journal-title":"Chin. Pharm. J."},{"key":"10.1016\/j.ijbiomac.2024.133459_bb0065","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.ijbiomac.2018.03.022","article-title":"Structural characterization of polysaccharides from Saposhnikovia divaricata and their antagonistic effects against the immunosuppression by the culture supernatants of melanoma cells on RAW264.7 macrophages","volume":"113","author":"Dong","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"issue":"5","key":"10.1016\/j.ijbiomac.2024.133459_bb0070","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1248\/cpb.37.1329","article-title":"The major Pectic arabinogalactan having activity on the reticuloendothelial system from the roots and rhizomes of Saposhnikovia divaricate","volume":"37","author":"Shimizu","year":"1989","journal-title":"Chem. Pharm. Bull."},{"issue":"07","key":"10.1016\/j.ijbiomac.2024.133459_bb0075","first-page":"1916","article-title":"Immune regulation mechanism of Saposhnikoviae Radix polysaccharide based on zebrafish model","volume":"48","author":"Sun","year":"2022","journal-title":"China J. Chin. Mater. Med."},{"key":"10.1016\/j.ijbiomac.2024.133459_bb0080","first-page":"1","article-title":"Study on the evaluation of immunoregulatory activity of polysaccharide from Saposhnikovia divaricata in vitro and in vivo","author":"Sun","year":"2023","journal-title":"Chin. Arch. Tradit. Chin. Med."},{"key":"10.1016\/j.ijbiomac.2024.133459_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.123502","article-title":"Structure characterization and immunomodulatory activity of a polysaccharide from Saposhnikoviae Radix","volume":"233","author":"Fan","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2024.133459_bb0090","article-title":"An integrated strategy for rapid discovery and identification of the potential effective fragments of poly- saccharides from Saposhnikoviae Radix","volume":"319","author":"Li","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"5","key":"10.1016\/j.ijbiomac.2024.133459_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2020.e03888","article-title":"Box-Behnken design-based optimization for deproteinization of crude polysaccharides in Lycium barbarum berry residue using the Sevag method","volume":"6","author":"Long","year":"2020","journal-title":"Heliyon"},{"key":"10.1016\/j.ijbiomac.2024.133459_bb0100","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.ijbiomac.2018.12.211","article-title":"Physicochemical, rheological and thermal properties of Mesona chinensis polysaccharides obtained by sodium carbonate assisted and cellulase assisted extraction","volume":"126","author":"Xiao","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2024.133459_bb0105","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.carbpol.2018.11.097","article-title":"Structural characteristics and hepatoprotective potential of Aralia elata root bark polysaccharides and their effects on SCFAs produced by intestinal florametabolism","volume":"207","author":"Xia","year":"2019","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2024.133459_bb0110","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.carbpol.2018.05.028","article-title":"Isolation, purification, characterization and antioxidant activity of polysaccharides from the stem barks of Acanthopanax leucorrhizus","volume":"196","author":"Hu","year":"2018","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2024.133459_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2019.115680","article-title":"Purification and structural characterization of polysaccharides isolated from Auricularia cornea var. Li","volume":"230","author":"Wang","year":"2020","journal-title":"Carbohydr. Polym."},{"issue":"4","key":"10.1016\/j.ijbiomac.2024.133459_bb0120","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1039\/C9RA10853J","article-title":"Structure characterization and anticoagulant activity of a novel polysaccharide from Leonurus artemisia (Laur.) S. Y. Hu F","volume":"10","author":"Hu","year":"2020","journal-title":"RSC Adv."},{"key":"10.1016\/j.ijbiomac.2024.133459_bb0125","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.ijbiomac.2022.04.045","article-title":"Clarification of the structural features of Rhamnogalacturonan-I type polysaccharide purified from radish leaves","volume":"209","author":"Son","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2024.133459_bb0130","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1016\/j.ijbiomac.2019.06.176","article-title":"Chromatography and mass spectrometry-based approaches for perception of polysaccharides in wild and cultured fruit bodies of Auricularia auricular-judae","volume":"137","author":"Xia","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2024.133459_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2019.115222","article-title":"Structural elucidation of an anti-metastatic polysaccharide from the peels of Korean citrus Hallabong","volume":"225","author":"Park","year":"2019","journal-title":"Carbohydr. Polym."},{"issue":"4","key":"10.1016\/j.ijbiomac.2024.133459_bb0140","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.jgr.2019.05.002","article-title":"Structural characteristics of a red ginseng acidic polysaccharide rhamnogalacturonan I with immunostimulating activity from red ginseng","volume":"44","author":"Lee","year":"2020","journal-title":"J. Ginseng Res."},{"key":"10.1016\/j.ijbiomac.2024.133459_bb0145","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.ijbiomac.2020.03.057","article-title":"Novel polysaccha- ride from Chaenomeles speciosa seeds: structural characterization, \u03b1-amylase and \u03b1-glucosidase inhibitory activity evaluation","volume":"153","author":"Deng","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2024.133459_bb0150","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/nature12111","article-title":"The zebrafish reference genome sequence and its relationship to the human genome","volume":"496","author":"Howe","year":"2013","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.ijbiomac.2024.133459_bb0155","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/nrd4627","article-title":"Zebrafish as tools for drug discovery","volume":"14","author":"MacRae","year":"2015","journal-title":"Nat. Rev. Drug Discov."},{"issue":"7","key":"10.1016\/j.ijbiomac.2024.133459_bb0160","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.dci.2007.11.011","article-title":"Immunology and zebrafish: spawning new models of human disease","volume":"32","author":"Meeker","year":"2008","journal-title":"Dev. Comp. Immunol."},{"issue":"24","key":"10.1016\/j.ijbiomac.2024.133459_bb0165","doi-asserted-by":"crossref","first-page":"4076","DOI":"10.3390\/cells11244076","article-title":"Anti-inflammatory neutrophil functions in the resolution of inflammation and tissue repair","volume":"11","author":"Loh","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.ijbiomac.2024.133459_bb0170","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.carbpol.2016.05.068","article-title":"Extraction optimization, preliminary characterization and immunological activities in vitro of poly- saccharides from Elaeagnus angustifolia L. pulp","volume":"151","author":"Du","year":"2016","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2024.133459_bb0175","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.ijbiomac.2017.12.017","article-title":"Physicochemical properties and biological activities of polysaccharides from Lycium barbarum prepared by fractional precipitation","volume":"109","author":"Gong","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"issue":"10","key":"10.1016\/j.ijbiomac.2024.133459_bb0180","first-page":"792","article-title":"Purification, structure characterization and antioxidant activity of polysaccharides from Saposhnikovia divaricata","volume":"17","author":"Meng","year":"2019","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.ijbiomac.2024.133459_bb0185","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.ijbiomac.2020.06.128","article-title":"A new water-soluble polysaccharide from Echinops pungens Trautv roots. Part I. Isolation, purification, characterization and antioxidant activity","volume":"161","author":"Hoseiniyan Benvidi","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2024.133459_bb0190","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.ijbiomac.2022.02.073","article-title":"Structural characterization of a low molecular weight Bletilla striata polysaccharide and antitumor activity on H22 tumor-bearing mice","volume":"205","author":"Liu","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2024.133459_bb0195","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.ijbiomac.2022.05.096","article-title":"Purification, structural characterization and immunomodulatory activities of a polysaccharide from the fruiting body of Morchella sextelata","volume":"213","author":"Kuang","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2024.133459_bb0200","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.ijbiomac.2021.09.175","article-title":"Structural characterization of polysaccharide from yellow sweet potato and ameliorates DSS-induced mice colitis by active GPR41\/MEK\/ERK 1\/2 signaling pathway","volume":"192","author":"Feng","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2024.133459_bb0205","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.ijbiomac.2022.04.204","article-title":"Structural characterization and immunoregulatory activity of a novel acidicpolysaccharide from Scapharca subcrenata","volume":"210","author":"Li","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2024.133459_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2020.117078","article-title":"Isolation, purification, structure and antioxidant activity of polysaccharide from pinecones of Pinus koraiensis","volume":"251","author":"Zhang","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2024.133459_bb0215","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.ijbiomac.2021.03.176","article-title":"Purification, structural characterization and immunostimulatory activity of polysaccharides from Umbilicaria esculenta","volume":"181","author":"Shi","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2024.133459_bb0220","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.carbpol.2018.02.009","article-title":"Purification, characterization and immunomodulatory activity of polysaccharides from stem lettuce","volume":"188","author":"Nie","year":"2018","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2024.133459_bb0225","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.ijbiomac.2021.03.088","article-title":"Extraction, purification, physicochemical properties and antioxidant activity of a new polysaccharide from Ocimum album L. seed","volume":"180","author":"Arab","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2024.133459_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2020.116301","article-title":"Microwave-assisted extraction of polysaccharides from the marshmallow roots: optimization, purification, structure, and bioactivity","volume":"240","author":"Hashemifesharaki","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2024.133459_bb0235","article-title":"Immunomodulatory peptides from thick-shelled mussel (Mytilus coruscus): isolation, identification, molecular docking and immunomodulatory effects on RAW264.7 cells","volume":"59","author":"Wang","year":"2024","journal-title":"Food Biosci."},{"issue":"1\u20132","key":"10.1016\/j.ijbiomac.2024.133459_bb0240","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.brainresrev.2011.01.002","article-title":"Interleukin-6, a mental cytokine","volume":"67","author":"Spooren","year":"2011","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.ijbiomac.2024.133459_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.127256","article-title":"Structural characteristics and structure-activity relationship of four polysa- ccharides from Lycii fructus","volume":"253","author":"Liang","year":"2023","journal-title":"Int. J. Biol. Macromol."}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813024042648?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813024042648?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T20:30:54Z","timestamp":1782765054000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0141813024042648"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":49,"alternative-id":["S0141813024042648"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2024.133459","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chemical structure and immunomodulatory activity of a polysaccharide from Saposhnikoviae Radix","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2024.133459","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"133459"}}