{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T02:44:38Z","timestamp":1782873878081,"version":"3.54.5"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004000","name":"Guangzhou Municipal Science and Technology Program key projects","doi-asserted-by":"publisher","award":["2023B03J0022"],"award-info":[{"award-number":["2023B03J0022"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017688","name":"Guangdong Provincial Key Laboratory of Construction Foundation","doi-asserted-by":"publisher","award":["2023B1212060022"],"award-info":[{"award-number":["2023B1212060022"]}],"id":[{"id":"10.13039\/501100017688","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81973264"],"award-info":[{"award-number":["81973264"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82104080"],"award-info":[{"award-number":["82104080"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273870"],"award-info":[{"award-number":["82273870"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515012909"],"award-info":[{"award-number":["2023A1515012909"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024A1515011193"],"award-info":[{"award-number":["2024A1515011193"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.ijbiomac.2024.136757","type":"journal-article","created":{"date-parts":[[2024,10,20]],"date-time":"2024-10-20T18:34:53Z","timestamp":1729449293000},"page":"136757","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"P1","title":["Antibacterial activity and mechanism of colistin-loaded polymeric nanoparticles for combating multidrug-resistant Pseudomonas aeruginosa biofilms: A synergistic approach"],"prefix":"10.1016","volume":"282","author":[{"given":"Shihui","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieyi","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijbiomac.2024.136757_bb0005","unstructured":"M.A.-O.X. McDaniel, N.A.-O. Lindgren, C.A.-O. Billiot, K.A.-O. Valladares, N.A.-O. Sumpter, W.A.-O.X. Swords, Pseudomonas aeruginosa Promotes Persistence of Stenotrophomonas maltophilia via Increased Adherence to Depolarized Respiratory Epithelium, (2165\u20130497 (Electronic))."},{"key":"10.1016\/j.ijbiomac.2024.136757_bb0010","unstructured":"J. Vanderwoude, S. Azimi, T.D. Read, T.D. Read, S.P. Diggle, Evolutionary Drivers of Antimicrobial Resistance Diversity of Pseudomonas aeruginosa in Cystic Fibrosis Lung Infection, bioRxiv (2023)."},{"issue":"4","key":"10.1016\/j.ijbiomac.2024.136757_bb0015","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.02564-18","article-title":"A combination antibiogram evaluation for Pseudomonas aeruginosa in respiratory and blood sources from intensive care unit (ICU) and non-ICU settings in U.S. hospitals","volume":"63","author":"Puzniak","year":"2019","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ijbiomac.2024.136757_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.coi.2023.102328","article-title":"Microevolution of Pseudomonas aeruginosa in the airways of people with cystic fibrosis","volume":"83","author":"Cramer","year":"2023","journal-title":"Curr. Opin. Immunol."},{"issue":"7","key":"10.1016\/j.ijbiomac.2024.136757_bb0025","article-title":"OprF impacts Pseudomonas aeruginosa biofilm matrix eDNA levels in a nutrient-dependent manner","volume":"205","author":"Cassin Erin","year":"2023","journal-title":"J. Bacteriol."},{"issue":"2","key":"10.1016\/j.ijbiomac.2024.136757_bb0030","article-title":"Regulatory landscape of the Pseudomonas aeruginosa phosphoethanolamine transferase gene eptA in the context of colistin resistance","volume":"12","author":"Cervoni","year":"2023","journal-title":"Antibiotics (Basel)"},{"issue":"11","key":"10.1016\/j.ijbiomac.2024.136757_bb0035","doi-asserted-by":"crossref","first-page":"3243","DOI":"10.1007\/s00210-023-02531-4","article-title":"In vivo evaluation of nephrotoxicity and neurotoxicity of colistin formulated with sodium deoxycholate sulfate in a mice model","volume":"396","author":"Bintang","year":"2023","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"issue":"2","key":"10.1016\/j.ijbiomac.2024.136757_bb0040","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1111\/wrr.12890","article-title":"Antibiofilm activity of chitosan\/epsilon-poly-L-lysine hydrogels in a porcine ex vivo skin wound polymicrobial biofilm model","volume":"29","author":"Pati","year":"2021","journal-title":"Wound Repair Regen."},{"issue":"10","key":"10.1016\/j.ijbiomac.2024.136757_bb0045","doi-asserted-by":"crossref","first-page":"6688","DOI":"10.1021\/acsabm.0c00569","article-title":"epsilon-Polylysine nanoconjugates: value-added antimicrobials for drug-resistant bacteria","volume":"3","author":"Prasad","year":"2020","journal-title":"ACS Appl. Bio Mater."},{"key":"10.1016\/j.ijbiomac.2024.136757_bb0050","doi-asserted-by":"crossref","unstructured":"A. Moreno-Lanceta, M. Medrano-Bosch, E.R. Edelman, P.J.N.i.t.L.S. Melgar-Lesmes, Polymeric Nanoparticles for Targeted Drug and Gene Delivery Systems, (2022).","DOI":"10.1007\/978-3-031-12658-1_19"},{"issue":"1","key":"10.1016\/j.ijbiomac.2024.136757_bb0055","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s13567-022-01097-y","article-title":"Pseudomonas aeruginosa biofilm dispersion by the mouse antimicrobial peptide CRAMP","volume":"53","author":"Zhang","year":"2022","journal-title":"Vet. Res."},{"key":"10.1016\/j.ijbiomac.2024.136757_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioflm.2020.100027","article-title":"Biofilm dispersion: the key to biofilm eradication or opening Pandora\u2019s box?","volume":"2","author":"Wille","year":"2020","journal-title":"Biofilm"},{"issue":"3","key":"10.1016\/j.ijbiomac.2024.136757_bb0065","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27030674","article-title":"Recent developments in nitric oxide donors and delivery for antimicrobial and anti-biofilm applications","volume":"27","author":"Poh","year":"2022","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.ijbiomac.2024.136757_bb0070","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1186\/s12951-023-02167-9","article-title":"Functionalized MoS(2)-nanosheets with NIR-triggered nitric oxide delivery and photothermal activities for synergistic antibacterial and regeneration-promoting therapy","volume":"21","author":"Mu","year":"2023","journal-title":"J Nanobiotechnology"},{"key":"10.1016\/j.ijbiomac.2024.136757_bb0075","series-title":"Photodynamic and nitric oxide therapy-based synergistic antimicrobial nanoplatform: an advanced root canal irrigation system for endodontic bacterial infections","volume":"22(1)","author":"Zeng","year":"2024"},{"issue":"3","key":"10.1016\/j.ijbiomac.2024.136757_bb0080","doi-asserted-by":"crossref","first-page":"326","DOI":"10.2174\/1567201820666230116164511","article-title":"Poly(glutamic acid)-engineered nanoplatforms for enhanced cancer phototherapy","volume":"21","author":"Zhang","year":"2024","journal-title":"Curr. Drug Deliv."},{"issue":"21","key":"10.1016\/j.ijbiomac.2024.136757_bb0085","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1056\/NEJMoa1709847","article-title":"Tezacaftor-ivacaftor in residual-function heterozygotes with cystic fibrosis","volume":"377","author":"Rowe","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijbiomac.2024.136757_bb0090","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.ijbiomac.2022.06.111","article-title":"Comparative study of the immunomodulatory effects of different fucoidans from Saccharina japonica mediated by scavenger receptors on RAW 264.7 macrophages","volume":"215","author":"Cui","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"issue":"8","key":"10.1016\/j.ijbiomac.2024.136757_bb0095","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1007\/s00284-020-01949-w","article-title":"Synergistic activity of ceragenins against carbapenem-resistant Acinetobacter baumannii strains in both checkerboard and dynamic time-kill assays","volume":"77","author":"Bozkurt-Guzel","year":"2020","journal-title":"Curr. Microbiol."},{"issue":"9","key":"10.1016\/j.ijbiomac.2024.136757_bb0100","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1021\/acsinfecdis.2c00193","article-title":"Synergy by perturbing the gram-negative outer membrane: opening the door for gram-positive specific antibiotics","volume":"8","author":"Wesseling","year":"2022","journal-title":"ACS Infect Dis"},{"issue":"9","key":"10.1016\/j.ijbiomac.2024.136757_bb0105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1009909","article-title":"Elucidating the mechanism by which synthetic helper peptides sensitize Pseudomonas aeruginosa to multiple antibiotics","volume":"17","author":"Xia","year":"2021","journal-title":"PLoS Pathog."},{"issue":"14","key":"10.1016\/j.ijbiomac.2024.136757_bb0110","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27144325","article-title":"Membrane permeabilization and antimicrobial activity of recombinant defensin-d2 and actifensin against multidrug-resistant Pseudomonas aeruginosa and Candida albicans","volume":"27","author":"Gbala","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.ijbiomac.2024.136757_bb0115","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.842921","article-title":"PKPD modeling of the inoculum effect of Acinetobacter baumannii on Polymyxin B in vivo","volume":"13","author":"Chauzy","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.ijbiomac.2024.136757_bb0120","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s12860-022-00442-5","article-title":"Effects of growth hormone\/estrogen\/androgen on COVID-19-type proinflammatory responses in normal human lung epithelial BEAS-2B cells","volume":"23","author":"Zhu","year":"2022","journal-title":"BMC Mol Cell Biol"},{"issue":"2","key":"10.1016\/j.ijbiomac.2024.136757_bb0125","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s00284-023-03182-7","article-title":"Antibacterial potential of bacterial cellulose impregnated with green synthesized silver nanoparticle against S. aureus and P. aeruginosa","volume":"80","author":"Shaaban","year":"2023","journal-title":"Curr. Microbiol."},{"key":"10.1016\/j.ijbiomac.2024.136757_bb0130","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.mimet.2014.12.021","article-title":"Actinomyces naeslundii GroEL-dependent initial attachment and biofilm formation in a flow cell system","volume":"109","author":"Arai","year":"2015","journal-title":"J. Microbiol. Methods"},{"issue":"2","key":"10.1016\/j.ijbiomac.2024.136757_bb0135","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.nano.2016.10.003","article-title":"Nanoscale imaging and characterization of Caenorhabditis elegans epicuticle using atomic force microscopy","volume":"13","author":"Fakhrullina","year":"2017","journal-title":"Nanomedicine"},{"key":"10.1016\/j.ijbiomac.2024.136757_bb0140","doi-asserted-by":"crossref","unstructured":"E. Le Chatelier, T. Nielsen, J. Qin, E. Prifti, F. Hildebrand, G. Falony, M. Almeida, M. Arumugam, J.M. Batto, S. Kennedy, P. Leonard, J. Li, K. Burgdorf, N. Grarup, T. Jorgensen, I. Brandslund, H.B. Nielsen, A.S. Juncker, M. Bertalan, F. Levenez, N. Pons, S. Rasmussen, S. Sunagawa, J. Tap, S. Tims, E.G. Zoetendal, S. Brunak, K. Clement, J. Dore, M. Kleerebezem, K. Kristiansen, P. Renault, T. Sicheritz-Ponten, W.M. de Vos, J.D. Zucker, J. Raes, T. Hansen, H.I.T.c. Meta, P. Bork, J. Wang, S.D. Ehrlich, O. Pedersen, Richness of human gut microbiome correlates with metabolic markers, Nature 500(7464) (2013) 541\u20136.","DOI":"10.1038\/nature12506"},{"issue":"21","key":"10.1016\/j.ijbiomac.2024.136757_bb0145","doi-asserted-by":"crossref","DOI":"10.1128\/JB.00250-21","article-title":"Impact of artificial sputum medium formulation on Pseudomonas aeruginosa secondary metabolite production","volume":"203","author":"Neve","year":"2021","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.ijbiomac.2024.136757_bb0150","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.jconrel.2019.02.039","article-title":"Mucus penetration enhanced lipid polymer nanoparticles improve the eradication rate of Helicobacter pylori biofilm","volume":"300","author":"Li","year":"2019","journal-title":"J. Control. Release"},{"issue":"24","key":"10.1016\/j.ijbiomac.2024.136757_bb0155","doi-asserted-by":"crossref","DOI":"10.3390\/cells11244038","article-title":"Role of endogenous lipopolysaccharides in neurological disorders","volume":"11","author":"Kalyan","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.ijbiomac.2024.136757_bb0160","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.65836","article-title":"Colistin kills bacteria by targeting lipopolysaccharide in the cytoplasmic membrane","volume":"10","author":"Sabnis","year":"2021","journal-title":"Elife"},{"key":"10.1016\/j.ijbiomac.2024.136757_bb0165","article-title":"Long term chronic Pseudomonas aeruginosa airway infection in mice","volume":"85","author":"Facchini","year":"2014","journal-title":"J. Vis. Exp."},{"issue":"25","key":"10.1016\/j.ijbiomac.2024.136757_bb0170","doi-asserted-by":"crossref","first-page":"eabn7162","DOI":"10.1126\/sciadv.abn7162","article-title":"Inhaled siRNA nanoparticles targeting IL11 inhibit lung fibrosis and improve pulmonary function post-bleomycin challenge","volume":"8","author":"Bai","year":"2022","journal-title":"Sci. Adv."},{"issue":"5","key":"10.1016\/j.ijbiomac.2024.136757_bb0175","doi-asserted-by":"crossref","first-page":"3173","DOI":"10.1016\/j.bbagen.2013.02.004","article-title":"S-nitrosoglutathione","volume":"1830","author":"Broniowska","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"issue":"3","key":"10.1016\/j.ijbiomac.2024.136757_bb0180","doi-asserted-by":"crossref","first-page":"3546","DOI":"10.1021\/acsnano.9b09871","article-title":"Near-infrared light-triggered nitric-oxide-enhanced photodynamic therapy and low-temperature photothermal therapy for biofilm elimination","volume":"14","author":"Yuan","year":"2020","journal-title":"ACS Nano"},{"issue":"1","key":"10.1016\/j.ijbiomac.2024.136757_bb0185","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/s12951-021-00845-0","article-title":"On-demand pH-sensitive surface charge-switchable polymeric micelles for targeting Pseudomonas aeruginosa biofilms development","volume":"19","author":"Chen","year":"2021","journal-title":"J Nanobiotechnology"},{"key":"10.1016\/j.ijbiomac.2024.136757_bb0190","doi-asserted-by":"crossref","unstructured":"M.E. Levison, J.H. Levison, Pharmacokinetics and pharmacodynamics of antibacterial agents, Infect Dis Clin North Am 23(4) (2009) 791\u2013815, vii.","DOI":"10.1016\/j.idc.2009.06.008"},{"issue":"21","key":"10.1016\/j.ijbiomac.2024.136757_bb0195","doi-asserted-by":"crossref","first-page":"7344","DOI":"10.1128\/JB.00779-06","article-title":"Involvement of nitric oxide in biofilm dispersal of Pseudomonas aeruginosa","volume":"188","author":"Barraud","year":"2006","journal-title":"J. Bacteriol."},{"issue":"10","key":"10.1016\/j.ijbiomac.2024.136757_bb0200","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/s41579-020-0385-0","article-title":"Biofilm dispersion","volume":"18","author":"Rumbaugh","year":"2020","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.ijbiomac.2024.136757_bb0205","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bcp.2018.08.002","article-title":"Don\u2019t just say no: differential pathways and pharmacological responses to diverse nitric oxide donors","volume":"156","author":"Chiesa","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ijbiomac.2024.136757_bb0210","unstructured":"M.J. Barraud N Fau - Kelso, S.A. Kelso Mj Fau - Rice, S. Rice Sa Fau - Kjelleberg, S. Kjelleberg, Nitric oxide: a key mediator of biofilm dispersal with applications in infectious diseases, (1873\u20134286 (Electronic))."}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813024075664?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813024075664?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T01:56:10Z","timestamp":1782870970000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0141813024075664"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":42,"alternative-id":["S0141813024075664"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2024.136757","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antibacterial activity and mechanism of colistin-loaded polymeric nanoparticles for combating multidrug-resistant Pseudomonas aeruginosa biofilms: A synergistic approach","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2024.136757","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"136757"}}