{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T21:31:27Z","timestamp":1782768687255,"version":"3.54.5"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.ijbiomac.2024.137699","type":"journal-article","created":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T12:10:18Z","timestamp":1731672618000},"page":"137699","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"P3","title":["Putting forward novel sulfonamide-thiazole-pyrazoline hybrids as potential central core structure for the development of non-specific b-TNAP and c-IAP inhibitors"],"prefix":"10.1016","volume":"283","author":[{"given":"Mian Bilal","family":"Haider","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7112-9296","authenticated-orcid":false,"given":"Aamer","family":"Saeed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Azeem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayyed Aqib","family":"Ullah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syeda Abida","family":"Ejaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hafiz Muhammad","family":"Attaullah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"49","key":"10.1016\/j.ijbiomac.2024.137699_bb0005","first-page":"14302","article-title":"Catalytic activity of human placental alkaline phosphatase (PLAP): insights from a computational study","volume":"118","author":"Borosky","year":"2014","journal-title":"JPC B"},{"issue":"4","key":"10.1016\/j.ijbiomac.2024.137699_bb0010","first-page":"1163","article-title":"Dephosphorylation of endotoxin by alkaline phosphatase in vivo","volume":"151","author":"Poelstra","year":"1997","journal-title":"AJP"},{"issue":"20","key":"10.1016\/j.ijbiomac.2024.137699_bb0015","doi-asserted-by":"crossref","first-page":"4932","DOI":"10.1111\/bph.13261","article-title":"Alkaline phosphatase protects against renal inflammation through dephosphorylation of lipopolysaccharide and adenosine triphosphate","volume":"172","author":"Peters","year":"2015","journal-title":"Br. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.ijbiomac.2024.137699_bb0020","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1159\/000481409","article-title":"Evaluation of the relationship between the serum alkaline phosphatase level at dialysis initiation and all-cause mortality: a multicenter, prospective study","volume":"7","author":"Owaki","year":"2018","journal-title":"Nephron Extra"},{"issue":"6","key":"10.1016\/j.ijbiomac.2024.137699_bb0025","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.urolonc.2014.03.024","article-title":"In elevated alkaline phosphatase velocity strongly predicts overall survival and the risk of bone metastases in castrate-resistant prostate cancer","volume":"32","author":"Metwalli","year":"2014","journal-title":"Urol. Oncol."},{"key":"10.1016\/j.ijbiomac.2024.137699_bb0030","series-title":"Assessment of Lung Eosinophils In Situ Using Immunohistological Staining","first-page":"237","author":"Nazaroff","year":"2021"},{"key":"10.1016\/j.ijbiomac.2024.137699_bb0035","series-title":"Alkaline phosphatase","author":"Lowe","year":"2023"},{"key":"10.1016\/j.ijbiomac.2024.137699_bb0040","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/978-3-319-91442-8_2","article-title":"Lapatinib","author":"Voigtlaender","year":"2018","journal-title":"Small Mol. Oncol."},{"key":"10.1016\/j.ijbiomac.2024.137699_bb0045","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.bioorg.2017.01.003","article-title":"Synthesis, characterization and biological evaluation of novel chalcone sulfonamide hybrids as potent intestinal alkaline phosphatase inhibitors","volume":"70","author":"Ejaz","year":"2017","journal-title":"Bioorg. Chem."},{"issue":"10","key":"10.1016\/j.ijbiomac.2024.137699_bb0050","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1016\/j.bmc.2015.03.054","article-title":"Diarylsulfonamides and their bioisosteres as dual inhibitors of alkaline phosphatase and carbonic anhydrase: structure activity relationship and molecular modelling studies","volume":"23","author":"Al-Rashida","year":"2015","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ijbiomac.2024.137699_bb0055","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.bioorg.2017.01.008","article-title":"Facile dimethyl amino group triggered cyclic sulfonamides synthesis and evaluation as alkaline phosphatase inhibitors","volume":"71","author":"Bhatti","year":"2017","journal-title":"Bioorg. Chem."},{"issue":"22","key":"10.1016\/j.ijbiomac.2024.137699_bb0060","doi-asserted-by":"crossref","first-page":"12601","DOI":"10.3390\/ijms222212601","article-title":"Inhibitory effects of sulfonamide derivatives on the \u03b2-carbonic anhydrase (MpaCA) from Malassezia pachydermatis, a commensal, pathogenic fungus present in domestic animals","volume":"22","author":"De Luca","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ijbiomac.2024.137699_bb0065","series-title":"Present Knowledge in Nutrition","first-page":"171","article-title":"Thiamine","author":"Bettendorff","year":"2020"},{"key":"10.1016\/j.ijbiomac.2024.137699_bb0070","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1007\/s40262-020-00872-4","article-title":"Clinical pharmacokinetics and pharmacodynamics of dasatinib","volume":"59","author":"Lev\u00eaque","year":"2020","journal-title":"Clin. Pharmacokinet."},{"issue":"4","key":"10.1016\/j.ijbiomac.2024.137699_bb0075","doi-asserted-by":"crossref","first-page":"324","DOI":"10.3390\/jof6040324","article-title":"Isavuconazole: mechanism of action, clinical efficacy, and resistance","volume":"6","author":"Ellsworth","year":"2020","journal-title":"J. Fungus"},{"issue":"11","key":"10.1016\/j.ijbiomac.2024.137699_bb0080","doi-asserted-by":"crossref","first-page":"11169","DOI":"10.1007\/s11033-022-07822-2","article-title":"Nitazoxanide and COVID-19: a review","volume":"49","author":"Al-Kuraishy","year":"2022","journal-title":"Mol. Biol. Rep."},{"issue":"21","key":"10.1016\/j.ijbiomac.2024.137699_bb0085","doi-asserted-by":"crossref","first-page":"13262","DOI":"10.3390\/ijms232113262","article-title":"Potent alkaline phosphatase inhibitors, pyrazolo-oxothiazolidines: synthesis, biological evaluation, molecular docking, and kinetic studies","volume":"23","author":"Hosseini Nasab","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.ijbiomac.2024.137699_bb0090","doi-asserted-by":"crossref","first-page":"3241","DOI":"10.1007\/s11030-022-10385-w","article-title":"A zomethine-clubbed thiazoles as human tissue non-specific alkaline phosphatase (h-TNAP) and intestinal alkaline phosphatase (h-IAP) inhibitors: kinetics and molecular docking studies","volume":"26","author":"Saeed","year":"2022","journal-title":"Mol. Divers."},{"issue":"1","key":"10.1016\/j.ijbiomac.2024.137699_bb0095","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s11224-023-02171-7","article-title":"Synthesis, single crystal X-ray structure determination, Hirshfeld surface analysis, crystal voids studies, and density functional theory calculations of N-carbamothioylbenzamide and 1, 3, 5-triazinane-2, 4, 6-trithione co-crystal","volume":"35","author":"Aziz","year":"2024","journal-title":"Struct. Chem."},{"key":"10.1016\/j.ijbiomac.2024.137699_bb0100","series-title":"DFT of Chemical Reactivity","author":"Fuentealba","year":"2014"},{"issue":"1","key":"10.1016\/j.ijbiomac.2024.137699_bb0105","doi-asserted-by":"crossref","first-page":"42717","DOI":"10.1038\/srep42717","article-title":"SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules","volume":"7","author":"Daina","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ijbiomac.2024.137699_bb0110","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1134\/S1068162021050186","article-title":"Synthesis, in vitro, and in silico studies of N-(substituted-phenyl)-3-(4-Phenyl-1-Piperazinyl) propanamides as potent alkaline phosphatase inhibitors","volume":"47","author":"Abbasi","year":"2021","journal-title":"Russ. J. Bioorg. Chem."},{"issue":"1","key":"10.1016\/j.ijbiomac.2024.137699_bb0115","first-page":"188","article-title":"Comparing self-directed methods for training staff to create graphs using Graphpad prism","volume":"52","author":"Berkman","year":"2019","journal-title":"JABA"},{"key":"10.1016\/j.ijbiomac.2024.137699_bb0120","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1016\/j.saa.2014.10.012","article-title":"Quantum mechanical study and spectroscopic (FT-IR, FT-Raman, 13C, 1H) study, first order hyperpolarizability, NBO analysis, HOMO and LUMO analysis of 2-acetoxybenzoic acid by density functional methods","volume":"136","author":"Bhavani","year":"2015","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.ijbiomac.2024.137699_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2021.131212","article-title":"Design, synthesis, characterization, molecular docking and computational studies of 3-phenyl-2-thioxoimidazolidin-4-one derivatives","volume":"1246","author":"Vanitha","year":"2021","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.ijbiomac.2024.137699_bb0130","series-title":"GaussView 6.0. 16","author":"Dennington","year":"2016"},{"issue":"18","key":"10.1016\/j.ijbiomac.2024.137699_bb0135","doi-asserted-by":"crossref","first-page":"4612","DOI":"10.3390\/ijms20184612","article-title":"Application of the SwissDrugDesign online resources in virtual screening","volume":"20","author":"Daina","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.ijbiomac.2024.137699_bb0140","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.drudis.2019.10.014","article-title":"A drug-likeness toolbox facilitates ADMET study in drug discovery","volume":"25","author":"Jia","year":"2020","journal-title":"Drug Discov. Today"},{"issue":"1\u20133","key":"10.1016\/j.ijbiomac.2024.137699_bb0145","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0169-409X(96)00423-1","article-title":"Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings","volume":"23","author":"Lipinski","year":"1997","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"10","key":"10.1016\/j.ijbiomac.2024.137699_bb0150","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1016\/j.bmc.2015.03.054","article-title":"Diarylsulfonamides and their bioisosteres as dual inhibitors of alkaline phosphatase and carbonic anhydrase: structure activity relationship and molecular modelling studies","volume":"23","author":"Al-Rashida","year":"2015","journal-title":"Bioorg. Med. Chem."},{"issue":"1","key":"10.1016\/j.ijbiomac.2024.137699_bb0155","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/pro.3934","article-title":"The AutoDock suite at 30","volume":"30","author":"Goodsell","year":"2021","journal-title":"Protein Sci."},{"issue":"2","key":"10.1016\/j.ijbiomac.2024.137699_bb0160","first-page":"67","article-title":"ChemDraw","volume":"81","author":"Brown","year":"2014","journal-title":"Sci. Teach."},{"issue":"2","key":"10.1016\/j.ijbiomac.2024.137699_bb0165","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1039\/D3RA06812A","article-title":"Novel pyrazoline linked acyl thiourea pharmacophores as antimicrobial, urease, amylase and \u03b1-glucosidase inhibitors: design, synthesis, SAR and molecular docking studies","volume":"14","author":"Saeed","year":"2024","journal-title":"RSC Adv."}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014181302408509X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014181302408509X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T17:47:45Z","timestamp":1782755265000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S014181302408509X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":33,"alternative-id":["S014181302408509X"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2024.137699","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Putting forward novel sulfonamide-thiazole-pyrazoline hybrids as potential central core structure for the development of non-specific b-TNAP and c-IAP inhibitors","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2024.137699","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"137699"}}