{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T18:51:44Z","timestamp":1793731904820,"version":"4.6.1"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004000","name":"Guangzhou Municipal Science and Technology Program key projects","doi-asserted-by":"publisher","award":["2024A04J3478"],"award-info":[{"award-number":["2024A04J3478"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["11623410"],"award-info":[{"award-number":["11623410"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82102113"],"award-info":[{"award-number":["82102113"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32171369"],"award-info":[{"award-number":["32171369"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.ijbiomac.2025.140751","type":"journal-article","created":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T11:56:53Z","timestamp":1738843013000},"page":"140751","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"P1","title":["Near-infrared light-triggered nitric oxide-releasing hyaluronic acid hydrogel for precision transdermal therapy of androgenic alopecia"],"prefix":"10.1016","volume":"304","author":[{"given":"Hui","family":"Xing","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yucheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengling","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanqi","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxu","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guowei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.ijbiomac.2025.140751_bb0005","doi-asserted-by":"crossref","first-page":"147","DOI":"10.4103\/ijt.ijt_6_19","article-title":"Quality of life assessment in patients with androgenetic alopecia","volume":"11","author":"Gupta","year":"2019","journal-title":"Int. J. Trichology"},{"issue":"3","key":"10.1016\/j.ijbiomac.2025.140751_bb0010","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.mehy.2009.03.032","article-title":"Androgenic alopecia: a counterproductive outcome of the anabolic effect of androgens","volume":"73","author":"Soni","year":"2009","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.ijbiomac.2025.140751_bb0015","unstructured":"W. Cranwell, R. Sinclair, Male androgenetic alopecia, (2015)."},{"key":"10.1016\/j.ijbiomac.2025.140751_bb0020","first-page":"2401176","article-title":"Platinum Nanozyme-loaded dissolving microneedles scavenge ROS and Promote lineage progression for androgenetic alopecia treatment, small","author":"Hu","year":"2024","journal-title":"Methods"},{"key":"10.1016\/j.ijbiomac.2025.140751_bb0025","article-title":"Octopus-inspired adaptive molecular motion for synergistic Photothermal and nitric oxide antibacterial therapy in diabetic wound repair","volume":"2402591","author":"Chen","year":"2024","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.ijbiomac.2025.140751_bb0030","first-page":"190","article-title":"Nitric oxide synergizes minoxidil delivered by transdermal hyaluronic acid liposomes for multimodal androgenetic-alopecia therapy","volume":"32","author":"Xing","year":"2024","journal-title":"Bioact. Mater."},{"issue":"6","key":"10.1016\/j.ijbiomac.2025.140751_bb0035","doi-asserted-by":"crossref","first-page":"1701043","DOI":"10.1002\/advs.201701043","article-title":"Progress and promise of nitric oxide-releasing platforms","volume":"5","author":"Yang","year":"2018","journal-title":"Adv. Sci."},{"issue":"9","key":"10.1016\/j.ijbiomac.2025.140751_bb0040","doi-asserted-by":"crossref","first-page":"791","DOI":"10.3390\/antiox9090791","article-title":"Nitric oxide nano-delivery systems for cancer therapeutics: advances and challenges","volume":"9","author":"Vong","year":"2020","journal-title":"Antioxidants"},{"key":"10.1016\/j.ijbiomac.2025.140751_bb0045","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.actbio.2024.09.017","article-title":"A photo-modulated nitric oxide delivering hydrogel for the accelerated healing of biofilm infected chronic wounds","volume":"188","author":"Ma","year":"2024","journal-title":"Acta Biomater."},{"issue":"41","key":"10.1016\/j.ijbiomac.2025.140751_bb0050","doi-asserted-by":"crossref","first-page":"2402591","DOI":"10.1002\/adfm.202402591","article-title":"Octopus-inspired adaptive molecular motion for synergistic Photothermal and nitric oxide antibacterial therapy in diabetic wound repair","volume":"34","author":"Chen","year":"2024","journal-title":"Adv. Funct. Mater."},{"issue":"8","key":"10.1016\/j.ijbiomac.2025.140751_bb0055","first-page":"574","article-title":"An overview of hydrogels and their role in transdermal drug delivery, international journal of polymeric materials and polymeric","volume":"70","author":"Ahsan","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.ijbiomac.2025.140751_bb0060","first-page":"214","article-title":"Molecular design of an ultra-strong tissue adhesive hydrogel with tunable multifunctionality","volume":"29","author":"Zheng","year":"2023","journal-title":"Bioact. Mater."},{"issue":"6","key":"10.1016\/j.ijbiomac.2025.140751_bb0065","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1021\/acs.chemmater.1c03944","article-title":"Injectable adhesive self-healing multiple-dynamic-bond crosslinked hydrogel with photothermal antibacterial activity for infected wound healing","volume":"34","author":"Guo","year":"2022","journal-title":"Chem. Mater."},{"key":"10.1016\/j.ijbiomac.2025.140751_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.120838","article-title":"A physicochemical double cross-linked multifunctional hydrogel for dynamic burn wound healing: shape adaptability, injectable self-healing property and enhanced adhesion","volume":"276","author":"Yuan","year":"2021","journal-title":"Biomaterials"},{"issue":"12","key":"10.1016\/j.ijbiomac.2025.140751_bb0075","doi-asserted-by":"crossref","first-page":"4484","DOI":"10.1039\/D1BM00406A","article-title":"Hyaluronidase-responsive phototheranostic nanoagents for fluorescence imaging and photothermal\/photodynamic therapy of methicillin-resistant Staphylococcus aureus infections","volume":"9","author":"Yuwen","year":"2021","journal-title":"Biomater. Sci."},{"issue":"22","key":"10.1016\/j.ijbiomac.2025.140751_bb0080","doi-asserted-by":"crossref","first-page":"6399","DOI":"10.1039\/D2BM01154A","article-title":"Dynamic covalent crosslinked hyaluronic acid hydrogels and nanomaterials for biomedical applications","volume":"10","author":"Wang","year":"2022","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.ijbiomac.2025.140751_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2023.143778","article-title":"Review of characteristics, generation pathways and detection methods of singlet oxygen generated in advanced oxidation processes (AOPs)","volume":"468","author":"Xie","year":"2023","journal-title":"Chem. Eng. J."},{"issue":"11","key":"10.1016\/j.ijbiomac.2025.140751_bb0090","doi-asserted-by":"crossref","first-page":"2206959","DOI":"10.1002\/advs.202206959","article-title":"Enhanced bacterial-infected wound healing by nitric oxide-releasing topological supramolecular nanocarriers with self-optimized cooperative multi-point anchoring","volume":"10","author":"Li","year":"2023","journal-title":"Adv. Sci."},{"key":"10.1016\/j.ijbiomac.2025.140751_bb0095","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.jconrel.2020.05.010","article-title":"Dual-responsive injectable hydrogels encapsulating drug-loaded micelles for on-demand antimicrobial activity and accelerated wound healing","volume":"324","author":"Hu","year":"2020","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ijbiomac.2025.140751_bb0100","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.jconrel.2020.03.033","article-title":"Delivery of thymoquinone through hyaluronic acid-decorated mixed Pluronic\u00ae nanoparticles to attenuate angiogenesis and metastasis of triple-negative breast cancer","volume":"322","author":"Bhattacharya","year":"2020","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ijbiomac.2025.140751_bb0105","first-page":"81","article-title":"A combination therapy for androgenic alopecia based on quercetin and zinc\/copper dual-doped mesoporous silica nanocomposite microneedle patch","volume":"24","author":"Zhang","year":"2023","journal-title":"Bioact. mater."},{"key":"10.1016\/j.ijbiomac.2025.140751_bb0110","first-page":"95","article-title":"Hydrogel forming microneedles loaded with VEGF and Ritlecitinib\/polyhydroxyalkanoates nanoparticles for mini-invasive androgenetic alopecia treatment","volume":"38","author":"Ding","year":"2024","journal-title":"Bioact. Mater."},{"issue":"8","key":"10.1016\/j.ijbiomac.2025.140751_bb0115","doi-asserted-by":"crossref","first-page":"2200052","DOI":"10.1002\/adtp.202200052","article-title":"Dual-mode vasodilator M119 delivery to hair follicle via dissolving microneedle for advanced alopecia treatment","volume":"5","author":"Kim","year":"2022","journal-title":"Adv. Therap."},{"key":"10.1016\/j.ijbiomac.2025.140751_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2022.119843","article-title":"Solid phase synthesis of oxidized sodium alginate-tobramycin conjugate and its application for infected wound healing","volume":"295","author":"Liang","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2025.140751_bb0125","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.jconrel.2023.12.009","article-title":"Transdermal delivery of Fn14 siRNA using a novel composite ionic liquid for treatment of psoriasis-like skin lesions","volume":"365","author":"Li","year":"2024","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ijbiomac.2025.140751_bb0130","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.ijbiomac.2022.04.025","article-title":"Carboxymethyl chitosan-based electrospun nanofibers with high citral-loading for potential anti-infection wound dressings","volume":"209","author":"Li","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"issue":"51","key":"10.1016\/j.ijbiomac.2025.140751_bb0135","doi-asserted-by":"crossref","first-page":"61638","DOI":"10.1021\/acsami.1c18701","article-title":"Injectable and self-healing hydrogels with double-dynamic bond tunable mechanical, gel\u2013sol transition and drug delivery properties for promoting periodontium regeneration in periodontitis","volume":"13","author":"Guo","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.ijbiomac.2025.140751_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2022.119154","article-title":"Rheology and texture analysis of gelatin\/dialdehyde starch hydrogel carriers for curcumin controlled release","volume":"283","author":"Cui","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2025.140751_bb0145","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.jconrel.2020.04.027","article-title":"Photo-triggered self-destructive ROS-responsive nanoparticles of high paclitaxel\/chlorin e6 co-loading capacity for synergetic chemo-photodynamic therapy","volume":"323","author":"Yang","year":"2020","journal-title":"J. Control. Release"},{"issue":"8","key":"10.1016\/j.ijbiomac.2025.140751_bb0150","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1016\/j.jid.2022.01.003","article-title":"Androgen receptor\u2013mediated paracrine signaling induces regression of blood vessels in the dermal papilla in androgenetic alopecia","volume":"142","author":"Deng","year":"2022","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.ijbiomac.2025.140751_bb0155","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.reth.2022.10.005","article-title":"Regenerative medicine strategies for hair growth and regeneration: a narrative review of literature","volume":"21","author":"Shimizu","year":"2022","journal-title":"Regen. ther."},{"issue":"1","key":"10.1016\/j.ijbiomac.2025.140751_bb0160","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/jid.2011.274","article-title":"Dihydrotestosterone-inducible IL-6 inhibits elongation of human hair shafts by suppressing matrix cell proliferation and promotes regression of hair follicles in mice","volume":"132","author":"Kwack","year":"2012","journal-title":"J. Invest. Dermatol."},{"issue":"2","key":"10.1016\/j.ijbiomac.2025.140751_bb0165","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/sj.onc.1205045","article-title":"Low plasma levels of matrix metalloproteinase 9 permit increased tumor angiogenesis","volume":"21","author":"Pozzi","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.ijbiomac.2025.140751_bb0170","series-title":"Double Immunofluorescence Labeling for CD31 and CD105 as a Marker for Polyether Polyurethane-Induced Angiogenesis in Mice","author":"Figueiredo","year":"2019"},{"issue":"4","key":"10.1016\/j.ijbiomac.2025.140751_bb0175","first-page":"1187","article-title":"Cutoff of 25% for Ki67 expression is a good classification tool for prognosis in colorectal cancer in the AJCC-8 stratification","volume":"43","author":"Tong","year":"2020","journal-title":"Oncol. Rep."},{"issue":"10","key":"10.1016\/j.ijbiomac.2025.140751_bb0180","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1016\/j.humimm.2013.06.009","article-title":"3-Nitrotyrosine: a biomarker of nitrogen free radical species modified proteins in systemic autoimmunogenic conditions","volume":"74","author":"Ahsan","year":"2013","journal-title":"Hum. Immunol."},{"issue":"5","key":"10.1016\/j.ijbiomac.2025.140751_bb0185","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1046\/j.1365-2133.2000.03784.x","article-title":"High-dose proinflammatory cytokines induce apoptosis of hair bulb keratinocytes in vivo","volume":"143","author":"R\u00fcckert","year":"2000","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.ijbiomac.2025.140751_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111247","article-title":"Dihydrotestosterone-induced hair regrowth inhibition by activating androgen receptor in C57BL6 mice simulates androgenetic alopecia","volume":"137","author":"Fu","year":"2021","journal-title":"Biomed. Pharmacother."},{"issue":"2","key":"10.1016\/j.ijbiomac.2025.140751_bb0195","first-page":"455","article-title":"Vascular endothelial growth factor (VEGF)-key factor in normal and pathological angiogenesis","volume":"59","author":"Melincovici","year":"2018","journal-title":"Romanian J. Morphol. Embryol."},{"issue":"6","key":"10.1016\/j.ijbiomac.2025.140751_bb0200","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1902\/jop.2013.130318","article-title":"Platelet-rich plasma, low-level laser therapy, or their combination promotes periodontal regeneration in fenestration defects: a preliminary in vivo study","volume":"85","author":"Nagata","year":"2014","journal-title":"J. Periodontol."}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813025013005?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813025013005?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T04:03:35Z","timestamp":1776571415000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0141813025013005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":40,"alternative-id":["S0141813025013005"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2025.140751","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Near-infrared light-triggered nitric oxide-releasing hyaluronic acid hydrogel for precision transdermal therapy of androgenic alopecia","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2025.140751","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"140751"}}