{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T21:54:06Z","timestamp":1791064446095,"version":"4.1.0"},"update-to":[{"DOI":"10.1016\/j.ijbiomac.2025.141815","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000}}],"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172109"],"award-info":[{"award-number":["82172109"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.ijbiomac.2025.141815","type":"journal-article","created":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T05:35:32Z","timestamp":1741239332000},"page":"141815","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"P4","title":["RETRACTED: Single-cell RNA-seq reveals the immune response of Co-infection with streptococcus pneumoniae after influenza A virus by a lung-on-chip: The molecular structure and mechanism of tight junction protein ZO-1"],"prefix":"10.1016","volume":"306","author":[{"given":"Shaoyan","family":"Gu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxuan","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongkuo","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingze","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixin","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.ijbiomac.2025.141815_bb0005","first-page":"659","article-title":"Influenza update: a review of currently available vaccines","volume":"36","author":"Clayville","year":"2011","journal-title":"P T."},{"issue":"7","key":"10.1016\/j.ijbiomac.2025.141815_bb0010","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1086\/591708","article-title":"Predominant role of bacterial pneumonia as a cause of death in pandemic influenza: implications for pandemic influenza preparedness","volume":"198","author":"Morens","year":"2008","journal-title":"J Infect Dis"},{"issue":"2","key":"10.1016\/j.ijbiomac.2025.141815_bb0015","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1086\/498911","article-title":"Influenza-induced expression of indoleamine 2,3-dioxygenase enhances interleukin-10 production and bacterial outgrowth during secondary pneumococcal pneumonia","volume":"193","author":"van der Sluijs","year":"2006","journal-title":"J Infect Dis"},{"issue":"3","key":"10.1016\/j.ijbiomac.2025.141815_bb0020","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1093\/infdis\/jir749","article-title":"Impact of the 2009 influenza pandemic on pneumococcal pneumonia hospitalizations in the United States","volume":"205","author":"Weinberger","year":"2012","journal-title":"J Infect Dis"},{"issue":"6","key":"10.1016\/j.ijbiomac.2025.141815_bb0025","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1111\/irv.12410","article-title":"Pulmonary changes in Norwegian fatal cases of pandemic influenza H1N1 (2009) infection: a morphologic and molecular genetic study","volume":"10","author":"Voltersvik","year":"2016","journal-title":"Influenza Other Respi. Viruses"},{"issue":"4","key":"10.1016\/j.ijbiomac.2025.141815_bb0030","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1055\/s-0040-1702193","article-title":"The role of Streptococcus pneumoniae in community-acquired pneumonia","volume":"41","author":"Feldman","year":"2020","journal-title":"Semin. Respir. Crit. Care Med."},{"issue":"10","key":"10.1016\/j.ijbiomac.2025.141815_bb0035","doi-asserted-by":"crossref","first-page":"3799","DOI":"10.1073\/pnas.1400593111","article-title":"Mapping the innate signaling cascade essential for cytokine storm during influenza virus infection","volume":"111","author":"Teijaro","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.ijbiomac.2025.141815_bb0040","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/nri3166","article-title":"Regulating the adaptive immune response to respiratory virus infection","volume":"12","author":"Braciale","year":"2012","journal-title":"Nat. Rev. Immunol."},{"issue":"5","key":"10.1016\/j.ijbiomac.2025.141815_bb0045","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/nri3665","article-title":"Innate immunity to influenza virus infection","volume":"14","author":"Iwasaki","year":"2014","journal-title":"Nat. Rev. Immunol."},{"issue":"5","key":"10.1016\/j.ijbiomac.2025.141815_bb0050","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1183\/09031936.00186214","article-title":"Influenza virus-induced lung injury: pathogenesis and implications for treatment","volume":"45","author":"Herold","year":"2015","journal-title":"Eur. Respir. J."},{"issue":"2","key":"10.1016\/j.ijbiomac.2025.141815_bb0055","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1097\/QCO.0000000000000347","article-title":"Bacterial pneumonia as an influenza complication","volume":"30","author":"Martin-Loeches","year":"2017","journal-title":"Curr. Opin. Infect. Dis."},{"key":"10.1016\/j.ijbiomac.2025.141815_bb0060","doi-asserted-by":"crossref","first-page":"420","DOI":"10.3389\/fmed.2020.00420","article-title":"Secondary bacterial infections in patients with viral pneumonia","volume":"7","author":"Manohar","year":"2020","journal-title":"Front Med (Lausanne)."},{"key":"10.1016\/j.ijbiomac.2025.141815_bb0065","doi-asserted-by":"crossref","first-page":"205","DOI":"10.3389\/fcimb.2018.00205","article-title":"Detection of pulmonary infectious pathogens from lung biopsy tissues by metagenomic next-generation sequencing","volume":"8","author":"Li","year":"2018","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"2","key":"10.1016\/j.ijbiomac.2025.141815_bb0070","doi-asserted-by":"crossref","first-page":"383","DOI":"10.4049\/jimmunol.1700453","article-title":"Of mice, dirty mice, and men: using mice to understand human immunology","volume":"199","author":"Masopust","year":"2017","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.ijbiomac.2025.141815_bb0075","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/nmeth.2429","article-title":"Model organisms: mouse models challenged","volume":"10","author":"de Souza","year":"2013","journal-title":"Nat. Methods"},{"issue":"1","key":"10.1016\/j.ijbiomac.2025.141815_bb0080","first-page":"170","article-title":"Mouse models of human disease: an evolutionary perspective","volume":"2016","author":"Perlman","year":"2016","journal-title":"Evol Med Public Health."},{"issue":"5","key":"10.1016\/j.ijbiomac.2025.141815_bb0085","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.4049\/jimmunol.172.5.2731","article-title":"Of mice and not men: differences between mouse and human immunology","volume":"172","author":"Mestas","year":"2004","journal-title":"J. Immunol."},{"issue":"5","key":"10.1016\/j.ijbiomac.2025.141815_bb0090","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.molmed.2017.02.007","article-title":"Disease modeling in stem cell-derived 3D organoid systems","volume":"23","author":"Dutta","year":"2017","journal-title":"Trends Mol. Med."},{"issue":"8","key":"10.1016\/j.ijbiomac.2025.141815_bb0095","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1038\/nbt.2989","article-title":"Microfluidic organs-on-chips","volume":"32","author":"Bhatia","year":"2014","journal-title":"Nat. Biotechnol."},{"issue":"12","key":"10.1016\/j.ijbiomac.2025.141815_bb0100","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1039\/c2lc40074j","article-title":"Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow","volume":"12","author":"Kim","year":"2012","journal-title":"Lab Chip"},{"issue":"Suppl. 1","key":"10.1016\/j.ijbiomac.2025.141815_bb0105","doi-asserted-by":"crossref","first-page":"S42","DOI":"10.1513\/AnnalsATS.201410-442MG","article-title":"A human breathing lung-on-a-chip","volume":"12","author":"Huh","year":"2015","journal-title":"Ann Am Thorac Soc."},{"issue":"5","key":"10.1016\/j.ijbiomac.2025.141815_bb0110","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1039\/C4LC01252F","article-title":"A lung-on-a-chip array with an integrated bio-inspired respiration mechanism","volume":"15","author":"Stucki","year":"2015","journal-title":"Lab Chip"},{"issue":"5986","key":"10.1016\/j.ijbiomac.2025.141815_bb0115","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1126\/science.1188302","article-title":"Reconstituting organ-level lung functions on a chip","volume":"328","author":"Huh","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.ijbiomac.2025.141815_bb0120","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.media.2016.11.007","article-title":"Migration and interaction tracking for quantitative analysis of phagocyte-pathogen confrontation assays","volume":"36","author":"Brandes","year":"2017","journal-title":"Med. Image Anal."},{"key":"10.1016\/j.ijbiomac.2025.141815_bb0125","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.media.2014.10.002","article-title":"Automated segmentation and tracking of non-rigid objects in time-lapse microscopy videos of polymorphonuclear neutrophils","volume":"20","author":"Brandes","year":"2015","journal-title":"Med. Image Anal."},{"issue":"5","key":"10.1016\/j.ijbiomac.2025.141815_bb0130","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1002\/bit.21360","article-title":"An artificial liver sinusoid with a microfluidic endothelial-like barrier for primary hepatocyte culture","volume":"97","author":"Lee","year":"2007","journal-title":"Biotechnol. Bioeng."},{"issue":"3","key":"10.1016\/j.ijbiomac.2025.141815_bb0135","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1021\/bp0300568","article-title":"Microfluidic PDMS (polydimethylsiloxane) bioreactor for large-scale culture of hepatocytes","volume":"20","author":"Leclerc","year":"2004","journal-title":"Biotechnol. Prog."},{"issue":"18","key":"10.1016\/j.ijbiomac.2025.141815_bb0140","doi-asserted-by":"crossref","first-page":"4597","DOI":"10.1016\/j.cell.2021.08.005","article-title":"Organs-on-a-chip models for biological research","volume":"184","author":"Vunjak-Novakovic","year":"2021","journal-title":"Cell"},{"issue":"177","key":"10.1016\/j.ijbiomac.2025.141815_bb0145","doi-asserted-by":"crossref","first-page":"539","DOI":"10.24976\/Discov.Med.202335177.55","article-title":"Exploring influenza A virus-induced lung injury and immune response based on humanized lung-on-chip","volume":"35","author":"Gu","year":"2023","journal-title":"Discov. Med."},{"issue":"5986","key":"10.1016\/j.ijbiomac.2025.141815_bb0150","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1126\/science.1188302","article-title":"Reconstituting organ-level lung functions on a chip","volume":"328","author":"Huh","year":"2010","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.ijbiomac.2025.141815_bb0155","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1165\/rcmb.2006-0410OC","article-title":"Differentiated human alveolar epithelial cells and reversibility of their phenotype in vitro","volume":"36","author":"Wang","year":"2007","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"7","key":"10.1016\/j.ijbiomac.2025.141815_bb0160","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1513\/pats.200803-028HR","article-title":"Knowns and unknowns of the alveolus","volume":"5","author":"Herzog","year":"2008","journal-title":"Proc. Am. Thorac. Soc."},{"issue":"22","key":"10.1016\/j.ijbiomac.2025.141815_bb0165","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1001\/jama.2011.1755","article-title":"Drug for severe sepsis is withdrawn from market, fails to reduce mortality [J]","volume":"306","author":"Mitka","year":"2011","journal-title":"Jama"},{"issue":"6","key":"10.1016\/j.ijbiomac.2025.141815_bb0170","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.immuni.2008.12.003","article-title":"A prescription for human immunology [J]","volume":"29","author":"Davis","year":"2008","journal-title":"Immunity"},{"issue":"4","key":"10.1016\/j.ijbiomac.2025.141815_bb0175","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1055\/s-0040-1702193","article-title":"The role of Streptococcus pneumoniae in community-acquired pneumonia","volume":"41","author":"Feldman","year":"2020","journal-title":"Semin. Respir. Crit. Care Med."},{"issue":"2","key":"10.1016\/j.ijbiomac.2025.141815_bb0180","doi-asserted-by":"crossref","first-page":"235","DOI":"10.5858\/134.2.235","article-title":"Pulmonary pathologic findings of fatal 2009 pandemic influenza A\/H1N1 viral infections","volume":"134","author":"Gill","year":"2010","journal-title":"Arch. Pathol. Lab. Med."},{"issue":"3","key":"10.1016\/j.ijbiomac.2025.141815_bb0185","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1128\/CMR.00058-05","article-title":"Insights into the interaction between influenza virus and pneumococcus","volume":"19","author":"McCullers","year":"2006","journal-title":"Clin. Microbiol. Rev."},{"issue":"5","key":"10.1016\/j.ijbiomac.2025.141815_bb0190","doi-asserted-by":"crossref","first-page":"609","DOI":"10.2217\/fmb.12.29","article-title":"Interactions between Streptococcus pneumoniae and influenza virus: a mutually beneficial relationship?","volume":"7","author":"Short","year":"2012","journal-title":"Future Microbiol."},{"issue":"10","key":"10.1016\/j.ijbiomac.2025.141815_bb0195","doi-asserted-by":"crossref","first-page":"4166","DOI":"10.1007\/s12325-023-02610-1","article-title":"Understanding the global burden of influenza in adults aged 18\u201364 years: a systematic literature review from 2012 to 2022","volume":"40","author":"Maleki","year":"2023","journal-title":"Adv. Ther."},{"issue":"3","key":"10.1016\/j.ijbiomac.2025.141815_bb0200","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1093\/infdis\/jir749","article-title":"Impact of the 2009 influenza pandemic on pneumococcal pneumonia hospitalizations in the United States","volume":"205","author":"Weinberger","year":"2012","journal-title":"J Infect Dis"},{"issue":"9","key":"10.1016\/j.ijbiomac.2025.141815_bb0205","doi-asserted-by":"crossref","first-page":"e01101","DOI":"10.1128\/JVI.01101-19","article-title":"Benefits and perils of necroptosis in influenza virus infection","volume":"94","author":"Balachandran","year":"2020","journal-title":"J. Virol."},{"issue":"8","key":"10.1016\/j.ijbiomac.2025.141815_bb0210","doi-asserted-by":"crossref","first-page":"108062","DOI":"10.1016\/j.celrep.2020.108062","article-title":"Influenza-induced oxidative stress sensitizes lung cells to bacterial-toxin-mediated necroptosis","volume":"32","author":"Gonzalez-Juarbe","year":"2020","journal-title":"Cell Rep."}],"updated-by":[{"DOI":"10.1016\/j.ijbiomac.2025.141815","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000}},{"DOI":"10.1016\/j.ijbiomac.2026.153571","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000}},{"DOI":"10.1016\/j.ijbiomac.2026.153571","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"record-id":"72452"},{"DOI":"10.1016\/j.ijbiomac.2026.153571","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000}}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813025023669?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813025023669?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T21:22:00Z","timestamp":1791062520000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0141813025023669"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":42,"alternative-id":["S0141813025023669"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2025.141815","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"RETRACTED: Single-cell RNA-seq reveals the immune response of Co-infection with streptococcus pneumoniae after influenza A virus by a lung-on-chip: The molecular structure and mechanism of tight junction protein ZO-1","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2025.141815","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"141815"}}