{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:30:51Z","timestamp":1792031451805,"version":"4.4.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.ijbiomac.2025.144166","type":"journal-article","created":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T07:37:33Z","timestamp":1747121853000},"page":"144166","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Injectable nanocomposite hydrogel of dapagliflozin\u2013CeO\u2082-loaded polyaniline\/hyaluronic acid for suppressing cardiomyocyte oxidative stress in myocardial infarction therapy"],"prefix":"10.1016","volume":"313","author":[{"given":"Zheng","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinjian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolong","family":"Mi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijbiomac.2025.144166_bb0005","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1016\/j.jacc.2021.02.041","article-title":"Long-term outcomes of patients with late presentation of ST-segment elevation myocardial infarction","volume":"77","author":"Cho","year":"2021","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijbiomac.2025.144166_bb0010","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1161\/CIRCULATIONAHA.119.042157","article-title":"A proposal for modest revision of the definition of type 1 and type 2 myocardial infarction","volume":"140","author":"de Lemos","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.ijbiomac.2025.144166_bb0015","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1161\/01.CIR.101.25.2981","article-title":"Left ventricular remodeling after myocardial infarction: pathophysiology and therapy","volume":"25","author":"Sutton","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.ijbiomac.2025.144166_bb0020","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1056\/NEJMra071667","article-title":"Myocardial reperfusion injury","volume":"357","author":"Yellon","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijbiomac.2025.144166_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2024.122998","article-title":"Myocardial ischemia-reperfusion injury: the balance mechanism between mitophagy and NLRP3 inflammasome","volume":"355","author":"Chen","year":"2024","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/j.ijbiomac.2025.144166_bb0030","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jacc.2018.09.086","article-title":"Multitarget strategies to reduce myocardial ischemia\/reperfusion injury: JACC review topic of the week","volume":"73","author":"Davidson","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijbiomac.2025.144166_bb0035","doi-asserted-by":"crossref","first-page":"393","DOI":"10.3390\/biomedicines10020393","article-title":"Involvement of oxidative stress in the development of subcellular defects and heart disease","volume":"2","author":"Dhalla","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.ijbiomac.2025.144166_bb0040","doi-asserted-by":"crossref","first-page":"20230711","DOI":"10.1515\/med-2023-0711","article-title":"Nrf2 protects against myocardial ischemia-reperfusion injury in diabetic rats by inhibiting Drp1-mediated mitochondrial fission","volume":"1","author":"Wang","year":"2023","journal-title":"Open Med. (Wars)"},{"key":"10.1016\/j.ijbiomac.2025.144166_bb0045","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1146\/annurev-pharmtox-011112-140320","article-title":"Role of nrf2 in oxidative stress and toxicity","volume":"53","author":"Szklarz","year":"2013","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.ijbiomac.2025.144166_bb0050","doi-asserted-by":"crossref","first-page":"5300","DOI":"10.1038\/s41598-024-53836-0","article-title":"NRF2 activation ameliorates blood\u2013brain barrier injury after cerebral ischemic stroke by regulating ferroptosis and inflammation","volume":"1","author":"Fan","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ijbiomac.2025.144166_bb0055","first-page":"5695723","article-title":"The Nrf-2\/HO-1 signaling axis: a ray of hope in cardiovascular diseases","volume":"1","author":"Zhang","year":"2020","journal-title":"Cardiol. Res. Pract."},{"key":"10.1016\/j.ijbiomac.2025.144166_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabres.2023.110644","article-title":"Glycaemic control in people with diabetes following acute myocardial infarction","volume":"199","author":"Esdaile","year":"2023","journal-title":"Diabetes Res. Clin. Pr."},{"key":"10.1016\/j.ijbiomac.2025.144166_bb0065","article-title":"Impact of diabetes on outcomes in patients hospitalized with acute myocardial infarction: insights from the atherosclerosis risk in communities study community surveillance","volume":"10","author":"Jain","year":"2023","journal-title":"J. Am. Heart Assoc."},{"issue":"10","key":"10.1016\/j.ijbiomac.2025.144166_bb0070","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.2337\/dc18-2356","article-title":"Effects of metformin therapy on coronary endothelial dysfunction in patients with prediabetes with stable angina and nonobstructive coronary artery stenosis: the CODYCE multicenter prospective study","volume":"42","author":"Sardu","year":"2019","journal-title":"Diabetes Care"},{"key":"10.1016\/j.ijbiomac.2025.144166_bb0075","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1186\/s13098-024-01459-w","article-title":"A systematic review and meta-analysis of the effect of hyperglycemia on admission for acute myocardial infarction in diabetic and non-diabetic patients","volume":"1","author":"Alawaji","year":"2024","journal-title":"Diabetol. Metab. Syndr."},{"key":"10.1016\/j.ijbiomac.2025.144166_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116202","article-title":"Pathogenesis of diabetic complications: exploring hypoxic niche formation and HIF-1\u03b1 activation","volume":"172","author":"Bi","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ijbiomac.2025.144166_bb0085","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1007\/s13300-018-0471-8","article-title":"SGLT2 inhibitors in type 2 diabetes management: key evidence and implications for clinical practice","volume":"9","author":"Wilding","year":"2018","journal-title":"Diabet. Ther."},{"key":"10.1016\/j.ijbiomac.2025.144166_bb0090","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1007\/s40265-014-0324-3","article-title":"Dapagliflozin: a review of its use in patients with type 2 diabetes","volume":"74","author":"Plosker","year":"2014","journal-title":"Drugs"},{"key":"10.1016\/j.ijbiomac.2025.144166_bb0095","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1111\/jgs.12881","article-title":"Dapagliflozin added to usual care in individuals with type 2 diabetes mellitus with preexisting cardiovascular disease: a 24-week, multicenter, randomized, double-blind, placebo-controlled study with a 28-week extension","volume":"62","author":"Leiter","year":"2014","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.ijbiomac.2025.144166_bb0100","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1056\/NEJMoa2206286","article-title":"Dapagliflozin in heart failure with mildly reduced or preserved ejection fraction","volume":"387","author":"Solomon","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijbiomac.2025.144166_bb0105","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.jconrel.2021.05.023","article-title":"Biotherapeutic-loaded injectable hydrogels as a synergistic strategy to support myocardial repair after myocardial infarction","volume":"335","author":"Zheng","year":"2021","journal-title":"J. Control. Release"},{"issue":"2","key":"10.1016\/j.ijbiomac.2025.144166_bb0110","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1039\/C9TB01971E","article-title":"Sustained release of bioactive IGF-1 from a silk fibroin microsphere-based injectable alginate hydrogel for the treatment of myocardial infarction","volume":"8","author":"Feng","year":"2020","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.ijbiomac.2025.144166_bb0115","doi-asserted-by":"crossref","first-page":"56892","DOI":"10.1021\/acsami.1c16481","article-title":"Restoring cardiac functions after myocardial infarction\u2013ischemia\/reperfusion via an exosome anchoring conductive hydrogel","volume":"13, no. 48","author":"Zou","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.ijbiomac.2025.144166_bb0120","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.actbio.2017.06.036","article-title":"Electrospun conductive nanofibrous scaffolds for engineering cardiac tissue and 3D bioactuators","volume":"59","author":"Wang","year":"2017","journal-title":"Acta Biomater."},{"issue":"14","key":"10.1016\/j.ijbiomac.2025.144166_bb0125","doi-asserted-by":"crossref","first-page":"6766","DOI":"10.1021\/acs.chemrev.6b00275","article-title":"Conductive polymers: opportunities and challenges in biomedical applications","volume":"118","author":"Nezakati","year":"2018","journal-title":"Chem. Rev."},{"issue":"3","key":"10.1016\/j.ijbiomac.2025.144166_bb0130","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1089\/bioe.2020.0025","article-title":"Electroconductive hydrogels for tissue engineering: current status and future perspectives","volume":"2","author":"Rogers","year":"2020","journal-title":"Bioelectricity"},{"key":"10.1016\/j.ijbiomac.2025.144166_bb0135","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.actbio.2021.08.031","article-title":"Electroconductive biomaterials for cardiac tissue engineering","volume":"139","author":"Esmaeili","year":"2022","journal-title":"Acta Biomater."},{"issue":"3","key":"10.1016\/j.ijbiomac.2025.144166_bb0140","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1002\/jbm.a.33200","article-title":"Polypyrrole-contained electrospun conductive nanofibrous membranes for cardiac tissue engineering","volume":"99","author":"Kai","year":"2011","journal-title":"J. Biomed. Mater. Res. Part A"},{"key":"10.1016\/j.ijbiomac.2025.144166_bb0145","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s43094-024-00636-y","article-title":"Hyaluronic acid: comprehensive review of a multifunctional biopolymer","volume":"1","author":"Salih","year":"2024","journal-title":"Futur. J. Pharm. Sci."},{"key":"10.1016\/j.ijbiomac.2025.144166_bb0150","article-title":"The role of extracellular matrix in angiogenesis: beyond adhesion and structure","volume":"8","author":"Libby","year":"2024","journal-title":"Biomater. Biosyst."},{"key":"10.1016\/j.ijbiomac.2025.144166_bb0155","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.ijbiomac.2020.09.107","article-title":"Hyaluronic acid containing scaffolds ameliorate stem cell function for tissue repair and regeneration","volume":"165","author":"Agarwal","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2025.144166_bb0160","doi-asserted-by":"crossref","first-page":"117251","DOI":"10.1016\/j.synthmet.2022.117251","article-title":"Three-dimensional polyaniline\/cerium oxide composite aerogel with enhanced microwave absorption properties","volume":"293","author":"Hou","year":"2023","journal-title":"Synth. Met."},{"key":"10.1016\/j.ijbiomac.2025.144166_bb0165","doi-asserted-by":"crossref","first-page":"3767","DOI":"10.1039\/C4TB01738B","article-title":"Water-soluble hyaluronic acid\u2013hybridized polyaniline nanoparticles for effectively targeted photothermal therapy","volume":"18","author":"Jiang","year":"2015","journal-title":"J. Mater. Chem. B"},{"issue":"6","key":"10.1016\/j.ijbiomac.2025.144166_bb0170","doi-asserted-by":"crossref","first-page":"5474","DOI":"10.1021\/acsnano.7b00221","article-title":"Injectable fullerenol\/alginate hydrogel for suppression of oxidative stress damage in brown adipose-derived stem cells and cardiac repair","volume":"11","author":"Hao","year":"2017","journal-title":"ACS Nano"},{"key":"10.1016\/j.ijbiomac.2025.144166_bb0175","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1152\/japplphysiol.00033.2007","article-title":"Myocardial infarct size measurement in the mouse chronic infarction model: comparison of area- and length-based approaches","volume":"102","author":"Takagawa","year":"2007","journal-title":"J. Appl. Physiol."},{"issue":"12","key":"10.1016\/j.ijbiomac.2025.144166_bb0180","doi-asserted-by":"crossref","first-page":"7073","DOI":"10.1021\/jp300576b","article-title":"Water adsorption and its effect on the stability of low index stoichiometric and reduced surfaces of ceria","volume":"116","author":"Molinari","year":"2012","journal-title":"J. Phys. Chem. C"},{"key":"10.1016\/j.ijbiomac.2025.144166_bb0185","doi-asserted-by":"crossref","first-page":"14155","DOI":"10.1039\/C8CP00160J","article-title":"Cerium oxide immobilized reduced graphene oxide hybrids with excellent microwave absorbing performance","volume":"20","author":"Wang","year":"2018","journal-title":"Phys. Chem. Chem. Phys."},{"key":"10.1016\/j.ijbiomac.2025.144166_bb0190","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1002\/celc.201701341","article-title":"Preparation of hollow CeO2\/CePO4 with N, P-codoped carbon shell for enhanced oxygen reduction reaction catalytic activity","volume":"5","author":"Yu","year":"2018","journal-title":"ChemElectroChem"},{"key":"10.1016\/j.ijbiomac.2025.144166_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2021.101306","article-title":"Chinese herb-crosslinked hydrogel bearing rBMSCs-laden polyzwitterion microgels: self-adaptive manipulation of micromilieu and stemness maintenance for restoring infarcted myocardium","volume":"41","author":"Liu","year":"2021","journal-title":"Nano Today"},{"key":"10.1016\/j.ijbiomac.2025.144166_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120285","article-title":"The conductive function of biopolymer corrects myocardial scar conduction blockage and resynchronizes contraction to prevent heart failure","volume":"258","author":"He","year":"2020","journal-title":"Biomaterials"},{"issue":"20","key":"10.1016\/j.ijbiomac.2025.144166_bb0205","doi-asserted-by":"crossref","first-page":"2100505","DOI":"10.1002\/advs.202100505","article-title":"Natural melanin\/alginate hydrogels achieve cardiac repair through ROS scavenging and macrophage polarization","volume":"8","author":"Zhou","year":"2021","journal-title":"Adv. Sci."},{"issue":"2","key":"10.1016\/j.ijbiomac.2025.144166_bb0210","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1152\/physiolgenomics.00041.2017","article-title":"Nrf2 at the heart of oxidative stress and cardiac protection","volume":"50","author":"Chen","year":"2018","journal-title":"Physiol. Genomics"},{"issue":"9","key":"10.1016\/j.ijbiomac.2025.144166_bb0215","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.tips.2021.06.005","article-title":"Nrf2 for cardiac protection: pharmacological options against oxidative stress","volume":"42","author":"Chen","year":"2021","journal-title":"Trends Pharmacol. Sci."},{"issue":"9","key":"10.1016\/j.ijbiomac.2025.144166_bb0220","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1016\/j.bbadis.2014.06.002","article-title":"Myocardial ischemic reperfusion induces de novo Nrf2 protein translation","volume":"1842","author":"Xu","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"issue":"9","key":"10.1016\/j.ijbiomac.2025.144166_bb0225","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1093\/aje\/kwu024","article-title":"Association between heme oxygenase 1 gene promoter polymorphisms and susceptibility to coronary artery disease: a HuGE review and meta-analysis","volume":"179","author":"Qiao","year":"2014","journal-title":"Am. J. Epidemiol."},{"issue":"18","key":"10.1016\/j.ijbiomac.2025.144166_bb0230","first-page":"9665","article-title":"FULLEROL alleviates myocardial ischemia-reperfusion injury by reducing inflammation and oxidative stress in cardiomyocytes via activating the Nrf2\/HO-1 signaling pathway","volume":"24","author":"Ding","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"issue":"2","key":"10.1016\/j.ijbiomac.2025.144166_bb0235","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.neuint.2011.11.009","article-title":"Reactive oxygen species and ischemic cerebrovascular disease","volume":"60","author":"Olmez","year":"2012","journal-title":"Neurochem. Int."},{"issue":"1","key":"10.1016\/j.ijbiomac.2025.144166_bb0240","doi-asserted-by":"crossref","first-page":"C45","DOI":"10.1152\/ajpcell.00229.2006","article-title":"Bcl-2 family members and apoptosis, taken to heart","volume":"292","author":"Gustafsson","year":"2007","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"7","key":"10.1016\/j.ijbiomac.2025.144166_bb0245","doi-asserted-by":"crossref","first-page":"11965","DOI":"10.1002\/jcb.28480","article-title":"Curcumin ameliorated myocardial infarction by inhibition of cardiotoxicity in the rat model","volume":"120","author":"Rahnavard","year":"2019","journal-title":"J. Cell. Biochem."}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014181302504718X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014181302504718X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T07:11:41Z","timestamp":1762240301000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S014181302504718X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":49,"alternative-id":["S014181302504718X"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2025.144166","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Injectable nanocomposite hydrogel of dapagliflozin\u2013CeO\u2082-loaded polyaniline\/hyaluronic acid for suppressing cardiomyocyte oxidative stress in myocardial infarction therapy","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2025.144166","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"144166"}}