{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:07:41Z","timestamp":1756426061005,"version":"3.44.0"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82360197"],"award-info":[{"award-number":["82360197"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.ijbiomac.2025.145458","type":"journal-article","created":{"date-parts":[[2025,6,22]],"date-time":"2025-06-22T17:35:52Z","timestamp":1750613752000},"page":"145458","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P1","title":["Deciphering the mucin defense mechanisms against SARS-CoV-2 using molecular simulations"],"prefix":"10.1016","volume":"319","author":[{"given":"Ruijie","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingtong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengxin","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaoyi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.ijbiomac.2025.145458_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijantimicag.2020.105924","article-title":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): the epidemic and the challenges","volume":"55","author":"Lai","year":"2020","journal-title":"Int. J. Antimicrob. Agents"},{"issue":"5","key":"10.1016\/j.ijbiomac.2025.145458_bb0010","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1053\/j.akdh.2024.03.004","article-title":"Coronavirus disease 2019 in kidney transplantation - a 2024 update","volume":"31","author":"Abu Jawdeh","year":"2024","journal-title":"Adv Kidney Dis Health."},{"issue":"7","key":"10.1016\/j.ijbiomac.2025.145458_bb0015","first-page":"1494","article-title":"SARS-COV-2 notable mutations and variants: a review article","volume":"51","author":"Farhud","year":"2022","journal-title":"Iran. J. Public Health"},{"issue":"8","key":"10.1016\/j.ijbiomac.2025.145458_bb0020","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1011571","article-title":"Glycosylated extracellular mucin domains protect against SARS-CoV-2 infection at the respiratory surface","volume":"19","author":"Chatterjee","year":"2023","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.ijbiomac.2025.145458_bb0025","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.jdsr.2023.09.003","article-title":"Efficacy of different mouthwashes against COVID-19: a systematic review and network meta-analysis","volume":"59","author":"Sbricoli","year":"2023","journal-title":"Jpn Dent Sci Rev."},{"issue":"3","key":"10.1016\/j.ijbiomac.2025.145458_bb0030","doi-asserted-by":"crossref","first-page":"e48","DOI":"10.1016\/j.jinf.2020.06.059","article-title":"Viral dynamics of SARS-CoV-2 in saliva from infected patients","volume":"81","author":"Zhu","year":"2020","journal-title":"J. Infect."},{"key":"10.1016\/j.ijbiomac.2025.145458_bb0035","doi-asserted-by":"crossref","first-page":"29759","DOI":"10.3402\/jom.v7.29759","article-title":"Salivary mucins in host defense and disease prevention","volume":"7","author":"Frenkel","year":"2015","journal-title":"J. Oral Microbiol."},{"issue":"6","key":"10.1016\/j.ijbiomac.2025.145458_bb0040","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.02374-20","article-title":"Defensive properties of mucin glycoproteins during respiratory infections-relevance for SARS-CoV-2","volume":"11","author":"Chatterjee","year":"2020","journal-title":"mBio"},{"issue":"9","key":"10.1016\/j.ijbiomac.2025.145458_bb0045","doi-asserted-by":"crossref","DOI":"10.3390\/v14091856","article-title":"Mucin transiently sustains coronavirus infectivity through heterogenous changes in phase morphology of evaporating aerosol","volume":"14","author":"Alexander","year":"2022","journal-title":"Viruses"},{"issue":"1","key":"10.1016\/j.ijbiomac.2025.145458_bb0050","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.14701","article-title":"Mucin signature as a potential tool to predict susceptibility to COVID-19","volume":"9","author":"Bose","year":"2021","journal-title":"Physiol. Rep."},{"issue":"3","key":"10.1016\/j.ijbiomac.2025.145458_bb0055","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1165\/rcmb.2007-0336RC","article-title":"MUC1 mucin is a negative regulator of toll-like receptor signaling","volume":"38","author":"Ueno","year":"2008","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"4","key":"10.1016\/j.ijbiomac.2025.145458_bb0060","doi-asserted-by":"crossref","first-page":"L558","DOI":"10.1152\/ajplung.00225.2009","article-title":"Anti-inflammatory effect of MUC1 during respiratory syncytial virus infection of lung epithelial cells in vitro","volume":"298","author":"Li","year":"2010","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"issue":"6","key":"10.1016\/j.ijbiomac.2025.145458_bb0065","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1038\/mi.2017.16","article-title":"The cell surface mucin MUC1 limits the severity of influenza A virus infection","volume":"10","author":"McAuley","year":"2017","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.ijbiomac.2025.145458_bb0070","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3389\/fcimb.2019.00117","article-title":"The role of the cell surface mucin MUC1 as a barrier to infection and regulator of inflammation","volume":"9","author":"Dhar","year":"2019","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"1","key":"10.1016\/j.ijbiomac.2025.145458_bb0075","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.cell.2022.11.030","article-title":"SARS-CoV-2 replication in airway epithelia requires motile cilia and microvillar reprogramming","volume":"186","author":"Wu","year":"2023","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.ijbiomac.2025.145458_bb0080","doi-asserted-by":"crossref","first-page":"20221","DOI":"10.1038\/s42003-021-02946-w","article-title":"Inferring the stabilization effects of SARS-CoV-2 variants on the binding with ACE2 receptor","volume":"5","author":"Miotto","year":"2022","journal-title":"Commun Biol."},{"key":"10.1016\/j.ijbiomac.2025.145458_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173836","article-title":"Unraveling the mechanism of arbidol binding and inhibition of SARS-CoV-2: insights from atomistic simulations","volume":"894","author":"Padhi","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ijbiomac.2025.145458_bb0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/07391102.2024.2402695","article-title":"Kaempferol as a novel inhibitor of SARS-CoV-2 RNA-dependent RNA polymerase","author":"Medoro","year":"2024","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.ijbiomac.2025.145458_bb0095","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2022.992473","article-title":"Structural insights into the binding of zoledronic acid with RANKL via computational simulations","volume":"9","author":"Wang","year":"2022","journal-title":"Front. Mol. Biosci."},{"issue":"5","key":"10.1016\/j.ijbiomac.2025.145458_bb0100","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0063906","article-title":"Serverification of molecular modeling applications: the Rosetta Online Server that Includes Everyone (ROSIE)","volume":"8","author":"Lyskov","year":"2013","journal-title":"PloS One"},{"issue":"2","key":"10.1016\/j.ijbiomac.2025.145458_bb0105","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/nprot.2016.169","article-title":"The ClusPro web server for protein-protein docking","volume":"12","author":"Kozakov","year":"2017","journal-title":"Nat. Protoc."},{"issue":"15","key":"10.1016\/j.ijbiomac.2025.145458_bb0110","doi-asserted-by":"crossref","first-page":"3073","DOI":"10.1002\/prot.22818","article-title":"Docking and scoring protein interactions: CAPRI 2009","volume":"78","author":"Lensink","year":"2010","journal-title":"Proteins"},{"issue":"4","key":"10.1016\/j.ijbiomac.2025.145458_bb0115","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1002\/prot.21804","article-title":"Docking and scoring protein complexes: CAPRI 3rd Edition","volume":"69","author":"Lensink","year":"2007","journal-title":"Proteins"},{"issue":"6","key":"10.1016\/j.ijbiomac.2025.145458_bb0120","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1021\/acsptsci.2c00180","article-title":"Engineering an ACE2-derived fragment as a decoy for novel SARS-CoV-2 virus","volume":"6","author":"Renzi","year":"2023","journal-title":"ACS Pharmacol Transl Sci."},{"issue":"Web Server issue","key":"10.1016\/j.ijbiomac.2025.145458_bb0125","doi-asserted-by":"crossref","first-page":"W233","DOI":"10.1093\/nar\/gkn216","article-title":"The RosettaDock server for local protein-protein docking","volume":"36","author":"Lyskov","year":"2008","journal-title":"Nucleic Acids Res."},{"issue":"9","key":"10.1016\/j.ijbiomac.2025.145458_bb0130","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0108928","article-title":"Protein-RNA complexes and efficient automatic docking: expanding RosettaDock possibilities","volume":"9","author":"Guilhot-Gaudeffroy","year":"2014","journal-title":"PloS One"},{"issue":"20","key":"10.1016\/j.ijbiomac.2025.145458_bb0135","doi-asserted-by":"crossref","first-page":"3461","DOI":"10.1093\/bioinformatics\/bty355","article-title":"Efficient flexible backbone protein-protein docking for challenging targets","volume":"34","author":"Marze","year":"2018","journal-title":"Bioinformatics"},{"issue":"16","key":"10.1016\/j.ijbiomac.2025.145458_bb0140","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1002\/jcc.20291","article-title":"GROMACS: fast, flexible, and free","volume":"26","author":"Van Der Spoel","year":"2005","journal-title":"J. Comput. Chem."},{"issue":"7","key":"10.1016\/j.ijbiomac.2025.145458_bb0145","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1093\/bioinformatics\/btt055","article-title":"GROMACS 4.5: a high-throughput and highly parallel open source molecular simulation toolkit","volume":"29","author":"Pronk","year":"2013","journal-title":"Bioinformatics"},{"issue":"8","key":"10.1016\/j.ijbiomac.2025.145458_bb0150","doi-asserted-by":"crossref","first-page":"3696","DOI":"10.1021\/acs.jctc.5b00255","article-title":"ff14SB: improving the accuracy of protein side chain and backbone parameters from ff99SB","volume":"11","author":"Maier","year":"2015","journal-title":"J Chem Theory Comput."},{"issue":"3","key":"10.1016\/j.ijbiomac.2025.145458_bb0155","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1002011","article-title":"Blockade of neuronal \u03b17-nAChR by \u03b1-conotoxin ImI explained by computational scanning and energy calculations","volume":"7","author":"Yu","year":"2011","journal-title":"PLoS Comput. Biol."},{"issue":"45","key":"10.1016\/j.ijbiomac.2025.145458_bb0160","doi-asserted-by":"crossref","first-page":"26390","DOI":"10.1039\/D0CP04162A","article-title":"DNA-binding mechanisms of human and mouse cGAS: a comparative MD and MM\/GBSA study","volume":"22","author":"Wang","year":"2020","journal-title":"Phys. Chem. Chem. Phys."},{"issue":"6","key":"10.1016\/j.ijbiomac.2025.145458_bb0165","doi-asserted-by":"crossref","DOI":"10.1093\/bib\/bbab188","article-title":"In silico binding profile characterization of SARS-CoV-2 spike protein and its mutants bound to human ACE2 receptor","volume":"22","author":"Zhang","year":"2021","journal-title":"Brief. Bioinform."},{"issue":"32","key":"10.1016\/j.ijbiomac.2025.145458_bb0170","doi-asserted-by":"crossref","first-page":"22129","DOI":"10.1039\/C6CP03670H","article-title":"Assessing the performance of the MM\/PBSA and MM\/GBSA methods. 6. Capability to predict protein-protein binding free energies and re-rank binding poses generated by protein-protein docking","volume":"18","author":"Chen","year":"2016","journal-title":"Phys. Chem. Chem. Phys."},{"issue":"2","key":"10.1016\/j.ijbiomac.2025.145458_bb0175","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1021\/ct8003707","article-title":"MM-PBSA captures key role of intercalating water molecules at a protein-protein interface","volume":"5","author":"Wong","year":"2009","journal-title":"J Chem Theory Comput."},{"issue":"1","key":"10.1016\/j.ijbiomac.2025.145458_bb0180","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1021\/ci100275a","article-title":"Assessing the performance of the MM\/PBSA and MM\/GBSA methods. 1. The accuracy of binding free energy calculations based on molecular dynamics simulations","volume":"51","author":"Hou","year":"2011","journal-title":"J. Chem. Inf. Model."},{"issue":"10","key":"10.1016\/j.ijbiomac.2025.145458_bb0185","doi-asserted-by":"crossref","first-page":"6281","DOI":"10.1021\/acs.jctc.1c00645","article-title":"gmx_MMPBSA: a new tool to perform end-state free energy calculations with GROMACS","volume":"17","author":"Vald\u00e9s-Tresanco","year":"2021","journal-title":"J. Chem. Theory Comput."},{"issue":"5","key":"10.1016\/j.ijbiomac.2025.145458_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijantimicag.2020.105960","article-title":"Structural and molecular modelling studies reveal a new mechanism of action of chloroquine and hydroxychloroquine against SARS-CoV-2 infection","volume":"55","author":"Fantini","year":"2020","journal-title":"Int. J. Antimicrob. Agents"},{"issue":"2","key":"10.1016\/j.ijbiomac.2025.145458_bb0195","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1002\/jmv.26406","article-title":"Elevated MUC1 and MUC5AC mucin protein levels in airway mucus of critical ill COVID-19 patients","volume":"93","author":"Lu","year":"2021","journal-title":"J. Med. Virol."},{"issue":"1","key":"10.1016\/j.ijbiomac.2025.145458_bb0200","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/s12985-018-1035-2","article-title":"Human \u03b2-defensin 2 plays a regulatory role in innate antiviral immunity and is capable of potentiating the induction of antigen-specific immunity","volume":"15","author":"Kim","year":"2018","journal-title":"Virol. J."},{"issue":"6","key":"10.1016\/j.ijbiomac.2025.145458_bb0205","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1021\/acsinfecdis.1c00096","article-title":"Human cathelicidin inhibits SARS-CoV-2 infection: killing two birds with one stone","volume":"7","author":"Wang","year":"2021","journal-title":"ACS Infect Dis."},{"issue":"3","key":"10.1016\/j.ijbiomac.2025.145458_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2022.103856","article-title":"HBD-2 binds SARS-CoV-2 RBD and blocks viral entry: strategy to combat COVID-19","volume":"25","author":"Zhang","year":"2022","journal-title":"iScience"},{"issue":"8","key":"10.1016\/j.ijbiomac.2025.145458_bb0215","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1038\/s41588-022-01131-x","article-title":"Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection","volume":"54","author":"Biering","year":"2022","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ijbiomac.2025.145458_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.mehy.2021.110680","article-title":"Mucus targeting as a plausible approach to improve lung function in COVID-19 patients","volume":"156","author":"Kumar","year":"2021","journal-title":"Med. Hypotheses"},{"issue":"15","key":"10.1016\/j.ijbiomac.2025.145458_bb0225","doi-asserted-by":"crossref","first-page":"3115","DOI":"10.1002\/prot.22765","article-title":"A generalized approach to sampling backbone conformations with RosettaDock for CAPRI rounds 13-19","volume":"78","author":"Sircar","year":"2010","journal-title":"Proteins"},{"issue":"2","key":"10.1016\/j.ijbiomac.2025.145458_bb0230","first-page":"175","article-title":"Omicron variant of SARS-CoV-2 and its potential impact on dental practice","volume":"53","author":"Ren","year":"2022","journal-title":"Sichuan Da Xue Xue Bao Yi Xue Ban"},{"key":"10.1016\/j.ijbiomac.2025.145458_bb0235","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.csbj.2020.12.015","article-title":"Crystal structure of AmpC BER and molecular docking lead to the discovery of broad inhibition activities of halisulfates against \u03b2-lactamases","volume":"19","author":"Jeong","year":"2021","journal-title":"Comput. Struct. Biotechnol. J."},{"issue":"7807","key":"10.1016\/j.ijbiomac.2025.145458_bb0240","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/s41586-020-2180-5","article-title":"Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor","volume":"581","author":"Lan","year":"2020","journal-title":"Nature"},{"issue":"Pt 4","key":"10.1016\/j.ijbiomac.2025.145458_bb0245","article-title":"Effect of chitooligosaccharide on the binding domain of the SARS-COV-2 receptor","volume":"278","author":"Li","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"9","key":"10.1016\/j.ijbiomac.2025.145458_bb0250","doi-asserted-by":"crossref","first-page":"844","DOI":"10.3390\/membranes12090844","article-title":"Applications of molecular dynamics simulation in protein study","volume":"12","author":"Sinha","year":"2022","journal-title":"Membranes (Basel)."},{"key":"10.1016\/j.ijbiomac.2025.145458_bb0255","doi-asserted-by":"crossref","first-page":"3111","DOI":"10.2147\/IDR.S360973","article-title":"A new variant of mutational and polymorphic signatures in the ERG11 gene of fluconazole-resistant Candida albicans","volume":"15","author":"Odiba","year":"2022","journal-title":"Infect Drug Resist."},{"issue":"24","key":"10.1016\/j.ijbiomac.2025.145458_bb0260","doi-asserted-by":"crossref","first-page":"7967","DOI":"10.1007\/s00018-021-04008-0","article-title":"Structural and functional insights into the spike protein mutations of emerging SARS-CoV-2 variants","volume":"78","author":"Gupta","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"issue":"Pt 2","key":"10.1016\/j.ijbiomac.2025.145458_bb0265","article-title":"Insights into the structural and biophysical mechanisms of benzamidine-driven inhibition of human lysozyme aggregation","volume":"305","author":"Hima","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"issue":"1","key":"10.1016\/j.ijbiomac.2025.145458_bb0270","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/s43141-023-00569-8","article-title":"A computational simulation appraisal of banana lectin as a potential anti-SARS-CoV-2 candidate by targeting the receptor-binding domain","volume":"21","author":"Hessel","year":"2023","journal-title":"J. Genet. Eng. Biotechnol."},{"key":"10.1016\/j.ijbiomac.2025.145458_bb0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2022.106035","article-title":"Molecular dynamics simulations highlight the altered binding landscape at the spike-ACE2 interface between the Delta and Omicron variants compared to the SARS-CoV-2 original strain","volume":"149","author":"Pitsillou","year":"2022","journal-title":"Comput. Biol. Med."}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813025060131?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813025060131?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T18:22:50Z","timestamp":1756405370000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0141813025060131"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":55,"alternative-id":["S0141813025060131"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2025.145458","relation":{},"ISSN":["0141-8130"],"issn-type":[{"type":"print","value":"0141-8130"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Deciphering the mucin defense mechanisms against SARS-CoV-2 using molecular simulations","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2025.145458","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"145458"}}