{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T14:50:22Z","timestamp":1762267822230,"version":"build-2065373602"},"reference-count":78,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82302486"],"award-info":[{"award-number":["82302486"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2023JJ50093"],"award-info":[{"award-number":["2023JJ50093"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017594","name":"Medical Science and Technology Project of Zhejiang Province","doi-asserted-by":"publisher","award":["2021RC085"],"award-info":[{"award-number":["2021RC085"]}],"id":[{"id":"10.13039\/501100017594","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017599","name":"Science and Technology Program of Zhejiang Province","doi-asserted-by":"publisher","award":["2024ZF001,2025ZL160"],"award-info":[{"award-number":["2024ZF001,2025ZL160"]}],"id":[{"id":"10.13039\/501100017599","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012175","name":"Zhejiang Administration Bureau of Traditional Chinese Medicine","doi-asserted-by":"publisher","award":["2025ZL160","2024ZF001"],"award-info":[{"award-number":["2025ZL160","2024ZF001"]}],"id":[{"id":"10.13039\/501100012175","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Zhejiang Province Natural Science Foundation","doi-asserted-by":"publisher","award":["LBY22H180013","LBY24H170005"],"award-info":[{"award-number":["LBY22H180013","LBY24H170005"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.ijbiomac.2025.145752","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T20:33:55Z","timestamp":1751661235000},"page":"145752","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P3","title":["Raman spectroscopy of deuterium-labeled macromolecules: Emerging strategies in biomedical research"],"prefix":"10.1016","volume":"320","author":[{"given":"Zefeng","family":"Zheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boyou","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongjie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanji","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaying","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijbiomac.2025.145752_bb0005","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1038\/s41467-023-37403-1","article-title":"Single test-based diagnosis of multiple cancer types using exosome-SERS-AI for early stage cancers","volume":"14","author":"Shin","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0010","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1039\/D4CS00861H","article-title":"A practical approach to quantitative analytical surface-enhanced Raman spectroscopy","volume":"54","author":"Xu","year":"2025","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0015","article-title":"Accurate and rapid detection of peritoneal metastasis from gastric cancer by AI-assisted stimulated Raman molecular cytology","volume":"10","author":"Chen","year":"2023","journal-title":"Adv. Sci."},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0020","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.ado9721","article-title":"Endomicroscopic AI-driven morphochemical imaging and fs-laser ablation for selective tumor identification and selective tissue removal","volume":"10","author":"Calvarese","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0025","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.biotechadv.2018.01.010","article-title":"Stable isotope compounds - production, detection, and application","volume":"36","author":"Zachleder","year":"2018","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0030","doi-asserted-by":"crossref","first-page":"3737","DOI":"10.1021\/acs.analchem.7b03382","article-title":"Antibiotic susceptibility determination within one cell cycle at single-bacterium level by stimulated Raman metabolic imaging","volume":"90","author":"Hong","year":"2018","journal-title":"Anal. Chem."},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0035","doi-asserted-by":"crossref","first-page":"6240","DOI":"10.7150\/thno.55953","article-title":"Deuterium oxide as a contrast medium for real-time MRI-guided endovascular neurointervention","volume":"11","author":"Chen","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0040","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1039\/C7AN01287J","article-title":"Dynamic characterization of drug resistance and heterogeneity of the gastric cancer cell BGC823 using single-cell Raman spectroscopy","volume":"143","author":"Zhang","year":"2017","journal-title":"Analyst"},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0045","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.7150\/ijms.73150","article-title":"Research progress in the medical application of heavy water, especially in the field of D2O-Raman spectroscopy","volume":"19","author":"Wang","year":"2022","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0050","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1039\/D0CC07824G","article-title":"Synthesis of deuterated \u03b3-linolenic acid and application for biological studies: metabolic tuning and Raman imaging","volume":"57","author":"Dodo","year":"2021","journal-title":"Chem. Commun."},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0055","doi-asserted-by":"crossref","first-page":"7220","DOI":"10.1021\/acs.analchem.4c00802","article-title":"Quantification of hydrogen isotopes utilizing Raman spectroscopy paired with chemometric analysis for application across multiple systems","volume":"96","author":"Felmy","year":"2024","journal-title":"Anal. Chem."},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0060","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1021\/acscentsci.9b01196","article-title":"Live-cell imaging and quantification of PolyQ aggregates by stimulated Raman scattering of selective deuterium labeling","volume":"6","author":"Miao","year":"2020","journal-title":"ACS Cent. Sci."},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0065","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1038\/s41564-019-0394-9","article-title":"An automated Raman-based platform for the sorting of live cells by functional properties","volume":"4","author":"Lee","year":"2019","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0070","doi-asserted-by":"crossref","first-page":"7729","DOI":"10.1021\/acs.analchem.9b01010","article-title":"Single-cell and time-resolved profiling of intracellular Salmonella metabolism in primary human cells","volume":"91","author":"Xu","year":"2019","journal-title":"Anal. Chem."},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0075","doi-asserted-by":"crossref","first-page":"11226","DOI":"10.1073\/pnas.1303768110","article-title":"Vibrational imaging of newly synthesized proteins in live cells by stimulated Raman scattering microscopy","volume":"110","author":"Wei","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0080","doi-asserted-by":"crossref","first-page":"9443","DOI":"10.1021\/acs.analchem.6b01602","article-title":"Reverse and multiple stable isotope probing to study bacterial metabolism and interactions at the single cell level","volume":"88","author":"Wang","year":"2016","journal-title":"Anal. Chem."},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpa.2022.102181","article-title":"Deuterium Raman imaging for lipid analysis","volume":"70","author":"Egoshi","year":"2022","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0090","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.trac.2017.12.002","article-title":"Ultraviolet resonance Raman spectroscopic markers for protein structure and dynamics","volume":"103","author":"Jakubek","year":"2018","journal-title":"Trends Anal. Chem."},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0095","doi-asserted-by":"crossref","first-page":"8504","DOI":"10.1021\/jacs.2c01991","article-title":"Alkyne-tagged Raman probes for local environmental sensing by hydrogen-deuterium exchange","volume":"144","author":"Bi","year":"2022","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0100","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1039\/D3AN02162A","article-title":"Assessing CaDPA levels, metabolic activity, and spore detection through deuterium labeling","volume":"149","author":"\u00d6berg","year":"2024","journal-title":"Analyst"},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0105","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1039\/D3CB00217A","article-title":"Biomedical applications, perspectives and tag design concepts in the cell \u2013 silent Raman window","volume":"5","author":"Vardaki","year":"2024","journal-title":"RSC Chem. Biol."},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0110","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.1038\/s41467-018-05401-3","article-title":"Optical imaging of metabolic dynamics in animals","volume":"9","author":"Shi","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0115","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/s41551-019-0393-4","article-title":"Spectral tracing of deuterium for imaging glucose metabolism","volume":"3","author":"Zhang","year":"2019","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0120","doi-asserted-by":"crossref","first-page":"4108","DOI":"10.1021\/acs.analchem.6b05051","article-title":"Metabolic-activity-based assessment of antimicrobial effects by D2 O-labeled single-cell Raman microspectroscopy","volume":"89","author":"Tao","year":"2017","journal-title":"Anal. Chem."},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0125","doi-asserted-by":"crossref","first-page":"13305","DOI":"10.1021\/acs.analchem.7b03461","article-title":"Raman deuterium isotope probing reveals microbial metabolism at the single-cell level","volume":"89","author":"Xu","year":"2017","journal-title":"Anal. Chem."},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0130","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s12873-018-0178-1","article-title":"Cross sectional study of multiresistant bacteria in Danish emergency departments: prevalence, patterns and risk factors for colonization (AB-RED project)","volume":"18","author":"Mogensen","year":"2018","journal-title":"BMC Emerg. Med."},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0135","doi-asserted-by":"crossref","DOI":"10.1002\/jbio.202200341","article-title":"Monitoring of microbial proteome dynamics using Raman stable isotope probing","volume":"16","author":"Karlo","year":"2023","journal-title":"J. Biophotonics"},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0140","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1039\/D2AN02047E","article-title":"Monitoring bacterial spore metabolic activity using heavy water-induced Raman peak evolution","volume":"148","author":"\u00d6berg","year":"2023","journal-title":"Analyst"},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0145","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s44328-025-00039-w","article-title":"Metabolite microextraction on surface-enhanced Raman scattering nanofibres and D2O probing accelerate antibiotic susceptibility testing","volume":"2","author":"Chisanga","year":"2025","journal-title":"Npj Biosens."},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.136160","article-title":"Antibiotic resistance at environmental multi-media interfaces through integrated genotype and phenotype analysis","volume":"480","author":"Fu","year":"2024","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2024.142500","article-title":"Application of single-cell Raman-deuterium isotope probing to reveal the resistance of marine ammonia-oxidizing archaea SCM1 against common antibiotics","volume":"362","author":"Kong","year":"2024","journal-title":"Chemosphere"},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0160","article-title":"An isotope-labeled single-cell Raman spectroscopy approach for tracking the physiological evolution trajectory of bacteria toward antibiotic resistance","volume":"62","author":"Yang","year":"2023","journal-title":"Angew. Chem. Int. Ed. Eng."},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0165","doi-asserted-by":"crossref","first-page":"15472","DOI":"10.1021\/acs.analchem.0c03218","article-title":"Phenotypic tracking of antibiotic resistance spread via transformation from environment to clinic by reverse D2O single-cell Raman probing","volume":"92","author":"Li","year":"2020","journal-title":"Anal. Chem."},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0170","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.1111\/1462-2920.14962","article-title":"Raman-activated sorting of antibiotic-resistant bacteria in human gut microbiota","volume":"22","author":"Wang","year":"2020","journal-title":"Environ. Microbiol."},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0175","doi-asserted-by":"crossref","first-page":"6296","DOI":"10.1021\/acs.analchem.9b01064","article-title":"Rapid antibiotic susceptibility testing of pathogenic bacteria using heavy-water-labeled single-cell Raman spectroscopy in clinical samples","volume":"91","author":"Yang","year":"2019","journal-title":"Anal. Chem."},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0180","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1039\/D1AN01210J","article-title":"A rapid procedure for bacterial identification and antimicrobial susceptibility testing directly from positive blood cultures","volume":"147","author":"Sun","year":"2021","journal-title":"Analyst"},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0185","doi-asserted-by":"crossref","first-page":"16202","DOI":"10.1021\/acsami.4c21938","article-title":"A surface-enhanced Raman spectroscopy platform integrating dual signal enhancement and machine learning for rapid detection of veterinary drug residues in meat products","volume":"17","author":"Wang","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0190","doi-asserted-by":"crossref","first-page":"8722","DOI":"10.1021\/acs.analchem.9b05387","article-title":"Heteroresistant bacteria detected by an extended Raman-based antibiotic susceptibility test","volume":"92","author":"Bauer","year":"2020","journal-title":"Anal. Chem."},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0195","doi-asserted-by":"crossref","first-page":"5098","DOI":"10.1021\/acs.analchem.0c04709","article-title":"Development of a fast Raman-assisted antibiotic susceptibility test (FRAST) for the antibiotic resistance analysis of clinical urine and blood samples","volume":"93","author":"Yi","year":"2021","journal-title":"Anal. Chem."},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0200","article-title":"Rapid antimicrobial susceptibility testing by stimulated Raman scattering imaging of deuterium incorporation in a single bacterium","author":"Zhang","year":"2022","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2021.338622","article-title":"Rapid antimicrobial susceptibility testing by stimulated Raman scattering metabolic imaging and morphological deformation of bacteria","volume":"1168","author":"Zhang","year":"2021","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0210","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1126\/science.1223813","article-title":"Host-gut microbiota metabolic interactions","volume":"336","author":"Nicholson","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0215","doi-asserted-by":"crossref","first-page":"7714","DOI":"10.1021\/acs.analchem.1c01076","article-title":"Monitoring deuterium uptake in single bacterial cells via two-dimensional Raman correlation spectroscopy","volume":"93","author":"Azemtsop Matanfack","year":"2021","journal-title":"Anal. Chem."},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0220","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2203519119","article-title":"SRS-FISH: a high-throughput platform linking microbiome metabolism to identity at the single-cell level","volume":"119","author":"Ge","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0225","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1111\/1751-7915.13519","article-title":"Raman-deuterium isotope probing to study metabolic activities of single bacterial cells in human intestinal microbiota","volume":"13","author":"Wang","year":"2020","journal-title":"Microb. Biotechnol."},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2021.120300","article-title":"Raman spectroscopy and machine learning for the classification of breast cancers","volume":"264","author":"Zhang","year":"2022","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2025.137363","article-title":"Bioorthogonal Raman and IR probes for live cell metabolomics: a library","volume":"430","author":"Korona","year":"2025","journal-title":"Sensors Actuators B Chem."},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0240","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/jrs.6489","article-title":"The Raman Deuterium Isotope Probing method as a new assay for evaluating the cytotoxicity level of the GSK2334470 to the MCF-7 cells","volume":"54","author":"Huang","year":"2023","journal-title":"J. Raman Spectrosc."},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0245","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1021\/acs.analchem.0c03925","article-title":"D2O-probed Raman microspectroscopy distinguishes the metabolic dynamics of macromolecules in organellar anticancer drug response","volume":"93","author":"Hekmatara","year":"2021","journal-title":"Anal. Chem."},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0250","doi-asserted-by":"crossref","first-page":"811","DOI":"10.3390\/cancers15030811","article-title":"Metabolic reprogramming in colon cancer cells persistently infected with Newcastle Disease Virus","volume":"15","author":"Yu","year":"2023","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0255","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1039\/D1CC06857A","article-title":"Determination of IC50 values of anticancer drugs on cells by D2O - single cell Raman spectroscopy","volume":"58","author":"Lv","year":"2022","journal-title":"Chem. Commun. (Camb.)"},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0260","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1039\/C6CC10226C","article-title":"Nanoscale mapping of newly-synthesised phospholipid molecules in a biological cell using tip-enhanced Raman spectroscopy","volume":"53","author":"Kumar","year":"2017","journal-title":"Chem. Commun."},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0265","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2024.118099","article-title":"The applications of bio-orthogonal Raman labels for visualizing lipids in eukaryotic cells","volume":"183","author":"Xu","year":"2025","journal-title":"TrAC Trends Anal. Chem."},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0270","doi-asserted-by":"crossref","DOI":"10.1002\/ntls.202103304","article-title":"Bioorthogonal chemical imaging of solid lipid nanoparticles with minimal labeling by stimulated Raman scattering microscopy","volume":"3","author":"Lang","year":"2023","journal-title":"Nat. Sci."},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0275","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1002\/jrs.6252","article-title":"Deep-UV resonance Raman spectroscopy of hydrated and dehydrated model \u03b1-helical transmembrane peptides in liposomes","volume":"53","author":"Wei","year":"2022","journal-title":"J. Raman Spectrosc."},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0280","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1038\/s42003-021-02679-w","article-title":"Raman microscopy-based quantification of the physical properties of intracellular lipids","volume":"4","author":"Uematsu","year":"2021","journal-title":"Commun. Biol."},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0285","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1039\/C7CC08217G","article-title":"Two-color vibrational imaging of glucose metabolism using stimulated Raman scattering","volume":"54","author":"Long","year":"2017","journal-title":"Chem. Commun."},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0290","doi-asserted-by":"crossref","first-page":"10237","DOI":"10.1021\/acs.jpclett.4c01994","article-title":"Probing deuteration-induced phase separation in supported lipid monolayers using hyperspectral TERS imaging","volume":"15","author":"Xu","year":"2024","journal-title":"J. Phys. Chem. Lett."},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0295","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1007\/s00018-022-04616-4","article-title":"What is the ability of inflamed endothelium to uptake exogenous saturated fatty acids? A proof-of-concept study using spontaneous Raman, SRS and CARS microscopy","volume":"79","author":"Borek-Dorosz","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0300","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1021\/acs.jpcb.1c08343","article-title":"Probing methionine uptake in live cells by deuterium labeling and stimulated Raman scattering","volume":"126","author":"Spratt","year":"2022","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0305","doi-asserted-by":"crossref","DOI":"10.1063\/5.0063250","article-title":"Visualization of intracellular lipid metabolism in brown adipocytes by time-lapse ultra-multiplex CARS microspectroscopy with an onstage incubator","volume":"155","author":"Takei","year":"2021","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0310","doi-asserted-by":"crossref","first-page":"4447","DOI":"10.1039\/D0TB00620C","article-title":"Molecular imaging of extracellular vesicles in vitro via Raman metabolic labelling","volume":"8","author":"Horgan","year":"2020","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0315","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.31635\/ccschem.020.202000346","article-title":"Live-cell imaging of NADPH production from specific pathways","volume":"3","author":"Hong","year":"2021","journal-title":"CCS Chem."},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0320","article-title":"Direct and simultaneous identification of multiple mitochondrial reactive oxygen species in living cells using a SERS borrowing strategy","volume":"61","author":"Lin","year":"2022","journal-title":"Angew. Chem. Int. Ed. Eng."},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0325","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2024.125044","article-title":"Probing metabolism in mouse embryos using Raman spectroscopy and deuterium tags","volume":"325","author":"Omelchenko","year":"2025","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0330","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1021\/acs.analchem.8b04875","article-title":"Quantitative imaging of lipid synthesis and lipolysis dynamics in Caenorhabditis elegans by stimulated Raman scattering microscopy","volume":"91","author":"Li","year":"2019","journal-title":"Anal. Chem."},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0335","doi-asserted-by":"crossref","first-page":"4008","DOI":"10.1021\/acs.biomac.9b01092","article-title":"Alkyne-tagged PLGA allows direct visualization of nanoparticles in vitro and ex vivo by stimulated Raman scattering microscopy","volume":"20","author":"Vanden-Hehir","year":"2019","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0340","article-title":"Stimulated Raman scattering tomography for rapid three-dimensional chemical imaging of cells and tissue","volume":"6","author":"Wang","year":"2024","journal-title":"AP"},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0345","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/s41592-023-01779-1","article-title":"Super-resolution SRS microscopy with A-PoD","volume":"20","author":"Jang","year":"2023","journal-title":"Nat. Methods"},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0350","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2023.102221","article-title":"Protocol to image deuterated propofol in living rat neurons using multimodal stimulated Raman scattering microscopy","volume":"4","author":"Zhong","year":"2023","journal-title":"STAR Protoc."},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0355","doi-asserted-by":"crossref","first-page":"7106","DOI":"10.1021\/acs.chemrev.3c00776","article-title":"Fluorescent probes for disease diagnosis","volume":"124","author":"Wang","year":"2024","journal-title":"Chem. Rev."},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0360","doi-asserted-by":"crossref","first-page":"3873","DOI":"10.1039\/D2CS00172A","article-title":"Recent progress in the development of fluorescent probes for imaging pathological oxidative stress","volume":"52","author":"Geng","year":"2023","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0365","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2024.117657","article-title":"Single cell mass spectrometry: towards quantification of small molecules in individual cells","volume":"174","author":"Lan","year":"2024","journal-title":"TrAC Trends Anal. Chem."},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0370","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2024.117626","article-title":"Mass spectrometry for biomarkers, disease mechanisms, and drug development in cerebrospinal fluid metabolomics","volume":"173","author":"Xu","year":"2024","journal-title":"TrAC Trends Anal. Chem."},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0375","doi-asserted-by":"crossref","first-page":"6753","DOI":"10.1038\/s41467-022-34275-9","article-title":"Deep learning-based image analysis predicts PD-L1 status from H&E-stained histopathology images in breast cancer","volume":"13","author":"Shamai","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0380","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/s42256-022-00471-x","article-title":"Deep learning-inferred multiplex immunofluorescence for immunohistochemical image quantification","volume":"4","author":"Ghahremani","year":"2022","journal-title":"Nat. Mach. Intell."},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0385","doi-asserted-by":"crossref","DOI":"10.1021\/acs.chemrev.2c00897","article-title":"The emerging role of Raman spectroscopy as an omics approach for metabolic profiling and biomarker detection toward precision medicine","author":"Cutshaw","year":"2023","journal-title":"Chem. Rev."},{"key":"10.1016\/j.ijbiomac.2025.145752_bb0390","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2023.117357","article-title":"Recent progress of responsive Raman scattering probes for biosensing and bioimaging","volume":"169","author":"Liao","year":"2023","journal-title":"TrAC Trends Anal. Chem."}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014181302506307X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014181302506307X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T14:42:21Z","timestamp":1762267341000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S014181302506307X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":78,"alternative-id":["S014181302506307X"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2025.145752","relation":{},"ISSN":["0141-8130"],"issn-type":[{"type":"print","value":"0141-8130"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Raman spectroscopy of deuterium-labeled macromolecules: Emerging strategies in biomedical research","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2025.145752","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"145752"}}