{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:18:24Z","timestamp":1791919104703,"version":"4.3.4"},"reference-count":77,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.ijbiomac.2025.146302","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T15:51:40Z","timestamp":1753372300000},"page":"146302","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"P2","title":["Development of bioactive chitosan patch with ciprofloxacin loaded TiO\u2082 nanoparticles for wound healing application"],"prefix":"10.1016","volume":"321","author":[{"given":"Samantha Raj","family":"Sah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Prema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Anusuya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Prakash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Sreenidhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Devanand","family":"Venkatasubbu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.ijbiomac.2025.146302_bb0005","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1111\/j.1600-0625.2008.00752.x","article-title":"The skin: an indispensable barrier","volume":"17","author":"Guan","year":"2008","journal-title":"Exp. Dermatol."},{"issue":"3","key":"10.1016\/j.ijbiomac.2025.146302_bb0010","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.fsc.2011.06.010","article-title":"Use of hair grafting in scar camouflage","volume":"19","author":"Barr","year":"2011","journal-title":"Facial Plastic Surgery Clinics"},{"issue":"3","key":"10.1016\/j.ijbiomac.2025.146302_bb0015","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1177\/0022034509359125","article-title":"Factors affecting wound healing","volume":"89","author":"Guo","year":"2010","journal-title":"J. Dent. Res."},{"issue":"265","key":"10.1016\/j.ijbiomac.2025.146302_bb0020","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3009337","article-title":"Wound repair and regeneration: mechanisms, signaling, and translation","volume":"6","author":"Eming","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.ijbiomac.2025.146302_bb0025","article-title":"Homeopathic preparations of quartz, sulfur and copper sulfate assessed by UV-spectroscopy","volume":"2011.1","author":"Wolf","year":"2011","journal-title":"Evid. Based. Complement. Alternat. Med."},{"key":"10.1016\/j.ijbiomac.2025.146302_bb0030","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.jddst.2018.05.001","article-title":"Development and in vitro evaluation of cost effective amphotericin B polymeric emulsion","volume":"46","author":"Ishaq","year":"2018","journal-title":"Journal of Drug Delivery Science and Technology"},{"issue":"5","key":"10.1016\/j.ijbiomac.2025.146302_bb0035","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1111\/j.1365-2672.2012.05253.x","article-title":"Silver nanoparticles: the powerful nanoweapon against multidrug resistant bacteria","volume":"112","author":"Rai","year":"2012","journal-title":"J. Appl. Microbiol."},{"key":"10.1016\/j.ijbiomac.2025.146302_bb0040","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s40820-015-0040-x","article-title":"Review on zinc oxide nanoparticles: antibacterial activity and toxicity mechanism","volume":"7","author":"Sirelkhatim","year":"2015","journal-title":"Nano-micro letters"},{"issue":"19","key":"10.1016\/j.ijbiomac.2025.146302_bb0045","doi-asserted-by":"crossref","DOI":"10.3390\/ijms251910519","article-title":"Review of antimicrobial properties of titanium dioxide nanoparticles","volume":"25","author":"Serov","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.ijbiomac.2025.146302_bb0050","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1211\/0022357011776441","article-title":"Chitosan: some pharmaceutical and biological aspects-an update","volume":"53","author":"Singla","year":"2001","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.ijbiomac.2025.146302_bb0055","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.carbpol.2017.06.032","volume":"174","author":"Lam","year":"2017","journal-title":"Carbohydr. Polym."},{"issue":"3","key":"10.1016\/j.ijbiomac.2025.146302_bb0060","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.biotechadv.2011.01.005","article-title":"Biomaterials based on chitin and chitosan in wound dressing applications","volume":"29","author":"Jayakumar","year":"2011","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.ijbiomac.2025.146302_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2019.115329","article-title":"Accurate quantification of small and large starch granules in barley and malt","volume":"227","author":"De Schepper","year":"2020","journal-title":"Carbohydr. Polym."},{"issue":"8","key":"10.1016\/j.ijbiomac.2025.146302_bb0070","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.progpolymsci.2011.02.001","article-title":"Chitosan\u2014A versatile semi-synthetic polymer in biomedical applications","volume":"36","author":"Dash","year":"2011","journal-title":"Prog. Polym. Sci."},{"key":"10.1016\/j.ijbiomac.2025.146302_bb0075","first-page":"283","article-title":"\u201cchitosan: A good candidate for sustained release ocular drug delivery systems.\u201d chitin-chitosan\u2014myriad functionalities","author":"Popa","year":"2018","journal-title":"Sci. Technol."},{"issue":"4","key":"10.1016\/j.ijbiomac.2025.146302_bb0080","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1080\/1061186X.2018.1512112","article-title":"Chitosan-based nanoparticles as drug delivery systems: a review on two decades of research","volume":"27","author":"Naskar","year":"2019","journal-title":"J. Drug Target."},{"issue":"21","key":"10.1016\/j.ijbiomac.2025.146302_bb0085","doi-asserted-by":"crossref","first-page":"24370","DOI":"10.1021\/acsami.0c05604","article-title":"Superclear, porous cellulose membranes with chitosan-coated nanofibers for visualized cutaneous wound healing dressing","volume":"12","author":"Xia","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"1","key":"10.1016\/j.ijbiomac.2025.146302_bb0090","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1021\/acsabm.8b00585","article-title":"Ciprofloxacin-and fluconazole-containing fibrin nanoparticle-incorporated chitosan bandages for the treatment of polymicrobial wound infections","volume":"2","author":"Thattaruparambil Raveendran","year":"2018","journal-title":"ACS Appl. Bio Mater."},{"issue":"25","key":"10.1016\/j.ijbiomac.2025.146302_bb0095","doi-asserted-by":"crossref","first-page":"5995","DOI":"10.1016\/j.biomaterials.2013.04.042","article-title":"3D matrix microenvironment for targeted differentiation of embryonic stem cells into neural and glial lineages","volume":"34","author":"Kothapalli","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.ijbiomac.2025.146302_bb0100","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.msec.2018.04.092","article-title":"Polymer coating on a micropillar chip for robust attachment of PuraMatrix peptide hydrogel for 3D hepatic cell culture","volume":"90","author":"Roth","year":"2018","journal-title":"Mater. Sci. Eng. C"},{"issue":"3","key":"10.1016\/j.ijbiomac.2025.146302_bb0105","first-page":"303","article-title":"Mechanical, bioadhesive strength and biological evaluations of chitosan films for wound dressing","volume":"3","author":"Khan","year":"2000","journal-title":"J. Pharm. Pharm. Sci."},{"issue":"10","key":"10.1016\/j.ijbiomac.2025.146302_bb0110","doi-asserted-by":"crossref","first-page":"4324","DOI":"10.1021\/acsabm.9b00589","article-title":"In vivo wound healing performance of halloysite clay and gentamicin incorporated cellulose ether-PVA electrospun nanofiber mats","volume":"2","author":"Wali","year":"2019","journal-title":"ACS Applied Bio Materials"},{"issue":"7","key":"10.1016\/j.ijbiomac.2025.146302_bb0115","doi-asserted-by":"crossref","first-page":"4266","DOI":"10.1021\/acsbiomaterials.0c00657","article-title":"Novel ECM patch combines poly (vinyl alcohol), human fibroblast-derived matrix, and mesenchymal stem cells for advanced wound healing","volume":"6","author":"Ha","year":"2020","journal-title":"ACS Biomater Sci. Eng."},{"key":"10.1016\/j.ijbiomac.2025.146302_bb0120","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.ijbiomac.2019.10.029","article-title":"Fabrication of chitosan\/PVA\/GO\/CuO patch for potential wound healing application","volume":"143","author":"Venkataprasanna","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2025.146302_bb0125","series-title":"Medical Imaging 2009: Visualization, Image-Guided Procedures, and Modeling","article-title":"Constrained hyperelastic parameters reconstruction of PVA (polyvinyl alcohol) phantom undergoing large deformation","volume":"vol. 7261","author":"Mehrabian","year":"2009"},{"issue":"5","key":"10.1016\/j.ijbiomac.2025.146302_bb0130","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0233021","article-title":"Mechanical characterization of PVA hydrogels\u2019 rate dependent response using multi-axial loading","volume":"15","author":"Nafo","year":"2020","journal-title":"PloS One"},{"issue":"3","key":"10.1016\/j.ijbiomac.2025.146302_bb0135","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.ejpb.2014.07.005","article-title":"Polyethylene glycol (PEG)\u2013poly (N isopropylacrylamide)(PNIPAAm) based thermosensitive injectable hydrogels for biomedical applications","volume":"88","author":"Alexander","year":"2014","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ijbiomac.2025.146302_bb0140","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.msec.2016.11.092","article-title":"Polymer based microspheres of aceclofenac as sustained release parenterals for prolonged anti-inflammatory effect","volume":"72","author":"Kaur","year":"2017","journal-title":"Mater. Sci. Eng. C"},{"issue":"8","key":"10.1016\/j.ijbiomac.2025.146302_bb0145","doi-asserted-by":"crossref","first-page":"2892","DOI":"10.1002\/jps.21210","article-title":"Wound healing dressings and drug delivery systems: a review","volume":"97","author":"Boateng","year":"2008","journal-title":"J. Pharm. Sci."},{"issue":"11","key":"10.1016\/j.ijbiomac.2025.146302_bb0150","doi-asserted-by":"crossref","first-page":"3083","DOI":"10.1016\/j.biomaterials.2012.01.005","article-title":"The antithrombotic and antimicrobial properties of PEG-protected silver nanoparticle coated surfaces","volume":"33","author":"Ragaseema","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.ijbiomac.2025.146302_bb0155","series-title":"Drug Delivery Systems for Wound Healing","first-page":"71","article-title":"Polymeric drug delivery systems for wound healing","author":"Majie","year":"2024"},{"key":"10.1016\/j.ijbiomac.2025.146302_bb0160","series-title":"Nanomedicine","first-page":"501","article-title":"Chitosan-based functionalized scaffolds for nanobone tissue regeneration","author":"Ghosh","year":"2023"},{"issue":"10","key":"10.1016\/j.ijbiomac.2025.146302_bb0165","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1166\/jbn.2015.2115","article-title":"Metallic nanomaterials for bone tissue engineering","volume":"11","author":"Dhivya","year":"2015","journal-title":"J. Biomed. Nanotechnol."},{"key":"10.1016\/j.ijbiomac.2025.146302_bb0170","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.micromeso.2018.10.025","article-title":"Mesoporous zinc silicate bio-composite: preparation, characterization and in vitro evaluation","volume":"277","author":"Jindal","year":"2019","journal-title":"Microporous Mesoporous Mater."},{"key":"10.1016\/j.ijbiomac.2025.146302_bb0175","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/978-981-13-8855-2_18","article-title":"Chitosan-based biocomposite scaffolds and hydrogels for bone tissue regeneration","author":"Saravanan","year":"2019","journal-title":"Marine-Derived Biomaterials for Tissue Engineering Applications"},{"issue":"7","key":"10.1016\/j.ijbiomac.2025.146302_bb0180","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1016\/j.ceramint.2010.04.006","article-title":"Synthesis and characterization of TiO2 nanoparticles","volume":"36","author":"Viana","year":"2010","journal-title":"Ceram. Int."},{"issue":"1","key":"10.1016\/j.ijbiomac.2025.146302_bb0185","doi-asserted-by":"crossref","first-page":"4864","DOI":"10.1038\/s41598-019-41446-0","article-title":"Synthesis of Ag\/NiO honeycomb structured nanoarrays as the electrode material for high performance asymmetric supercapacitor devices","volume":"9","author":"Nagamuthu","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ijbiomac.2025.146302_bb0190","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s13205-011-0021-9","article-title":"Nanocrystalline hydroxyapatite and zinc-doped hydroxyapatite as carrier material for controlled delivery of ciprofloxacin","volume":"1","author":"Devanand Venkatasubbu","year":"2011","journal-title":"3 Biotech"},{"key":"10.1016\/j.ijbiomac.2025.146302_bb0195","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.ijbiomac.2020.01.067","article-title":"Multilayer nanofibrous patch comprising chamomile loaded carboxyethyl chitosan\/poly (vinyl alcohol) and polycaprolactone as a potential wound dressing","volume":"147","author":"Shokrollahi","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2025.146302_bb0200","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.apsusc.2018.01.143","article-title":"Metal oxide curcumin incorporated polymer patches for wound healing","volume":"449","author":"Prasanna","year":"2018","journal-title":"Appl. Surf. Sci."},{"issue":"10","key":"10.1016\/j.ijbiomac.2025.146302_bb0205","doi-asserted-by":"crossref","first-page":"4324","DOI":"10.1021\/acsabm.9b00589","article-title":"In vivo wound healing performance of halloysite clay and gentamicin incorporated cellulose ether-PVA electrospun nanofiber mats","volume":"2","author":"Wali","year":"2019","journal-title":"ACS Appl. Bio Mater."},{"key":"10.1016\/j.ijbiomac.2025.146302_bb0210","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.colsurfb.2012.04.046","article-title":"Physicochemical characterization and biocompatibility in vitro of biphasic calcium phosphate\/polyvinyl alcohol scaffolds prepared by freeze-drying method for bone tissue engineering applications","volume":"100","author":"Nie","year":"2012","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.ijbiomac.2025.146302_bb0215","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.ijbiomac.2020.03.095","article-title":"Nanocomposite chitosan film containing graphene oxide\/hydroxyapatite\/gold for bone tissue engineering","volume":"154","author":"Prakash","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"issue":"2","key":"10.1016\/j.ijbiomac.2025.146302_bb0220","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1021\/am201669z","article-title":"Co-electrospun nanofibrous membranes of collagen and zein for wound healing","volume":"4","author":"Lin","year":"2012","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"6","key":"10.1016\/j.ijbiomac.2025.146302_bb0225","first-page":"74","article-title":"Spectrophotometric determination of ciprofloxacin hydrochloride in ophthalmic solution","volume":"2","author":"Cazedey","year":"2012","journal-title":"Adv. Anal. Chem."},{"key":"10.1016\/j.ijbiomac.2025.146302_bb0230","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.ijbiomac.2019.09.013","article-title":"Drug release and kinetic models of anticancer drug (BTZ) from a pH-responsive alginate polydopamine hydrogel: towards cancer chemotherapy","volume":"141","author":"Rezk","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"issue":"8","key":"10.1016\/j.ijbiomac.2025.146302_bb0235","doi-asserted-by":"crossref","first-page":"2987","DOI":"10.1021\/ie402807y","article-title":"Influence of surface modification and the pH on the release mechanisms and kinetics of erlotinib from antibody-functionalized chitosan nanoparticles","volume":"53","author":"Srinivasan","year":"2014","journal-title":"Ind. Eng. Chem. Res."},{"issue":"02","key":"10.1016\/j.ijbiomac.2025.146302_bb0240","first-page":"1","article-title":"Application of mathematical models in drug release kinetics of carbidopa and levodopa ER tablets","volume":"6","author":"Gouda","year":"2017","journal-title":"J. Dev. Drugs"},{"key":"10.1016\/j.ijbiomac.2025.146302_bb0245","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.jiec.2024.03.017","article-title":"Accelerated wound healing by PrO2 incorporated PVA\/SA fibers","volume":"137","author":"Hiytesh","year":"2024","journal-title":"J. Ind. Eng. Chem."},{"issue":"3","key":"10.1016\/j.ijbiomac.2025.146302_bb0250","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1134\/S0036024412030351","article-title":"Enhancement of the photocatalytic activity of modified TiO2 nanoparticles with Zn 2+. Correlation between structure and properties","volume":"86","author":"Zhang","year":"2012","journal-title":"Russ. J. Phys. Chem. A"},{"key":"10.1016\/j.ijbiomac.2025.146302_bb0255","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1023\/A:1008602718987","article-title":"A raman scattering study of PbTiO3 and TiO2 obtained by sol gel","volume":"13","author":"Bersani","year":"1998","journal-title":"J. Sol-Gel Sci. Technol."},{"issue":"6","key":"10.1016\/j.ijbiomac.2025.146302_bb0260","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1002\/jrs.1250070606","article-title":"Raman spectrum of anatase, TiO2","volume":"7","author":"Ohsaka","year":"1978","journal-title":"J. Raman Spectrosc."},{"issue":"1\u20133","key":"10.1016\/j.ijbiomac.2025.146302_bb0265","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.desal.2011.04.019","article-title":"Investigation of the effect of sol\u2013gel synthesis variables on structural and photocatalytic properties of TiO2 nanoparticles","volume":"278","author":"Behnajady","year":"2011","journal-title":"Desalination"},{"issue":"1","key":"10.1016\/j.ijbiomac.2025.146302_bb0270","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3311\/PPch.11789","article-title":"Synthesis and characterisation of mesoporous TiO2 nanoparticles by novel surfactant assisted sol-gel method for the degradation of organic compounds","volume":"63","author":"Phattepur","year":"2019","journal-title":"Period. Polytech. Chem. Eng."},{"key":"10.1016\/j.ijbiomac.2025.146302_bb0275","article-title":"Synthesis, characterization, and photocatalysis of well-dispersible phase-pure Anatase TiO2 nanoparticles","volume":"2013.1","author":"Wei","year":"2013","journal-title":"Int. J. Photoenergy"},{"issue":"11","key":"10.1016\/j.ijbiomac.2025.146302_bb0280","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.37358\/RC.17.11.5944","article-title":"Preparation and characterization of ultrafiltration TiO2 nanoparticles-polysulfone membranes","volume":"68","author":"Enache","year":"2017","journal-title":"Rev. Chim."},{"key":"10.1016\/j.ijbiomac.2025.146302_bb0285","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s10812-012-9623-1","article-title":"Detection of ibuprofen and ciprofloxacin by solid-phase extraction and UV\/Vis spectroscopy","volume":"79","author":"Zhou","year":"2012","journal-title":"J. Appl. Spectrosc."},{"key":"10.1016\/j.ijbiomac.2025.146302_bb0290","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1007\/s10544-013-9767-7","article-title":"In vitro and in vivo anticancer activity of modified paclitaxel attached hydroxyapatite and titanium dioxide nanoparticles","volume":"15","author":"Venkatasubbu","year":"2013","journal-title":"Biomed. Microdevices"},{"issue":"9","key":"10.1016\/j.ijbiomac.2025.146302_bb0295","article-title":"pH dependent synthesis of TiO2 nanoparticles exerts its effect on bacterial growth inhibition and osteoblasts proliferation","volume":"10","author":"Dv","year":"2020","journal-title":"AIP Adv."},{"issue":"2","key":"10.1016\/j.ijbiomac.2025.146302_bb0300","doi-asserted-by":"crossref","DOI":"10.1088\/2053-1591\/aaa936","article-title":"TiO2 nanocomposite for the controlled release of drugs against pathogens causing wound infections","volume":"5","author":"Venkatasubbu","year":"2018","journal-title":"Mater Res Express"},{"issue":"3","key":"10.1016\/j.ijbiomac.2025.146302_bb0305","doi-asserted-by":"crossref","first-page":"195","DOI":"10.4103\/2231-4040.85541","article-title":"Qualitative analysis of controlled release ciprofloxacin\/carbopol 934 mucoadhesive suspension","volume":"2","author":"Sahoo","year":"2011","journal-title":"J. Adv. Pharm. Technol. Res."},{"key":"10.1016\/j.ijbiomac.2025.146302_bb0310","doi-asserted-by":"crossref","DOI":"10.1016\/j.clay.2020.105768","article-title":"Synthesis and characterization of montmorillonite\/ciprofloxacin\/TiO2 porous structure for controlled drug release of ciprofloxacin tablet with oral administration","volume":"197","author":"Gulen","year":"2020","journal-title":"Appl. Clay Sci."},{"key":"10.1016\/j.ijbiomac.2025.146302_bb0315","first-page":"558","article-title":"Qualitative analysis of a ciprofloxacin\/HPMC mucoadhesive suspension","volume":"3","author":"Sahoo","year":"2012","journal-title":"Int J Pharma and Bio Sci"},{"issue":"6","key":"10.1016\/j.ijbiomac.2025.146302_bb0320","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.apt.2013.01.008","article-title":"Folate targeted PEGylated titanium dioxide nanoparticles as a nanocarrier for targeted paclitaxel drug delivery","volume":"24","author":"Venkatasubbu","year":"2013","journal-title":"Adv. Powder Technol."},{"issue":"1","key":"10.1016\/j.ijbiomac.2025.146302_bb0325","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3390\/app7010049","article-title":"FTIR and Raman characterization of TiO2 nanoparticles coated with polyethylene glycol as carrier for 2-methoxyestradiol","volume":"7","author":"Le\u00f3n","year":"2017","journal-title":"Appl. Sci."},{"key":"10.1016\/j.ijbiomac.2025.146302_bb0330","doi-asserted-by":"crossref","DOI":"10.4028\/www.scientific.net\/MSF.901.79","article-title":"Effect of blend ratio on morphology and swelling properties of PVA\/chitosan nanofibers","volume":"901","author":"Nasikhudin","year":"2017","journal-title":"Mater. Sci. Forum."},{"key":"10.1016\/j.ijbiomac.2025.146302_bb0335","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.ijbiomac.2019.07.125","article-title":"PVA\/SA\/TiO2-CUR patch for enhanced wound healing application: in vitro and in vivo analysis","volume":"138","author":"Niranjan","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2025.146302_bb0340","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1007\/s10934-012-9655-1","article-title":"Development of ciprofloxacin hydrochloride loaded poly (ethylene glycol)\/chitosan scaffold as wound dressing","volume":"20","author":"Sinha","year":"2013","journal-title":"J. Porous. Mater."},{"issue":"3","key":"10.1016\/j.ijbiomac.2025.146302_bb0345","first-page":"583","article-title":"The chemical composition of the cell wall in some gram positive bacteria and its possible value as a taxonomic character","volume":"14","author":"Cummins","year":"1956","journal-title":"Microbiology"},{"issue":"2","key":"10.1016\/j.ijbiomac.2025.146302_bb0350","doi-asserted-by":"crossref","first-page":"114","DOI":"10.4103\/2231-0762.155736","article-title":"Bactericidal activity of propylene glycol, glycerine, polyethylene glycol 400, and polyethylene glycol 1000 against selected microorganisms","volume":"5","author":"Nalawade","year":"2015","journal-title":"J. Int. Soc. Prev. Community Dent."},{"issue":"1","key":"10.1016\/j.ijbiomac.2025.146302_bb0355","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.ijpharm.2013.09.028","article-title":"Design of antibiotic containing hydrogel wound dressings: biomedical properties and histological study of wound healing","volume":"457","author":"Singh","year":"2013","journal-title":"Int. J. Pharm."},{"issue":"11","key":"10.1016\/j.ijbiomac.2025.146302_bb0360","doi-asserted-by":"crossref","first-page":"4294","DOI":"10.1016\/j.conbuildmat.2011.05.005","article-title":"The relationship between porosity and strength for porous concrete","volume":"25","author":"Lian","year":"2011","journal-title":"Construct. Build Mater."},{"key":"10.1016\/j.ijbiomac.2025.146302_bb0365","doi-asserted-by":"crossref","first-page":"4297","DOI":"10.1007\/s00289-017-1953-y","article-title":"Chitosan\/oxidized pectin\/PVA blend film: mechanical and biological properties","volume":"74","author":"Chetouani","year":"2017","journal-title":"Polym. Bull."},{"issue":"3","key":"10.1016\/j.ijbiomac.2025.146302_bb0370","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1021\/acs.analchem.7b03800","article-title":"Simple ciprofloxacin resistance test and determination of minimal inhibitory concentration within 2 h using Raman spectroscopy","volume":"90","author":"Kirchhoff","year":"2018","journal-title":"Anal. Chem."},{"issue":"4","key":"10.1016\/j.ijbiomac.2025.146302_bb0375","first-page":"110","article-title":"Analysis of Fickian and non-Fickian drug release from polymers","volume":"60","author":"Peppas","year":"1985","journal-title":"Pharm. Acta Helv."},{"issue":"1","key":"10.1016\/j.ijbiomac.2025.146302_bb0380","doi-asserted-by":"crossref","first-page":"15448","DOI":"10.1038\/s41598-017-15792-w","article-title":"Dispersion of TiO2 nanoparticles improves burn wound healing and tissue regeneration through specific interaction with blood serum proteins","volume":"7","author":"Seisenbaeva","year":"2017","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.ijbiomac.2025.146302_bb0385","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/j.1468-3083.2010.03775.x","article-title":"Management of minor acute cutaneous wounds: importance of wound healing in a moist environment","volume":"25","author":"Korting","year":"2011","journal-title":"J. Eur. Acad. Dermatol. Venereol."}],"updated-by":[{"DOI":"10.1016\/j.ijbiomac.2025.146657","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000}}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014181302506859X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014181302506859X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T21:56:47Z","timestamp":1757627807000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S014181302506859X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":77,"alternative-id":["S014181302506859X"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2025.146302","relation":{"erratum":[{"id-type":"doi","id":"10.1016\/j.ijbiomac.2025.146657","asserted-by":"object"}]},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of bioactive chitosan patch with ciprofloxacin loaded TiO\u2082 nanoparticles for wound healing application","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2025.146302","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"146302"}}