{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T16:49:05Z","timestamp":1775580545128,"version":"3.50.1"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.ijbiomac.2025.147335","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T15:50:46Z","timestamp":1756828246000},"page":"147335","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Integrating single-cell transcriptomics, molecular docking, and dynamics simulations to characterize protein kinase X-linked mechanisms in osteosarcoma"],"prefix":"10.1016","volume":"325","author":[{"given":"Zongye","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi","family":"Sha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhendong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingbo","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenxing","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongdong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhichang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanzheng","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ijbiomac.2025.147335_bb0005","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1186\/s12943-025-02365-z","article-title":"Targeting metastasis in paediatric bone sarcomas","volume":"24","author":"Bull","year":"2025","journal-title":"Mol. Cancer"},{"issue":"10","key":"10.1016\/j.ijbiomac.2025.147335_bb0010","doi-asserted-by":"crossref","first-page":"9188","DOI":"10.18632\/aging.205863","article-title":"Comprehensive analysis to identify PUS7 as a prognostic biomarker from pan-cancer analysis to osteosarcoma validation","volume":"16","author":"Dong","year":"2024","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.ijbiomac.2025.147335_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.pbiomolbio.2025.07.001","article-title":"Advances and challenges in the treatment of osteosarcoma","author":"Wang","year":"2025","journal-title":"Prog. Biophys. Mol. Biol."},{"issue":"4","key":"10.1016\/j.ijbiomac.2025.147335_bb0020","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.hoc.2025.04.005","article-title":"Osteosarcoma: diagnosis, treatment, and emerging opportunities","volume":"39","author":"Bishop","year":"2025","journal-title":"Hematol. Oncol. Clin. North Am."},{"issue":"20","key":"10.1016\/j.ijbiomac.2025.147335_bb0025","doi-asserted-by":"crossref","first-page":"8633","DOI":"10.1039\/D4DT00568F","article-title":"An ALP-responsive, anionic iridium complex for specific recognition of osteosarcoma cells","volume":"53","author":"Shen","year":"2024","journal-title":"Dalton Trans."},{"key":"10.1016\/j.ijbiomac.2025.147335_bb0030","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.ejca.2022.11.032","article-title":"Rationale for LDH-targeted cancer immunotherapy","volume":"181","author":"Miholjcic","year":"2023","journal-title":"Eur. J. Cancer"},{"issue":"4","key":"10.1016\/j.ijbiomac.2025.147335_bb0035","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1016\/j.ymthe.2025.02.023","article-title":"Immunological responses and clinical outcomes in dogs with osteosarcoma receiving standard therapy and a Listeria vaccine expressing HER2","volume":"33","author":"Mason","year":"2025","journal-title":"Mol. Ther."},{"key":"10.1016\/j.ijbiomac.2025.147335_bb0040","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2024.1367331","article-title":"Therapeutic potential of tyrosine-protein kinase MET in osteosarcoma","volume":"11","author":"Zeng","year":"2024","journal-title":"Front. Mol. Biosci."},{"issue":"6","key":"10.1016\/j.ijbiomac.2025.147335_bb0045","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1007\/s00428-024-03801-z","article-title":"Correlation of high-grade osteosarcoma response to chemotherapy with enhanced tissue immunological response: analysis of CD95R, IFN-\u03b3, catalase, Hsp70, and VEGF","volume":"484","author":"Mustokoweni","year":"2024","journal-title":"Virchows Arch."},{"issue":"2","key":"10.1016\/j.ijbiomac.2025.147335_bb0050","doi-asserted-by":"crossref","first-page":"E45","DOI":"10.1002\/ijc.26486","article-title":"PRKX, TTBK2 and RSK4 expression causes Sunitinib resistance in kidney carcinoma- and melanoma-cell lines","volume":"131","author":"Bender","year":"2012","journal-title":"Int. J. Cancer"},{"issue":"3","key":"10.1016\/j.ijbiomac.2025.147335_bb0055","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1093\/biolre\/ioab212","article-title":"Long non-coding RNA NRSN2-AS1 facilitates tumorigenesis and progression of ovarian cancer via miR-744-5p\/PRKX axis","volume":"106","author":"Chen","year":"2022","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.ijbiomac.2025.147335_bb0060","doi-asserted-by":"crossref","first-page":"55","DOI":"10.2147\/ITT.S439289","article-title":"Identification of CXC Chemokine Receptor 2 (CXCR2) as a novel eosinophils-independent diagnostic biomarker of pediatric eosinophilic esophagitis by integrated bioinformatic and machine-learning analysis","volume":"13","author":"Wu","year":"2024","journal-title":"Immunotargets Ther."},{"issue":"4","key":"10.1016\/j.ijbiomac.2025.147335_bb0065","doi-asserted-by":"crossref","first-page":"e173","DOI":"10.1016\/S1470-2045(14)71116-7","article-title":"Nomograms in oncology: more than meets the eye","volume":"16","author":"Balachandran","year":"2015","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.ijbiomac.2025.147335_bb0070","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2022.992044","article-title":"Identification and verification of ferroptosis-related genes in the synovial tissue of osteoarthritis using bioinformatics analysis","volume":"9","author":"Xia","year":"2022","journal-title":"Front. Mol. Biosci."},{"issue":"4","key":"10.1016\/j.ijbiomac.2025.147335_bb0075","doi-asserted-by":"crossref","first-page":"299","DOI":"10.3233\/CBM-230086","article-title":"Identification of TNFRSF1A as a potential biomarker for osteosarcoma","volume":"39","author":"Zhang","year":"2024","journal-title":"Cancer Biomark."},{"issue":"1","key":"10.1016\/j.ijbiomac.2025.147335_bb0080","doi-asserted-by":"crossref","first-page":"10624","DOI":"10.1038\/s41598-020-67476-7","article-title":"Co-expression based cancer staging and application","volume":"10","author":"Yu","year":"2020","journal-title":"Sci. Rep."},{"issue":"43","key":"10.1016\/j.ijbiomac.2025.147335_bb0085","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"4&5","key":"10.1016\/j.ijbiomac.2025.147335_bb0090","doi-asserted-by":"crossref","first-page":"598","DOI":"10.4103\/ijmr.ijmr_1821_22","article-title":"Cancer incidence estimates for 2022 & projection for 2025: result from National Cancer Registry Programme, India","volume":"156","author":"Sathishkumar","year":"2022","journal-title":"Indian J. Med. Res."},{"key":"10.1016\/j.ijbiomac.2025.147335_bb0095","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/978-1-4939-7493-1_12","article-title":"Profiling tumor infiltrating immune cells with CIBERSORT","volume":"1711","author":"Chen","year":"2018","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.ijbiomac.2025.147335_bb0100","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.freeradbiomed.2024.10.312","article-title":"Nampt\/SIRT2\/LDHA pathway-mediated lactate production regulates follicular dysplasia in polycystic ovary syndrome","volume":"225","author":"Liu","year":"2024","journal-title":"Free Radic. Biol. Med."},{"issue":"4","key":"10.1016\/j.ijbiomac.2025.147335_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.molcel.2017.01.023","article-title":"Comparative analysis of single-cell RNA sequencing methods","volume":"65","author":"Ziegenhain","year":"2017","journal-title":"Mol. Cell"},{"issue":"1","key":"10.1016\/j.ijbiomac.2025.147335_bb0110","doi-asserted-by":"crossref","DOI":"10.3390\/biom13010078","article-title":"Integration of scrna-seq and bulk rna-seq reveals molecular characterization of the immune microenvironment in acute pancreatitis","volume":"13","author":"Fang","year":"2022","journal-title":"Biomolecules"},{"issue":"1","key":"10.1016\/j.ijbiomac.2025.147335_bb0115","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1186\/s12967-023-04056-z","article-title":"Comprehensive analysis of scRNA-Seq and bulk RNA-Seq reveals dynamic changes in the tumor immune microenvironment of bladder cancer and establishes a prognostic model","volume":"21","author":"Tan","year":"2023","journal-title":"J. Transl. Med."},{"issue":"1","key":"10.1016\/j.ijbiomac.2025.147335_bb0120","doi-asserted-by":"crossref","DOI":"10.1186\/s12943-024-02140-6","article-title":"Artificial intelligence alphafold model for molecular biology and drug discovery: a machine-learning-driven informatics investigation","volume":"23","author":"Guo","year":"2024","journal-title":"Mol. Cancer"},{"issue":"8016","key":"10.1016\/j.ijbiomac.2025.147335_bb0125","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/s41586-024-07487-w","article-title":"Accurate structure prediction of biomolecular interactions with AlphaFold 3","volume":"630","author":"Abramson","year":"2024","journal-title":"Nature"},{"issue":"7873","key":"10.1016\/j.ijbiomac.2025.147335_bb0130","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","article-title":"Highly accurate protein structure prediction with AlphaFold","volume":"596","author":"Jumper","year":"2021","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.ijbiomac.2025.147335_bb0135","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1111\/cbdd.14038","article-title":"Application of molecular dynamics simulation in biomedicine","volume":"99","author":"Wu","year":"2022","journal-title":"Chem. Biol. Drug Des."},{"issue":"Pt A","key":"10.1016\/j.ijbiomac.2025.147335_bb0140","article-title":"Molecular dynamics simulation of the interaction of food proteins with small molecules","volume":"405","author":"Hu","year":"2023","journal-title":"Food Chem."},{"issue":"3","key":"10.1016\/j.ijbiomac.2025.147335_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbagen.2019.129475","article-title":"Molecular dynamics in cells: a neutron view","volume":"1864","author":"Zaccai","year":"2020","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"issue":"2","key":"10.1016\/j.ijbiomac.2025.147335_bb0150","doi-asserted-by":"crossref","DOI":"10.1093\/bib\/bbab585","article-title":"Analysis of cancer omics data: a selective review of statistical techniques","volume":"23","author":"Ma","year":"2022","journal-title":"Brief. Bioinform."},{"issue":"1","key":"10.1016\/j.ijbiomac.2025.147335_bb0155","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/s41392-025-02299-4","article-title":"Glioblastoma at the crossroads: current understanding and future therapeutic horizons","volume":"10","author":"Singh","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"issue":"11","key":"10.1016\/j.ijbiomac.2025.147335_bb0160","doi-asserted-by":"crossref","DOI":"10.1002\/jcla.24698","article-title":"Silencing of lncRNA KLF3-AS1 represses cell growth in osteosarcoma via miR-338-3p\/MEF2C axis","volume":"36","author":"Chen","year":"2022","journal-title":"J. Clin. Lab. Anal."},{"issue":"7","key":"10.1016\/j.ijbiomac.2025.147335_bb0165","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0288180","article-title":"Construction and validation of a novel cuproptosis-mitochondrion prognostic model related with tumor immunity in osteosarcoma","volume":"18","author":"Feng","year":"2023","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.ijbiomac.2025.147335_bb0170","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/s00223-016-0231-6","article-title":"Effects of SOST gene silencing on proliferation, apoptosis, invasion, and migration of human osteosarcoma cells through the Wnt\/\u03b2-catenin signaling pathway","volume":"100","author":"Zou","year":"2017","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.ijbiomac.2025.147335_bb0175","doi-asserted-by":"crossref","first-page":"8812","DOI":"10.12659\/MSM.911972","article-title":"miR-29 family inhibits resistance to methotrexate and promotes cell apoptosis by targeting COL3A1 and MCL1 in osteosarcoma","volume":"24","author":"Xu","year":"2018","journal-title":"Med. Sci. Monit."},{"issue":"1","key":"10.1016\/j.ijbiomac.2025.147335_bb0180","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-55170-2","article-title":"Microrna-509-3p inhibits cellular migration, invasion, and proliferation, and sensitizes osteosarcoma to cisplatin","volume":"9","author":"Patil","year":"2019","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.ijbiomac.2025.147335_bb0185","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1002\/jcb.25304","article-title":"PRKX, a novel cAMP-dependent protein kinase member, plays an important role in development","volume":"117","author":"Huang","year":"2016","journal-title":"J. Cell. Biochem."},{"issue":"14","key":"10.1016\/j.ijbiomac.2025.147335_bb0190","doi-asserted-by":"crossref","first-page":"9260","DOI":"10.1073\/pnas.132051799","article-title":"PRKX, a phylogenetically and functionally distinct cAMP-dependent protein kinase, activates renal epithelial cell migration and morphogenesis","volume":"99","author":"Li","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"9","key":"10.1016\/j.ijbiomac.2025.147335_bb0195","doi-asserted-by":"crossref","first-page":"4545","DOI":"10.21873\/anticanres.11002","article-title":"Altered expression of PRKX, WNT3 and WNT16 in human nodular basal cell carcinoma","volume":"36","author":"DOC","year":"2016","journal-title":"Anticancer Res."},{"issue":"27","key":"10.1016\/j.ijbiomac.2025.147335_bb0200","doi-asserted-by":"crossref","first-page":"3029","DOI":"10.1200\/JCO.2014.59.4895","article-title":"Osteosarcoma: current treatment and a collaborative pathway to success","volume":"33","author":"Isakoff","year":"2015","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.ijbiomac.2025.147335_bb0205","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1097\/00003086-197509000-00009","article-title":"Radiotherapy in osteosarcoma","volume":"111","author":"Suit","year":"1975","journal-title":"Clin. Orthop. Relat. Res."},{"issue":"1","key":"10.1016\/j.ijbiomac.2025.147335_bb0210","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20010096","article-title":"Chemokines and chemokine receptors: orchestrating tumor metastasization","volume":"20","author":"Marcuzzi","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.ijbiomac.2025.147335_bb0215","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.immuni.2019.03.024","article-title":"Transforming growth factor-\u03b2 signaling in immunity and cancer","volume":"50","author":"Batlle","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.ijbiomac.2025.147335_bb0220","article-title":"PRKX down-regulates TAK1\/IRF7 signaling in the antiviral innate immunity of black carp Mylopharyngodon piceus","volume":"13","author":"Yang","year":"2022","journal-title":"Front. Immunol."},{"issue":"7","key":"10.1016\/j.ijbiomac.2025.147335_bb0225","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1034\/j.1600-6143.2002.20706.x","article-title":"CD2 is a dominant target for allogeneic responses","volume":"2","author":"Bai","year":"2002","journal-title":"Am. J. Transplant."},{"issue":"5","key":"10.1016\/j.ijbiomac.2025.147335_bb0230","doi-asserted-by":"crossref","DOI":"10.26508\/lsa.202000908","article-title":"Dendritic cell entry to lymphatic capillaries is orchestrated by CD44 and the hyaluronan glycocalyx","volume":"4","author":"Johnson","year":"2021","journal-title":"Life Sci. Alliance"},{"issue":"2","key":"10.1016\/j.ijbiomac.2025.147335_bb0235","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1002\/glia.24104","article-title":"NEK6 is an injury-responsive kinase cooperating with STAT3 in regulation of reactive astrogliosis","volume":"70","author":"Yu","year":"2022","journal-title":"Glia"},{"issue":"6","key":"10.1016\/j.ijbiomac.2025.147335_bb0240","doi-asserted-by":"crossref","first-page":"5311","DOI":"10.18632\/aging.205650","article-title":"Construction of an oxidative phosphorylation-related gene signature for predicting prognosis and identifying immune infiltration in osteosarcoma","volume":"16","author":"Zhou","year":"2024","journal-title":"Aging (Albany NY)"},{"issue":"11","key":"10.1016\/j.ijbiomac.2025.147335_bb0245","doi-asserted-by":"crossref","DOI":"10.3390\/biom14111359","article-title":"Oxidative phosphorylation as a predictive biomarker of Oxaliplatin response in colorectal Cancer","volume":"14","author":"Martinez-Bernabe","year":"2024","journal-title":"Biomolecules"},{"issue":"15","key":"10.1016\/j.ijbiomac.2025.147335_bb0250","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.18511","article-title":"Identification of prostate cancer bone metastasis related genes and potential therapy targets by bioinformatics and in vitro experiments","volume":"28","author":"Jiang","year":"2024","journal-title":"J. Cell. Mol. Med."},{"issue":"8","key":"10.1016\/j.ijbiomac.2025.147335_bb0255","doi-asserted-by":"crossref","first-page":"4921","DOI":"10.1074\/jbc.M808436200","article-title":"The chaperones Hsp90 and Cdc37 mediate the maturation and stabilization of protein kinase C through a conserved PXXP motif in the C-terminal tail","volume":"284","author":"Gould","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.ijbiomac.2025.147335_bb0260","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0014-5793(03)00451-4","article-title":"MAP kinase-mediated phosphoacetylation of histone H3 and inducible gene regulation","volume":"546","author":"Clayton","year":"2003","journal-title":"FEBS Lett."},{"issue":"6","key":"10.1016\/j.ijbiomac.2025.147335_bb0265","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/j.burns.2019.04.003","article-title":"Thromboprophylaxis in adult and paediatric burn patients: a survey of practice in the United Kingdom","volume":"45","author":"Vermaak","year":"2019","journal-title":"Burns"},{"issue":"440","key":"10.1016\/j.ijbiomac.2025.147335_bb0270","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aaf3273","article-title":"Histone deacetylase 3 supports endochondral bone formation by controlling cytokine signaling and matrix remodeling","volume":"9","author":"Carpio","year":"2016","journal-title":"Sci. Signal."},{"issue":"1","key":"10.1016\/j.ijbiomac.2025.147335_bb0275","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1186\/s10020-024-00928-2","article-title":"Integrating network pharmacology, molecular docking and experimental verification to explore the therapeutic effect and potential mechanism of nomilin against triple-negative breast cancer","volume":"30","author":"Wu","year":"2024","journal-title":"Mol. Med."},{"issue":"11","key":"10.1016\/j.ijbiomac.2025.147335_bb0280","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26113251","article-title":"Molecular dynamics of cobalt Protoporphyrin antagonism of the cancer suppressor REV-ERB\u03b2","volume":"26","author":"Fakih","year":"2021","journal-title":"Molecules"}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813025078924?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813025078924?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T09:26:33Z","timestamp":1757582793000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0141813025078924"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":56,"alternative-id":["S0141813025078924"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2025.147335","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrating single-cell transcriptomics, molecular docking, and dynamics simulations to characterize protein kinase X-linked mechanisms in osteosarcoma","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2025.147335","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"147335"}}