{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T15:11:09Z","timestamp":1785510669710,"version":"3.56.0"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002947","name":"Anhui Medical University","doi-asserted-by":"publisher","award":["2021GMFY03"],"award-info":[{"award-number":["2021GMFY03"]}],"id":[{"id":"10.13039\/501100002947","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072305"],"award-info":[{"award-number":["82072305"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.ijbiomac.2025.148776","type":"journal-article","created":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T08:09:05Z","timestamp":1762330145000},"page":"148776","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"P1","title":["Circular RNA Gsr-0002 promotes schistosomiasis-induced liver fibrosis by regulating the DNMT3A\/PTEN pathway"],"prefix":"10.1016","volume":"333","author":[{"given":"Bingxin","family":"Dai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijia","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyue","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gangqiang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangting","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailan","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siwei","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weice","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzhong","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuiping","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jijia","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9936","key":"10.1016\/j.ijbiomac.2025.148776_bb0005","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1016\/S0140-6736(13)61949-2","article-title":"Human schistosomiasis","volume":"383","author":"Colley","year":"2014","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.ijbiomac.2025.148776_bb0010","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s13071-022-05178-x","article-title":"Determining the optimal strategies to achieve elimination of transmission for Schistosoma mansoni","volume":"15","author":"Kura","year":"2022","journal-title":"Parasit. Vectors"},{"issue":"11","key":"10.1016\/j.ijbiomac.2025.148776_bb0015","doi-asserted-by":"crossref","first-page":"e327","DOI":"10.1016\/S1473-3099(22)00221-3","article-title":"Review of 2022 WHO guidelines on the control and elimination of schistosomiasis","volume":"22","author":"Lo","year":"2022","journal-title":"Lancet Infect. Dis."},{"issue":"1","key":"10.1016\/j.ijbiomac.2025.148776_bb0020","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s40249-024-01199-z","article-title":"Accelerating snail vector genomics","volume":"13","author":"Pennance","year":"2024","journal-title":"Infect. Dis. Poverty"},{"issue":"3","key":"10.1016\/j.ijbiomac.2025.148776_bb0025","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s00281-020-00789-x","article-title":"Schistosomiasis-from immunopathology to vaccines","volume":"42","author":"McManus","year":"2020","journal-title":"Semin. Immunopathol."},{"issue":"1","key":"10.1016\/j.ijbiomac.2025.148776_bb0030","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/s41572-018-0013-8","article-title":"Schistosomiasis","volume":"4","author":"McManus","year":"2018","journal-title":"Nat. Rev. Dis. Primers"},{"issue":"9541","key":"10.1016\/j.ijbiomac.2025.148776_bb0035","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/S0140-6736(06)69440-3","article-title":"Human schistosomiasis","volume":"368","author":"Gryseels","year":"2006","journal-title":"Lancet"},{"issue":"7","key":"10.1016\/j.ijbiomac.2025.148776_bb0040","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nrgastro.2017.38","article-title":"Mechanisms of hepatic stellate cell activation","volume":"14","author":"Tsuchida","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"1","key":"10.1016\/j.ijbiomac.2025.148776_bb0045","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/nri.2017.90","article-title":"Type 2 immunity in tissue repair and fibrosis","volume":"18","author":"Gieseck","year":"2018","journal-title":"Nat. Rev. Immunol."},{"issue":"2","key":"10.1016\/j.ijbiomac.2025.148776_bb0050","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1172\/JCI24282","article-title":"Liver fibrosis","volume":"115","author":"Bataller","year":"2005","journal-title":"J. Clin. Invest."},{"issue":"5","key":"10.1016\/j.ijbiomac.2025.148776_bb0055","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1053\/j.gastro.2019.07.029","article-title":"Fibrogenic activity of MECP2 is regulated by phosphorylation in hepatic stellate cells","volume":"157","author":"Moran-Salvador","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ijbiomac.2025.148776_bb0060","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.addr.2017.05.007","article-title":"Hepatic stellate cells as key target in liver fibrosis","volume":"121","author":"Higashi","year":"2017","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"1","key":"10.1016\/j.ijbiomac.2025.148776_bb0065","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s12931-018-0962-1","article-title":"Circular RNAs: a rising star in respiratory diseases","volume":"20","author":"Wang","year":"2019","journal-title":"Respir. Res."},{"issue":"16","key":"10.1016\/j.ijbiomac.2025.148776_bb0070","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2018100836","article-title":"Past, present, and future of circRNAs","volume":"38","author":"Patop","year":"2019","journal-title":"EMBO J."},{"issue":"2","key":"10.1016\/j.ijbiomac.2025.148776_bb0075","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.canlet.2015.06.003","article-title":"Circular RNA: a new star of noncoding RNAs","volume":"365","author":"Qu","year":"2015","journal-title":"Cancer Lett."},{"issue":"1","key":"10.1016\/j.ijbiomac.2025.148776_bb0080","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/s13045-020-00976-1","article-title":"The functions and clinical significance of circRNAs in hematological malignancies","volume":"13","author":"Zhou","year":"2020","journal-title":"J. Hematol. Oncol."},{"issue":"6","key":"10.1016\/j.ijbiomac.2025.148776_bb0085","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00012-2022","article-title":"The role of circular RNAs in pulmonary hypertension","volume":"60","author":"Ali","year":"2022","journal-title":"Eur. Respir. J."},{"issue":"12","key":"10.1016\/j.ijbiomac.2025.148776_bb0090","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1001233","article-title":"Expression of linear and novel circular forms of an INK4\/ARF-associated non-coding RNA correlates with atherosclerosis risk","volume":"6","author":"Burd","year":"2010","journal-title":"PLoS Genet."},{"issue":"3","key":"10.1016\/j.ijbiomac.2025.148776_bb0095","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/s41418-022-00948-7","article-title":"Specific expression and functions of circular RNAs","volume":"29","author":"Misir","year":"2022","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.ijbiomac.2025.148776_bb0100","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/978-981-13-1426-1_21","article-title":"Circular RNAs in organ fibrosis","volume":"1087","author":"Yao","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"issue":"1","key":"10.1016\/j.ijbiomac.2025.148776_bb0105","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s12964-023-01051-1","article-title":"CircRNAs: versatile players and new targets in organ fibrosis","volume":"21","author":"Wei","year":"2023","journal-title":"Cell Commun. Signal."},{"issue":"3","key":"10.1016\/j.ijbiomac.2025.148776_bb0110","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/s41419-022-04612-3","article-title":"The mmu_circRNA_37492\/hsa_circ_0012138 function as potential ceRNA to attenuate obstructive renal fibrosis","volume":"13","author":"Cheng","year":"2022","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.ijbiomac.2025.148776_bb0115","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/s11658-023-00518-w","article-title":"CircZNF609 regulates pulmonary fibrosis via miR-145-5p\/KLF4 axis and its translation function","volume":"28","author":"Sun","year":"2023","journal-title":"Cell. Mol. Biol. Lett."},{"key":"10.1016\/j.ijbiomac.2025.148776_bb0120","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.gene.2018.08.052","article-title":"Preliminary screening and functional analysis of circular RNAs associated with hepatic stellate cell activation","volume":"677","author":"Zhou","year":"2018","journal-title":"Gene"},{"issue":"11","key":"10.1016\/j.ijbiomac.2025.148776_bb0125","doi-asserted-by":"crossref","first-page":"4851","DOI":"10.7150\/thno.42423","article-title":"Circular RNA circFBXW4 suppresses hepatic fibrosis via targeting the miR-18b-3p\/FBXW7 axis","volume":"10","author":"Chen","year":"2020","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.ijbiomac.2025.148776_bb0130","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.cell.2020.08.009","article-title":"Targeting mitochondria-located circRNA SCAR alleviates NASH via reducing mROS output","volume":"183","author":"Zhao","year":"2020","journal-title":"Cell"},{"issue":"1\u20132","key":"10.1016\/j.ijbiomac.2025.148776_bb0135","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0304-3835(93)90071-G","article-title":"Effects of carbon tetrachloride, ethanol and acetaldehyde on diethylnitrosamine-induced hepatocarcinogenesis in rats","volume":"70","author":"Cho","year":"1993","journal-title":"Cancer Lett."},{"key":"10.1016\/j.ijbiomac.2025.148776_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109551","article-title":"miR-383 inhibits cell growth and promotes cell apoptosis in hepatocellular carcinoma by targeting IL-17 via STAT3 signaling pathway","volume":"120","author":"Wang","year":"2019","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.ijbiomac.2025.148776_bb0145","doi-asserted-by":"crossref","first-page":"11094","DOI":"10.1038\/s41598-018-29271-3","article-title":"Biostatistics mining associated method identifies AKR1B10 enhancing hepatocellular carcinoma cell growth and degenerated by miR-383-5p","volume":"8","author":"Wang","year":"2018","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.ijbiomac.2025.148776_bb0150","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1186\/s13046-022-02482-3","article-title":"Hsa_circ_0000098 is a novel therapeutic target that promotes hepatocellular carcinoma development and resistance to doxorubicin","volume":"41","author":"Li","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"3","key":"10.1016\/j.ijbiomac.2025.148776_bb0155","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1053\/jhep.2001.22507","article-title":"Expression of mRNA for DNA methyltransferases and methyl-CpG-binding proteins and DNA methylation status on CpG islands and pericentromeric satellite regions during human hepatocarcinogenesis","volume":"33","author":"Saito","year":"2001","journal-title":"Hepatology"},{"key":"10.1016\/j.ijbiomac.2025.148776_bb0160","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.freeradbiomed.2023.04.009","article-title":"Caveolin-1 depletion attenuates hepatic fibrosis via promoting SQSTM1-mediated PFKL degradation in HSCs","volume":"204","author":"Zhang","year":"2023","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.ijbiomac.2025.148776_bb0165","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s12072-023-10559-0","article-title":"Autophagic degradation of MVBs in LSECs promotes aldosterone induced-HSCs activation","volume":"18","author":"Chen","year":"2024","journal-title":"Hepatol. Int."},{"issue":"5","key":"10.1016\/j.ijbiomac.2025.148776_bb0170","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/0092-8674(93)90279-Y","article-title":"Circular transcripts of the testis-determining gene Sry in adult mouse testis","volume":"73","author":"Capel","year":"1993","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.ijbiomac.2025.148776_bb0175","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1096\/fasebj.7.1.7678559","article-title":"Mis-splicing yields circular RNA molecules","volume":"7","author":"Cocquerelle","year":"1993","journal-title":"FASEB J."},{"issue":"2","key":"10.1016\/j.ijbiomac.2025.148776_bb0180","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s11010-021-04286-z","article-title":"circRNA is a potential target for cardiovascular diseases treatment","volume":"477","author":"Ju","year":"2022","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.ijbiomac.2025.148776_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2023.114826","article-title":"Clinical delivery of circular RNA: lessons learned from RNA drug development","volume":"197","author":"Loan Young","year":"2023","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"5","key":"10.1016\/j.ijbiomac.2025.148776_bb0190","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1053\/gast.2002.33367","article-title":"Reversibility of liver fibrosis and cirrhosis following treatment for hepatitis C","volume":"122","author":"Arthur","year":"2002","journal-title":"Gastroenterology"},{"issue":"6","key":"10.1016\/j.ijbiomac.2025.148776_bb0195","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13432","article-title":"Proangiogenic role of circRNA-007371 in liver fibrosis","volume":"56","author":"Zhao","year":"2023","journal-title":"Cell Prolif."},{"issue":"21","key":"10.1016\/j.ijbiomac.2025.148776_bb0200","doi-asserted-by":"crossref","first-page":"9569","DOI":"10.18632\/aging.102405","article-title":"TGF-\u03b2- and lipopolysaccharide-induced upregulation of circular RNA PWWP2A promotes hepatic fibrosis via sponging miR-203 and miR-223","volume":"11","author":"Liu","year":"2019","journal-title":"Aging (Albany NY)"},{"issue":"12","key":"10.1016\/j.ijbiomac.2025.148776_bb0205","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.pt.2012.09.005","article-title":"Role of resident liver cells in the pathogenesis of schistosomiasis","volume":"28","author":"Anthony","year":"2012","journal-title":"Trends Parasitol."},{"issue":"3","key":"10.1016\/j.ijbiomac.2025.148776_bb0210","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/s41575-020-00372-7","article-title":"Molecular and cellular mechanisms of liver fibrosis and its regression","volume":"18","author":"Kisseleva","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"3","key":"10.1016\/j.ijbiomac.2025.148776_bb0215","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1128\/iai.49.3.635-640.1985","article-title":"Regulation of egg antigen-induced in vitro proliferative response by splenic suppressor T cells in murine Schistosoma japonicum infection","volume":"49","author":"Stavitsky","year":"1985","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijbiomac.2025.148776_bb0220","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.570524","article-title":"The differential and dynamic progression of hepatic inflammation and immune responses during liver fibrosis induced by Schistosoma japonicum or carbon tetrachloride in mice","volume":"11","author":"Song","year":"2020","journal-title":"Front. Immunol."},{"issue":"7","key":"10.1016\/j.ijbiomac.2025.148776_bb0225","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0003965","article-title":"Circulating miRNAs: potential novel biomarkers for Hepatopathology progression and diagnosis of schistosomiasis japonica in two murine models","volume":"9","author":"Cai","year":"2015","journal-title":"PLoS Negl. Trop. Dis."},{"issue":"11","key":"10.1016\/j.ijbiomac.2025.148776_bb0230","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/s41576-019-0158-7","article-title":"The biogenesis, biology and characterization of circular RNAs","volume":"20","author":"Kristensen","year":"2019","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.ijbiomac.2025.148776_bb0235","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.955486","article-title":"MicroRNA-383: a tumor suppressor miRNA in human cancer","volume":"10","author":"Jafarzadeh","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.ijbiomac.2025.148776_bb0240","doi-asserted-by":"crossref","first-page":"313","DOI":"10.7150\/jca.64846","article-title":"A concise review of MicroRNA-383: exploring the insights of its function in tumorigenesis","volume":"13","author":"Yi","year":"2022","journal-title":"J. Cancer"},{"key":"10.1016\/j.ijbiomac.2025.148776_bb0245","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0074-7696(08)61327-3","article-title":"DNA methylation in eukaryotic cells","volume":"92","author":"Razin","year":"1984","journal-title":"Int. Rev. Cytol."},{"issue":"2","key":"10.1016\/j.ijbiomac.2025.148776_bb0250","doi-asserted-by":"crossref","first-page":"247","DOI":"10.2217\/epi.14.80","article-title":"Genetic alterations of DNA methylation machinery in human diseases","volume":"7","author":"Hamidi","year":"2015","journal-title":"Epigenomics"},{"issue":"11","key":"10.1016\/j.ijbiomac.2025.148776_bb0255","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.2174\/13816128113199990534","article-title":"De novo DNMTs and DNA methylation: novel insights into disease pathogenesis and therapy from epigenomics","volume":"20","author":"Leppert","year":"2014","journal-title":"Curr. Pharm. Des."},{"issue":"15","key":"10.1016\/j.ijbiomac.2025.148776_bb0260","doi-asserted-by":"crossref","first-page":"9901","DOI":"10.1074\/jbc.M511100200","article-title":"CpG sites preferentially methylated by Dnmt3a in vivo","volume":"281","author":"Oka","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"10","key":"10.1016\/j.ijbiomac.2025.148776_bb0265","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2022.102462","article-title":"DNA methyltransferase DNMT3A forms interaction networks with the CpG site and flanking sequence elements for efficient methylation","volume":"298","author":"Dukatz","year":"2022","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ijbiomac.2025.148776_bb0270","doi-asserted-by":"crossref","DOI":"10.1155\/2010\/737535","article-title":"Depletion of DNMT3A suppressed cell proliferation and restored PTEN in hepatocellular carcinoma cell","volume":"2010","author":"Zhao","year":"2010","journal-title":"J. Biomed. Biotechnol."},{"issue":"11","key":"10.1016\/j.ijbiomac.2025.148776_bb0275","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1113\/EP088894","article-title":"Overexpression of Dnmt3a ameliorates diabetic muscle atrophy by modulating the Pten\/Akt pathway","volume":"105","author":"Wang","year":"2020","journal-title":"Exp. Physiol."},{"issue":"9","key":"10.1016\/j.ijbiomac.2025.148776_bb0280","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/s41580-018-0015-0","article-title":"The functions and regulation of the PTEN tumour suppressor: new modes and prospects","volume":"19","author":"Lee","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ijbiomac.2025.148776_bb0285","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/978-3-030-02771-1_5","article-title":"Targeting PTEN in colorectal cancers","volume":"1110","author":"Kotelevets","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"issue":"1","key":"10.1016\/j.ijbiomac.2025.148776_bb0290","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1080\/10717544.2022.2030428","article-title":"Mesenchymal stem cell-originated exosomal circDIDO1 suppresses hepatic stellate cell activation by miR-141-3p\/PTEN\/AKT pathway in human liver fibrosis","volume":"29","author":"Ma","year":"2022","journal-title":"Drug Deliv."},{"issue":"10","key":"10.1016\/j.ijbiomac.2025.148776_bb0295","doi-asserted-by":"crossref","first-page":"3537","DOI":"10.1016\/j.bbadis.2018.08.012","article-title":"Adiponectin inhibits hepatic stellate cell activation by targeting the PTEN\/AKT pathway","volume":"1864","author":"Kumar","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. basis Dis."}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014181302509333X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014181302509333X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T17:24:57Z","timestamp":1766078697000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S014181302509333X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":59,"alternative-id":["S014181302509333X"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2025.148776","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Circular RNA Gsr-0002 promotes schistosomiasis-induced liver fibrosis by regulating the DNMT3A\/PTEN pathway","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2025.148776","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"148776"}}