{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:50:19Z","timestamp":1791849019378,"version":"4.3.4"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007062","name":"Yangzhou University","doi-asserted-by":"publisher","award":["137013152"],"award-info":[{"award-number":["137013152"]}],"id":[{"id":"10.13039\/501100007062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Jiangsu Province Natural Science Foundation","doi-asserted-by":"publisher","award":["BK20240907"],"award-info":[{"award-number":["BK20240907"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.ijbiomac.2025.149223","type":"journal-article","created":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T16:03:50Z","timestamp":1765037030000},"page":"149223","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"P1","title":["Hypothalamic FTO-IGF2BP2-mediated m6A regulation of ANXA2: A novel axis preventing HS-induced sperm motility decline"],"prefix":"10.1016","volume":"340","author":[{"given":"Bin","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruixi","family":"Ming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guobin","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongzhou","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijbiomac.2025.149223_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2025.120844","article-title":"Climate change and occupational health and safety. Risk of injuries, productivity loss and the co-benefits perspective","volume":"269","author":"Marinaccio","year":"2025","journal-title":"Environ. Res."},{"issue":"10301","key":"10.1016\/j.ijbiomac.2025.149223_bb0010","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/S0140-6736(21)01208-3","article-title":"Hot weather and heat extremes: health risks","volume":"398","author":"Ebi","year":"2021","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.ijbiomac.2025.149223_bb0015","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.fertnstert.2022.06.005","article-title":"Systematic review of climate change effects on reproductive health","volume":"118","author":"Segal","year":"2022","journal-title":"Fertil. Steril."},{"issue":"4","key":"10.1016\/j.ijbiomac.2025.149223_bb0020","first-page":"710","article-title":"The impact of high ambient temperature on human sperm parameters: a meta-analysis","volume":"51","author":"Hoang-Thi","year":"2022","journal-title":"Iran. J. Public Health"},{"key":"10.1016\/j.ijbiomac.2025.149223_bb0025","series-title":"Testicular Heat Stress and Sperm Quality","first-page":"105","author":"Durairajanayagam","year":"2014"},{"issue":"5","key":"10.1016\/j.ijbiomac.2025.149223_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e26765","article-title":"Effects of temperature anomaly on sperm quality: a multi-center study of 33,234 men","volume":"10","author":"Xiao","year":"2024","journal-title":"Heliyon"},{"issue":"1","key":"10.1016\/j.ijbiomac.2025.149223_bb0035","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s10815-023-02992-9","article-title":"The role of the intrinsic pathway of apoptosis in human ejaculated sperm damage under a state of scrotal heat stress","volume":"41","author":"Budzinska","year":"2024","journal-title":"J. Assist. Reprod. Genet."},{"issue":"4","key":"10.1016\/j.ijbiomac.2025.149223_bb0040","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1093\/humrep\/det020","article-title":"Seminal and molecular evidence that sauna exposure affects human spermatogenesis","volume":"28","author":"Garolla","year":"2013","journal-title":"Hum. Reprod."},{"issue":"10","key":"10.1016\/j.ijbiomac.2025.149223_bb0045","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1002\/mrd.23123","article-title":"Heat stress, a serious threat to reproductive function in animals and humans","volume":"86","author":"Boni","year":"2019","journal-title":"Mol. Reprod. Dev."},{"issue":"4","key":"10.1016\/j.ijbiomac.2025.149223_bb0050","doi-asserted-by":"crossref","DOI":"10.3390\/biom15040500","article-title":"Mechanisms of hormonal, genetic, and temperature regulation of germ cell proliferation, differentiation, and death during spermatogenesis","volume":"15","author":"Maroto","year":"2025","journal-title":"Biomolecules"},{"issue":"17","key":"10.1016\/j.ijbiomac.2025.149223_bb0055","doi-asserted-by":"crossref","DOI":"10.3390\/nu16173032","article-title":"Effects of heat stress-induced sex hormone dysregulation on reproduction and growth in male adolescents and beneficial foods","volume":"16","author":"Ko","year":"2024","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.ijbiomac.2025.149223_bb0060","doi-asserted-by":"crossref","DOI":"10.3390\/toxins12010016","article-title":"Ephedra sinica Stapf and gypsum attenuates heat-induced hypothalamic inflammation in mice","volume":"12","author":"Kim","year":"2019","journal-title":"Toxins (Basel)"},{"issue":"8","key":"10.1016\/j.ijbiomac.2025.149223_bb0065","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1089\/neu.2010.1323","article-title":"Attenuation of heat-induced hypothalamic ischemia, inflammation, and damage by hyperbaric oxygen in rats","volume":"38","author":"Tai","year":"2021","journal-title":"J. Neurotrauma"},{"issue":"9","key":"10.1016\/j.ijbiomac.2025.149223_bb0070","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1002\/mrd.22859","article-title":"Physiological mechanisms through which heat stress compromises reproduction in pigs","volume":"84","author":"Ross","year":"2017","journal-title":"Mol. Reprod. Dev."},{"issue":"4","key":"10.1016\/j.ijbiomac.2025.149223_bb0075","doi-asserted-by":"crossref","DOI":"10.3892\/mmr.2022.12659","article-title":"LKB1 alleviates high glucose- and high fat-induced inflammation and the expression of GnRH and sexual precocity-related genes, in mouse hypothalamic cells by activating the AMPK\/FOXO1 signaling pathway","volume":"25","author":"Liu","year":"2022","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.ijbiomac.2025.149223_bb0080","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s40104-018-0267-8","article-title":"Effect of CD14\/TLR4 antagonist on GnRH\/LH secretion in ewe during central inflammation induced by intracerebroventricular administration of LPS","volume":"9","author":"Haziak","year":"2018","journal-title":"J Anim Sci Biotechnol"},{"issue":"1","key":"10.1016\/j.ijbiomac.2025.149223_bb0085","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/ptr.6801","article-title":"Saponins derived from the stems and leaves of Panax ginseng attenuate scrotal heat-induced spermatogenic damage via inhibiting the MAPK mediated oxidative stress and apoptosis in mice","volume":"35","author":"Liu","year":"2021","journal-title":"Phytother. Res."},{"issue":"2","key":"10.1016\/j.ijbiomac.2025.149223_bb0090","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1177\/0748233711425082","article-title":"Heat stress decreases testicular germ cell proliferation and increases apoptosis in short term: an immunohistochemical and ultrastructural study","volume":"29","author":"Kanter","year":"2013","journal-title":"Toxicol. Ind. Health"},{"issue":"4","key":"10.1016\/j.ijbiomac.2025.149223_bb0095","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1111\/nph.17970","article-title":"Epigenetic regulation of thermomorphogenesis and heat stress tolerance","volume":"234","author":"Perrella","year":"2022","journal-title":"New Phytol."},{"issue":"6","key":"10.1016\/j.ijbiomac.2025.149223_bb0100","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1093\/icb\/icaa049","article-title":"Epigenetic responses to temperature and climate","volume":"60","author":"McCaw","year":"2020","journal-title":"Integr. Comp. Biol."},{"issue":"7","key":"10.1016\/j.ijbiomac.2025.149223_bb0105","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/j.cell.2017.05.045","article-title":"Dynamic RNA modifications in gene expression regulation","volume":"169","author":"Roundtree","year":"2017","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.ijbiomac.2025.149223_bb0110","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/s41422-018-0040-8","article-title":"Dynamic transcriptomic m(6)A decoration: writers, erasers, readers and functions in RNA metabolism","volume":"28","author":"Yang","year":"2018","journal-title":"Cell Res."},{"issue":"1","key":"10.1016\/j.ijbiomac.2025.149223_bb0115","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s13059-020-02249-z","article-title":"N6-methyladenosine dynamics in neurodevelopment and aging, and its potential role in Alzheimer\u2019s disease","volume":"22","author":"Shafik","year":"2021","journal-title":"Genome Biol."},{"issue":"5","key":"10.1016\/j.ijbiomac.2025.149223_bb0120","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1210\/er.2018-00248","article-title":"Delayed puberty-phenotypic diversity, molecular genetic mechanisms, and recent discoveries","volume":"40","author":"Howard","year":"2019","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.ijbiomac.2025.149223_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2023.109512","article-title":"Hypothalamic FTO promotes high-fat diet-induced leptin resistance in mice through increasing CX3CL1 expression","volume":"123","author":"Liu","year":"2024","journal-title":"J. Nutr. Biochem."},{"issue":"18","key":"10.1016\/j.ijbiomac.2025.149223_bb0130","doi-asserted-by":"crossref","first-page":"4919","DOI":"10.1038\/s44318-025-00503-3","article-title":"FTO promotes weight gain via altering Kif1a splicing and axonal vesicle trafficking in AgRP neurons","volume":"44","author":"Kohno","year":"2025","journal-title":"EMBO J"},{"issue":"1","key":"10.1016\/j.ijbiomac.2025.149223_bb0135","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1038\/s42003-023-05677-2","article-title":"FTO-mediated m(6)A demethylation regulates GnRH expression in the hypothalamus via the PLCbeta3\/Ca(2+)\/CAMK signalling pathway","volume":"6","author":"Zang","year":"2023","journal-title":"Commun Biol"},{"issue":"3","key":"10.1016\/j.ijbiomac.2025.149223_bb0140","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0549-19.2020","article-title":"Early-life m(6)A RNA demethylation by fat mass and obesity-associated protein (FTO) influences resilience or vulnerability to heat stress later in life","volume":"7","author":"Kisliouk","year":"2020","journal-title":"eNeuro"},{"issue":"621","key":"10.1016\/j.ijbiomac.2025.149223_bb0145","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abd5758","article-title":"Importance of the pig as a human biomedical model","volume":"13","author":"Lunney","year":"2021","journal-title":"Sci. Transl. Med."},{"issue":"1","key":"10.1016\/j.ijbiomac.2025.149223_bb0150","doi-asserted-by":"crossref","first-page":"5196","DOI":"10.1038\/s41467-020-19042-y","article-title":"Transplantation of hPSC-derived pericyte-like cells promotes functional recovery in ischemic stroke mice","volume":"11","author":"Sun","year":"2020","journal-title":"Nat. Commun."},{"issue":"11","key":"10.1016\/j.ijbiomac.2025.149223_bb0155","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1038\/s41593-019-0497-x","article-title":"Profiling the mouse brain endothelial transcriptome in health and disease models reveals a core blood-brain barrier dysfunction module","volume":"22","author":"Munji","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ijbiomac.2025.149223_bb0160","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.expneurol.2019.03.014","article-title":"Impairment of pericyte-endothelium crosstalk leads to blood-brain barrier dysfunction following traumatic brain injury","volume":"317","author":"Bhowmick","year":"2019","journal-title":"Exp. Neurol."},{"issue":"1","key":"10.1016\/j.ijbiomac.2025.149223_bb0165","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1186\/s40168-024-01942-6","article-title":"Melatonin alleviates heat stress-induced spermatogenesis dysfunction in male dairy goats by regulating arachidonic acid metabolism mediated by remodeling the gut microbiota","volume":"12","author":"Guo","year":"2024","journal-title":"Microbiome"},{"issue":"3","key":"10.1016\/j.ijbiomac.2025.149223_bb0170","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12819","article-title":"Melatonin alleviates the heat stress-induced impairment of Sertoli cells by reprogramming glucose metabolism","volume":"73","author":"Deng","year":"2022","journal-title":"J. Pineal Res."},{"issue":"1","key":"10.1016\/j.ijbiomac.2025.149223_bb0175","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1186\/s12917-020-02505-1","article-title":"Proteomic study of hypothalamus in pigs exposed to heat stress","volume":"16","author":"Yu","year":"2020","journal-title":"BMC Vet. Res."},{"issue":"3","key":"10.1016\/j.ijbiomac.2025.149223_bb0180","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1093\/cvr\/cvu148","article-title":"HDL and cholesterol handling in the brain","volume":"103","author":"Vitali","year":"2014","journal-title":"Cardiovasc. Res."},{"issue":"1","key":"10.1016\/j.ijbiomac.2025.149223_bb0185","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/s41392-020-00450-x","article-title":"The role of m6A modification in the biological functions and diseases","volume":"6","author":"Jiang","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"issue":"3","key":"10.1016\/j.ijbiomac.2025.149223_bb0190","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.bbagrm.2018.12.001","article-title":"The role of RNA adenosine demethylases in the control of gene expression","volume":"1862","author":"Rajecka","year":"2019","journal-title":"Biochim. Biophys. Acta Gene Regul. Mech."},{"issue":"4","key":"10.1016\/j.ijbiomac.2025.149223_bb0195","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1161\/CIRCULATIONAHA.118.033794","article-title":"FTO-dependent N(6)-methyladenosine regulates cardiac function during remodeling and repair","volume":"139","author":"Mathiyalagan","year":"2019","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.ijbiomac.2025.149223_bb0200","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/s41467-023-36008-y","article-title":"FTO-dependent m(6)A modification of Plpp3 in circSCMH1-regulated vascular repair and functional recovery following stroke","volume":"14","author":"Li","year":"2023","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.ijbiomac.2025.149223_bb0205","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s12943-019-1004-4","article-title":"RNA N6-methyladenosine demethylase FTO promotes breast tumor progression through inhibiting BNIP3","volume":"18","author":"Niu","year":"2019","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.ijbiomac.2025.149223_bb0210","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1186\/s12943-024-02117-5","article-title":"FTO-mediated DSP m(6)A demethylation promotes an aggressive subtype of growth hormone-secreting pituitary neuroendocrine tumors","volume":"23","author":"Zou","year":"2024","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.ijbiomac.2025.149223_bb0215","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s12915-024-01905-1","article-title":"GnRH-driven FTO-mediated RNA m(6)A modification promotes gonadotropin synthesis and secretion","volume":"22","author":"Wang","year":"2024","journal-title":"BMC Biol."},{"issue":"6","key":"10.1016\/j.ijbiomac.2025.149223_bb0220","doi-asserted-by":"crossref","DOI":"10.3390\/cells9061499","article-title":"Annexin A2 in inflammation and host defense","volume":"9","author":"Dallacasagrande","year":"2020","journal-title":"Cells"},{"issue":"34","key":"10.1016\/j.ijbiomac.2025.149223_bb0225","doi-asserted-by":"crossref","first-page":"24764","DOI":"10.1074\/jbc.M113.474023","article-title":"Lipid segregation and membrane budding induced by the peripheral membrane binding protein annexin A2","volume":"288","author":"Dr\u00fccker","year":"2013","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.ijbiomac.2025.149223_bb0230","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1002\/cac2.12413","article-title":"N6-methyladenosine-modified DBT alleviates lipid accumulation and inhibits tumor progression in clear cell renal cell carcinoma through the ANXA2\/YAP axis-regulated Hippo pathway","volume":"43","author":"Miao","year":"2023","journal-title":"Cancer Commun. (Lond.)"},{"issue":"4","key":"10.1016\/j.ijbiomac.2025.149223_bb0235","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1007\/s12072-023-10622-w","article-title":"The upregulation of Annexin A2 by TLR4 pathway facilitates lipid accumulation and liver injury via blocking AMPK\/mTOR-mediated autophagy flux during the development of non-alcoholic fatty liver disease","volume":"18","author":"Wu","year":"2024","journal-title":"Hepatol. Int."},{"issue":"35","key":"10.1016\/j.ijbiomac.2025.149223_bb0240","doi-asserted-by":"crossref","first-page":"30911","DOI":"10.1074\/jbc.M111.271155","article-title":"Lipid raft endocytosis and exosomal transport facilitate extracellular trafficking of annexin A2","volume":"286","author":"Valapala","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.ijbiomac.2025.149223_bb0245","doi-asserted-by":"crossref","first-page":"175","DOI":"10.18388\/pb.2018_129","article-title":"Lipid-mediated regulation of pro-inflammatory responses induced by lipopolysaccharide","volume":"64","author":"Kwiatkowska","year":"2018","journal-title":"Postepy Biochem."},{"issue":"18","key":"10.1016\/j.ijbiomac.2025.149223_bb0250","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2221097120","article-title":"High fried food consumption impacts anxiety and depression due to lipid metabolism disturbance and neuroinflammation","volume":"120","author":"Wang","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ijbiomac.2025.149223_bb0255","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3389\/fnmol.2018.00010","article-title":"Neuronal lipid metabolism: multiple pathways driving functional outcomes in health and disease","volume":"11","author":"Tracey","year":"2018","journal-title":"Front. Mol. Neurosci."},{"issue":"1","key":"10.1016\/j.ijbiomac.2025.149223_bb0260","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/s13578-022-00828-0","article-title":"Lipid metabolism and storage in neuroglia: role in brain development and neurodegenerative diseases","volume":"12","author":"Yang","year":"2022","journal-title":"Cell Biosci."},{"issue":"3","key":"10.1016\/j.ijbiomac.2025.149223_bb0265","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s11883-021-00906-7","article-title":"APOA1: a protein with multiple therapeutic functions","volume":"23","author":"Cochran","year":"2021","journal-title":"Curr. Atheroscler. Rep."},{"issue":"1","key":"10.1016\/j.ijbiomac.2025.149223_bb0270","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s13195-019-0497-9","article-title":"ApoA-I deficiency increases cortical amyloid deposition, cerebral amyloid angiopathy, cortical and hippocampal astrogliosis, and amyloid-associated astrocyte reactivity in APP\/PS1 mice","volume":"11","author":"Button","year":"2019","journal-title":"Alzheimer\u2019s Res. Ther."},{"issue":"1","key":"10.1016\/j.ijbiomac.2025.149223_bb0275","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/liv.15448","article-title":"Apolipoprotein A-1 protected hepatic ischaemia-reperfusion injury through suppressing macrophage pyroptosis via TLR4-NF-kappaB pathway","volume":"43","author":"Chen","year":"2023","journal-title":"Liver Int."},{"issue":"6","key":"10.1016\/j.ijbiomac.2025.149223_bb0280","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1161\/STROKEAHA.119.027898","article-title":"Protective effect of ApoA1 (apolipoprotein A1)-Milano in a rat model of large vessel occlusion stroke","volume":"51","author":"Ducroux","year":"2020","journal-title":"Stroke"}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813025097806?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813025097806?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T19:56:53Z","timestamp":1769803013000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0141813025097806"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":56,"alternative-id":["S0141813025097806"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2025.149223","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hypothalamic FTO-IGF2BP2-mediated m6A regulation of ANXA2: A novel axis preventing HS-induced sperm motility decline","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2025.149223","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"149223"}}