{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:13:04Z","timestamp":1786990384940,"version":"build-2736575974"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82572833"],"award-info":[{"award-number":["82572833"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82360098"],"award-info":[{"award-number":["82360098"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019006","name":"State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Ministry of Education","doi-asserted-by":"publisher","award":["CMEMR2022-A08"],"award-info":[{"award-number":["CMEMR2022-A08"]}],"id":[{"id":"10.13039\/501100019006","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004607","name":"Natural Science Foundation of Guangxi Province","doi-asserted-by":"publisher","award":["2025GXNSFAA069358"],"award-info":[{"award-number":["2025GXNSFAA069358"]}],"id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.ijbiomac.2025.149233","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:33:06Z","timestamp":1764117186000},"page":"149233","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"P1","title":["Molecular regulation of coagulation by heparin-bound plasma Latexin"],"prefix":"10.1016","volume":"335","author":[{"given":"Qiuyang","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanmei","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zain","family":"Ul Abideen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruijiong","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaohua","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.ijbiomac.2025.149233_bb0005","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/s41569-023-00877-z","article-title":"Cardiovascular risk in diabetes mellitus: epidemiology, assessment and prevention","volume":"20","author":"Wong","year":"2023","journal-title":"Nat. Rev. Cardiol."},{"issue":"4","key":"10.1016\/j.ijbiomac.2025.149233_bb0010","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1161\/CIRCRESAHA.115.306301","article-title":"Endothelial cell dysfunction and the pathobiology of atherosclerosis","volume":"118","author":"Gimbrone","year":"2016","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.ijbiomac.2025.149233_bb0015","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s41392-022-00955-7","article-title":"Inflammation and atherosclerosis: signaling pathways and therapeutic intervention","volume":"7","author":"Kong","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"issue":"1","key":"10.1016\/j.ijbiomac.2025.149233_bb0020","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/s12933-023-01846-z","article-title":"Association between the triglyceride-glucose index and the presence and prognosis of coronary microvascular dysfunction in patients with chronic coronary syndrome","volume":"22","author":"Zhang","year":"2023","journal-title":"Cardiovasc. Diabetol."},{"issue":"15","key":"10.1016\/j.ijbiomac.2025.149233_bb0025","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.119.012811","article-title":"Angina severity, mortality, and healthcare utilization among veterans with stable angina","volume":"8","author":"Owlia","year":"2019","journal-title":"J. Am. Heart Assoc."},{"issue":"10","key":"10.1016\/j.ijbiomac.2025.149233_bb0030","doi-asserted-by":"crossref","first-page":"16812","DOI":"10.1002\/jcp.28350","article-title":"A review on coronary artery disease, its risk factors, and therapeutics","volume":"234","author":"Malakar","year":"2019","journal-title":"J. Cell. Physiol."},{"issue":"2","key":"10.1016\/j.ijbiomac.2025.149233_bb0035","doi-asserted-by":"crossref","first-page":"346","DOI":"10.3390\/medicina61020346","article-title":"Helicobacter pylori, atherosclerosis, and coronary artery disease: a narrative review","volume":"61","author":"Saviano","year":"2025","journal-title":"Medicina (Kaunas)"},{"issue":"2","key":"10.1016\/j.ijbiomac.2025.149233_bb0040","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1056\/NEJM199901143400207","article-title":"Atherosclerosis\u2014an inflammatory disease","volume":"340","author":"Ross","year":"1999","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.ijbiomac.2025.149233_bb0045","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1161\/01.CIR.102.1.118","article-title":"A classification of unstable angina revisited","volume":"102","author":"Hamm","year":"2000","journal-title":"Circulation"},{"issue":"38","key":"10.1016\/j.ijbiomac.2025.149233_bb0050","doi-asserted-by":"crossref","first-page":"3738","DOI":"10.1093\/eurheartj\/ehaf284","article-title":"Refractory angina: mechanisms and stratified treatment in obstructive and non-obstructive chronic myocardial ischaemic syndromes","volume":"46","author":"De Silva","year":"2025","journal-title":"Eur. Heart J."},{"issue":"22","key":"10.1016\/j.ijbiomac.2025.149233_bb0055","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1016\/j.jacc.2024.11.009","article-title":"2025 ACC\/AHA\/ACEP\/NAEMSP\/SCAI guideline for the management of patients with acute coronary syndromes: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"85","author":"Rao","year":"2025","journal-title":"J. Am. Coll. Cardiol."},{"issue":"2","key":"10.1016\/j.ijbiomac.2025.149233_bb0060","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.str.2004.12.013","article-title":"An inflammatory role for the mammalian carboxypeptidase inhibitor latexin: relationship to cystatins and the tumor suppressor TIG1","volume":"13","author":"Aagaard","year":"2005","journal-title":"Structure"},{"issue":"3","key":"10.1016\/j.ijbiomac.2025.149233_bb0065","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/S0950-3536(05)80015-0","article-title":"Mechanism of heparin action","volume":"3","author":"Jackson","year":"1990","journal-title":"Baillieres Clin. Haematol."},{"issue":"4","key":"10.1016\/j.ijbiomac.2025.149233_bb0070","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1097\/MOH.0000000000000428","article-title":"Latexin and hematopoiesis","volume":"25","author":"Zhang","year":"2018","journal-title":"Curr. Opin. Hematol."},{"issue":"3","key":"10.1016\/j.ijbiomac.2025.149233_bb0075","doi-asserted-by":"crossref","first-page":"573","DOI":"10.3324\/haematol.2018.207092","article-title":"Latexin regulation by HMGB2 is required for hematopoietic stem cell maintenance","volume":"105","author":"Zhang","year":"2020","journal-title":"Haematologica"},{"issue":"9","key":"10.1016\/j.ijbiomac.2025.149233_bb0080","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0044979","article-title":"Latexin is down-regulated in hematopoietic malignancies and restoration of expression inhibits lymphoma growth","volume":"7","author":"Liu","year":"2012","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.ijbiomac.2025.149233_bb0085","doi-asserted-by":"crossref","first-page":"3464","DOI":"10.3324\/haematol.2022.282028","article-title":"Latexin deletion protects against radiation-induced hematopoietic damages via selective activation of Bcl-2 prosurvival pathway","volume":"108","author":"Zhang","year":"2023","journal-title":"Haematologica"},{"issue":"10","key":"10.1016\/j.ijbiomac.2025.149233_bb0090","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/s41419-024-07141-3","article-title":"Latexin deficiency limits foam cell formation and ameliorates atherosclerosis by promoting macrophage phenotype differentiation","volume":"15","author":"He","year":"2024","journal-title":"Cell Death Dis."},{"issue":"1 Suppl","key":"10.1016\/j.ijbiomac.2025.149233_bb0095","doi-asserted-by":"crossref","first-page":"64S","DOI":"10.1378\/chest.119.1_suppl.64S","article-title":"Heparin and low-molecular-weight heparin: mechanisms of action, pharmacokinetics, dosing, monitoring, efficacy, and safety","volume":"119","author":"Hirsh","year":"2001","journal-title":"Chest"},{"issue":"1","key":"10.1016\/j.ijbiomac.2025.149233_bb0100","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1177\/1358836X9800300109","article-title":"Unfractionated versus low-molecular-weight heparin in the treatment of venous thromboembolism","volume":"3","author":"Bounameaux","year":"1998","journal-title":"Vasc. Med."},{"issue":"7","key":"10.1016\/j.ijbiomac.2025.149233_bb0105","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.2741\/4462","article-title":"Heparin and anticoagulation","volume":"21","author":"Onishi","year":"2016","journal-title":"Front. Biosci."},{"key":"10.1016\/j.ijbiomac.2025.149233_bb0110","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/978-3-642-23056-1_3","article-title":"The anticoagulant and antithrombotic mechanisms of heparin","volume":"207","author":"Gray","year":"2012","journal-title":"Handb. Exp. Pharmacol."},{"issue":"46","key":"10.1016\/j.ijbiomac.2025.149233_bb0115","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202203751","article-title":"Heparin-peptide nanogranules for thrombosis-actuated anticoagulation","volume":"18","author":"Lawanprasert","year":"2022","journal-title":"Small"},{"issue":"3","key":"10.1016\/j.ijbiomac.2025.149233_bb0120","first-page":"135","article-title":"Helsinki-yfirl\u00fdsingin [The Helsinki Declaration]","volume":"100","author":"Snaedal","year":"2014","journal-title":"Laeknabladid"},{"issue":"3","key":"10.1016\/j.ijbiomac.2025.149233_bb0125","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1093\/eurheartj\/ehz425","article-title":"2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes","volume":"41","author":"Knuuti","year":"2020","journal-title":"Eur. Heart J."},{"issue":"14","key":"10.1016\/j.ijbiomac.2025.149233_bb0130","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1093\/eurheartj\/ehaa575","article-title":"2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation","volume":"42","author":"Collet","year":"2021","journal-title":"Eur. Heart J."},{"issue":"9","key":"10.1016\/j.ijbiomac.2025.149233_bb0135","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1182\/blood.2024026476","article-title":"Deficiency of neutrophil gelatinase-associated lipocalin elicits a hemophilia-like bleeding and clotting disorder in mice","volume":"145","author":"Xue","year":"2025","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.ijbiomac.2025.149233_bb0140","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1111\/j.1432-1033.1991.tb15769.x","article-title":"Characterization of the cellular binding domain and the effects of monoclonal antibodies and thrombin inhibitors on the binding and internalization of the antithrombin-III\u2014thrombin complex by cultured cells","volume":"195","author":"Knoller","year":"1991","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.ijbiomac.2025.149233_bb0145","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.sbi.2015.05.007","article-title":"Current structural biology of the heparin interactome","volume":"34","author":"Pomin","year":"2015","journal-title":"Curr. Opin. Struct. Biol."},{"issue":"2","key":"10.1016\/j.ijbiomac.2025.149233_bb0150","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/nrcardio.2015.164","article-title":"Pathophysiology of native coronary, vein graft, and in-stent atherosclerosis","volume":"13","author":"Yahagi","year":"2016","journal-title":"Nat. Rev. Cardiol."},{"issue":"9","key":"10.1016\/j.ijbiomac.2025.149233_bb0155","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1056\/NEJMoa0900428","article-title":"Early diagnosis of myocardial infarction with sensitive cardiac troponin assays","volume":"361","author":"Reichlin","year":"2009","journal-title":"N. Engl. J. Med."},{"issue":"4","key":"10.1016\/j.ijbiomac.2025.149233_bb0160","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.ahj.2004.04.030","article-title":"Diagnostic value of serial measurement of cardiac markers in patients with chest pain: limited value of adding myoglobin to troponin I for exclusion of myocardial infarction","volume":"148","author":"Eggers","year":"2004","journal-title":"Am. Heart J."},{"issue":"13","key":"10.1016\/j.ijbiomac.2025.149233_bb0165","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1093\/eurheartj\/ehm161","article-title":"Guidelines for the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes","volume":"28","author":"Task Force for D, Treatment of Non STSEACSoESoC","year":"2007","journal-title":"Eur. Heart J."},{"issue":"21","key":"10.1016\/j.ijbiomac.2025.149233_bb0170","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1182\/blood.V116.21.1095.1095","article-title":"Protein inhibitor of coagulation factor Xa (PifXa): a new protein-based specific factor Xa inhibitor is an effective, reversible inhibitor of blood coagulation","volume":"116","author":"Andersen","year":"2010","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.ijbiomac.2025.149233_bb0175","first-page":"391","article-title":"Heparin-protein interactions","volume":"41","author":"Capila","year":"2002","journal-title":"Angew. Chem. Int. Ed. Eng."},{"issue":"4","key":"10.1016\/j.ijbiomac.2025.149233_bb0180","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/s44161-023-00254-6","article-title":"Platelet glycoprotein V spatio-temporally controls fibrin formation","volume":"2","author":"Beck","year":"2023","journal-title":"Nat. Cardiovasc. Res."},{"issue":"10","key":"10.1016\/j.ijbiomac.2025.149233_bb0185","first-page":"625","article-title":"Comparison of the non-specific binding of unfractionated heparin and low molecular weight heparin (Enoxaparin) to plasma proteins","volume":"70","author":"Young","year":"1993","journal-title":"Thromb. Haemost."},{"issue":"1","key":"10.1016\/j.ijbiomac.2025.149233_bb0190","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S1474-4422(19)30446-6","article-title":"Rural origins of warfarin","volume":"19","author":"Nisar","year":"2020","journal-title":"Lancet Neurol."},{"issue":"7","key":"10.1016\/j.ijbiomac.2025.149233_bb0195","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/nrd2622","article-title":"Dabigatran etexilate","volume":"7","author":"Eriksson","year":"2008","journal-title":"Nat. Rev. Drug Discov."},{"issue":"4","key":"10.1016\/j.ijbiomac.2025.149233_bb0200","first-page":"397","article-title":"Rivaroxaban in stable cardiovascular disease","volume":"378","author":"Cahill","year":"2018","journal-title":"N. Engl. J. Med."},{"issue":"3","key":"10.1016\/j.ijbiomac.2025.149233_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112274","article-title":"Latexin regulates sex dimorphism in hematopoiesis via gender-specific differential expression of microRNA 98-3p and thrombospondin 1","volume":"42","author":"Cui","year":"2023","journal-title":"Cell Rep."},{"issue":"4","key":"10.1016\/j.ijbiomac.2025.149233_bb0210","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.stemcr.2017.02.009","article-title":"Latexin inactivation enhances survival and long-term engraftment of hematopoietic stem cells and expands the entire hematopoietic system in mice","volume":"8","author":"Liu","year":"2017","journal-title":"Stem Cell Rep."},{"issue":"3","key":"10.1016\/j.ijbiomac.2025.149233_bb0215","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1002\/jcp.22834","article-title":"Latexin regulates the abundance of multiple cellular proteins in hematopoietic stem cells","volume":"227","author":"Mitsunaga","year":"2012","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.ijbiomac.2025.149233_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2023.341993","article-title":"Covalent organic framework-based immunosensor to detect plasma Latexin reveals novel biomarker for coronary artery diseases","volume":"1284","author":"Li","year":"2023","journal-title":"Anal. Chim. Acta"}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813025097909?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813025097909?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T04:11:55Z","timestamp":1781842315000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0141813025097909"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":44,"alternative-id":["S0141813025097909"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2025.149233","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular regulation of coagulation by heparin-bound plasma Latexin","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2025.149233","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"149233"}}