{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T08:50:34Z","timestamp":1785919834477,"version":"3.56.0"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002797","name":"Government of Inner Mongolia Autonomous Region","doi-asserted-by":"publisher","award":["2023HZZX006"],"award-info":[{"award-number":["2023HZZX006"]}],"id":[{"id":"10.13039\/501100002797","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.ijbiomac.2025.149683","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T16:16:33Z","timestamp":1765556193000},"page":"149683","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P1","title":["Flexible cellulose-based plasmonic SERS-AI nanosensor for non-invasive salivary intelligent diagnosis of periodontal diseases"],"prefix":"10.1016","volume":"338","author":[{"given":"Jie","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaping","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoqiang","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wuliji","family":"Hasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narisu","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijbiomac.2025.149683_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2024.116097","article-title":"An IoT-based aptasensor biochip for the diagnosis of periodontal disease","volume":"251","author":"Nguyen","year":"2024","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.ijbiomac.2025.149683_bb0010","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1177\/0022034514552491","article-title":"Global burden of severe periodontitis in 1990-2010: a systematic review and metaregression","volume":"93","author":"Kassebaum","year":"2014","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.ijbiomac.2025.149683_bb0015","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/S0140-6736(18)32279-7","article-title":"Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017","volume":"392","author":"James","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.ijbiomac.2025.149683_bb0020","doi-asserted-by":"crossref","first-page":"B3","DOI":"10.1093\/eurheartj\/suq003","article-title":"European workshop in periodontal health and cardiovascular disease-scientific evidence on the association between periodontal and cardiovascular diseases: a review of the literature","volume":"12","author":"Sanz","year":"2010","journal-title":"Eur. Heart J. Suppl."},{"key":"10.1016\/j.ijbiomac.2025.149683_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2023.135171","article-title":"Activated silver nanoparticle-based platform for specific capture of Porphyromonas gingivalis in human saliva","volume":"403","author":"Zhang","year":"2024","journal-title":"Sens. Actuator B Chem."},{"key":"10.1016\/j.ijbiomac.2025.149683_bb0030","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1002\/JPER.18-0157","article-title":"A new classification scheme for periodontal and peri-implant diseases and conditions - introduction and key changes from the 1999 classification","volume":"89","author":"Caton","year":"2018","journal-title":"J. Periodontol."},{"key":"10.1016\/j.ijbiomac.2025.149683_bb0035","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1007\/s40496-019-0213-7","article-title":"Oral health and cancer","volume":"6","author":"Chung","year":"2019","journal-title":"Curr. Oral Health Rep."},{"key":"10.1016\/j.ijbiomac.2025.149683_bb0040","doi-asserted-by":"crossref","DOI":"10.5888\/pcd16.180641","article-title":"Current knowledge on correlations between highly prevalent dental conditions and chronic diseases: an umbrella review","volume":"16","author":"Seitz","year":"2019","journal-title":"Prev. Chronic Dis."},{"key":"10.1016\/j.ijbiomac.2025.149683_bb0045","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1177\/0022034520952401","article-title":"Periodontitis, edentulism, and risk of mortality: a systematic review with meta-analyses","volume":"100","author":"Romandini","year":"2021","journal-title":"J. Dent. Res."},{"issue":"95","key":"10.1016\/j.ijbiomac.2025.149683_bb0050","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/prd.12579","article-title":"Conventional diagnostic criteria for periodontal diseases (plaque-induced gingivitis and periodontitis)","volume":"2000","author":"Heitz-Mayfield","year":"2024","journal-title":"Periodontol"},{"issue":"95","key":"10.1016\/j.ijbiomac.2025.149683_bb0055","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/prd.12586","article-title":"Artificial intelligence and personalized diagnostics in periodontology: a narrative review","volume":"2000","author":"Pitchika","year":"2024","journal-title":"Periodontol"},{"issue":"42","key":"10.1016\/j.ijbiomac.2025.149683_bb0060","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1111\/j.1600-0757.2006.00174.x","article-title":"The breadth of bacterial diversity in the human periodontal pocket and other oral sites","volume":"2000","author":"Paster","year":"2006","journal-title":"Periodontol"},{"key":"10.1016\/j.ijbiomac.2025.149683_bb0065","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/j.1600-051X.1998.tb02419.x","article-title":"Microbial complexes in subgingival plaque","volume":"25","author":"Socransky","year":"1998","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.ijbiomac.2025.149683_bb0070","first-page":"5775","article-title":"Relationship between oral microbiota and periodontal disease: a systematic review","volume":"22","author":"Patini","year":"2018","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.ijbiomac.2025.149683_bb0075","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.mib.2014.11.013","article-title":"Fusobacterium nucleatum: a commensal-turned pathogen","volume":"23","author":"Han","year":"2015","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.ijbiomac.2025.149683_bb0080","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.mimet.2004.06.006","article-title":"Quantitative detection of periodontopathogens by real-time PCR","volume":"59","author":"Nonnenmacher","year":"2004","journal-title":"J. Microbiol. Methods"},{"key":"10.1016\/j.ijbiomac.2025.149683_bb0085","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/jre.12187","article-title":"Relationship between expression of human gingival beta-defensins and levels of periodontopathogens in subgingival plaque","volume":"50","author":"Wang","year":"2015","journal-title":"J. Periodontal Res."},{"key":"10.1016\/j.ijbiomac.2025.149683_bb0090","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1902\/jop.2006.050177","article-title":"Description of the subgingival microbiota of periodontally untreated Mexican subjects: chronic periodontitis and periodontal health","volume":"77","author":"Ximenez-Fyvie","year":"2006","journal-title":"J. Periodontol."},{"key":"10.1016\/j.ijbiomac.2025.149683_bb0095","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1007\/s11912-024-01591-w","article-title":"Unveiling the hidden links: periodontal disease, Fusobacterium nucleatum, and cancers","volume":"26","author":"Akbari","year":"2024","journal-title":"Curr. Oncol. Rep."},{"key":"10.1016\/j.ijbiomac.2025.149683_bb0100","doi-asserted-by":"crossref","DOI":"10.1038\/s41522-023-00417-0","article-title":"Akkermansia muciniphila inhibited the periodontitis caused by Fusobacterium nucleatum","volume":"9","author":"Song","year":"2023","journal-title":"NPJ Biofilms Microbiomes"},{"key":"10.1016\/j.ijbiomac.2025.149683_bb0105","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1007\/s00784-011-0654-4","article-title":"Quantitative analysis of microbiota in saliva, supragingival, and subgingival plaque of Chinese adults with chronic periodontitis","volume":"16","author":"He","year":"2012","journal-title":"Clin. Oral Investig."},{"key":"10.1016\/j.ijbiomac.2025.149683_bb0110","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1902\/jop.2007.060078","article-title":"Comparison of subgingival bacterial sampling with oral lavage for detection and quantification of periodontal pathogens by real-time polymerase chain reaction","volume":"78","author":"Boutaga","year":"2007","journal-title":"J. Periodontol."},{"key":"10.1016\/j.ijbiomac.2025.149683_bb0115","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1902\/jop.1998.69.7.828","article-title":"The utility of whole saliva to detect the oral presence of periodontopathic bacteria","volume":"69","author":"Umeda","year":"1998","journal-title":"J. Periodontol."},{"key":"10.1016\/j.ijbiomac.2025.149683_bb0120","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/j.1399-302X.1996.tb00201.x","article-title":"Similarity of salivary and subgingival Prevotella intermedia and Prevotella nigrescens isolates by arbitrarily primed polymerase chain reaction","volume":"11","author":"Matto","year":"1996","journal-title":"Oral Microbiol. Immunol."},{"key":"10.1016\/j.ijbiomac.2025.149683_bb0125","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.mimet.2014.02.002","article-title":"Quantification of E. coli O157 and STEC in feces of farm animals using direct multiplex real time PCR (qPCR) and a modified most probable number assay comprised of immunomagnetic bead separation and qPCR detection","volume":"99","author":"Guy","year":"2014","journal-title":"J. Microbiol. Methods"},{"key":"10.1016\/j.ijbiomac.2025.149683_bb0130","doi-asserted-by":"crossref","first-page":"163","DOI":"10.2334\/josnusd.15-0665","article-title":"Loop-mediated isothermal amplification combined with PCR and immunohistochemistry for detecting Porphyromonas gingivalis in periapical periodontitis","volume":"58","author":"Kitano","year":"2016","journal-title":"J. Oral Sci."},{"key":"10.1016\/j.ijbiomac.2025.149683_bb0135","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.cll.2007.05.008","article-title":"Cellular image analysis and imaging by flow cytometry","volume":"27","author":"Basiji","year":"2007","journal-title":"Clin. Lab. Med."},{"key":"10.1016\/j.ijbiomac.2025.149683_bb0140","doi-asserted-by":"crossref","DOI":"10.29026\/oea.2022.210121","article-title":"Label-free trace detection of bio-molecules by liquid-interface assisted surface-enhanced Raman scattering using a microfluidic chip","volume":"5","author":"Bai","year":"2022","journal-title":"Opto-Electron. Adv."},{"key":"10.1016\/j.ijbiomac.2025.149683_bb0145","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.actbio.2024.09.054","article-title":"Versatile self-assembled near-infrared SERS nanoprobes for multidrug-resistant bacterial infection-specific surveillance and therapy","volume":"189","author":"Gao","year":"2024","journal-title":"Acta Biomater."},{"key":"10.1016\/j.ijbiomac.2025.149683_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2023.115497","article-title":"Bioinspired hot-spot engineering strategy towards ultrasensitive SERS sandwich biosensor for bacterial detection","volume":"237","author":"Wang","year":"2023","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.ijbiomac.2025.149683_bb0155","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1021\/acssensors.1c00166","article-title":"In search of spectroscopic signatures of periodontitis: a SERS-based magnetomicrofluidic sensor for detection of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans","volume":"6","author":"Witkowska","year":"2021","journal-title":"ACS Sens."},{"key":"10.1016\/j.ijbiomac.2025.149683_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.128773","article-title":"Machine learning enabled multiplex detection of periodontal pathogens by surface-enhanced Raman spectroscopy","volume":"257","author":"Rathnayake","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2025.149683_bb0165","doi-asserted-by":"crossref","first-page":"21550","DOI":"10.1021\/acs.analchem.5c03876","article-title":"Sensitive, low-cost, early detection of periodontal disease using surface-enhanced Raman spectroscopy with easy-to-use silver nanomesh-coated periopaper","volume":"97","author":"Jiang","year":"2025","journal-title":"Anal. Chem."},{"key":"10.1016\/j.ijbiomac.2025.149683_bb0170","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1039\/D0AN01997F","article-title":"Label-free analysis of gingival crevicular fluid (GCF) by surface enhanced Raman scattering (SERS)","volume":"146","author":"Fornasaro","year":"2021","journal-title":"Analyst"},{"key":"10.1016\/j.ijbiomac.2025.149683_bb0175","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1111\/1541-4337.13118","article-title":"Advances in surface-enhanced Raman spectroscopy technology for detection of foodborne pathogens","volume":"22","author":"Zhu","year":"2023","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"10.1016\/j.ijbiomac.2025.149683_bb0180","doi-asserted-by":"crossref","DOI":"10.3390\/nano9040619","article-title":"Highly sensitive and selective nanogap-enhanced SERS sensing platform","volume":"9","author":"Mun","year":"2019","journal-title":"Nanomaterials"},{"key":"10.1016\/j.ijbiomac.2025.149683_bb0185","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1021\/acssensors.2c02808","article-title":"Plasmonic coupling of au nanoclusters on a flexible MXene\/graphene oxide fiber for ultrasensitive SERS sensing","volume":"8","author":"Liu","year":"2023","journal-title":"ACS Sens."},{"key":"10.1016\/j.ijbiomac.2025.149683_bb0190","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s12551-023-01059-4","article-title":"Raman spectroscopy for viral diagnostics","volume":"15","author":"Lukose","year":"2023","journal-title":"Biophys. Rev."},{"key":"10.1016\/j.ijbiomac.2025.149683_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2023.115779","article-title":"3D plasmonic hexaplex paper sensor for label-free human saliva sensing and machine learning-assisted early-stage lung cancer screening","volume":"244","author":"Linh","year":"2024","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.ijbiomac.2025.149683_bb0200","article-title":"Paper-based plasmonic substrates as surface-enhanced Raman scattering spectroscopy platforms for cell culture applications","volume":"11","author":"Romo-Herrera","year":"2021","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.ijbiomac.2025.149683_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2020.118104","article-title":"Flexible paper-based SERS substrate strategy for rapid detection of methyl parathion on the surface of fruit","volume":"231","author":"Xie","year":"2020","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.ijbiomac.2025.149683_bb0210","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.aca.2019.08.073","article-title":"Paper swab based SERS detection of non-permitted colourants from dals and vegetables using a portable spectrometer","volume":"1090","author":"Kumar","year":"2019","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.ijbiomac.2025.149683_bb0215","doi-asserted-by":"crossref","first-page":"4982","DOI":"10.1021\/acs.jafc.3c00134","article-title":"Two-dimensional printed AgNPs@paper swab for SERS screening of pesticide residues on apples and pears","volume":"71","author":"Wang","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ijbiomac.2025.149683_bb0220","doi-asserted-by":"crossref","DOI":"10.1002\/adom.202203104","article-title":"Recent progresses in machine learning assisted Raman spectroscopy","volume":"11","author":"Qi","year":"2023","journal-title":"Adv. Opt. Mater."},{"key":"10.1016\/j.ijbiomac.2025.149683_bb0225","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202205519","article-title":"Label-free identification of exosomes using Raman spectroscopy and machine learning","volume":"19","author":"Parlatan","year":"2023","journal-title":"Small"},{"key":"10.1016\/j.ijbiomac.2025.149683_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2024.116753","article-title":"Cerebrospinal fluid-induced stable and reproducible SERS sensing for various meningitis discrimination assisted with machine learning","volume":"267","author":"Song","year":"2025","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.ijbiomac.2025.149683_bb0235","doi-asserted-by":"crossref","first-page":"3429","DOI":"10.1021\/acs.analchem.3c04717","article-title":"Aptamer-based multiparameter analysis for molecular profiling of hematological malignancies","volume":"96","author":"Liu","year":"2024","journal-title":"Anal. Chem."},{"key":"10.1016\/j.ijbiomac.2025.149683_bb0240","article-title":"Combining array-assisted SERS microfluidic chips and machine learning algorithms for clinical leukemia phenotyping","volume":"283","author":"Yang","year":"2024","journal-title":"Talanta"},{"key":"10.1016\/j.ijbiomac.2025.149683_bb0245","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1002\/bit.24429","article-title":"The effect of surface charge property on Escherichia coli initial adhesion and subsequent biofilm formation","volume":"109","author":"Terada","year":"2012","journal-title":"Biotechnol. Bioeng."},{"key":"10.1016\/j.ijbiomac.2025.149683_bb0250","doi-asserted-by":"crossref","first-page":"15381","DOI":"10.1021\/acsami.7b19347","article-title":"Highly sensitive and reproducible SERS sensor for biological pH detection based on a uniform gold nanorod array platform","volume":"10","author":"Bi","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.ijbiomac.2025.149683_bb0255","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1002\/jrs.4874","article-title":"Why and how do the shapes of surface-enhanced Raman scattering spectra change? Recent progress from mechanistic studies","volume":"47","author":"Yamamoto","year":"2016","journal-title":"J. Raman Spectrosc."},{"key":"10.1016\/j.ijbiomac.2025.149683_bb0260","doi-asserted-by":"crossref","first-page":"7655","DOI":"10.1021\/acs.nanolett.0c03189","article-title":"Plasmonic and electrostatic interactions enable uniformly enhanced liquid bacterial surface-enhanced Raman scattering (SERS)","volume":"20","author":"Tadesse","year":"2020","journal-title":"Nano Lett."},{"key":"10.1016\/j.ijbiomac.2025.149683_bb0265","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1177\/00220345950740111201","article-title":"Salivary levels of suspected periodontal pathogens in relation to periodontal status and treatment","volume":"74","author":"vonTroilLinden","year":"1995","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.ijbiomac.2025.149683_bb0270","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms11020318","article-title":"The contribution of the human oral microbiome to oral disease: a review","volume":"11","author":"Morrison","year":"2023","journal-title":"Microorganisms"},{"key":"10.1016\/j.ijbiomac.2025.149683_bb0275","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/odi.12224","article-title":"Microbiota and their role in the pathogenesis of oral mucositis","volume":"21","author":"Vanhoecke","year":"2015","journal-title":"Oral Dis."},{"key":"10.1016\/j.ijbiomac.2025.149683_bb0280","doi-asserted-by":"crossref","first-page":"12639","DOI":"10.1021\/acs.analchem.8b02806","article-title":"Electrochemical surface-enhanced Raman spectroscopy as a platform for bacterial detection and identification","volume":"90","author":"Lynk","year":"2018","journal-title":"Anal. Chem."},{"key":"10.1016\/j.ijbiomac.2025.149683_bb0285","doi-asserted-by":"crossref","first-page":"4631","DOI":"10.1007\/s00216-016-9540-x","article-title":"The biochemical origins of the surface-enhanced Raman spectra of bacteria: a metabolomics profiling by SERS","volume":"408","author":"Premasiri","year":"2016","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.ijbiomac.2025.149683_bb0290","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/j.0303-6979.2004.00468.x","article-title":"Plaque development in relation to the periodontal condition and bacterial load of the saliva","volume":"31","author":"Rowshani","year":"2004","journal-title":"J. Clin. Periodontol."}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813025102407?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813025102407?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T08:25:19Z","timestamp":1785918319000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0141813025102407"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":58,"alternative-id":["S0141813025102407"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2025.149683","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Flexible cellulose-based plasmonic SERS-AI nanosensor for non-invasive salivary intelligent diagnosis of periodontal diseases","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2025.149683","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"149683"}}