{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T06:28:08Z","timestamp":1789021688098,"version":"build-2803163510"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004479","name":"Jiangxi Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["20242BAB26161"],"award-info":[{"award-number":["20242BAB26161"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004479","name":"Jiangxi Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["20224BAB216051"],"award-info":[{"award-number":["20224BAB216051"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52163016"],"award-info":[{"award-number":["52163016"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52463017"],"award-info":[{"award-number":["52463017"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52263015"],"award-info":[{"award-number":["52263015"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82201078"],"award-info":[{"award-number":["82201078"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.ijbiomac.2025.149869","type":"journal-article","created":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T16:33:33Z","timestamp":1766594013000},"page":"149869","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"P1","title":["Immunomodulatory mesoporous bioactive glass\/interleukin-4 nanocomplex promotes bone regeneration"],"prefix":"10.1016","volume":"339","author":[{"given":"Nan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangqing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaolong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junchao","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijbiomac.2025.149869_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2024.158132","article-title":"An all-in-one \u201cmultifunctional hydrogel\u201d: through antibacterial, anti-inflammatory, and angiogenic to promoting MRSA-infected bone defect repair","volume":"503","author":"Duan","year":"2025","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.ijbiomac.2025.149869_bb0010","article-title":"Osteomimix: a multidimensional biomimetic cascade strategy for bone defect repair","volume":"37","author":"Wu","year":"2025","journal-title":"Adv. Mater."},{"key":"10.1016\/j.ijbiomac.2025.149869_bb0015","first-page":"197","article-title":"Dose-dependent osteoimmunomodulatory effects of amorphous calcium phosphate nanoparticles promote 3D-printed scaffold-mediated bone regeneration","volume":"51","author":"Yan","year":"2025","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.ijbiomac.2025.149869_bb0020","doi-asserted-by":"crossref","DOI":"10.1088\/1758-5090\/addc9c","article-title":"3D printed bioactive coated scaffolds boost osteogenesis and angiogenesis via the regulation of scaffold microstructure","volume":"17","author":"Jiang","year":"2025","journal-title":"Biofabrication"},{"key":"10.1016\/j.ijbiomac.2025.149869_bb0025","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/nri2062","article-title":"Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems","volume":"7","author":"Takayanagi","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.ijbiomac.2025.149869_bb0030","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/35046196","article-title":"Bone versus immune system","volume":"408","author":"Arron","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.ijbiomac.2025.149869_bb0035","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/s41368-023-00234-3","article-title":"Role of dendritic cells in MYD88-mediated immune recognition and osteoinduction initiated by the implantation of biomaterials","volume":"15","author":"Zhao","year":"2023","journal-title":"Int. J. Oral Sci."},{"key":"10.1016\/j.ijbiomac.2025.149869_bb0040","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202208639","article-title":"Bone repair biomaterials: a perspective from immunomodulation","volume":"32","author":"Wang","year":"2022","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.ijbiomac.2025.149869_bb0045","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/nri3073","article-title":"Protective and pathogenic functions of macrophage subsets","volume":"11","author":"Murray","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.ijbiomac.2025.149869_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2025.123261","article-title":"Endogenous dual-responsive and self-adaptive silk fibroin-based scaffold with enhancement of immunomodulation for skull regeneration","volume":"320","author":"Bi","year":"2025","journal-title":"Biomaterials"},{"key":"10.1016\/j.ijbiomac.2025.149869_bb0055","article-title":"Melatonin-loaded bioactive microspheres accelerate aged bone regeneration by formation of tunneling nanotubes to enhance mitochondrial transfer","volume":"28","author":"Xiong","year":"2024","journal-title":"Mater Today Bio"},{"key":"10.1016\/j.ijbiomac.2025.149869_bb0060","doi-asserted-by":"crossref","first-page":"5980","DOI":"10.1002\/anie.200460598","article-title":"Highly ordered mesoporous bioactive glasses with superior in vitro bone-forming bioactivities","volume":"43","author":"Yan","year":"2004","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.ijbiomac.2025.149869_bb0065","first-page":"271","article-title":"Unraveling osteogenesis mechanisms of the empowered VitaFlux adaptive regeneration biomaterials for bone tissue engineering: insights into the role of BBGs\/BSBGs","volume":"49","author":"Li","year":"2025","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.ijbiomac.2025.149869_bb0070","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.jcis.2018.05.099","article-title":"Effects of a mesoporous bioactive glass on osteoblasts, osteoclasts and macrophages","volume":"528","author":"G\u00f3mez-Cerezo","year":"2018","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.ijbiomac.2025.149869_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120216","article-title":"Modulation of macrophages by bioactive glass\/sodium alginate hydrogel is crucial in skin regeneration enhancement","volume":"256","author":"Zhu","year":"2020","journal-title":"Biomaterials"},{"key":"10.1016\/j.ijbiomac.2025.149869_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.compositesb.2024.111202","article-title":"Porous PLGA\/MBG scaffold enhanced bone regeneration through osteoimmunomodulation","volume":"272","author":"Liu","year":"2024","journal-title":"Compos. Part B Eng."},{"key":"10.1016\/j.ijbiomac.2025.149869_bb0085","article-title":"Effect of hierarchical porous scaffold on osteoimmunomodulation and bone formation","volume":"20","author":"Liu","year":"2020","journal-title":"Appl. Mater. Today"},{"key":"10.1016\/j.ijbiomac.2025.149869_bb0090","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1039\/D1BM01842F","article-title":"Local delivery of naringin in beta-cyclodextrin modified mesoporous bioactive glass promotes bone regeneration: from anti-inflammatory to synergistic osteogenesis and osteoclastogenesis","volume":"10","author":"Mo","year":"2022","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.ijbiomac.2025.149869_bb0095","article-title":"Bioactive glass in tissue regeneration: unveiling recent advances in regenerative strategies and applications","volume":"37","author":"Zhu","year":"2025","journal-title":"Adv. Mater."},{"key":"10.1016\/j.ijbiomac.2025.149869_bb0100","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.actbio.2021.08.023","article-title":"Immunomodulatory bioactive glasses for tissue regeneration","volume":"133","author":"Zheng","year":"2021","journal-title":"Acta Biomater."},{"key":"10.1016\/j.ijbiomac.2025.149869_bb0105","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1080\/21691401.2017.1369428","article-title":"The osteoimmunomodulatory properties of MBG scaffold coated with amino functional groups","volume":"46","author":"Zeng","year":"2018","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"10.1016\/j.ijbiomac.2025.149869_bb0110","doi-asserted-by":"crossref","first-page":"67491","DOI":"10.1021\/acsami.4c17540","article-title":"Biomolecule and ion releasing mesoporous nanoparticles: nonconvergent osteogenic and osteo-immunogenic performance","volume":"16","author":"Khodaei","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.ijbiomac.2025.149869_bb0115","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1186\/s12951-024-02865-y","article-title":"From ROS scavenging to boosted osseointegration: cerium-containing mesoporous bioactive glass nanoparticles functionalized implants in diabetes","volume":"22","author":"Jiang","year":"2024","journal-title":"J Nanobiotechnology"},{"key":"10.1016\/j.ijbiomac.2025.149869_bb0120","doi-asserted-by":"crossref","first-page":"3923","DOI":"10.1021\/acsbiomaterials.4c00228","article-title":"Sr-incorporated bioactive glass remodels the immunological microenvironment by enhancing the mitochondrial function of macrophage via the PI3K\/AKT\/mTOR signaling pathway","volume":"10","author":"Qiu","year":"2024","journal-title":"ACS Biomater Sci. Eng."},{"key":"10.1016\/j.ijbiomac.2025.149869_bb0125","doi-asserted-by":"crossref","first-page":"34378","DOI":"10.1021\/acsami.3c03446","article-title":"Selenium-doped mesoporous bioactive glass regulates macrophage metabolism and polarization by scavenging ROS and promotes bone regeneration in vivo","volume":"15","author":"Chen","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.ijbiomac.2025.149869_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.138888","article-title":"Development of a multi-functional naringin-loaded bioglass\/carboxymethyl chitosan\/silk fibroin porous scaffold for hemostasis and critical size bone regeneration","volume":"290","author":"Wang","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2025.149869_bb0135","doi-asserted-by":"crossref","first-page":"3114","DOI":"10.1039\/D4TB01778A","article-title":"Regulation of the diabetic immune microenvironment by metformin-loaded strontium-doped mesoporous bioactive glass facilitates bone regeneration","volume":"13","author":"Ye","year":"2025","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.ijbiomac.2025.149869_bb0140","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/s12951-024-02352-4","article-title":"Quercetin-loaded mesoporous nano-delivery system remodels osteoimmune microenvironment to regenerate alveolar bone in periodontitis via the miR-21a-5p\/PDCD4\/NF-\u03baB pathway","volume":"22","author":"Yang","year":"2024","journal-title":"J Nanobiotechnology"},{"key":"10.1016\/j.ijbiomac.2025.149869_bb0145","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202304585","article-title":"A genetically engineered \u201creinforced concrete\u201d scaffold regulates the N2 neutrophil innate immune cascade to repair bone defects","volume":"13","author":"Shi","year":"2024","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.ijbiomac.2025.149869_bb0150","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.actbio.2007.01.008","article-title":"Surface functionalization of bioglass-derived porous scaffolds","volume":"3","author":"Chen","year":"2007","journal-title":"Acta Biomater."},{"key":"10.1016\/j.ijbiomac.2025.149869_bb0155","doi-asserted-by":"crossref","first-page":"3799","DOI":"10.1016\/j.jnoncrysol.2008.05.001","article-title":"Functionalization and bioactivity in vitro of mesoporous bioactive glasses","volume":"354","author":"Sun","year":"2008","journal-title":"J. Non Cryst. Solids"},{"key":"10.1016\/j.ijbiomac.2025.149869_bb0160","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s41413-022-00224-x","article-title":"Strontium-incorporated bioceramic scaffolds for enhanced osteoporosis bone regeneration","volume":"10","author":"Wu","year":"2022","journal-title":"Bone Res"},{"key":"10.1016\/j.ijbiomac.2025.149869_bb0165","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.jconrel.2021.05.043","article-title":"Bioactive glass: a multifunctional delivery system","volume":"335","author":"Gupta","year":"2021","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ijbiomac.2025.149869_bb0170","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics13111952","article-title":"Polyelectrolyte-coated mesoporous bioactive glasses via layer-by-layer deposition for sustained co-delivery of therapeutic ions and drugs","volume":"13","author":"Pontremoli","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ijbiomac.2025.149869_bb0175","first-page":"1878","article-title":"Poly(\u03b1-l-lysine)-based nanomaterials for versatile biomedical applications: current advances and perspectives","volume":"6","author":"Zheng","year":"2021","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.ijbiomac.2025.149869_bb0180","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41573-022-00557-6","article-title":"Emerging principles of cytokine pharmacology and therapeutics","volume":"22","author":"Saxton","year":"2023","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ijbiomac.2025.149869_bb0185","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1038\/s41467-025-56379-8","article-title":"Genetic variation in IL-4 activated tissue resident macrophages determines strain-specific synergistic responses to LPS epigenetically","volume":"16","author":"Zhao","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ijbiomac.2025.149869_bb0190","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1016\/j.immuni.2022.10.004","article-title":"The epigenetic state of IL-4-polarized macrophages enables inflammatory cistromic expansion and extended synergistic response to TLR ligands","volume":"55","author":"Czimmerer","year":"2022","journal-title":"Immunity"},{"key":"10.1016\/j.ijbiomac.2025.149869_bb0195","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.jcis.2016.01.065","article-title":"Controlling particle size in the St\u00f6ber process and incorporation of calcium","volume":"469","author":"Greasley","year":"2016","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.ijbiomac.2025.149869_bb0200","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.tibtech.2024.11.011","article-title":"Artificial intelligence in biomaterials: a call for unified biocompatibility standards","volume":"43","author":"Mozafari","year":"2025","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.ijbiomac.2025.149869_bb0205","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41565-021-00858-8","article-title":"Key principles and methods for studying the endocytosis of biological and nanoparticle therapeutics","volume":"16","author":"Rennick","year":"2021","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.ijbiomac.2025.149869_bb0210","first-page":"3987","article-title":"Polylysine-decorated macroporous microcarriers laden with adipose-derived stem cells promote nerve regeneration in vivo","volume":"6","author":"Sun","year":"2021","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.ijbiomac.2025.149869_bb0215","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.2147\/IJN.S156029","article-title":"Interaction of poly-l-lysine coating and heparan sulfate proteoglycan on magnetic nanoparticle uptake by tumor cells","volume":"13","author":"Siow","year":"2018","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.ijbiomac.2025.149869_bb0220","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.jconrel.2013.01.019","article-title":"DNA delivery with hyperbranched polylysine: a comparative study with linear and dendritic polylysine","volume":"169","author":"Kadlecova","year":"2013","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ijbiomac.2025.149869_bb0225","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1021\/bc800206r","article-title":"Cellular uptake and intracellular pathways of PLL-g-PEG-DNA nanoparticles","volume":"19","author":"L\u00fchmann","year":"2008","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.ijbiomac.2025.149869_bb0230","first-page":"364","article-title":"A programmed surface on polyetheretherketone for sequentially dictating osteoimmunomodulation and bone regeneration to achieve ameliorative osseointegration under osteoporotic conditions","volume":"14","author":"Zheng","year":"2022","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.ijbiomac.2025.149869_bb0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.136375","article-title":"An immunomodulatory and osteogenic bacterial cellulose scaffold for bone regeneration via regulating the immune microenvironment","volume":"281","author":"Jiang","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2025.149869_bb0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2023.122254","article-title":"Atmosphere-inspired multilayered nanoarmor with modulable protection and delivery of Interleukin-4 for inflammatory microenvironment modulation","volume":"301","author":"Ge","year":"2023","journal-title":"Biomaterials"},{"key":"10.1016\/j.ijbiomac.2025.149869_bb0245","doi-asserted-by":"crossref","first-page":"58148","DOI":"10.1021\/acsami.4c08996","article-title":"Dual-mode release of IL-4 and TCP from a PGA-SF core-shell electrospinning scaffold for enhanced bone regeneration through synergistic immunoregulation and osteogenesis","volume":"16","author":"Jiang","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.ijbiomac.2025.149869_bb0250","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1021\/acs.nanolett.6b04130","article-title":"Extra-large pore mesoporous silica nanoparticles for directing in vivo M2 macrophage polarization by delivering IL-4","volume":"17","author":"Kwon","year":"2017","journal-title":"Nano Lett."}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813025104261?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813025104261?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T09:23:26Z","timestamp":1769505806000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0141813025104261"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":50,"alternative-id":["S0141813025104261"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2025.149869","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immunomodulatory mesoporous bioactive glass\/interleukin-4 nanocomplex promotes bone regeneration","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2025.149869","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"149869"}}