{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T22:48:19Z","timestamp":1780440499634,"version":"3.54.1"},"reference-count":75,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007049","name":"Korea Institute of Ocean Science & Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003566","name":"Ministry of Oceans and Fisheries","doi-asserted-by":"publisher","award":["RS-2023-00254674"],"award-info":[{"award-number":["RS-2023-00254674"]}],"id":[{"id":"10.13039\/501100003566","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011705","name":"Korea Institute of Marine Science and Technology promotion","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011705","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Korea Ministry of Science and ICT","doi-asserted-by":"publisher","award":["RS-2023-00262645"],"award-info":[{"award-number":["RS-2023-00262645"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.ijbiomac.2026.150378","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T07:59:36Z","timestamp":1769155176000},"page":"150378","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"P2","title":["TPGS-coated zein nanoparticles encapsulating Haematococcus pluvialis extract for Alzheimer's disease: An in vitro evaluation towards brain-targeted delivery"],"prefix":"10.1016","volume":"344","author":[{"given":"Yoo-Na","family":"Jeon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Suep","family":"Baek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijbiomac.2026.150378_bb0005","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.nbd.2016.07.007","article-title":"The blood-brain barrier in Alzheimer\u2019s disease","volume":"107","author":"Zenaro","year":"2017","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.ijbiomac.2026.150378_bb0010","doi-asserted-by":"crossref","first-page":"5541","DOI":"10.2147\/IJN.S200490","article-title":"Alzheimer\u2019s disease: pathogenesis, diagnostics, and therapeutics","author":"Tiwari","year":"2019","journal-title":"Int. J. Nanomedicine"},{"issue":"1","key":"10.1016\/j.ijbiomac.2026.150378_bb0015","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/s41392-023-01481-w","article-title":"The blood\u2013brain barrier: structure, regulation, and drug delivery","volume":"8","author":"Wu","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"issue":"1","key":"10.1016\/j.ijbiomac.2026.150378_bb0020","doi-asserted-by":"crossref","first-page":"4790","DOI":"10.1038\/s41467-020-18525-2","article-title":"Chiral gold nanoparticles enantioselectively rescue memory deficits in a mouse model of Alzheimer\u2019s disease","volume":"11","author":"Hou","year":"2020","journal-title":"Nat. Commun."},{"issue":"21\u221222","key":"10.1016\/j.ijbiomac.2026.150378_bb0025","first-page":"1743","article-title":"Decitabine enclosed biotin-zein conjugated nanoparticles: synthesis, characterization, in vitro and in vivo evaluation","volume":"19","author":"Mhaske","year":"2024","journal-title":"Nanomedicine"},{"key":"10.1016\/j.ijbiomac.2026.150378_bb0030","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.foodchem.2015.03.009","article-title":"Core\u2013shell biopolymer nanoparticle delivery systems: synthesis and characterization of curcumin fortified zein\u2013pectin nanoparticles","volume":"182","author":"Hu","year":"2015","journal-title":"Food Chem."},{"key":"10.1016\/j.ijbiomac.2026.150378_bb0035","article-title":"The use of TPGS in drug delivery systems to overcome biological barriers","volume":"142","author":"Luiz","year":"2021","journal-title":"Eur. Polym. J."},{"key":"10.1016\/j.ijbiomac.2026.150378_bb0040","doi-asserted-by":"crossref","DOI":"10.4137\/DTI.S12519","article-title":"P-glycoprotein inhibition for optimal drug delivery","volume":"7","author":"Amin","year":"2013","journal-title":"Drug Target Insights"},{"key":"10.1016\/j.ijbiomac.2026.150378_bb0045","doi-asserted-by":"crossref","first-page":"531","DOI":"10.3389\/fpls.2016.00531","article-title":"Astaxanthin-producing green microalga Haematococcus pluvialis: from single cell to high value commercial products","volume":"7","author":"Shah","year":"2016","journal-title":"Front. Plant Sci."},{"issue":"3","key":"10.1016\/j.ijbiomac.2026.150378_bb0050","doi-asserted-by":"crossref","first-page":"147","DOI":"10.4103\/2278-344X.138587","article-title":"Oxidative stress and astaxanthin: the novel supernutrient carotenoid","volume":"3","author":"Biswal","year":"2014","journal-title":"Int. J. Health Allied Sci."},{"issue":"1","key":"10.1016\/j.ijbiomac.2026.150378_bb0055","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.jss.2014.05.029","article-title":"Astaxanthin offers neuroprotection and reduces neuroinflammation in experimental subarachnoid hemorrhage","volume":"192","author":"Zhang","year":"2014","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.ijbiomac.2026.150378_bb0060","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.brainresbull.2021.04.020","article-title":"The effects of astaxanthin treatment on a rat model of Alzheimer\u2019s disease","volume":"172","author":"Chen","year":"2021","journal-title":"Brain Res. Bull."},{"issue":"2","key":"10.1016\/j.ijbiomac.2026.150378_bb0065","doi-asserted-by":"crossref","first-page":"102","DOI":"10.3164\/jcbn.D-11-00017","article-title":"Effects of astaxanthin-rich Haematococcus pluvialis extract on cognitive function: a randomised, double-blind, placebo-controlled study","volume":"51","author":"Katagiri","year":"2012","journal-title":"J. Clin. Biochem. Nutr."},{"issue":"3","key":"10.1016\/j.ijbiomac.2026.150378_bb0070","doi-asserted-by":"crossref","first-page":"253","DOI":"10.4490\/algae.2020.35.5.22","article-title":"Ultrastructural changes of Haematococcus pluvialis (Chlorophyta) in process of astaxanthin accumulation and cell damage under condition of high light with acetate","volume":"35","author":"He","year":"2020","journal-title":"Algae"},{"key":"10.1016\/j.ijbiomac.2026.150378_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.fhfh.2023.100167","article-title":"Enhanced antioxidant and anti-inflammatory effects of bee pollen and honey hybrid formulation by hot-melt extrusion","volume":"4","author":"Lee","year":"2023","journal-title":"Food Hydrocoll. Health"},{"key":"10.1016\/j.ijbiomac.2026.150378_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.130070","article-title":"Stability and encapsulation properties of daidzein in zein\/carrageenan\/sodium alginate nanoparticles with ultrasound treatment","volume":"262","author":"Yang","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2026.150378_bb0085","doi-asserted-by":"crossref","first-page":"343","DOI":"10.2147\/IJN.S485722","article-title":"Antibiofilm and anticancer activity of multi-walled carbon nanotubes fabricated with hot-melt extruded Astaxanthin-mediated synthesized silver nanoparticles","author":"You","year":"2025","journal-title":"Int. J. Nanomedicine"},{"issue":"8","key":"10.1016\/j.ijbiomac.2026.150378_bb0090","doi-asserted-by":"crossref","first-page":"686","DOI":"10.3390\/antibiotics13080686","article-title":"Green synthesis of silver nanoparticle using black mulberry and characterization, phytochemical, and bioactivity","volume":"13","author":"Jeon","year":"2024","journal-title":"Antibiotics"},{"key":"10.1016\/j.ijbiomac.2026.150378_bb0095","doi-asserted-by":"crossref","first-page":"8309","DOI":"10.2147\/IJN.S184379","article-title":"Curcumin-loaded galactosylated BSA nanoparticles as targeted drug delivery carriers inhibit hepatocellular carcinoma cell proliferation and migration","author":"Huang","year":"2018","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.ijbiomac.2026.150378_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2022.128436","article-title":"Dissection of the antibacterial mechanism of zinc oxide nanoparticles with manipulable nanoscale morphologies","volume":"430","author":"Zhu","year":"2022","journal-title":"J. Hazard. Mater."},{"issue":"21","key":"10.1016\/j.ijbiomac.2026.150378_bb0105","doi-asserted-by":"crossref","first-page":"27127","DOI":"10.1021\/acsami.4c02825","article-title":"Multifunctional Nanocarrier for synergistic treatment of Alzheimer\u2019s disease by inhibiting \u03b2-amyloid aggregation and scavenging reactive oxygen species","volume":"16","author":"Wang","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.ijbiomac.2026.150378_bb0110","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.foodhyd.2017.03.033","article-title":"Pectin coating improves physicochemical properties of caseinate\/zein nanoparticles as oral delivery vehicles for curcumin","volume":"70","author":"Chang","year":"2017","journal-title":"Food Hydrocoll."},{"key":"10.1016\/j.ijbiomac.2026.150378_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2019.118529","article-title":"Rapamycin loaded TPGS-Lecithins-Zein nanoparticles based on core-shell structure for oral drug administration","volume":"568","author":"Xie","year":"2019","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ijbiomac.2026.150378_bb0120","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.jconrel.2016.06.017","article-title":"DLS and zeta potential\u2013what they are and what they are not?","volume":"235","author":"Bhattacharjee","year":"2016","journal-title":"J. Control. Release"},{"issue":"2","key":"10.1016\/j.ijbiomac.2026.150378_bb0125","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.jfoodeng.2013.05.038","article-title":"Preparation of water-soluble antimicrobial zein nanoparticles by a modified antisolvent approach and their characterization","volume":"119","author":"Li","year":"2013","journal-title":"J. Food Eng."},{"issue":"2","key":"10.1016\/j.ijbiomac.2026.150378_bb0130","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.jconrel.2011.08.017","article-title":"Transport of drugs across the blood\u2013brain barrier by nanoparticles","volume":"161","author":"Wohlfart","year":"2012","journal-title":"J. Control. Release"},{"issue":"3","key":"10.1016\/j.ijbiomac.2026.150378_bb0135","doi-asserted-by":"crossref","first-page":"3662","DOI":"10.1021\/acsami.1c17861","article-title":"Gold nanorods with spatial separation of CeO2 deposition for plasmonic-enhanced antioxidant stress and photothermal therapy of alzheimer\u2019s disease","volume":"14","author":"Ge","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"48","key":"10.1016\/j.ijbiomac.2026.150378_bb0140","doi-asserted-by":"crossref","first-page":"9558","DOI":"10.1039\/C7TB01314K","article-title":"Size-and shape-dependent effects of titanium dioxide nanoparticles on the permeabilization of the blood\u2013brain barrier","volume":"5","author":"Liu","year":"2017","journal-title":"J. Mater. Chem. B"},{"issue":"4","key":"10.1016\/j.ijbiomac.2026.150378_bb0145","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1007\/s11051-021-05218-0","article-title":"Lipid nanoparticles for the transport of drugs like dopamine through the blood-brain barrier","volume":"23","author":"Ortega","year":"2021","journal-title":"J. Nanopart. Res."},{"issue":"4","key":"10.1016\/j.ijbiomac.2026.150378_bb0150","doi-asserted-by":"crossref","first-page":"2800","DOI":"10.1039\/C5RA17517H","article-title":"Implications for blood-brain-barrier permeability, in vitro oxidative stress and neurotoxicity potential induced by mesoporous silica nanoparticles: effects of surface modification","volume":"6","author":"Zhou","year":"2016","journal-title":"RSC Adv."},{"issue":"10","key":"10.1016\/j.ijbiomac.2026.150378_bb0155","doi-asserted-by":"crossref","first-page":"12161","DOI":"10.1021\/acsami.3c14709","article-title":"Angiopep-2-functionalized lipid cubosomes for blood\u2013brain barrier crossing and glioblastoma treatment","volume":"16","author":"Cai","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"2","key":"10.1016\/j.ijbiomac.2026.150378_bb0160","doi-asserted-by":"crossref","DOI":"10.1002\/btm2.10153","article-title":"Size, shape, and flexibility influence nanoparticle transport across brain endothelium under flow","volume":"5","author":"Nowak","year":"2020","journal-title":"Bioeng. Transl. Med."},{"key":"10.1016\/j.ijbiomac.2026.150378_bb0165","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.foodhyd.2019.02.003","article-title":"Encapsulation of curcumin in zein\/caseinate\/sodium alginate nanoparticles with improved physicochemical and controlled release properties","volume":"93","author":"Liu","year":"2019","journal-title":"Food Hydrocoll."},{"key":"10.1016\/j.ijbiomac.2026.150378_bb0170","series-title":"Impact of Oil Phase Composition on the Efficacy of Nanoemulsions for Verteporfin-Mediated Photodynamic Therapy in Ovarian cancer","author":"Varela","year":"2025"},{"key":"10.1016\/j.ijbiomac.2026.150378_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2024.114514","article-title":"Stabilization of zein nanoparticles with tween-80 and fucoidan for encapsulation of eugenol via a nozzle simulation chip","volume":"188","author":"Lei","year":"2024","journal-title":"Food Res. Int."},{"key":"10.1016\/j.ijbiomac.2026.150378_bb0180","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jfoodeng.2019.04.010","article-title":"Alginate\/chitosan-coated zein nanoparticles for the delivery of resveratrol","volume":"258","author":"Khan","year":"2019","journal-title":"J. Food Eng."},{"issue":"1","key":"10.1016\/j.ijbiomac.2026.150378_bb0185","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.ejpb.2007.11.004","article-title":"Formulation and characterization of ternary solid dispersions made up of Itraconazole and two excipients, TPGS 1000 and PVPVA 64, that were selected based on a supersaturation screening study","volume":"69","author":"Janssens","year":"2008","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"8","key":"10.1016\/j.ijbiomac.2026.150378_bb0190","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/j.1745-7270.2007.00320.x","article-title":"Fourier transform infrared spectroscopic analysis of protein secondary structures","volume":"39","author":"Kong","year":"2007","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"10.1016\/j.ijbiomac.2026.150378_bb0195","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.ijbiomac.2022.02.041","article-title":"Fabrication, characterization and in vitro cell exposure study of zein-chitosan nanoparticles for co-delivery of curcumin and berberine","volume":"204","author":"Ghobadi-Oghaz","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2026.150378_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2023.112552","article-title":"Interactions between zein and anthocyanins at different pH: structural characterization, binding mechanism and stability","volume":"166","author":"Li","year":"2023","journal-title":"Food Res. Int."},{"issue":"65","key":"10.1016\/j.ijbiomac.2026.150378_bb0205","doi-asserted-by":"crossref","first-page":"60126","DOI":"10.1039\/C6RA09347G","article-title":"Synthesis and characterization of TPGS\u2013gemcitabine prodrug micelles for pancreatic cancer therapy","volume":"6","author":"Khare","year":"2016","journal-title":"RSC Adv."},{"key":"10.1016\/j.ijbiomac.2026.150378_bb0210","first-page":"5219","article-title":"D-\u03b1-tocopherol polyethylene glycol succinate-based derivative nanoparticles as a novel carrier for paclitaxel delivery","author":"Wu","year":"2015","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.ijbiomac.2026.150378_bb0215","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.procbio.2020.03.017","article-title":"Fabrication of curcumin-loaded zein nanoparticles stabilized by sodium caseinate\/sodium alginate: curcumin solubility, thermal properties, rheology, and stability","volume":"94","author":"Liu","year":"2020","journal-title":"Process Biochem."},{"key":"10.1016\/j.ijbiomac.2026.150378_bb0220","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.foodhyd.2019.01.029","article-title":"Development and characterization of Pickering emulsion stabilized by zein\/corn fiber gum (CFG) complex colloidal particles","volume":"91","author":"Zhu","year":"2019","journal-title":"Food Hydrocoll."},{"issue":"10","key":"10.1016\/j.ijbiomac.2026.150378_bb0225","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1016\/j.biomaterials.2005.11.008","article-title":"In vitro and in vivo studies on vitamin E TPGS-emulsified poly (D, L-lactic-co-glycolic acid) nanoparticles for paclitaxel formulation","volume":"27","author":"Win","year":"2006","journal-title":"Biomaterials"},{"issue":"21","key":"10.1016\/j.ijbiomac.2026.150378_bb0230","doi-asserted-by":"crossref","first-page":"7092","DOI":"10.1039\/D0BM01536A","article-title":"Development of curcumin-loaded zein nanoparticles for transport across the blood\u2013brain barrier and inhibition of glioblastoma cell growth","volume":"9","author":"Zhang","year":"2021","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.ijbiomac.2026.150378_bb0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2020.111523","article-title":"Enhanced cellular uptake and cytotoxicity of vorinostat through encapsulation in TPGS-modified liposomes","volume":"199","author":"Farooq","year":"2021","journal-title":"Colloids Surf. B Biointerfaces"},{"issue":"1\u20132","key":"10.1016\/j.ijbiomac.2026.150378_bb0240","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.ijpharm.2018.02.014","article-title":"Functionalization of nanodiamond with vitamin E TPGS to facilitate oral absorption of curcumin","volume":"540","author":"Cheng","year":"2018","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ijbiomac.2026.150378_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.molliq.2023.123718","article-title":"Epigallocatechin-3-gallate loaded-zein nanoparticles: molecular interaction, antioxidant, antienzimatic, hemolytic and cytotoxic activities","volume":"394","author":"Vale","year":"2024","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.ijbiomac.2026.150378_bb0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2021.130542","article-title":"Fabrication of zein-lecithin-EGCG complex nanoparticles: characterization, controlled release in simulated gastrointestinal digestion","volume":"365","author":"Xie","year":"2021","journal-title":"Food Chem."},{"key":"10.1016\/j.ijbiomac.2026.150378_bb0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2024.140066","article-title":"Caseinate-coated zein nanoparticles as potential delivery vehicles for guavinoside B from guava: molecular interactions and encapsulation properties","volume":"456","author":"Yang","year":"2024","journal-title":"Food Chem."},{"issue":"9","key":"10.1016\/j.ijbiomac.2026.150378_bb0260","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.3390\/pharmaceutics13091476","article-title":"Improvement of imiquimod solubilization and skin retention via TPGS micelles: exploiting the co-solubilizing effect of oleic acid","volume":"13","author":"Ghezzi","year":"2021","journal-title":"Pharmaceutics"},{"issue":"3","key":"10.1016\/j.ijbiomac.2026.150378_bb0265","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.bbrc.2016.10.086","article-title":"Lipid peroxidation in cell death","volume":"482","author":"Gaschler","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ijbiomac.2026.150378_bb0270","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.colsurfb.2016.02.011","article-title":"Vitamin E TPGS conjugated carbon nanotubes improved efficacy of docetaxel with safety for lung cancer treatment","volume":"141","author":"Singh","year":"2016","journal-title":"Colloids Surf. B Biointerfaces"},{"issue":"5","key":"10.1016\/j.ijbiomac.2026.150378_bb0275","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1016\/j.msec.2009.01.002","article-title":"Standardization of incubation conditions for hemolysis testing of biomaterials","volume":"29","author":"Henkelman","year":"2009","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.ijbiomac.2026.150378_bb0280","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1007\/s13346-020-00750-3","article-title":"Nanoencapsulation of sophorolipids in PEGylated poly (lactide-co-glycolide) as a novel approach to target colon carcinoma in the murine model","volume":"10","author":"Haggag","year":"2020","journal-title":"Drug Deliv. Transl. Res."},{"key":"10.1016\/j.ijbiomac.2026.150378_bb0285","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/j.jcis.2024.02.219","article-title":"Erythrocyte membrane coated with nitrogen-doped quantum dots and polydopamine composite nano-system combined with photothermal treatment of Alzheimer\u2019s disease","volume":"663","author":"Liu","year":"2024","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.ijbiomac.2026.150378_bb0290","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1007\/s10439-014-1086-5","article-title":"Permeability analysis of neuroactive drugs through a dynamic microfluidic in vitro blood\u2013brain barrier model","volume":"42","author":"Booth","year":"2014","journal-title":"Ann. Biomed. Eng."},{"issue":"1","key":"10.1016\/j.ijbiomac.2026.150378_bb0295","doi-asserted-by":"crossref","first-page":"2000092","DOI":"10.1002\/adtp.202000092","article-title":"From adsorption to covalent bonding: apolipoprotein E functionalization of polymeric nanoparticles for drug delivery across the blood\u2013brain barrier","volume":"4","author":"Hartl","year":"2021","journal-title":"Adv. Therapeut."},{"issue":"4","key":"10.1016\/j.ijbiomac.2026.150378_bb0300","doi-asserted-by":"crossref","first-page":"485","DOI":"10.3390\/pharmaceutics17040485","article-title":"Recent advances in vitamin E TPGS-based organic nanocarriers for enhancing the oral bioavailability of active compounds: a systematic review","volume":"17","author":"Wong","year":"2025","journal-title":"Pharmaceutics"},{"issue":"4","key":"10.1016\/j.ijbiomac.2026.150378_bb0305","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1002\/ddr.21918","article-title":"Approaches to minimize the effects of P-glycoprotein in drug transport: a review","volume":"83","author":"Husain","year":"2022","journal-title":"Drug Dev. Res."},{"key":"10.1016\/j.ijbiomac.2026.150378_bb0310","doi-asserted-by":"crossref","first-page":"5555","DOI":"10.2147\/IJN.S213086","article-title":"Superiority of TPGS-loaded micelles in the brain delivery of vinpocetine via administration of thermosensitive intranasal gel","author":"Ahmed","year":"2019","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.ijbiomac.2026.150378_bb0315","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.msec.2017.02.008","article-title":"TPGS-chitosan cross-linked targeted nanoparticles for effective brain cancer therapy","volume":"74","author":"Agrawal","year":"2017","journal-title":"Mater. Sci. Eng. C"},{"issue":"2","key":"10.1016\/j.ijbiomac.2026.150378_bb0320","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3390\/pharmaceutics8020012","article-title":"Evaluation of P-glycoprotein inhibitory potential using a rhodamine 123 accumulation assay","volume":"8","author":"Jouan","year":"2016","journal-title":"Pharmaceutics"},{"issue":"2","key":"10.1016\/j.ijbiomac.2026.150378_bb0325","doi-asserted-by":"crossref","first-page":"325","DOI":"10.3109\/03639045.2015.1054396","article-title":"P-glycoprotein inhibition of drug resistant cell lines by nanoparticles","volume":"42","author":"Singh","year":"2016","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.ijbiomac.2026.150378_bb0330","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2023.121648","article-title":"Inhibition of P-glycoprotein-mediated efflux by thiolated cyclodextrins","volume":"327","author":"Veider","year":"2024","journal-title":"Carbohydr. Polym."},{"issue":"7","key":"10.1016\/j.ijbiomac.2026.150378_bb0335","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.3390\/pharmaceutics13071103","article-title":"Pharmaceutical formulations with P-glycoprotein inhibitory effect as promising approaches for enhancing oral drug absorption and bioavailability","volume":"13","author":"Nguyen","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ijbiomac.2026.150378_bb0340","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2022.123125","article-title":"Functionalised penetrating peptide-chondroitin sulphate-gold nanoparticles: synthesis, characterization, and applications as an anti-Alzheimer\u2019s disease drug","volume":"230","author":"Feng","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2026.150378_bb0345","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.ijbiomac.2018.10.168","article-title":"Comparative study on neuroprotective activities of fucoidans from Fucus vesiculosus and Undaria pinnatifida","volume":"122","author":"Alghazwi","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2026.150378_bb0350","doi-asserted-by":"crossref","first-page":"359","DOI":"10.3389\/fnagi.2018.00359","article-title":"The early events that initiate \u03b2-amyloid aggregation in Alzheimer\u2019s disease","volume":"10","author":"Zhang","year":"2018","journal-title":"Front. Aging Neurosci."},{"issue":"1","key":"10.1016\/j.ijbiomac.2026.150378_bb0355","article-title":"Ceramides in Alzheimer\u2019s disease: key mediators of neuronal apoptosis induced by oxidative stress and A\u03b2 accumulation","volume":"2015","author":"Jazvin\u0161\u0107ak Jembrek","year":"2015","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.ijbiomac.2026.150378_bb0360","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.redox.2017.10.014","article-title":"Oxidative stress and the amyloid beta peptide in Alzheimer\u2019s disease","volume":"14","author":"Cheignon","year":"2018","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.ijbiomac.2026.150378_bb0365","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3233\/ADR-200171","article-title":"Alzheimer\u2019s disease, inflammation, and the role of antioxidants","volume":"4","author":"Sinyor","year":"2020","journal-title":"J. Alzheimer\u2019s Dis. Rep."},{"issue":"9","key":"10.1016\/j.ijbiomac.2026.150378_bb0370","doi-asserted-by":"crossref","first-page":"613","DOI":"10.14348\/molcells.2017.0096","article-title":"Molecular and cellular basis of neurodegeneration in Alzheimer\u2019s disease","volume":"40","author":"Jeong","year":"2017","journal-title":"Mol. Cells"},{"issue":"7","key":"10.1016\/j.ijbiomac.2026.150378_bb0375","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1080\/1061186X.2022.2063297","article-title":"Formulation development of tocopherol polyethylene glycol nanoengineered polyamidoamine dendrimer for neuroprotection and treatment of Alzheimer disease","volume":"30","author":"Singh","year":"2022","journal-title":"J. Drug Target."}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813026003041?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813026003041?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T19:31:47Z","timestamp":1770233507000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0141813026003041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":75,"alternative-id":["S0141813026003041"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2026.150378","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TPGS-coated zein nanoparticles encapsulating Haematococcus pluvialis extract for Alzheimer's disease: An in vitro evaluation towards brain-targeted delivery","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2026.150378","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"150378"}}