{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T05:32:34Z","timestamp":1794375154314,"version":"4.9.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52063027"],"award-info":[{"award-number":["52063027"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52362039"],"award-info":[{"award-number":["52362039"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.ijbiomac.2026.150565","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T15:46:08Z","timestamp":1769442368000},"page":"150565","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"P2","title":["A hierarchical bilayer sponge dressing based on QCMCS@GO\/PLA for synergistic wound healing via hemostasis and anti-adhesion"],"prefix":"10.1016","volume":"344","author":[{"given":"Haishui","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiting","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingbo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijbiomac.2026.150565_bb0005","doi-asserted-by":"crossref","DOI":"10.1182\/blood-2024-193615","article-title":"Bleed patterns in infants, from birth to 12 months of age, with hemophilia A treated with emicizumab: exploratory analysis of the HAVEN 7 study","volume":"144","author":"Carpenter","year":"2024","journal-title":"Blood"},{"key":"10.1016\/j.ijbiomac.2026.150565_bb0010","first-page":"20","article-title":"Multifunctional hydrogel encapsulated with baicalin for full-layer regeneration of drug-resistant bacteria-infected wounds after radiotherapy","volume":"53","author":"Yuan","year":"2025","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.ijbiomac.2026.150565_bb0015","article-title":"Wider use of tranexamic acid to reduce surgical bleeding could benefit patients and health systems","volume":"385","author":"Roberts","year":"2024","journal-title":"bmj"},{"key":"10.1016\/j.ijbiomac.2026.150565_bb0020","series-title":"Global Status Report on Road Safety 2023","author":"World Health Organization","year":"2023"},{"issue":"22","key":"10.1016\/j.ijbiomac.2026.150565_bb0025","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202309485","article-title":"Preparation and application of hemostatic hydrogels","volume":"20","author":"Zhou","year":"2024","journal-title":"Small"},{"key":"10.1016\/j.ijbiomac.2026.150565_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.progpolymsci.2024.101792","article-title":"Multifunctional naturally derived bioadhesives: from strategic molecular design toward advanced biomedical applications","volume":"150","author":"Kharaziha","year":"2024","journal-title":"Prog. Polym. Sci."},{"issue":"4","key":"10.1016\/j.ijbiomac.2026.150565_bb0035","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202306528","article-title":"Hydro-sensitive, in situ ultrafast physical self-gelatinizing, and red blood cells strengthened hemostatic adhesive powder with antibiosis and immunoregulation for wound repair","volume":"11","author":"Shang","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.ijbiomac.2026.150565_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2024.122325","article-title":"Multifunctional chitosan-based hydrogels loaded with iridium nanoenzymes for skin wound repair","volume":"342","author":"Wang","year":"2024","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2026.150565_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2023.121058","article-title":"Hydrophilic chitosan\/graphene oxide composite sponge for rapid hemostasis and non-rebleeding removal","volume":"316","author":"Du","year":"2023","journal-title":"Carbohydr. Polym."},{"issue":"20","key":"10.1016\/j.ijbiomac.2026.150565_bb0050","doi-asserted-by":"crossref","first-page":"11381","DOI":"10.1039\/D0CS01138J","article-title":"Two-dimensional biomaterials: material science, biological effect and biomedical engineering applications","volume":"50","author":"Huang","year":"2021","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.ijbiomac.2026.150565_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2023.121058","article-title":"Hydrophilic chitosan\/graphene oxide composite sponge for rapid hemostasis and non-rebleeding removal","volume":"316","author":"Du","year":"2023","journal-title":"Carbohydr. Polym."},{"issue":"3","key":"10.1016\/j.ijbiomac.2026.150565_bb0060","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s42114-025-01326-w","article-title":"The additive manufacturing NiTi alloy surface modification scheme can be used for photothermal treatment and overcoming implant infection","volume":"8","author":"Yang","year":"2025","journal-title":"Adv. Compos. Hybrid Mater."},{"key":"10.1016\/j.ijbiomac.2026.150565_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbon.2025.120221","article-title":"The mitsunobu reaction for the gentle covalent attachment of biomolecules to graphene oxide","volume":"238","author":"Wolf","year":"2025","journal-title":"Carbon"},{"key":"10.1016\/j.ijbiomac.2026.150565_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2021.129466","article-title":"3D isotropic hole-in-platelet graphene hydrogels with high surface area and fast mass transfer ability as efficient adsorbents","volume":"416","author":"Wu","year":"2021","journal-title":"Chem. Eng. J."},{"issue":"11","key":"10.1016\/j.ijbiomac.2026.150565_bb0075","doi-asserted-by":"crossref","first-page":"10964","DOI":"10.1021\/acsnano.7b04836","article-title":"Construction of antithrombotic tissue-engineered blood vessel via reduced graphene oxide based dual-enzyme biomimetic cascade","volume":"11","author":"Huo","year":"2017","journal-title":"ACS Nano"},{"key":"10.1016\/j.ijbiomac.2026.150565_bb0080","first-page":"231","article-title":"Advances in haemostatic sponges: characteristics and the underlying mechanisms for rapid haemostasis","volume":"27","author":"Nepal","year":"2023","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.ijbiomac.2026.150565_bb0085","article-title":"Graphene oxide-gelatin aerogels as wound dressings with improved hemostatic properties","volume":"20","author":"uajardo","year":"2021","journal-title":"Mater. Today Chem."},{"issue":"2","key":"10.1016\/j.ijbiomac.2026.150565_bb0090","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.cclet.2021.06.029","article-title":"Graphene-based hemostatic sponge","volume":"33","author":"Wu","year":"2022","journal-title":"Chin. Chem. Lett."},{"issue":"26","key":"10.1016\/j.ijbiomac.2026.150565_bb0095","doi-asserted-by":"crossref","first-page":"30306","DOI":"10.1021\/acsami.2c03520","article-title":"Nonmonotonic relationship between the oxidation state of graphene-based materials and its cell membrane damage Effects","volume":"14","author":"Yin","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.ijbiomac.2026.150565_bb0100","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.carbon.2019.08.086","article-title":"Toxicity of graphene oxide against algae and cyanobacteria: nanoblade-morphology-induced mechanical injury and self-protection mechanism","volume":"155","author":"Malina","year":"2019","journal-title":"Carbon"},{"issue":"1","key":"10.1016\/j.ijbiomac.2026.150565_bb0105","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1021\/nn3047378","article-title":"Graphene oxide. Origin of acidity, its instability in water, and a new dynamic structural model","volume":"7","author":"Dimiev","year":"2013","journal-title":"ACS Nano"},{"issue":"21","key":"10.1016\/j.ijbiomac.2026.150565_bb0110","doi-asserted-by":"crossref","first-page":"21923","DOI":"10.1021\/acsnano.3c08260","article-title":"Decoding the interplay between topology and surface charge in graphene oxide membranes during humidity induced swelling","volume":"17","author":"Shaharudin","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.ijbiomac.2026.150565_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2024.122233","article-title":"Progress in chitin\/chitosan and their derivatives for biomedical applications: where we stand","volume":"343","author":"Mu","year":"2024","journal-title":"Carbohydr. Polym."},{"issue":"9","key":"10.1016\/j.ijbiomac.2026.150565_bb0120","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202414437","article-title":"Directional freeze-casting cryogel loaded with quaternized chitosan modified Gallium metal\u2013organic frameworks to capture and eradicate the resistant bacteria for guided regeneration in infected bone defects","volume":"37","author":"Liu","year":"2025","journal-title":"Adv. Mater."},{"key":"10.1016\/j.ijbiomac.2026.150565_bb0125","article-title":"Chitosan-based Janus dressing with asymmetric wettability for rapid hemostasis, antibacterial protection, and tissue regeneration in hemorrhagic wound management","author":"Wang","year":"2025","journal-title":"Carbohydr. Polym."},{"issue":"4","key":"10.1016\/j.ijbiomac.2026.150565_bb0130","doi-asserted-by":"crossref","first-page":"6134","DOI":"10.1021\/acsami.4c21171","article-title":"A Durable Ag@ MOF-545\/QCM-Cotton Fabric with \u201cIntelligent Bacteria-Capturing and Dual Antibacterial\u201d Properties","volume":"17","author":"Gao","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.ijbiomac.2026.150565_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2024.122817","article-title":"Carboxymethyl chitosan\/dialdehyde quaternized pullulan self-healing hydrogel loaded with tranexamic acid for rapid hemostasis","volume":"348","author":"Chen","year":"2025","journal-title":"Carbohydr. Polym."},{"issue":"5","key":"10.1016\/j.ijbiomac.2026.150565_bb0140","doi-asserted-by":"crossref","DOI":"10.3390\/polym11050777","article-title":"Synthesis and characterization of graphene oxide\/chitosan composite aerogels with high mechanical performance","volume":"11","author":"Gong","year":"2019","journal-title":"Polymers"},{"key":"10.1016\/j.ijbiomac.2026.150565_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2025.160208","article-title":"Silicone nanofilament embedded, superhydrophobic polylactic acid composite aerogel","volume":"507","author":"Xu","year":"2025","journal-title":"Chem. Eng. J."},{"issue":"27","key":"10.1016\/j.ijbiomac.2026.150565_bb0150","doi-asserted-by":"crossref","first-page":"34578","DOI":"10.1021\/acsami.4c05074","article-title":"Multifunctional porous bilayer artificial skin for enhanced wound healing","volume":"16","author":"Xia","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.ijbiomac.2026.150565_bb0165","article-title":"Graphene oxide-engineered chitosan nanoparticles: Synthesis, properties, and antibacterial activity for tissue engineering and regenerative medicine","author":"Farani","year":"2025","journal-title":"Chem. Eng. J."},{"issue":"9","key":"10.1016\/j.ijbiomac.2026.150565_bb0170","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1021\/acsmaterialslett.3c00177","article-title":"Graphene oxide nanosheets induce mitochondrial fragmentation by cutting through membrane","volume":"5","author":"Shao","year":"2023","journal-title":"ACS Mater. Lett."},{"issue":"1","key":"10.1016\/j.ijbiomac.2026.150565_bb0175","article-title":"Piezoelectric-immunomodulatory electrospun membrane for enhanced repair of refractory wounds","volume":"23","author":"Liu","year":"2025","journal-title":"J. Nanobiotechnol."},{"issue":"46","key":"10.1016\/j.ijbiomac.2026.150565_bb0180","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202407983","article-title":"Construction of a curcumin-loaded PLLA\/PCL micro-nano conjugated fibrous membrane to synergistically prevent postoperative adhesion from multiple perspectives","volume":"34","author":"Liao","year":"2024","journal-title":"Adv. Funct. Mater."},{"issue":"7","key":"10.1016\/j.ijbiomac.2026.150565_bb0185","doi-asserted-by":"crossref","first-page":"10470","DOI":"10.1021\/acsami.4c20592","article-title":"Metal-phenolic network (MPN) modified Janus fibrous hydrogel scaffold for infected diabetic wound healing","volume":"17","author":"Ullah","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.ijbiomac.2026.150565_bb0190","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.biomaterials.2016.09.005","article-title":"Ultrastrong trap of VEGF by graphene oxide: anti-angiogenesis application","volume":"109","author":"Lai","year":"2016","journal-title":"Biomaterials"},{"key":"10.1016\/j.ijbiomac.2026.150565_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioadv.2022.213007","article-title":"Novel and effective hemostats based on graphene oxide-polymer aerogels: In vitro and in vivo evaluation","volume":"139","author":"Borges-Vilches","year":"2022","journal-title":"Biomaterials Advances"},{"issue":"12","key":"10.1016\/j.ijbiomac.2026.150565_bb0200","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1039\/C7BM00554G","article-title":"Design and development of polysaccharide hemostatic materials and their hemostatic mechanism","volume":"5","author":"Yang","year":"2017","journal-title":"Biomater. Sci."},{"issue":"6","key":"10.1016\/j.ijbiomac.2026.150565_bb0205","doi-asserted-by":"crossref","first-page":"4987","DOI":"10.1021\/nn201092p","article-title":"Thrombus inducing property of atomically thin graphene oxide sheets","volume":"5","author":"Singh","year":"2011","journal-title":"ACS Nano"},{"key":"10.1016\/j.ijbiomac.2026.150565_bb0210","first-page":"459","article-title":"Smart design in biopolymer-based hemostatic sponges: From hemostasis to multiple functions","volume":"45","author":"Zou","year":"2025","journal-title":"Bioact. Mater."},{"issue":"06","key":"10.1016\/j.ijbiomac.2026.150565_bb0215","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1055\/a-1528-0499","article-title":"Mechanism, functions, and diagnostic relevance of FXII activation by foreign surfaces","volume":"41","author":"Konrath","year":"2021","journal-title":"H\u00e4mostaseologie"},{"key":"10.1016\/j.ijbiomac.2026.150565_bb0220","doi-asserted-by":"crossref","DOI":"10.1182\/blood.V73.6.1525.1525","article-title":"The activation of the contact phase of coagulation by physiologic surfaces in plasma: the effect of large negatively charged liposomal vesicles","author":"Mitropoulos","year":"1989","journal-title":"Blood"},{"key":"10.1016\/j.ijbiomac.2026.150565_bb0225","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.actbio.2022.10.028","article-title":"Nanofibrous hemostatic materials: Structural design, fabrication methods, and hemostatic mechanisms","volume":"154","author":"Lu","year":"2022","journal-title":"Acta Biomater."},{"issue":"6","key":"10.1016\/j.ijbiomac.2026.150565_bb0230","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1134\/S0006350913060031","article-title":"The in vitro influence of the external electrostatic field on the physical parameters of erythrocyte membranes","volume":"58","author":"Artsruni","year":"2013","journal-title":"Biophysics"},{"key":"10.1016\/j.ijbiomac.2026.150565_bb0235","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.cej.2013.10.034","article-title":"A facile method to produce graphene oxide-g-poly (L-lactic acid) as an promising reinforcement for PLLA nanocomposites","volume":"237","author":"Li","year":"2014","journal-title":"Chem. Eng. J."}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813026004915?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813026004915?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:08:30Z","timestamp":1778630910000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0141813026004915"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":45,"alternative-id":["S0141813026004915"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2026.150565","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A hierarchical bilayer sponge dressing based on QCMCS@GO\/PLA for synergistic wound healing via hemostasis and anti-adhesion","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2026.150565","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"150565"}}