{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:34:42Z","timestamp":1791549282216,"version":"4.3.4"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81630057"],"award-info":[{"award-number":["81630057"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003347","name":"Fudan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004751","name":"Ministry of Science and Technology of the People's Republic of China Department of Science and Technology for Social Development","doi-asserted-by":"publisher","award":["2018YFA0507304"],"award-info":[{"award-number":["2018YFA0507304"]}],"id":[{"id":"10.13039\/501100004751","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.ijbiomac.2026.150992","type":"journal-article","created":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T19:56:53Z","timestamp":1771358213000},"page":"150992","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Unveiling the mechanistic link between peroxiredoxin inhibition and ferroptosis-like cell death induced by Dinaciclib in Entamoeba histolytica"],"prefix":"10.1016","volume":"350","author":[{"given":"Wenjie","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruixue","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dai","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongze","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xunjia","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijbiomac.2026.150992_bb0005","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/S0140-6736(03)12830-9","article-title":"Amoebiasis","volume":"361","author":"Stanley","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.ijbiomac.2026.150992_bb0010","doi-asserted-by":"crossref","DOI":"10.1093\/ofid\/ofy161","article-title":"A review of the global burden, new diagnostics, and current therapeutics for amebiasis","volume":"5","author":"Shirley","year":"2018","journal-title":"Open Forum Infect. Dis."},{"key":"10.1016\/j.ijbiomac.2026.150992_bb0015","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241411755","article-title":"Amoebiasis: advances in diagnosis, treatment, immunology features and the interaction with the intestinal ecosystem","volume":"24","author":"Mor\u00e1n","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ijbiomac.2026.150992_bb0020","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1126\/science.6322306","article-title":"Entamoeba histolytica: a eukaryote without glutathione metabolism","volume":"224","author":"Fahey","year":"1984","journal-title":"Science"},{"key":"10.1016\/j.ijbiomac.2026.150992_bb0025","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1016\/j.bbagen.2012.08.020","article-title":"Entamoeba histolytica thioredoxin reductase: molecular and functional characterization of its atypical properties","volume":"1820","author":"Arias","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ijbiomac.2026.150992_bb0030","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.freeradbiomed.2013.07.036","article-title":"The thioredoxin antioxidant system","volume":"66","author":"Lu","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ijbiomac.2026.150992_bb0035","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.3390\/antiox13091078","article-title":"Exploring the thioredoxin system as a therapeutic target in cancer: mechanisms and implications","volume":"13","author":"Seitz","year":"2024","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.ijbiomac.2026.150992_bb0040","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1080\/14756366.2020.1867121","article-title":"Thioredoxin-dependent system. Application of inhibitors","volume":"36","author":"Jastrz\u0105b","year":"2021","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.ijbiomac.2026.150992_bb0045","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1042\/bj3260785","article-title":"Removal of hydrogen peroxide by the 29 kDa protein of Entamoeba histolytica","volume":"326","author":"Bruchhaus","year":"1997","journal-title":"Biochem. J."},{"key":"10.1016\/j.ijbiomac.2026.150992_bb0050","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.molbiopara.2016.01.004","article-title":"Entamoeba thiol-based redox metabolism: a potential target for drug development","volume":"206","author":"Jeelani","year":"2016","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.ijbiomac.2026.150992_bb0055","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.molbiopara.2003.10.006","article-title":"Genes induced by a high-oxygen environment in Entamoeba histolytica","volume":"133","author":"Akbar","year":"2004","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.ijbiomac.2026.150992_bb0060","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1080\/00034983.1992.11812660","article-title":"Oxido-reductive functions of Entamoeba histolytica in relation to virulence","volume":"86","author":"Kumar","year":"1992","journal-title":"Ann. Trop. Med. Parasitol."},{"key":"10.1016\/j.ijbiomac.2026.150992_bb0065","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1111\/j.1365-2958.2006.05344.x","article-title":"Comparative proteomic analysis of two Entamoeba histolytica strains with different virulence phenotypes identifies peroxiredoxin as an important component of amoebic virulence","volume":"61","author":"Davis","year":"2006","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.ijbiomac.2026.150992_bb0070","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.ijpara.2008.11.004","article-title":"Entamoeba histolytica: oxygen resistance and virulence","volume":"39","author":"Ramos-Mart\u00ednez","year":"2009","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.ijbiomac.2026.150992_bb0075","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1128\/IAI.74.1.340-351.2006","article-title":"Identification of differentially expressed genes in virulent and nonvirulent Entamoeba species: potential implications for amebic pathogenesis","volume":"74","author":"MacFarlane","year":"2006","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijbiomac.2026.150992_bb0080","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1128\/EC.00308-06","article-title":"The 29-kilodalton thiol-dependent peroxidase of Entamoeba histolytica is a factor involved in pathogenesis and survival of the parasite during oxidative stress","volume":"6","author":"Sen","year":"2007","journal-title":"Eukaryot. Cell"},{"key":"10.1016\/j.ijbiomac.2026.150992_bb0085","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.freeradbiomed.2014.10.504","article-title":"Even free radicals should follow some rules: a guide to free radical research terminology and methodology","volume":"78","author":"Forman","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ijbiomac.2026.150992_bb0090","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0107102","article-title":"Gene expression profiling in Entamoeba histolytica identifies key components in iron uptake and metabolism","volume":"9","author":"Hern\u00e1ndez-Cuevas","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ijbiomac.2026.150992_bb0095","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3389\/fcimb.2020.00075","article-title":"Lipids in Entamoeba histolytica: host-dependence and virulence factors","volume":"10","author":"Castellanos-Castro","year":"2020","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.ijbiomac.2026.150992_bb0100","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-15923-3","article-title":"Genetic, metabolomic and transcriptomic analyses of the de novo L-cysteine biosynthetic pathway in the enteric protozoan parasite Entamoeba histolytica","volume":"7","author":"Jeelani","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ijbiomac.2026.150992_bb0105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0008425","article-title":"Antineoplastic kinase inhibitors: a new class of potent anti-amoebic compounds","volume":"15","author":"Sauvey","year":"2021","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.ijbiomac.2026.150992_bb0110","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1038\/nm.2758","article-title":"A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target","volume":"18","author":"Debnath","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.ijbiomac.2026.150992_bb0115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1012364","article-title":"EhRacM differentially regulates macropinocytosis and motility in the enteric protozoan parasite Entamoeba histolytica","volume":"20","author":"Shimoyama","year":"2024","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.ijbiomac.2026.150992_bb0120","doi-asserted-by":"crossref","first-page":"214","DOI":"10.3389\/fcimb.2018.00214","article-title":"The sole DNA ligase in Entamoeba histolytica is a high-fidelity DNA ligase involved in DNA damage repair","volume":"8","author":"Azuara-Liceaga","year":"2018","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.ijbiomac.2026.150992_bb0125","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241311216","article-title":"In vitro evaluation of the antiamoebic activity of kaempferol against trophozoites of Entamoeba histolytica and in the interactions of amoebae with hamster neutrophils","volume":"24","author":"Levaro-Loquio","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ijbiomac.2026.150992_bb0130","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s10142-023-01055-7","article-title":"RefFinder: a web-based tool for comprehensively analyzing and identifying reference genes","volume":"23","author":"Xie","year":"2023","journal-title":"Funct. Integr. Genomics"},{"key":"10.1016\/j.ijbiomac.2026.150992_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.112742","article-title":"Ferroptosis plays an essential role in the antimalarial mechanism of low-dose dihydroartemisinin","volume":"148","author":"Li","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ijbiomac.2026.150992_bb0140","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3390\/ijms24010229","article-title":"Evaluation of the combined effect of artemisinin and ferroptosis inducer RSL3 against Toxoplasma gondii","volume":"24","author":"Huang","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ijbiomac.2026.150992_bb0145","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.37503","article-title":"Tryparedoxin peroxidase-deficiency commits trypanosomes to ferroptosis-type cell death","volume":"7","author":"Bogacz","year":"2018","journal-title":"Elife"},{"key":"10.1016\/j.ijbiomac.2026.150992_bb0150","doi-asserted-by":"crossref","DOI":"10.1080\/21505594.2025.2530164","article-title":"Ferroptosis is important for Toxoplasma gondii replication and virulence in vitro and in vivo","volume":"16","author":"Li","year":"2025","journal-title":"Virulence"},{"key":"10.1016\/j.ijbiomac.2026.150992_bb0155","first-page":"1","article-title":"Entamoeba histolytica: plasma membrane components and virulence factors in the invasive process","volume":"95","author":"Costa","year":"2025","journal-title":"Curr. Top. Membr."},{"key":"10.1016\/j.ijbiomac.2026.150992_bb0160","doi-asserted-by":"crossref","DOI":"10.1128\/msphere.00174-23","article-title":"Unique features of Entamoeba histolytica glycerophospholipid metabolism; has the E. histolytica lipid metabolism network evolved through gene loss and gain to enable parasitic life cycle adaptation?","volume":"8","author":"Mi-Ichi","year":"2023","journal-title":"mSphere"},{"issue":"1","key":"10.1016\/j.ijbiomac.2026.150992_bb0165","article-title":"Lipid metabolism in ferroptosis: unraveling key mechanisms and therapeutic potential in cancer","volume":"1880","author":"Lee","year":"2025","journal-title":"Biochim. Biophys. Acta (BBA) Rev. Cancer"},{"key":"10.1016\/j.ijbiomac.2026.150992_bb0170","doi-asserted-by":"crossref","first-page":"39160","DOI":"10.1074\/jbc.M110.167304","article-title":"Metabolome analysis revealed increase in S-methylcysteine and phosphatidylisopropanolamine synthesis upon l-cysteine deprivation in the anaerobic protozoan parasite Entamoeba histolytica","volume":"285","author":"Husain","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ijbiomac.2026.150992_bb0175","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/s41392-024-02095-6","article-title":"Redox regulation: mechanisms, biology and therapeutic targets in diseases","volume":"10","author":"Li","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.ijbiomac.2026.150992_bb0180","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.3390\/antiox14091142","article-title":"Beyond antioxidants: how redox pathways shape cellular signaling and disease outcomes","volume":"14","author":"Alhaj Sulaiman","year":"2025","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.ijbiomac.2026.150992_bb0185","doi-asserted-by":"crossref","first-page":"72","DOI":"10.14348\/molcells.2016.2351","article-title":"Peroxiredoxins and the regulation of cell death","volume":"39","author":"Hampton","year":"2016","journal-title":"Mol. Cell"},{"key":"10.1016\/j.ijbiomac.2026.150992_bb0190","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1089\/ars.2017.7422","article-title":"Peroxiredoxin involvement in the initiation and progression of human cancer","volume":"28","author":"Hampton","year":"2018","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.ijbiomac.2026.150992_bb0195","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.freeradbiomed.2014.10.009","article-title":"A primer on peroxiredoxin biochemistry","volume":"80","author":"Karplus","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ijbiomac.2026.150992_bb0200","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3389\/fcimb.2018.00019","article-title":"Utilization of different omic approaches to unravel stress response mechanisms in the parasite Entamoeba histolytica","volume":"8","author":"Nagaraja","year":"2018","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.ijbiomac.2026.150992_bb0205","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-40670-z","article-title":"Glycerol biosynthetic pathway plays an essential role in proliferation and antioxidative defense in the human enteric protozoan parasite Entamoeba histolytica","volume":"13","author":"Jeelani","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ijbiomac.2026.150992_bb0210","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0001831","article-title":"Dramatic increase in glycerol biosynthesis upon oxidative stress in the anaerobic protozoan parasite Entamoeba histolytica","volume":"6","author":"Husain","year":"2012","journal-title":"PLoS Negl. Trop. Dis."}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813026009189?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813026009189?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T02:23:48Z","timestamp":1775096628000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0141813026009189"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":42,"alternative-id":["S0141813026009189"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2026.150992","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Unveiling the mechanistic link between peroxiredoxin inhibition and ferroptosis-like cell death induced by Dinaciclib in Entamoeba histolytica","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2026.150992","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"150992"}}