{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T02:09:56Z","timestamp":1778724596137,"version":"3.51.4"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2025YFA1109200"],"award-info":[{"award-number":["2025YFA1109200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LMS25H010002"],"award-info":[{"award-number":["LMS25H010002"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LZ25H310003"],"award-info":[{"award-number":["LZ25H310003"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31871395"],"award-info":[{"award-number":["31871395"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32170841"],"award-info":[{"award-number":["32170841"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.ijbiomac.2026.152113","type":"journal-article","created":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T06:30:51Z","timestamp":1776493851000},"page":"152113","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Acetylation of GPRC5A at Lys348 facilitates cisplatin resistance and promotes the recurrence and poor prognosis in ovarian cancer"],"prefix":"10.1016","volume":"362","author":[{"given":"Qiangqiang","family":"He","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meiyu","family":"Qu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hangyang","family":"Bao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingyu","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiali","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengyun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ximei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangrui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling-Hui","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"17","key":"10.1016\/j.ijbiomac.2026.152113_bb0005","doi-asserted-by":"crossref","first-page":"5103","DOI":"10.1158\/0008-5472.CAN-15-2980","article-title":"Cross-cancer genome-wide analysis of lung, ovary, breast, prostate, and colorectal cancer reveals novel pleiotropic associations","volume":"76","author":"Fehringer","year":"2016","journal-title":"Cancer Res."},{"issue":"10177","key":"10.1016\/j.ijbiomac.2026.152113_bb0010","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1016\/S0140-6736(18)32552-2","article-title":"Epithelial ovarian cancer","volume":"393","author":"Lheureux","year":"2019","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.ijbiomac.2026.152113_bb0015","first-page":"280","article-title":"Epithelial ovarian cancer: evolution of management in the era of precision medicine","volume":"69","author":"Lheureux","year":"2019","journal-title":"CA Cancer J. Clin."},{"issue":"6","key":"10.1016\/j.ijbiomac.2026.152113_bb0020","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.annonc.2021.02.015","article-title":"The systemic treatment of recurrent ovarian cancer revisited","volume":"32","author":"Baert","year":"2021","journal-title":"Ann. Oncol."},{"issue":"8","key":"10.1016\/j.ijbiomac.2026.152113_bb0025","doi-asserted-by":"crossref","first-page":"E374","DOI":"10.1016\/S1470-2045(22)00139-5","article-title":"Clinical research in ovarian cancer: consensus recommendations from the gynecologic Cancer InterGroup","volume":"23","author":"Vergote","year":"2022","journal-title":"Lancet Oncol."},{"issue":"5","key":"10.1016\/j.ijbiomac.2026.152113_bb0030","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1093\/annonc\/mdz104","article-title":"Treatment of patients with recurrent epithelial ovarian cancer for whom platinum is still an option","volume":"30","author":"Buechel","year":"2019","journal-title":"Ann. Oncol."},{"issue":"15","key":"10.1016\/j.ijbiomac.2026.152113_bb0035","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1007\/s40265-020-01382-0","article-title":"Movement of poly-ADP ribose (PARP) inhibition into frontline treatment of ovarian Cancer","volume":"80","author":"Onstad","year":"2020","journal-title":"Drugs"},{"issue":"6","key":"10.1016\/j.ijbiomac.2026.152113_bb0040","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1007\/s11864-022-00938-4","article-title":"Appropriate selection of PARP inhibitors in ovarian Cancer","volume":"23","author":"Smith","year":"2022","journal-title":"Curr. Treat. Options Oncol."},{"issue":"15","key":"10.1016\/j.ijbiomac.2026.152113_bb0045","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23158125","article-title":"The molecular mechanisms of actions, effects, and clinical implications of PARP inhibitors in epithelial ovarian cancers: a systematic review","volume":"23","author":"Lau","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.ijbiomac.2026.152113_bb0050","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/s13046-021-01917-7","article-title":"Patient-derived organoids and high grade serous ovarian cancer: from disease modeling to personalized medicine","volume":"40","author":"Nero","year":"2021","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"5","key":"10.1016\/j.ijbiomac.2026.152113_bb0055","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/s41580-021-00441-y","article-title":"Modulation of cellular processes by histone and non-histone protein acetylation","volume":"23","author":"Shvedunova","year":"2022","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ijbiomac.2026.152113_bb0060","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1146\/annurev-biochem-082520-125411","article-title":"Understanding the function of mammalian sirtuins and protein lysine acylation","volume":"90","author":"Wang","year":"2021","journal-title":"Annu. Rev. Biochem."},{"issue":"11","key":"10.1016\/j.ijbiomac.2026.152113_bb0065","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1038\/s41594-023-01107-3","article-title":"PARylated PDHE1\u03b1 generates acetyl-CoA for local chromatin acetylation and DNA damage repair","volume":"30","author":"Zhang","year":"2023","journal-title":"Nat. Struct. Mol. Biol."},{"issue":"7","key":"10.1016\/j.ijbiomac.2026.152113_bb0070","doi-asserted-by":"crossref","first-page":"br10","DOI":"10.1091\/mbc.E23-02-0070","article-title":"Acetate regulates GAPDH acetylation and T helper 1 cell differentiation","volume":"34","author":"Jing","year":"2023","journal-title":"Mol. Biol. Cell"},{"issue":"2","key":"10.1016\/j.ijbiomac.2026.152113_bb0075","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.tibs.2010.09.003","article-title":"Regulation of intermediary metabolism by protein acetylation","volume":"36","author":"Guan","year":"2011","journal-title":"Trends Biochem. Sci."},{"issue":"3","key":"10.1016\/j.ijbiomac.2026.152113_bb0080","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.cmet.2020.01.009","article-title":"An acetylation switch of the NLRP3 inflammasome regulates aging-associated chronic inflammation and insulin resistance","volume":"31","author":"He","year":"2020","journal-title":"Cell Metab."},{"issue":"2","key":"10.1016\/j.ijbiomac.2026.152113_bb0085","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1011189","article-title":"Bacterial infection promotes tumorigenesis of colorectal cancer via regulating CDC42 acetylation","volume":"19","author":"Wang","year":"2023","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.ijbiomac.2026.152113_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101813","article-title":"Polysulfide-mediated sulfhydration of SIRT1 prevents diabetic nephropathy by suppressing phosphorylation and acetylation of p65 NF-\u03baB and STAT3","volume":"38","author":"Sun","year":"2021","journal-title":"Redox Biol."},{"issue":"11","key":"10.1016\/j.ijbiomac.2026.152113_bb0095","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1080\/14789450.2021.2007766","article-title":"Protein lysine acetylation and its role in different human pathologies: a proteomic approach","volume":"18","author":"Morales-Tarr\u00e9","year":"2021","journal-title":"Expert Rev. Proteomics"},{"issue":"4","key":"10.1016\/j.ijbiomac.2026.152113_bb0100","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.molcel.2021.12.004","article-title":"Now open: evolving insights to the roles of lysine acetylation in chromatin organization and function","volume":"82","author":"Chen","year":"2022","journal-title":"Mol. Cell"},{"issue":"3","key":"10.1016\/j.ijbiomac.2026.152113_bb0105","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/s41568-022-00543-5","article-title":"Acetyl-CoA metabolism in cancer","volume":"23","author":"Guertin","year":"2023","journal-title":"Nat. Rev. Cancer"},{"issue":"1","key":"10.1016\/j.ijbiomac.2026.152113_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2022.188837","article-title":"Acetyl-CoA regulates lipid metabolism and histone acetylation modification in cancer","volume":"1878","author":"He","year":"2023","journal-title":"Biochimica et Biophysica Acta (BBA) - Reviews on Cancer"},{"issue":"22","key":"10.1016\/j.ijbiomac.2026.152113_bb0115","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1093\/jnci\/djm208","article-title":"Identification of the retinoic acid-inducible Gprc5a as a new lung tumor suppressor gene","volume":"99","author":"Tao","year":"2007","journal-title":"J. Natl. Cancer Inst."},{"issue":"22","key":"10.1016\/j.ijbiomac.2026.152113_bb0120","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/djm227","article-title":"A new tumor suppressor gene, selective for lung cancer","volume":"99","author":"Sporn","year":"2007","journal-title":"J. Natl. Cancer Inst."},{"issue":"21","key":"10.1016\/j.ijbiomac.2026.152113_bb0125","doi-asserted-by":"crossref","first-page":"8917","DOI":"10.1158\/0008-5472.CAN-10-0518","article-title":"Deletion enhances the transformed phenotype in Normal and malignant lung epithelial cells by eliciting persistent Stat3 signaling induced by autocrine leukemia inhibitory factor","volume":"70","author":"Chen","year":"2010","journal-title":"Cancer Res."},{"issue":"12","key":"10.1016\/j.ijbiomac.2026.152113_bb0130","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1097\/JTO.0b013e31826bb1ff","article-title":"Wistuba, II, G-protein coupled receptor family C, group 5, member a (GPRC5A) expression is decreased in the adjacent field and normal bronchial epithelia of patients with chronic obstructive pulmonary disease and non-small-cell lung cancer","volume":"7","author":"Fujimoto","year":"2012","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.ijbiomac.2026.152113_bb0135","doi-asserted-by":"crossref","DOI":"10.1186\/1476-4598-13-233","article-title":"EGFR phosphorylates and inhibits lung tumor suppressor GPRC5A in lung cancer","volume":"13","author":"Lin","year":"2014","journal-title":"Mol. Cancer"},{"issue":"9","key":"10.1016\/j.ijbiomac.2026.152113_bb0140","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1158\/0008-5472.CAN-14-2005","article-title":"Lung tumor suppressor GPRC5A binds EGFR and restrains its effector signaling","volume":"75","author":"Zhong","year":"2015","journal-title":"Cancer Res."},{"key":"10.1016\/j.ijbiomac.2026.152113_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2024.101063","article-title":"Methylation of GPRC5A promotes liver metastasis and docetaxel resistance through activating mTOR signaling pathway in triple negative breast cancer","volume":"73","author":"Ou","year":"2024","journal-title":"Drug Resist. Updat."},{"issue":"1","key":"10.1016\/j.ijbiomac.2026.152113_bb0150","doi-asserted-by":"crossref","DOI":"10.1186\/s13046-022-02453-8","article-title":"Suppression of VEGFD expression by S-nitrosylation promotes the development of lung adenocarcinoma","volume":"41","author":"He","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"12","key":"10.1016\/j.ijbiomac.2026.152113_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2023.105395","article-title":"Smurf1 polyubiquitinates on K285\/K282 of the kinases Mst1\/2 to attenuate their tumor-suppressor functions","volume":"299","author":"Xu","year":"2023","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ijbiomac.2026.152113_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2024.216922","article-title":"Smoking-induced CCNA2 expression promotes lung adenocarcinoma tumorigenesis by boosting AT2\/AT2-like cell differentiation","volume":"592","author":"He","year":"2024","journal-title":"Cancer Lett."},{"issue":"1","key":"10.1016\/j.ijbiomac.2026.152113_bb0165","article-title":"Phosphorylation of human glioma-associated oncogene 1 on Ser937 regulates sonic hedgehog signaling in medulloblastoma","volume":"15","author":"Zeng","year":"2024","journal-title":"nature Communications"},{"issue":"1","key":"10.1016\/j.ijbiomac.2026.152113_bb0170","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.canlet.2016.05.010","article-title":"Phosphodiesterase 5\/protein kinase G signal governs stemness of prostate cancer stem cells through hippo pathway","volume":"378","author":"Liu","year":"2016","journal-title":"Cancer Lett."},{"key":"10.1016\/j.ijbiomac.2026.152113_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118655","article-title":"T851I mutation of human large tumor suppressor 1 disrupts its kinase activity and tumor-suppressor functions","volume":"264","author":"Zhang","year":"2021","journal-title":"Life Sci."},{"issue":"35","key":"10.1016\/j.ijbiomac.2026.152113_bb0180","doi-asserted-by":"crossref","first-page":"5357","DOI":"10.1038\/s41388-021-01937-9","article-title":"SUMOylation activates large tumour suppressor 1 to maintain the tissue homeostasis during hippo signalling","volume":"40","author":"Mei","year":"2021","journal-title":"Oncogene"},{"issue":"8","key":"10.1016\/j.ijbiomac.2026.152113_bb0185","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.chembiol.2020.07.002","article-title":"The chemical biology of reversible lysine post-translational modifications","volume":"27","author":"Wang","year":"2020","journal-title":"Cell Chem. Biol."},{"issue":"5","key":"10.1016\/j.ijbiomac.2026.152113_bb0190","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1158\/0008-5472.CAN-23-2625","article-title":"Lysine deacetylation is a key function of the Lysyl oxidase family of proteins in Cancer","volume":"84","author":"Wu","year":"2024","journal-title":"Cancer Res."},{"key":"10.1016\/j.ijbiomac.2026.152113_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106627","article-title":"Advancing targeted protein degradation for metabolic diseases therapy","volume":"188","author":"Zhou","year":"2023","journal-title":"Pharmacol. Res."},{"issue":"10","key":"10.1016\/j.ijbiomac.2026.152113_bb0200","doi-asserted-by":"crossref","first-page":"3124","DOI":"10.1080\/15548627.2020.1856493","article-title":"A high-throughput screening identifies ZNF418 as a novel regulator of the ubiquitin-proteasome system and autophagy-lysosomal pathway","volume":"17","author":"Singh","year":"2021","journal-title":"Autophagy"},{"issue":"4","key":"10.1016\/j.ijbiomac.2026.152113_bb0205","doi-asserted-by":"crossref","first-page":"3342","DOI":"10.3892\/mmr.2016.4897","article-title":"Oridonin effectively reverses cisplatin drug resistance in human ovarian cancer cells via induction of cell apoptosis and inhibition of matrix metalloproteinase expression","volume":"13","author":"Ma","year":"2016","journal-title":"Mol. Med. Rep."},{"issue":"6","key":"10.1016\/j.ijbiomac.2026.152113_bb0210","first-page":"498","article-title":"The effect of miR-3591-3p targeting P53 on cisplatin resistance in ovarian cancer SKOV3\/DDP cells","volume":"47","author":"Zheng","year":"2025","journal-title":"Zhonghua zhong liu za zhi"},{"issue":"16","key":"10.1016\/j.ijbiomac.2026.152113_bb0215","doi-asserted-by":"crossref","DOI":"10.1172\/JCI146186","article-title":"Cancer-associated mesothelial cells promote ovarian cancer chemoresistance through paracrine","volume":"131","author":"Qian","year":"2021","journal-title":"J. Clin. Investig."},{"issue":"43","key":"10.1016\/j.ijbiomac.2026.152113_bb0220","doi-asserted-by":"crossref","first-page":"48502","DOI":"10.1021\/acsami.2c15143","article-title":"Novel platinum nanoclusters activate PI3K\/AKT\/mTOR signaling pathway-mediated autophagy for cisplatin-resistant ovarian cancer therapy","volume":"14","author":"Zhang","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"1","key":"10.1016\/j.ijbiomac.2026.152113_bb0225","doi-asserted-by":"crossref","DOI":"10.1186\/s13048-023-01314-y","article-title":"Activation of PI3K\/AKT\/mTOR signaling axis by UBE2S inhibits autophagy leading to cisplatin resistance in ovarian cancer","volume":"16","author":"Zhang","year":"2023","journal-title":"J. Ovarian Res."},{"key":"10.1016\/j.ijbiomac.2026.152113_bb0230","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.semcancer.2021.06.019","article-title":"Attacking the PI3K\/Akt\/mTOR signaling pathway for targeted therapeutic treatment in human cancer","volume":"85","author":"Yu","year":"2022","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.ijbiomac.2026.152113_bb0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2024.107300","article-title":"PI3K\/AKT signaling pathway: molecular mechanisms and therapeutic potential in depression","volume":"206","author":"Guo","year":"2024","journal-title":"Pharmacol. Res."},{"issue":"9","key":"10.1016\/j.ijbiomac.2026.152113_bb0240","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-020-02998-6","article-title":"PI3K\/AKT pathway as a key link modulates the multidrug resistance of cancers","volume":"11","author":"Liu","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ijbiomac.2026.152113_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2024.111055","article-title":"Targeting PI3K\/AKT\/mTOR signaling to overcome drug resistance in cancer","volume":"396","author":"Tufail","year":"2024","journal-title":"Chem. Biol. Interact."},{"issue":"2","key":"10.1016\/j.ijbiomac.2026.152113_bb0250","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/s41568-019-0216-7","article-title":"The PI3K-AKT network at the interface of oncogenic signalling and cancer metabolism","volume":"20","author":"Hoxhaj","year":"2020","journal-title":"Nat. Rev. Cancer"},{"issue":"20","key":"10.1016\/j.ijbiomac.2026.152113_bb0255","doi-asserted-by":"crossref","first-page":"7315","DOI":"10.1128\/MCB.23.20.7315-7328.2003","article-title":"Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival","volume":"23","author":"Rathmell","year":"2003","journal-title":"Mol. Cell. Biol."},{"issue":"11","key":"10.1016\/j.ijbiomac.2026.152113_bb0260","doi-asserted-by":"crossref","first-page":"3892","DOI":"10.1158\/0008-5472.CAN-03-2904","article-title":"Akt stimulates aerobic glycolysis in cancer cells","volume":"64","author":"Elstrom","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.ijbiomac.2026.152113_bb0265","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.biopha.2017.04.001","article-title":"Baicalein increases cisplatin sensitivity of A549 lung adenocarcinoma cells via PI3K\/Akt\/NF-\u03baB pathway","volume":"90","author":"Yu","year":"2017","journal-title":"Biomed. Pharmacother."},{"issue":"19","key":"10.1016\/j.ijbiomac.2026.152113_bb0270","doi-asserted-by":"crossref","first-page":"19777","DOI":"10.1002\/cam4.6543","article-title":"Activation of PI3K\/Akt pathway by G protein-coupled receptor 37 promotes resistance to cisplatin-induced apoptosis in non-small cell lung cancer","volume":"12","author":"Liu","year":"2023","journal-title":"Cancer Med."},{"key":"10.1016\/j.ijbiomac.2026.152113_bb0275","doi-asserted-by":"crossref","first-page":"185","DOI":"10.3389\/fonc.2019.00185","article-title":"CACNA2D3 enhances the chemosensitivity of esophageal squamous cell carcinoma to cisplatin via inducing Ca(2+)-mediated apoptosis and suppressing PI3K\/Akt pathways","volume":"9","author":"Nie","year":"2019","journal-title":"Front. Oncol."},{"key":"10.1016\/j.ijbiomac.2026.152113_bb0280","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2021.776876","article-title":"Lanthanum chloride sensitizes cisplatin resistance of ovarian Cancer cells via PI3K\/Akt pathway","volume":"8","author":"Fang","year":"2021","journal-title":"Front. Med."},{"key":"10.1016\/j.ijbiomac.2026.152113_bb0285","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.semcancer.2019.05.012","article-title":"Role of the PI3K\/AKT\/mTOR signaling pathway in ovarian cancer: biological and therapeutic significance","volume":"59","author":"Ediriweera","year":"2019","journal-title":"Semin. Cancer Biol."},{"issue":"10","key":"10.1016\/j.ijbiomac.2026.152113_bb0290","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1038\/s41589-023-01328-z","article-title":"Chemoproteomics reveals microbiota-derived aromatic monoamine agonists for GPRC5A","volume":"19","author":"Zhao","year":"2023","journal-title":"Nat. Chem. Biol."},{"issue":"14","key":"10.1016\/j.ijbiomac.2026.152113_bb0295","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.4161\/cc.29584","article-title":"Phosphorylation of Akt at the C-terminal tail triggers Akt activation","volume":"13","author":"Liu","year":"2014","journal-title":"Cell Cycle"},{"issue":"3","key":"10.1016\/j.ijbiomac.2026.152113_bb0300","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.cell.2017.04.001","article-title":"AKT\/PKB signaling: navigating the network","volume":"169","author":"Manning","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.ijbiomac.2026.152113_bb0305","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.redox.2017.04.006","article-title":"Particular phosphorylation of PI3K\/Akt on Thr308 via PDK-1 and PTEN mediates melatonin\u2019s neuroprotective activity after focal cerebral ischemia in mice","volume":"12","author":"Kilic","year":"2017","journal-title":"Redox Biol."},{"issue":"11","key":"10.1016\/j.ijbiomac.2026.152113_bb0310","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1038\/leu.2011.146","article-title":"Low expression of PP2A regulatory subunit B55\u03b1 is associated with T308 phosphorylation of AKT and shorter complete remission duration in acute myeloid leukemia patients","volume":"25","author":"Ruvolo","year":"2011","journal-title":"Leukemia"},{"issue":"11","key":"10.1016\/j.ijbiomac.2026.152113_bb0315","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1038\/bjc.2011.132","article-title":"Akt phosphorylation on Thr308 but not on Ser473 correlates with Akt protein kinase activity in human non-small cell lung cancer","volume":"104","author":"Vincent","year":"2011","journal-title":"Br. J. Cancer"},{"issue":"24","key":"10.1016\/j.ijbiomac.2026.152113_bb0320","doi-asserted-by":"crossref","DOI":"10.3390\/cancers17243915","article-title":"The gynecologic oncology, management of patients with epithelial ovarian cancer: a systematic comparison of international guidelines from scientific societies (AIOM-BGCS-ESGO-ESMO-JGSO-NCCN-NICE)","volume":"17","author":"Arcieri","year":"2025","journal-title":"Cancers"}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813026020398?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813026020398?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T01:40:31Z","timestamp":1778722831000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0141813026020398"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":64,"alternative-id":["S0141813026020398"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2026.152113","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acetylation of GPRC5A at Lys348 facilitates cisplatin resistance and promotes the recurrence and poor prognosis in ovarian cancer","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2026.152113","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"152113"}}