{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T15:20:31Z","timestamp":1794496831196,"version":"4.9.1"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.ijbiomac.2026.154358","type":"journal-article","created":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T14:47:00Z","timestamp":1788706020000},"page":"154358","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P1","title":["Mycelial biotransformation of selenium-enriched polysaccharides from Pleurotus nebrodensis suppress breast cancer via mitochondrial apoptosis and immune microenvironment remodeling"],"prefix":"10.1016","volume":"382","author":[{"given":"Si-meng","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-li","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-cheng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling-bo","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-zeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua-jin","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijbiomac.2026.154358_bb0005","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.mpmed.2022.10.008","article-title":"Breast cancer","volume":"51","author":"Satherley","year":"2022","journal-title":"Medicine"},{"key":"10.1016\/j.ijbiomac.2026.154358_bb0010","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a041729","article-title":"Breast cancer","volume":"14","author":"Visvader","year":"2024","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.ijbiomac.2026.154358_bb0015","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"issue":"4","key":"10.1016\/j.ijbiomac.2026.154358_bb0020","doi-asserted-by":"crossref","first-page":"459","DOI":"10.3892\/ol.2023.14046","article-title":"Encapsulated papillary carcinoma of the breast: a single institution experience","volume":"26","author":"Xu","year":"2023","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.ijbiomac.2026.154358_bb0025","doi-asserted-by":"crossref","DOI":"10.1093\/ehjci\/jeab090.070","article-title":"Assessment of early cardiotoxic adverse effects of doxorubicin-containing regimens in breast cancer patients","volume":"22","author":"Rezaeian","year":"2021","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"10.1016\/j.ijbiomac.2026.154358_bb0030","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s10549-023-07055-2","article-title":"High neuroticism is associated with common late adverse effects in a nationwide sample of long-term breast cancer survivors","volume":"202","author":"Dahl","year":"2023","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.ijbiomac.2026.154358_bb0035","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2021.647563","article-title":"Impaired DNA repair fidelity in a breast cancer patient with adverse reactions to radiotherapy","volume":"9","author":"Alsbeih","year":"2021","journal-title":"Front. Public Health"},{"key":"10.1016\/j.ijbiomac.2026.154358_bb0040","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.carbpol.2018.10.088","article-title":"A combination of selenium and polysaccharides: promising therapeutic potential","volume":"206","author":"Li","year":"2019","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2026.154358_bb0045","doi-asserted-by":"crossref","first-page":"4834","DOI":"10.1039\/C9FO02026H","article-title":"Research progress on the biological activities of selenium polysaccharides","volume":"11","author":"Zhou","year":"2020","journal-title":"Food Funct."},{"key":"10.1016\/j.ijbiomac.2026.154358_bb0050","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2022.1032289","article-title":"Optimisation of the production of a selenium-enriched polysaccharides from Cordyceps cicadae S1 and its structure and antioxidant activity","volume":"9","author":"Zhuansun","year":"2022","journal-title":"Front. Nutr."},{"issue":"6","key":"10.1016\/j.ijbiomac.2026.154358_bb0055","doi-asserted-by":"crossref","DOI":"10.3390\/polym17060719","article-title":"Selenium-enriched polysaccharides from Lentinula edodes mycelium: biosynthesis, chemical characterisation, and assessment of antioxidant properties","volume":"17","author":"Malinowska","year":"2025","journal-title":"Polymers"},{"key":"10.1016\/j.ijbiomac.2026.154358_bb0060","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.ijbiomac.2020.12.070","article-title":"A water-soluble selenium-enriched polysaccharide produced by Pleurotus ostreatus: purification, characterization, antioxidant and antitumor activities in vitro","volume":"168","author":"Zhang","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2026.154358_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2021.110913","article-title":"Characterization, antioxidant, antineoplastic and immune activities of selenium modified Sagittaria sagittifolia L. polysaccharides","volume":"153","author":"Feng","year":"2022","journal-title":"Food Res. Int."},{"issue":"8","key":"10.1016\/j.ijbiomac.2026.154358_bb0070","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27082591","article-title":"The main structural unit elucidation and immunomodulatory activity in vitro of a selenium-enriched polysaccharide produced by Pleurotus ostreatus","volume":"27","author":"Wang","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.ijbiomac.2026.154358_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2020.127287","article-title":"Selenium biofortification in Hericium erinaceus (lion\u2019s mane mushroom) and its in vitro bioaccessibility","volume":"331","author":"Hu","year":"2020","journal-title":"Food Chem."},{"issue":"8","key":"10.1016\/j.ijbiomac.2026.154358_bb0080","doi-asserted-by":"crossref","DOI":"10.3390\/foods10081860","article-title":"Influence of selenium biofortification on the growth and bioactive metabolites of Ganoderma lucidum","volume":"10","author":"Xu","year":"2021","journal-title":"Foods"},{"key":"10.1016\/j.ijbiomac.2026.154358_bb0085","doi-asserted-by":"crossref","first-page":"236","DOI":"10.5941\/MYCO.2012.40.4.236","article-title":"Anticancer and Immunopotentiating activities of crude polysaccharides from Pleurotus nebrodensis on mouse sarcoma 180","volume":"40","author":"Cha","year":"2012","journal-title":"Mycobiology"},{"key":"10.1016\/j.ijbiomac.2026.154358_bb0090","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1039\/C6FO00027D","article-title":"Pleurotus nebrodensis polysaccharide (PN50G) evokes A549 cell apoptosis by the ROS\/AMPK\/PI3K\/AKT\/mTOR pathway to suppress tumor growth","volume":"7","author":"Cui","year":"2016","journal-title":"Food Funct."},{"key":"10.1016\/j.ijbiomac.2026.154358_bb0095","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1039\/C5FO00884K","article-title":"Polysaccharide from Pleurotus nebrodensis induces apoptosis via a mitochondrial pathway in HepG2 cells","volume":"7","author":"Cui","year":"2016","journal-title":"Food Funct."},{"key":"10.1016\/j.ijbiomac.2026.154358_bb0100","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1016\/j.ijbiomac.2020.10.071","article-title":"Polysaccharide from Pleurotus nebrodensis: physicochemical, structural characterization and in vitro fermentation characteristics","volume":"165","author":"Gao","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2026.154358_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.136434","article-title":"Liquid culture of Pleurotus nebrodensis mycelium with high yield and extraction and anti-fatigue activity of its polysaccharides","volume":"281","author":"Zeng","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2026.154358_bb0110","series-title":"The National Food Safety Standard-Determination of Selenium in Foods (GB 5009.93\u20132017)","author":"The State Food and Drug Administration of the People\u2019\u2019s Republic of China","year":"2016"},{"key":"10.1016\/j.ijbiomac.2026.154358_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2020.127895","article-title":"Investigations on the anti-aging activity of polysaccharides from Chinese yam and their regulation on klotho gene expression in mice","volume":"1208","author":"Wang","year":"2020","journal-title":"J. Mol. Struct."},{"issue":"8","key":"10.1016\/j.ijbiomac.2026.154358_bb0120","doi-asserted-by":"crossref","DOI":"10.3390\/app11083717","article-title":"Selenium-containing polysaccharides-structural diversity, biosynthesis, chemical modifications and biological activity","volume":"11","author":"Gorska","year":"2021","journal-title":"Appl. Sci."},{"issue":"6","key":"10.1016\/j.ijbiomac.2026.154358_bb0125","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.tibtech.2015.03.004","article-title":"Selenium biomineralization for biotechnological applications","volume":"33","author":"Nancharaiah","year":"2015","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.ijbiomac.2026.154358_bb0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2017\/4915185","article-title":"Lignin-carbohydrate complexes based spherical biocarriers: preparation, characterization, and biocompatibility","volume":"2017","author":"Zhao","year":"2017","journal-title":"Int. J. Polym. Sci."},{"key":"10.1016\/j.ijbiomac.2026.154358_bb0135","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.carbpol.2018.06.057","article-title":"Selenized polysaccharides-biosynthesis and structural analysis","volume":"198","author":"Malinowska","year":"2018","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2026.154358_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2025.143715","article-title":"Effects of steaming on the selenium form, structure, and bioavailability of selenopolysaccharides from Chlamys nobilis","volume":"478","author":"Yang","year":"2025","journal-title":"Food Chem."},{"key":"10.1016\/j.ijbiomac.2026.154358_bb0145","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.ijbiomac.2021.12.005","article-title":"Modulation of bovine serum albumin aggregation by glutathione functionalized MoS2 quantum dots","volume":"195","author":"Zeng","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"issue":"1","key":"10.1016\/j.ijbiomac.2026.154358_bb0150","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1002\/ep.10609","article-title":"XPS analysis of sorption of selenium (IV) and selenium (VI) to mackinawite (FeS)","volume":"32","author":"Han","year":"2013","journal-title":"Environ. Prog. Sustain. Energ."},{"key":"10.1016\/j.ijbiomac.2026.154358_bb0155","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1007\/s11694-023-02295-8","article-title":"Response surface methodology optimization extraction of polysaccharide from Tricholoma lobayense and its biological activities","volume":"18","author":"Moorthy","year":"2024","journal-title":"J. Food Meas. Charact."},{"key":"10.1016\/j.ijbiomac.2026.154358_bb0160","doi-asserted-by":"crossref","first-page":"2934","DOI":"10.1016\/j.ijbiomac.2020.10.168","article-title":"Physicochemical characterization and antitumor activity in vitro of a selenium polysaccharide from Pleurotus ostreatus","volume":"165","author":"Zhang","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2026.154358_bb0165","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.ijbiomac.2022.01.101","article-title":"A natural selenium polysaccharide from Pleurotus ostreatus: structural elucidation, anti-gastric cancer and anti-colon cancer activity in vitro","volume":"201","author":"Zhang","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2026.154358_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.crfs.2025.101207","article-title":"Bioactive properties of selenium-enriched polysaccharides extracted from Pleurotus ostreatus using ultrasonic-assisted extraction","volume":"11","author":"Warnasooriyaa","year":"2025","journal-title":"Curr. Res. Food Sci."},{"key":"10.1016\/j.ijbiomac.2026.154358_bb0175","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1016\/S0140-6736(20)32381-3","article-title":"Breast cancer","volume":"397","author":"Loibl","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.ijbiomac.2026.154358_bb0180","doi-asserted-by":"crossref","DOI":"10.1098\/rsob.210120","article-title":"The intrinsically disorderly story of Ki-67","volume":"11","author":"Remnant","year":"2021","journal-title":"Open Biol."},{"issue":"22","key":"10.1016\/j.ijbiomac.2026.154358_bb0185","doi-asserted-by":"crossref","DOI":"10.3390\/cancers15225383","article-title":"Cytokine profile in lung cancer patients: anti-tumor and oncogenic cytokines","volume":"15","author":"Essogmo","year":"2023","journal-title":"Cancers"},{"issue":"19","key":"10.1016\/j.ijbiomac.2026.154358_bb0190","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27196613","article-title":"Selenium: an antioxidant with a critical role in anti-aging","volume":"27","author":"Bj\u00f8rklund","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.ijbiomac.2026.154358_bb0195","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.ijbiomac.2020.04.063","article-title":"Saffron carotenoids change the superoxide dismutase activity in breast cancer: in vitro, in vivo and in silico studies","volume":"158","author":"Hashemi","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2026.154358_bb0200","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1016\/j.ijbiomac.2022.04.146","article-title":"Selenium-containing polysaccharides isolated from Rosa laevigata Michx fruits exhibit excellent anti-oxidant and neuroprotective activity in vitro","volume":"209","author":"Liu","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2026.154358_bb0205","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s12929-022-00859-2","article-title":"Mitochondrial oxidative stress in the tumor microenvironment and cancer immunoescape: foe or friend?","volume":"29","author":"Kuo","year":"2022","journal-title":"Biomed. Sci."},{"issue":"20","key":"10.1016\/j.ijbiomac.2026.154358_bb0210","doi-asserted-by":"crossref","first-page":"11600","DOI":"10.1093\/nar\/gkac948","article-title":"PARP1 proximity proteomics reveals interaction partners at stressed replication forks","volume":"50","author":"Mosler","year":"2022","journal-title":"Nucleic Acids Res."},{"issue":"4","key":"10.1016\/j.ijbiomac.2026.154358_bb0215","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-020-2476-2","article-title":"Chemotherapy-induced pyroptosis is mediated by BAK\/BAXcaspase-3-GSDME pathway and inhibited by 2-bromopalmitate","volume":"11","author":"Hu","year":"2020","journal-title":"Cell Death Dis."},{"issue":"5","key":"10.1016\/j.ijbiomac.2026.154358_bb0220","doi-asserted-by":"crossref","DOI":"10.3390\/cancers16050872","article-title":"Proguanil suppresses breast tumor growth in vitro and in vivo by inducing apoptosis via mitochondrial dysfunction","volume":"16","author":"Gupta","year":"2024","journal-title":"Cancers"}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813026043047?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813026043047?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T14:20:25Z","timestamp":1794493225000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0141813026043047"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":44,"alternative-id":["S0141813026043047"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2026.154358","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mycelial biotransformation of selenium-enriched polysaccharides from Pleurotus nebrodensis suppress breast cancer via mitochondrial apoptosis and immune microenvironment remodeling","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2026.154358","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"154358"}}