{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T18:23:23Z","timestamp":1794594203367,"version":"4.9.1"},"reference-count":156,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2026MS1325"],"award-info":[{"award-number":["ZR2026MS1325"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2025QB29"],"award-info":[{"award-number":["ZR2025QB29"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82200440"],"award-info":[{"award-number":["82200440"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22378218"],"award-info":[{"award-number":["22378218"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016106","name":"Science and Technology Bureau of Zhenjiang","doi-asserted-by":"publisher","award":["SH2025080"],"award-info":[{"award-number":["SH2025080"]}],"id":[{"id":"10.13039\/501100016106","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.ijbiomac.2026.154647","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T15:17:24Z","timestamp":1790608644000},"page":"154647","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P2","title":["Microfluidic-engineered hyaluronic acid multifunctional materials: From precision microstructure fabricating to programmable biomedical functions"],"prefix":"10.1016","volume":"383","author":[{"given":"Fenglan","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senpeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiyuan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangqing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wentao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingming","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6982","key":"10.1016\/j.ijbiomac.2026.154647_bb0005","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/nature02388","article-title":"Designing materials for biology and medicine","volume":"428","author":"Langer","year":"2004","journal-title":"NATURE"},{"issue":"18","key":"10.1016\/j.ijbiomac.2026.154647_bb0010","doi-asserted-by":"crossref","first-page":"11238","DOI":"10.1021\/acs.chemrev.0c01200","article-title":"Fabrication of biomedical scaffolds using biodegradable polymers","volume":"121","author":"Kirillova","year":"2021","journal-title":"Chem. Rev."},{"key":"10.1016\/j.ijbiomac.2026.154647_bb0015","first-page":"257","article-title":"Current status of nano-embedded growth factors and stem cells delivery to bone for targeted repair and regeneration","volume":"50","author":"Liang","year":"2025","journal-title":"J. Orthop. Transl."},{"issue":"31","key":"10.1016\/j.ijbiomac.2026.154647_bb0020","doi-asserted-by":"crossref","first-page":"8829","DOI":"10.1016\/j.biomaterials.2014.07.006","article-title":"Dual growth factor delivery from bilayered, biodegradable hydrogel composites for spatially-guided osteochondral tissue repair","volume":"35","author":"Lu","year":"2014","journal-title":"Biomaterials"},{"issue":"8","key":"10.1016\/j.ijbiomac.2026.154647_bb0025","doi-asserted-by":"crossref","first-page":"3951","DOI":"10.1016\/j.apsb.2025.05.039","article-title":"Engineering strategies of sequential drug delivery systems for combination tumor immunotherapy","volume":"15","author":"Xu","year":"2025","journal-title":"Acta Pharm. Sin. B"},{"issue":"1","key":"10.1016\/j.ijbiomac.2026.154647_bb0030","doi-asserted-by":"crossref","DOI":"10.1186\/s12943-025-02357-z","article-title":"Precision nanomedicine: navigating the tumor microenvironment for enhanced cancer immunotherapy and targeted drug delivery","volume":"24","author":"Sabit","year":"2025","journal-title":"Mol. Cancer"},{"issue":"31","key":"10.1016\/j.ijbiomac.2026.154647_bb0035","doi-asserted-by":"crossref","first-page":"6685","DOI":"10.2174\/0109298673319981241021063524","article-title":"Stimuli-responsive nano\/biomaterials for smart drug delivery in cardiovascular diseases: promises, challenges and outlooks","volume":"32","author":"Vosoughi","year":"2025","journal-title":"Curr. Med. Chem."},{"issue":"22","key":"10.1016\/j.ijbiomac.2026.154647_bb0040","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232214372","article-title":"Hyaluronic acid in biomedical fields: new trends from chemistry to biomaterial applications","volume":"23","author":"Di Mola","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.ijbiomac.2026.154647_bb0045","doi-asserted-by":"crossref","DOI":"10.3390\/gels11060424","article-title":"Hyaluronic acid: production strategies, gel-forming properties, and advances in drug delivery systems","volume":"11","author":"Grabowski","year":"2025","journal-title":"GELS"},{"issue":"7","key":"10.1016\/j.ijbiomac.2026.154647_bb0050","doi-asserted-by":"crossref","DOI":"10.3390\/polym10070701","article-title":"Hyaluronic acid in the third millennium","volume":"10","author":"Fallacara","year":"2018","journal-title":"Polymers (Basel)"},{"issue":"4","key":"10.1016\/j.ijbiomac.2026.154647_bb0055","doi-asserted-by":"crossref","DOI":"10.1002\/SMMD.20230029","article-title":"Modification and crosslinking strategies for hyaluronic acid-based hydrogel biomaterials","volume":"2","author":"Luo","year":"2023","journal-title":"Smart Med."},{"key":"10.1016\/j.ijbiomac.2026.154647_bb0060","article-title":"Advances in hyaluronic acid-based biomaterials: from chemistry and synthesis to biomedical implementation","volume":"53","author":"Heera","year":"2026","journal-title":"Mater. Today Chem."},{"issue":"1","key":"10.1016\/j.ijbiomac.2026.154647_bb0065","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s10856-025-06946-8","article-title":"Advances in hyaluronic acid-based biomaterials: applications in cancer therapy, wound healing, and disease management","volume":"36","author":"Wang","year":"2025","journal-title":"J. Mater. Sci. Mater. Med."},{"issue":"51","key":"10.1016\/j.ijbiomac.2026.154647_bb0070","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202510355","article-title":"Bacteria-responsive nanostructured drug delivery systems for targeted antimicrobial therapy","volume":"38","author":"Landa","year":"2026","journal-title":"Adv. Mater."},{"key":"10.1016\/j.ijbiomac.2026.154647_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2019.109427","article-title":"Involvement of hyaluronan and CD44 in cancer and viral infections","volume":"65","author":"Heldin","year":"2020","journal-title":"Cell. Signal."},{"key":"10.1016\/j.ijbiomac.2026.154647_bb0080","article-title":"Hyaluronic acid as a versatile building block for the development of biofunctional hydrogels: in vitro models and preclinical innovations","volume":"31","author":"Petit","year":"2025","journal-title":"Mater. Today Bio"},{"issue":"1","key":"10.1016\/j.ijbiomac.2026.154647_bb0085","doi-asserted-by":"crossref","DOI":"10.1186\/s12938-025-01498-y","article-title":"Advances in 3D bioprinting for medical application: opportunities and challenges","volume":"25","author":"Kazemi","year":"2025","journal-title":"Biomed. Eng. Online"},{"issue":"12","key":"10.1016\/j.ijbiomac.2026.154647_bb0090","doi-asserted-by":"crossref","DOI":"10.1002\/mame.202500274","article-title":"Microfluidic synthesis of hyaluronic acid microgels in a coaxial flow reactor","volume":"310","author":"Li","year":"2025","journal-title":"Macromol. Mater. Eng."},{"key":"10.1016\/j.ijbiomac.2026.154647_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2021.120465","article-title":"Recent advances in microfluidic-aided chitosan-based multifunctional materials for biomedical applications","volume":"600","author":"Gao","year":"2021","journal-title":"Int. J. Pharm."},{"issue":"1","key":"10.1016\/j.ijbiomac.2026.154647_bb0100","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/jssc.201600905","article-title":"Fluid manipulation on the micro-scale: basics of fluid behavior in microfluidics","volume":"40","author":"Novotny","year":"2017","journal-title":"J. Sep. Sci."},{"issue":"46","key":"10.1016\/j.ijbiomac.2026.154647_bb0105","doi-asserted-by":"crossref","first-page":"27560","DOI":"10.1039\/D0RA04566G","article-title":"Droplet microfluidics: fundamentals and its advanced applications","volume":"10","author":"Sohrabi","year":"2020","journal-title":"RSC Adv."},{"key":"10.1016\/j.ijbiomac.2026.154647_bb0110","article-title":"Innovative advances in droplet microfluidics","volume":"8","author":"Zhang","year":"2025","journal-title":"Research (Wash D C)"},{"issue":"2","key":"10.1016\/j.ijbiomac.2026.154647_bb0115","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s12551-025-01363-1","article-title":"Capillary microfluidics aided single-cell manipulation for optical detection of bacterial pathogens","volume":"18","author":"Pandey","year":"2026","journal-title":"Biophys. Rev."},{"issue":"1","key":"10.1016\/j.ijbiomac.2026.154647_bb0120","doi-asserted-by":"crossref","DOI":"10.3390\/mi14010223","article-title":"Monodisperse micro-droplet generation in microfluidic channel with asymmetric cross-sectional shape","volume":"14","author":"Cho","year":"2023","journal-title":"Micromachines"},{"key":"10.1016\/j.ijbiomac.2026.154647_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2024.124551","article-title":"Droplet-based microfluidics for drug delivery applications","volume":"663","author":"Fan","year":"2024","journal-title":"Int. J. Pharm."},{"issue":"8","key":"10.1016\/j.ijbiomac.2026.154647_bb0130","doi-asserted-by":"crossref","DOI":"10.3390\/mi16080926","article-title":"Cell partitioning design for microfluidic ATPS devices: a dynamic energy strategy and calculation using chondrocytes and model microparticles","volume":"16","author":"Garibaldi","year":"2025","journal-title":"Micromachines"},{"key":"10.1016\/j.ijbiomac.2026.154647_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmbbm.2024.106696","article-title":"Tuning viscoelasticity and stiffness in bioprinted hydrogels for enhanced 3D cell culture: a multi-scale mechanical analysis","volume":"159","author":"Pragnere","year":"2024","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"10.1016\/j.ijbiomac.2026.154647_bb0140","doi-asserted-by":"crossref","first-page":"15063","DOI":"10.2147\/IJN.S560798","article-title":"Bond-centric modifications of hyaluronic acid: synthesis, processing, and biomedical applications","volume":"20","author":"Yang","year":"2025","journal-title":"Int. J. Nanomedicine"},{"issue":"10","key":"10.1016\/j.ijbiomac.2026.154647_bb0145","article-title":"Hydrogel microspheres as versatile platforms for biomedical research: design, properties, and applications","volume":"6","author":"Yang","year":"2025","journal-title":"MedComm (2020)"},{"issue":"22","key":"10.1016\/j.ijbiomac.2026.154647_bb0150","doi-asserted-by":"crossref","first-page":"16839","DOI":"10.1021\/acs.chemrev.1c00798","article-title":"Microfluidic formulation of topological hydrogels for microtissue engineering","volume":"122","author":"Rojek","year":"2022","journal-title":"Chem. Rev."},{"issue":"1","key":"10.1016\/j.ijbiomac.2026.154647_bb0155","doi-asserted-by":"crossref","DOI":"10.1002\/smsc.202500453","article-title":"Hydrogel microspheres for biomedical applications","volume":"6","author":"Huang","year":"2026","journal-title":"Small Sci"},{"key":"10.1016\/j.ijbiomac.2026.154647_bb0160","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.actbio.2025.10.017","article-title":"Microfluidic engineering of microgels: fabrication methods, structural design, assembly strategies, and biomedical applications","volume":"207","author":"Sun","year":"2025","journal-title":"Acta Biomater."},{"issue":"1","key":"10.1016\/j.ijbiomac.2026.154647_bb0165","first-page":"3","article-title":"Microfluidics: a review","volume":"51","author":"Pecar","year":"2021","journal-title":"Inform. Midem"},{"issue":"5","key":"10.1016\/j.ijbiomac.2026.154647_bb0170","doi-asserted-by":"crossref","DOI":"10.1039\/D3LC00729D","article-title":"Development and future of droplet microfluidics","volume":"24","author":"Nan","year":"2024","journal-title":"Lab Chip"},{"issue":"15","key":"10.1016\/j.ijbiomac.2026.154647_bb0175","doi-asserted-by":"crossref","first-page":"3258","DOI":"10.1039\/D1TB00045D","article-title":"Flow-assembled chitosan membranes in microfluidics: recent advances and applications","volume":"9","author":"Ly","year":"2021","journal-title":"J. Mater. Chem. B"},{"issue":"5721","key":"10.1016\/j.ijbiomac.2026.154647_bb0180","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1126\/science.1109164","article-title":"Monodisperse double emulsions generated from a microcapillary device","volume":"308","author":"Utada","year":"2005","journal-title":"SCIENCE"},{"issue":"6","key":"10.1016\/j.ijbiomac.2026.154647_bb0185","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1109\/TBCAS.2024.3491594","article-title":"Integrated real-time CMOS luminescence sensing and impedance spectroscopy in droplet microfluidics","volume":"18","author":"Liu","year":"2024","journal-title":"IEEE Trans. Biomed. Circuits Syst."},{"issue":"7","key":"10.1016\/j.ijbiomac.2026.154647_bb0190","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1021\/ar010110q","article-title":"Poly(dimethylsiloxane) as a material for fabricating microfluidic devices","volume":"35","author":"McDonald","year":"2002","journal-title":"Acc. Chem. Res."},{"issue":"14","key":"10.1016\/j.ijbiomac.2026.154647_bb0195","doi-asserted-by":"crossref","first-page":"12663","DOI":"10.1039\/D5RA08490C","article-title":"A review of commercial and laboratory-based microfluidic devices based on glass and\/or silicon substrates","volume":"16","author":"Deb","year":"2026","journal-title":"RSC Adv."},{"issue":"12","key":"10.1016\/j.ijbiomac.2026.154647_bb0200","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1039\/b612140c","article-title":"PDMS absorption of small molecules and consequences in microfluidic applications","volume":"6","author":"Toepke","year":"2006","journal-title":"Lab Chip"},{"issue":"1","key":"10.1016\/j.ijbiomac.2026.154647_bb0205","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-97111-2","article-title":"Sorption and release of small molecules in PDMS and COC for organs on chip","volume":"15","author":"Grindulis","year":"2025","journal-title":"Sci. Rep."},{"issue":"11","key":"10.1016\/j.ijbiomac.2026.154647_bb0210","doi-asserted-by":"crossref","first-page":"17530","DOI":"10.1021\/acsami.4c21854","article-title":"Silica glass-based droplet generation microfluidic chips enabled by femtosecond laser: simulation analysis, controllable fabrication, and performance evaluation","volume":"17","author":"Liao","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"10","key":"10.1016\/j.ijbiomac.2026.154647_bb0215","doi-asserted-by":"crossref","first-page":"6497","DOI":"10.1111\/jace.19961","article-title":"Eco-friendly glass wet etching for MEMS application: a review","volume":"107","author":"Choi","year":"2024","journal-title":"J. Am. Ceram. Soc."},{"issue":"11","key":"10.1016\/j.ijbiomac.2026.154647_bb0220","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1038\/s41596-018-0051-4","article-title":"Design of capillary microfluidics for spinning cell-laden microfibers","volume":"13","author":"Yu","year":"2018","journal-title":"Nat. Protoc."},{"issue":"1","key":"10.1016\/j.ijbiomac.2026.154647_bb0225","doi-asserted-by":"crossref","DOI":"10.1002\/SMMD.20220012","article-title":"Bacterial infection microenvironment-responsive porous microspheres by microfluidics for promoting anti-infective therapy","volume":"1","author":"Gao","year":"2022","journal-title":"Smart Med."},{"issue":"3","key":"10.1016\/j.ijbiomac.2026.154647_bb0230","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1039\/b510841a","article-title":"Formation of droplets and bubbles in a microfluidic T-junction - scaling and mechanism of break-up","volume":"6","author":"Garstecki","year":"2006","journal-title":"Lab Chip"},{"issue":"3","key":"10.1016\/j.ijbiomac.2026.154647_bb0235","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1063\/1.1537519","article-title":"Formation of dispersions using \u201cflow focusing\u201d in microchannels","volume":"82","author":"Anna","year":"2003","journal-title":"Appl. Phys. Lett."},{"issue":"2","key":"10.1016\/j.ijbiomac.2026.154647_bb0240","doi-asserted-by":"crossref","DOI":"10.1088\/1758-5090\/ac5e12","article-title":"Heterogeneous spheroids with tunable interior morphologies by droplet-based microfluidics","volume":"14","author":"Zhan","year":"2022","journal-title":"Biofabrication"},{"issue":"15","key":"10.1016\/j.ijbiomac.2026.154647_bb0245","doi-asserted-by":"crossref","first-page":"6632","DOI":"10.1021\/acs.iecr.4c00337","article-title":"Microfluidic fabrication of monodisperse hyaluronic acid microspheres with excellent biocompatibility and tunable physicochemical properties","volume":"63","author":"Long","year":"2024","journal-title":"Ind. Eng. Chem. Res."},{"key":"10.1016\/j.ijbiomac.2026.154647_bb0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijmultiphaseflow.2025.105459","article-title":"Shear-thinning effects on dripping-to-jetting transition and droplet size regulation in a microchannel","volume":"194","author":"Zhang","year":"2026","journal-title":"Int. J. Multiphase Flow"},{"key":"10.1016\/j.ijbiomac.2026.154647_bb0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.fuel.2020.119229","article-title":"Emulsification in a microfluidic flow-focusing device: effect of the dispersed phase viscosity","volume":"283","author":"Liu","year":"2021","journal-title":"Fuel"},{"issue":"8","key":"10.1016\/j.ijbiomac.2026.154647_bb0260","doi-asserted-by":"crossref","DOI":"10.3390\/polym12081760","article-title":"Microfluidic fabrication of click chemistry-mediated hyaluronic acid microgels: a bottom-up material guide to tailor a Microgel\u2019s physicochemical and mechanical properties","volume":"12","author":"Heida","year":"2020","journal-title":"POLYMERS"},{"key":"10.1016\/j.ijbiomac.2026.154647_bb0265","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.jcis.2022.02.065","article-title":"Fabrication of pH-degradable supramacromolecular microgels with tunable size and shape via droplet-based microfluidics","volume":"617","author":"Jung","year":"2022","journal-title":"J. Colloid Interface Sci."},{"issue":"8","key":"10.1016\/j.ijbiomac.2026.154647_bb0270","doi-asserted-by":"crossref","first-page":"6012","DOI":"10.1021\/acsapm.3c00710","article-title":"Photocrosslinked gelatin Methacryloyl (GelMA)\/hyaluronic acid Methacryloyl (HAMA) composite scaffold using Anthocyanidin as a Photoinitiator for bone tissue regeneration","volume":"5","author":"Lin","year":"2023","journal-title":"ACS Appl. Polym. Mater."},{"issue":"14","key":"10.1016\/j.ijbiomac.2026.154647_bb0275","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202304386","article-title":"Deterministic single-cell encapsulation in PEG Norbornene microgels for promoting anti-inflammatory response and therapeutic delivery of mesenchymal stromal cells","volume":"13","author":"Si","year":"2024","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.ijbiomac.2026.154647_bb0280","article-title":"Development of chitosan\/hyaluronic acid hydrogel scaffolds via enzymatic reaction for cartilage tissue engineering","volume":"30","author":"Davachi","year":"2022","journal-title":"Mater. Today Commun."},{"issue":"17","key":"10.1016\/j.ijbiomac.2026.154647_bb0285","doi-asserted-by":"crossref","DOI":"10.3390\/polym16172470","article-title":"Coaxial bioprinting of enzymatically Crosslinkable hyaluronic acid-tyramine bioinks for tissue regeneration","volume":"16","author":"Banigo","year":"2024","journal-title":"POLYMERS"},{"key":"10.1016\/j.ijbiomac.2026.154647_bb0290","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.124484","article-title":"Comprehensive review on biosynthesis of hyaluronic acid with different molecular weights and its biomedical applications","volume":"240","author":"Jabbari","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"issue":"8","key":"10.1016\/j.ijbiomac.2026.154647_bb0295","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.ejcb.2006.05.009","article-title":"Hyaluronan fragments: An information-rich system","volume":"85","author":"Stern","year":"2006","journal-title":"Eur. J. Cell Biol."},{"key":"10.1016\/j.ijbiomac.2026.154647_bb0300","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2024.122145","article-title":"Chemical modification of hyaluronic acid as a strategy for the development of advanced drug delivery systems","volume":"337","author":"Bokatyi","year":"2024","journal-title":"Carbohydr. Polym."},{"issue":"18","key":"10.1016\/j.ijbiomac.2026.154647_bb0305","doi-asserted-by":"crossref","DOI":"10.3390\/ijms231810518","article-title":"The rheology and physicochemical characteristics of hyaluronic acid fillers: their clinical implications","volume":"23","author":"Fundaro","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.ijbiomac.2026.154647_bb0310","doi-asserted-by":"crossref","DOI":"10.3390\/mi14030563","article-title":"Viscoelastic particle encapsulation using a hyaluronic acid solution in a T-junction microfluidic device","volume":"14","author":"Jeyasountharan","year":"2023","journal-title":"MICROMACHINES"},{"issue":"Pt 4","key":"10.1016\/j.ijbiomac.2026.154647_bb0315","article-title":"Antibacterial properties of photo-crosslinked chitosan\/methacrylated hyaluronic acid nanoparticles loaded with bacitracin","volume":"277","author":"Goncalves","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2026.154647_bb0320","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.colsurfb.2019.01.035","article-title":"Nano polydopamine crosslinked thiol-functionalized hyaluronic acid hydrogel for angiogenic drug delivery","volume":"177","author":"Yegappan","year":"2019","journal-title":"Colloids Surf. B Biointerfaces"},{"issue":"2","key":"10.1016\/j.ijbiomac.2026.154647_bb0325","doi-asserted-by":"crossref","DOI":"10.1007\/s10404-020-02413-8","article-title":"Production of hydrogel microparticles in microfluidic devices: a review","volume":"25","author":"Moreira","year":"2021","journal-title":"Microfluid. Nanofluid."},{"key":"10.1016\/j.ijbiomac.2026.154647_bb0330","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.142486","article-title":"Hyaluronic acid-functionalized nanomedicines for CD44-receptors-mediated targeted cancer therapy: a review of selective targetability and biodistribution to tumor microenvironment","volume":"308","author":"Jayoush","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"issue":"34","key":"10.1016\/j.ijbiomac.2026.154647_bb0335","doi-asserted-by":"crossref","first-page":"22780","DOI":"10.1021\/acsnano.4c06888","article-title":"Hybrid nanoparticle-hydrogel Systems for Drug Delivery Depots and Other Biomedical Applications","volume":"18","author":"Choi","year":"2024","journal-title":"ACS Nano"},{"issue":"1","key":"10.1016\/j.ijbiomac.2026.154647_bb0340","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-15206-y","article-title":"Exploiting the role of nanoparticle shape in enhancing hydrogel adhesive and mechanical properties","volume":"11","author":"Arno","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ijbiomac.2026.154647_bb0345","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2023.113416","article-title":"Dual-bioactive molecules loaded aligned core-shell microfibers for tendon tissue engineering","volume":"228","author":"Xuan","year":"2023","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.ijbiomac.2026.154647_bb0350","doi-asserted-by":"crossref","DOI":"10.1016\/j.jddst.2020.101768","article-title":"Preparation of non-spherical vaterite CaCO3 particles by flash nano precipitation technique for targeted and extended drug delivery","volume":"57","author":"Dou","year":"2020","journal-title":"J. Drug Delivery Sci. Technol."},{"issue":"3","key":"10.1016\/j.ijbiomac.2026.154647_bb0355","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1007\/s40242-024-4082-9","article-title":"Multi-functional hollow structures for intelligent drug delivery","volume":"40","author":"Hou","year":"2024","journal-title":"Chem. Res. Chin. Univ."},{"key":"10.1016\/j.ijbiomac.2026.154647_bb0360","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.129685","article-title":"Production of letrozole-loaded alginate oxide-gelatin microgels using microfluidic systems for drug delivery applications","volume":"263","author":"Mehraji","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2026.154647_bb0365","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.jcis.2020.02.095","article-title":"Controllable preparation of monodisperse alginate microcapsules with oil cores","volume":"569","author":"Mou","year":"2020","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.ijbiomac.2026.154647_bb0370","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.actbio.2025.09.007","article-title":"Development of oxidized hyaluronic acid based hydrogels for neuronal tissue engineering: effects of matrix stiffness on primary neurons","volume":"205","author":"Lorke","year":"2025","journal-title":"Acta Biomater."},{"key":"10.1016\/j.ijbiomac.2026.154647_bb0375","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2025.1710978","article-title":"Hydrogels with reversible stiffness modulation: new materials for studying dynamic mechanical cues that regulate cell behavior","volume":"13","author":"Li","year":"2025","journal-title":"Front. Bioeng. Biotechnol."},{"issue":"1","key":"10.1016\/j.ijbiomac.2026.154647_bb0380","article-title":"Generation of precision microstructures based on reconfigurable photoresponsive hydrogels for high-resolution polymer replication and microoptics","volume":"15","author":"Zhu","year":"2024","journal-title":"Nat. Commun."},{"issue":"16","key":"10.1016\/j.ijbiomac.2026.154647_bb0385","doi-asserted-by":"crossref","first-page":"4994","DOI":"10.1039\/D5TB02518D","article-title":"Rational design of microfluidic templated HA-LPEI nanogels for the targeted delivery of doxorubicin","volume":"14","author":"Limiti","year":"2026","journal-title":"J. Mater. Chem. B"},{"issue":"10","key":"10.1016\/j.ijbiomac.2026.154647_bb0390","doi-asserted-by":"crossref","first-page":"9109","DOI":"10.1021\/acsabm.5c01272","article-title":"Hyaluronic acid microgels as sequential drug delivery systems","volume":"8","author":"Maier","year":"2025","journal-title":"ACS Appl. Bio Mater."},{"issue":"2","key":"10.1016\/j.ijbiomac.2026.154647_bb0395","doi-asserted-by":"crossref","DOI":"10.1088\/1758-5090\/acb107","article-title":"One-step generation of core-shell biomimetic microspheres encapsulating double-layer cells using microfluidics for hair regeneration","volume":"15","author":"Huang","year":"2023","journal-title":"Biofabrication"},{"key":"10.1016\/j.ijbiomac.2026.154647_bb0400","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.ijbiomac.2022.11.133","article-title":"Sustain release of loaded insulin within biomimetic hydrogel microsphere for sciatic tissue engineering in vivo","volume":"225","author":"Zolfagharzadeh","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"issue":"46","key":"10.1016\/j.ijbiomac.2026.154647_bb0405","doi-asserted-by":"crossref","first-page":"63295","DOI":"10.1021\/acsami.4c14475","article-title":"pH-responsive modified HAMA microspheres regulate the inflammatory microenvironment of intervertebral discs","volume":"16","author":"Ma","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"12","key":"10.1016\/j.ijbiomac.2026.154647_bb0410","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1002\/jbm.a.37419","article-title":"Hyaluronic acid\/gelatin microcapsule functionalized with carbon nanotube through laccase-catalyzed crosslinking for fabrication of cardiac microtissue","volume":"110","author":"Sharifisistani","year":"2022","journal-title":"J. Biomed. Mater. Res. A"},{"key":"10.1016\/j.ijbiomac.2026.154647_bb0415","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ijbiomac.2021.05.148","article-title":"Preparation of microfluidic-based pectin microparticles loaded carbon dots conjugated with BMP-2 embedded in gelatin-elastin-hyaluronic acid hydrogel scaffold for bone tissue engineering application","volume":"184","author":"Rajabnejadkeleshteri","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2026.154647_bb0420","article-title":"Transplantation of human embryonic stem cell-derived retinal pigment epithelial cells via injectable microfluidic-templated microgels for retinal regeneration","volume":"32","author":"Wei","year":"2025","journal-title":"Mater. Today Bio"},{"issue":"12","key":"10.1016\/j.ijbiomac.2026.154647_bb0425","doi-asserted-by":"crossref","first-page":"9031","DOI":"10.1021\/acsnano.3c12796","article-title":"Microfluidic synthesis of CuH nanoparticles for antitumor therapy through hydrogen-enhanced apoptosis and Cuproptosis","volume":"18","author":"He","year":"2024","journal-title":"ACS Nano"},{"issue":"1","key":"10.1016\/j.ijbiomac.2026.154647_bb0430","doi-asserted-by":"crossref","first-page":"6028","DOI":"10.1038\/s41598-020-63234-x","article-title":"A microfluidic platform to design multimodal PEG - crosslinked hyaluronic acid nanoparticles (PEG-cHANPs) for diagnostic applications","volume":"10","author":"Tammaro","year":"2020","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.ijbiomac.2026.154647_bb0435","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics12030260","article-title":"On-Chip synthesis of hyaluronic acid-based nanoparticles for selective inhibition of CD44+ human mesenchymal stem cell proliferation","volume":"12","author":"Chiesa","year":"2020","journal-title":"Pharmaceutics"},{"issue":"7","key":"10.1016\/j.ijbiomac.2026.154647_bb0440","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1021\/acsbiomaterials.6b00331","article-title":"Microengineered multicomponent hydrogel fibers: combining polyelectrolyte complexation and microfluidics","volume":"3","author":"Costa-Almeida","year":"2017","journal-title":"ACS Biomater. Sci. Eng."},{"issue":"9","key":"10.1016\/j.ijbiomac.2026.154647_bb0445","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1039\/C8BM00647D","article-title":"Multifibrillar bundles of a self-assembling hyaluronic acid derivative obtained through a microfluidic technique for aortic smooth muscle cell orientation and differentiation","volume":"6","author":"Palumbo","year":"2018","journal-title":"Biomater. Sci."},{"issue":"11","key":"10.1016\/j.ijbiomac.2026.154647_bb0450","doi-asserted-by":"crossref","DOI":"10.1002\/mame.201700265","article-title":"Microfluidic fabrication of physically assembled Nanogels and micrometric fibers by using a hyaluronic acid derivative","volume":"302","author":"Agnello","year":"2017","journal-title":"Macromol. Mater. Eng."},{"key":"10.1016\/j.ijbiomac.2026.154647_bb0455","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.ijbiomac.2022.05.080","article-title":"Upregulation of biochemical and biophysical properties of cell-laden microfiber, silk-hyaluronic acid composite","volume":"211","author":"Fatahian","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2026.154647_bb0460","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2024.124700","article-title":"Development of dual drug loaded-hydrogel scaffold combining microfluidics and coaxial 3D-printing for intravitreal implantation","volume":"665","author":"Zingale","year":"2024","journal-title":"Int. J. Pharm."},{"issue":"11","key":"10.1016\/j.ijbiomac.2026.154647_bb0465","article-title":"Amphotericin B ocular films for fungal keratitis and a novel 3D-printed microfluidic ocular Lens infection model","volume":"10","author":"Rapti","year":"2024","journal-title":"J Fungi (Basel)"},{"issue":"8","key":"10.1016\/j.ijbiomac.2026.154647_bb0470","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics17081056","article-title":"Encapsulation of therapeutic, low-molecular-weight chemokines using a single emulsion, microfluidic, continuous manufacturing process","volume":"17","author":"Kobyra","year":"2025","journal-title":"PHARMACEUTICS"},{"issue":"31","key":"10.1016\/j.ijbiomac.2026.154647_bb0475","article-title":"Injectable microfluidic hydrogel microspheres for cell and drug delivery","volume":"31","author":"Zhao","year":"2021","journal-title":"Adv. Funct. Mater."},{"issue":"44","key":"10.1016\/j.ijbiomac.2026.154647_bb0480","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202206261","article-title":"Injectable amphipathic Artesunate prodrug-hydrogel microsphere as gene\/drug Nano-Microplex for rheumatoid arthritis therapy","volume":"32","author":"Li","year":"2022","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.ijbiomac.2026.154647_bb0485","article-title":"Microfluidic-engineering Prussian blue hydrogel microspheres for enhanced osteoarthritis antioxidant therapy","volume":"176","author":"Peng","year":"2025","journal-title":"Biomater. Adv."},{"issue":"2","key":"10.1016\/j.ijbiomac.2026.154647_bb0490","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1002\/jbm.a.35930","article-title":"Anti-Fas conjugated hyaluronic acid microsphere gels for neural stem cell delivery","volume":"105","author":"Shendi","year":"2017","journal-title":"J. Biomed. Mater. Res. A"},{"issue":"1","key":"10.1016\/j.ijbiomac.2026.154647_bb0495","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1039\/D0RA08607J","article-title":"Microfluidics for core-shell drug carrier particles - a review","volume":"11","author":"Kashani","year":"2021","journal-title":"RSC Adv."},{"issue":"16","key":"10.1016\/j.ijbiomac.2026.154647_bb0500","doi-asserted-by":"crossref","DOI":"10.1002\/app.43107","article-title":"Production of hyaluronic-acid-based cell-enclosing microparticles and microcapsules via enzymatic reaction using a microfluidic system","volume":"133","author":"Khanmohammadi","year":"2015","journal-title":"J. Appl. Polym. Sci."},{"key":"10.1016\/j.ijbiomac.2026.154647_bb0505","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.matlet.2016.07.014","article-title":"Microfluidic production of hyaluronic acid derivative microfibers to control drug release","volume":"182","author":"Agnello","year":"2016","journal-title":"Mater. Lett."},{"issue":"13","key":"10.1016\/j.ijbiomac.2026.154647_bb0510","doi-asserted-by":"crossref","first-page":"15653","DOI":"10.1021\/acsami.2c01295","article-title":"Assembling microgels via dynamic cross-linking reaction improves printability, microporosity, tissue-adhesion, and self-healing of microgel bioink for extrusion bioprinting","volume":"14","author":"Feng","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"Pt 2","key":"10.1016\/j.ijbiomac.2026.154647_bb0515","article-title":"Biomimetic 3D bioprinted bilayer GelMA scaffolds for the delivery of BMP-2 and VEGF exogenous growth factors to promote vascularized bone regeneration in a calvarial defect model in vivo","volume":"306","author":"Alarcin","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"issue":"4","key":"10.1016\/j.ijbiomac.2026.154647_bb0520","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1002\/adma.201503310","article-title":"Microfluidic bioprinting of heterogeneous 3D tissue constructs using low-viscosity bioink","volume":"28","author":"Colosi","year":"2016","journal-title":"Adv. Mater."},{"issue":"1","key":"10.1016\/j.ijbiomac.2026.154647_bb0525","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1186\/s12951-025-03666-7","article-title":"Natural multi-active nanoparticles integrated biological hydrogel microcarriers for wound healing","volume":"23","author":"Che","year":"2025","journal-title":"J. Nanobiotechnol."},{"issue":"13","key":"10.1016\/j.ijbiomac.2026.154647_bb0530","doi-asserted-by":"crossref","first-page":"4138","DOI":"10.1039\/D4TB02474E","article-title":"A smart drug delivery microgel system with phased intervention capabilities and dual physical state of use promotes healing of diabetic infected wounds","volume":"13","author":"Ma","year":"2025","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.ijbiomac.2026.154647_bb0535","first-page":"159","article-title":"Stem cell niche-inspired microcarriers with ADSCs encapsulation for diabetic wound treatment","volume":"26","author":"Wu","year":"2023","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.ijbiomac.2026.154647_bb0540","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2025.108035","article-title":"Immunomodulatory intraperitoneal chemotherapy with DACHPt-loaded biomaterial nanoparticles in colorectal carcinomatosis","volume":"222","author":"Catania","year":"2025","journal-title":"Pharmacol. Res."},{"issue":"4","key":"10.1016\/j.ijbiomac.2026.154647_bb0545","doi-asserted-by":"crossref","first-page":"3929","DOI":"10.1021\/acsami.7b15832","article-title":"Tailor-making fluorescent hyaluronic acid microgels via combining microfluidics and Photoclick chemistry for sustained and localized delivery of Herceptin in tumors","volume":"10","author":"Chen","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.ijbiomac.2026.154647_bb0550","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2025.114686","article-title":"Hydrogel microspheres based on aggregation induction to improve the solubility of insoluble drugs promoting bone repair","volume":"253","author":"Shang","year":"2025","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.ijbiomac.2026.154647_bb0555","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.114049","article-title":"Ultrasound-responsive piezoelectric analgesic microspheres alleviate osteoarthritis pain","volume":"385","author":"Li","year":"2025","journal-title":"J. Control. Release"},{"issue":"6","key":"10.1016\/j.ijbiomac.2026.154647_bb0560","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202303068","article-title":"Microfluidic encapsulation of exosomes derived from lipopolysaccharide-treated mesenchymal stem cells in hyaluronic acid methacryloyl to restore ovarian function in mice","volume":"13","author":"Li","year":"2024","journal-title":"Adv. Healthc. Mater."},{"issue":"Pt 3","key":"10.1016\/j.ijbiomac.2026.154647_bb0565","article-title":"Effectiveness of the injectable hyaluronic acid-based microparticles loaded with cannabidiol on rat sciatic nerve injury model","volume":"283","author":"Davachi","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"50","key":"10.1016\/j.ijbiomac.2026.154647_bb0570","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.201906690","article-title":"Injection and self-assembly of bioinspired stem cell-laden gelatin\/hyaluronic acid hybrid microgels promote cartilage repair in vivo","volume":"29","author":"Feng","year":"2019","journal-title":"Adv. Funct. Mater."},{"issue":"1","key":"10.1016\/j.ijbiomac.2026.154647_bb0575","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.ijpharm.2017.09.053","article-title":"Enhanced cell viability in hyaluronic acid coated poly(lactic-co-glycolic acid) porous scaffolds within microfluidic channels","volume":"532","author":"Zamboni","year":"2017","journal-title":"Int. J. Pharm."},{"issue":"12","key":"10.1016\/j.ijbiomac.2026.154647_bb0580","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.201800122","article-title":"Hydrophobic patterning-based 3D microfluidic cell culture assay","volume":"7","author":"Han","year":"2018","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.ijbiomac.2026.154647_bb0585","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.139133","article-title":"A review on multifunctional calcium alginate fibers for full-time and multipurposed wound treatment: from fundamentals to advanced applications","volume":"290","author":"Xu","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"issue":"43","key":"10.1016\/j.ijbiomac.2026.154647_bb0590","doi-asserted-by":"crossref","first-page":"48426","DOI":"10.1021\/acsami.2c13420","article-title":"All-aqueous microfluidics fabrication of multifunctional bioactive microcapsules promotes wound healing","volume":"14","author":"Gao","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.ijbiomac.2026.154647_bb0595","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2026.148705","article-title":"Hyaluronic acid-based control\/target delivery system: formation, control release and applications","volume":"510","author":"Luo","year":"2026","journal-title":"Food Chem."},{"issue":"1","key":"10.1016\/j.ijbiomac.2026.154647_bb0600","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1080\/13880209.2025.2511807","article-title":"Hyaluronic acid-engineered milk extracellular vesicles to target triple negative breast cancer through CD44","volume":"63","author":"Soares","year":"2025","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.ijbiomac.2026.154647_bb0605","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ejps.2019.02.022","article-title":"PEGylated hyaluronidase\/NIR induced drug controlled release system for synergetic chemo-photothermal therapy of hepatocellular carcinoma","volume":"133","author":"Li","year":"2019","journal-title":"Eur. J. Pharm. Sci."},{"issue":"29","key":"10.1016\/j.ijbiomac.2026.154647_bb0610","doi-asserted-by":"crossref","first-page":"41852","DOI":"10.1021\/acsami.5c10456","article-title":"Microfluidic fabrication of hyaluronic acid-cysteine-modified chitosan microspheres for CD44-targeted probiotic delivery in colitis treatment","volume":"17","author":"Qiao","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"12","key":"10.1016\/j.ijbiomac.2026.154647_bb0615","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.201702009","article-title":"A dual-layered microfluidic system for Long-term controlled in situ delivery of multiple anti-inflammatory factors for chronic neural applications","volume":"28","author":"Frey","year":"2018","journal-title":"Adv. Funct. Mater."},{"issue":"37","key":"10.1016\/j.ijbiomac.2026.154647_bb0620","article-title":"Supramolecular lubricating hydrogel microspheres reshape damaged matrix regeneration","volume":"12","author":"Yuan","year":"2025","journal-title":"Adv Sci (Weinh)"},{"key":"10.1016\/j.ijbiomac.2026.154647_bb0625","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2025.123195","article-title":"Cascade targeting selenium nanoparticles-loaded hydrogel microspheres for multifaceted antioxidant defense in osteoarthritis","volume":"318","author":"Liu","year":"2025","journal-title":"Biomaterials"},{"key":"10.1016\/j.ijbiomac.2026.154647_bb0630","first-page":"597","article-title":"Developing fibrin-based biomaterials\/scaffolds in tissue engineering","volume":"40","author":"Li","year":"2024","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.ijbiomac.2026.154647_bb0635","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2019.119536","article-title":"Progress in 3D bioprinting technology for tissue\/organ regenerative engineering","volume":"226","author":"Matai","year":"2020","journal-title":"BIOMATERIALS"},{"key":"10.1016\/j.ijbiomac.2026.154647_bb0640","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.actbio.2017.07.028","article-title":"Manufacturing of hydrogel biomaterials with controlled mechanical properties for tissue engineering applications","volume":"62","author":"Vedadghavami","year":"2017","journal-title":"Acta Biomater."},{"issue":"33","key":"10.1016\/j.ijbiomac.2026.154647_bb0645","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202102219","article-title":"Bioinspired 3D culture in nanoliter hyaluronic acid-rich core-shell hydrogel microcapsules isolates highly pluripotent human iPSCs","volume":"17","author":"Xu","year":"2021","journal-title":"Small"},{"key":"10.1016\/j.ijbiomac.2026.154647_bb0650","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.actbio.2020.02.015","article-title":"Probing prodrug metabolism and reciprocal toxicity with an integrated and humanized multi-tissue organ-on-a-chip platform","volume":"106","author":"Rajan","year":"2020","journal-title":"Acta Biomater."},{"issue":"6","key":"10.1016\/j.ijbiomac.2026.154647_bb0655","doi-asserted-by":"crossref","DOI":"10.4028\/b-XDTcg5","article-title":"Biomimetic vascularized iPSC-hepatocyte spheroids for liver regeneration","volume":"12","author":"Wang","year":"2025","journal-title":"Adv Sci (Weinh)"},{"key":"10.1016\/j.ijbiomac.2026.154647_bb0660","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.132454","article-title":"The bioengineering application of hyaluronic acid in tissue regeneration and repair","volume":"270","author":"Chang","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"10","key":"10.1016\/j.ijbiomac.2026.154647_bb0665","doi-asserted-by":"crossref","DOI":"10.1002\/pat.70388","article-title":"Hyaluronidase-loaded Hyaluronated liposomes for time-dependent structural destabilization and programmed drug release","volume":"36","author":"Kim","year":"2025","journal-title":"Polym. Adv. Technol."},{"key":"10.1016\/j.ijbiomac.2026.154647_bb0670","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2025.165827","article-title":"Recent advances in bacterial hyaluronidase-responsive nano-drug delivery systems for targeting antibiotic-resistant Staphylococcus aureus","volume":"520","author":"Konwar","year":"2025","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.ijbiomac.2026.154647_bb0675","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.123438","article-title":"Synthesis and evaluation of alginate, gelatin, and hyaluronic acid hybrid hydrogels for tissue engineering applications","volume":"233","author":"Serafin","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"issue":"39","key":"10.1016\/j.ijbiomac.2026.154647_bb0680","doi-asserted-by":"crossref","first-page":"13932","DOI":"10.1021\/acs.langmuir.3c01478","article-title":"Optimizing the production of hydrogel microspheres using microfluidic chips: the influence of surface treatment on droplet formation mechanism","volume":"39","author":"Zhang","year":"2023","journal-title":"Langmuir"},{"issue":"1","key":"10.1016\/j.ijbiomac.2026.154647_bb0685","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1039\/C9CS00466A","article-title":"Emerging aqueous two-phase systems: from fundamentals of interfaces to biomedical applications","volume":"49","author":"Chao","year":"2020","journal-title":"Chem. Soc. Rev."},{"issue":"6","key":"10.1016\/j.ijbiomac.2026.154647_bb0690","article-title":"Critical quality attributes of lipid nanoparticles and in vivo fate","volume":"20","author":"Di","year":"2025","journal-title":"Asian J. Pharm. Sci."},{"key":"10.1016\/j.ijbiomac.2026.154647_bb0695","doi-asserted-by":"crossref","first-page":"6895","DOI":"10.2147\/IJN.S465959","article-title":"In vivo fate of targeted drug delivery carriers","volume":"19","author":"Zhao","year":"2024","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.ijbiomac.2026.154647_bb0700","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.partic.2022.10.010","article-title":"High-throughput generation of uniform droplets from parallel microchannel droplet generators and the preparation of polystyrene microsphere material","volume":"77","author":"Zhang","year":"2023","journal-title":"Particuology"},{"issue":"3","key":"10.1016\/j.ijbiomac.2026.154647_bb0705","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202309718","article-title":"Micro-patterning wettability in very large scale microfluidic integrated chips for double emulsion generation","volume":"34","author":"Wu","year":"2024","journal-title":"Adv. Funct. Mater."},{"issue":"2","key":"10.1016\/j.ijbiomac.2026.154647_bb0710","doi-asserted-by":"crossref","DOI":"10.1007\/s10404-025-02869-6","article-title":"Numerical simulation and validation of stretchable inertial microfluidics for tunable particle focusing and separation","volume":"30","author":"Tavasoli","year":"2026","journal-title":"Microfluid. Nanofluid."},{"issue":"25","key":"10.1016\/j.ijbiomac.2026.154647_bb0715","doi-asserted-by":"crossref","first-page":"7166","DOI":"10.1021\/acs.langmuir.5b01514","article-title":"Membrane-integrated glass capillary device for preparing small-sized water-in-oil-in-water emulsion droplets","volume":"31","author":"Akamatsu","year":"2015","journal-title":"LANGMUIR"},{"issue":"23","key":"10.1016\/j.ijbiomac.2026.154647_bb0720","doi-asserted-by":"crossref","first-page":"12070","DOI":"10.1021\/acs.analchem.5c00076","article-title":"Modular centrifugal microfluidics for sample preparation","volume":"97","author":"Gholizadeh","year":"2025","journal-title":"Anal. Chem."},{"key":"10.1016\/j.ijbiomac.2026.154647_bb0725","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfa.2025.137466","article-title":"High-flexibility droplet generation via centrifugal capillary array platforms with machine learning-driven dimensional precision","volume":"724","author":"Zhao","year":"2025","journal-title":"Colloids Surf. A Physicochem. Eng. Asp."},{"issue":"6","key":"10.1016\/j.ijbiomac.2026.154647_bb0730","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/s41551-024-01315-2","article-title":"Microfluidic technologies for enhancing the potency, predictability and affordability of adoptive cell therapies","volume":"9","author":"Wang","year":"2025","journal-title":"Nat. Biomed. Eng."},{"issue":"4","key":"10.1016\/j.ijbiomac.2026.154647_bb0735","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1039\/D4LC00872C","article-title":"Advancing microfluidic design with machine learning: a Bayesian optimization approach","volume":"25","author":"Kundacina","year":"2025","journal-title":"Lab Chip"},{"issue":"7","key":"10.1016\/j.ijbiomac.2026.154647_bb0740","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1039\/D4LC00089G","article-title":"Recent developments and future perspectives of microfluidics and smart technologies in wearable devices","volume":"24","author":"Apoorva","year":"2024","journal-title":"Lab Chip"},{"issue":"1","key":"10.1016\/j.ijbiomac.2026.154647_bb0745","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10426914.2018.1512115","article-title":"Optimization of photochemical machining process parameters for manufacturing microfluidic channel","volume":"34","author":"Agrawal","year":"2019","journal-title":"Mater. Manuf. Process."},{"key":"10.1016\/j.ijbiomac.2026.154647_bb0750","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2024.343533","article-title":"A new platform of electrowetting-on-dielectric digital microfluidics for rapid detection of early-stage hepatocellular carcinoma(HCC) specific biomarker","volume":"1336","author":"Zhu","year":"2025","journal-title":"Anal. Chim. Acta"},{"issue":"15","key":"10.1016\/j.ijbiomac.2026.154647_bb0755","doi-asserted-by":"crossref","DOI":"10.3390\/ma15155457","article-title":"Additive manufacturing of biomaterials-design principles and their implementation","volume":"15","author":"Mirzaali","year":"2022","journal-title":"MATERIALS"},{"issue":"2","key":"10.1016\/j.ijbiomac.2026.154647_bb0760","doi-asserted-by":"crossref","DOI":"10.1088\/0256-307X\/42\/2\/027403","article-title":"AI-driven inverse design of materials: past, present, and future","volume":"42","author":"Han","year":"2025","journal-title":"Chin. Phys. Lett."},{"issue":"12","key":"10.1016\/j.ijbiomac.2026.154647_bb0765","doi-asserted-by":"crossref","first-page":"H41","DOI":"10.1002\/adma.201003963","article-title":"Hyaluronic acid hydrogels for biomedical applications","volume":"23","author":"Burdick","year":"2011","journal-title":"Adv. Mater."},{"issue":"5","key":"10.1016\/j.ijbiomac.2026.154647_bb0770","doi-asserted-by":"crossref","DOI":"10.3390\/jfb16050166","article-title":"Emerging trends in microfluidic biomaterials: from functional design to applications","volume":"16","author":"Lin","year":"2025","journal-title":"J. Funct. Biomater."},{"issue":"3","key":"10.1016\/j.ijbiomac.2026.154647_bb0775","first-page":"78","article-title":"Hyaluronic acid in inflammation and tissue regeneration","volume":"28","author":"Litwiniuk","year":"2016","journal-title":"Wounds"},{"issue":"30","key":"10.1016\/j.ijbiomac.2026.154647_bb0780","doi-asserted-by":"crossref","first-page":"38832","DOI":"10.1021\/acsami.4c07665","article-title":"AI-powered microfluidics: shaping the future of phenotypic drug discovery","volume":"16","author":"Liu","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813026045964?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813026045964?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T17:48:39Z","timestamp":1794592119000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0141813026045964"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":156,"alternative-id":["S0141813026045964"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2026.154647","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Microfluidic-engineered hyaluronic acid multifunctional materials: From precision microstructure fabricating to programmable biomedical functions","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2026.154647","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"154647"}}