{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T13:28:34Z","timestamp":1793971714230,"version":"4.8.0"},"reference-count":70,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.ijbiomac.2026.155016","type":"journal-article","created":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:04:18Z","timestamp":1792796658000},"page":"155016","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Structural characterization and structure-activity relationship of polysaccharides from Curcuma kwangsiensis extracted sequentially: Anti-Alzheimer's activity in an AlCl3-induced zebrafish model"],"prefix":"10.1016","volume":"386","author":[{"given":"Xiling","family":"Fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manjiao","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruoxi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaen","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzhong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijbiomac.2026.155016_bb0005","doi-asserted-by":"crossref","first-page":"3905","DOI":"10.3390\/ijms26083905","article-title":"Recent advances in drug development for Alzheimer\u2019s disease: a comprehensive review","volume":"26","author":"Xing","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ijbiomac.2026.155016_bb0010","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.ijbiomac.2021.02.016","article-title":"Structural characterization of a polysaccharide from Lycium barbarum and its neuroprotective effect against \u03b2-amyloid peptide neurotoxicity","volume":"176","author":"Wu","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2026.155016_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2023.121033","article-title":"Neuroprotection of low-molecular-weight galactan obtained from Cantharellus cibarius Fr. against Alzheimer\u2019s disease","volume":"316","author":"Zhou","year":"2023","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2026.155016_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.132372","article-title":"Pseudostellaria heterophylla polysaccharide mitigates Alzheimer's-like pathology via regulating the microbiota-gut-brain axis in 5\u00d7FAD mice","volume":"270","author":"He","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2026.155016_bb0025","first-page":"1232","article-title":"Reshaping the gut microbiota: a novel oppinion of Eucommiae cortex polysaccharide alleviate learning and memory impairments in Alzheimer\u2019s disease","author":"Zhao","year":"2025","journal-title":"J. Adv. Res."},{"issue":"2024","key":"10.1016\/j.ijbiomac.2026.155016_bb0030","first-page":"1671","article-title":"China Alzheimer Report","volume":"23","author":"Wang","year":"2024","journal-title":"J. Diag. Concep. Prac."},{"issue":"1","key":"10.1016\/j.ijbiomac.2026.155016_bb0035","article-title":"Recent advances in Alzheimer\u2019s disease: mechanisms, clinical trials and new drug development strategies","volume":"9","author":"Zhang","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.ijbiomac.2026.155016_bb0040","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.biopsych.2013.07.031","article-title":"Progress update: fluid and imaging biomarkers in Alzheimer\u2019s disease","volume":"75","author":"Sutphen","year":"2014","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.ijbiomac.2026.155016_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2026.158102","article-title":"Modified Kai-Xin-san ameliorates cognitive impairment in Alzheimer\u2019s disease model mice by regulating neuroinflammation and synaptic dysfunction","volume":"155","author":"Liu","year":"2026","journal-title":"Phytomedicine"},{"key":"10.1016\/j.ijbiomac.2026.155016_bb0050","article-title":"Unveiling the molecular mechanisms of Danggui-Shaoyao-san against Alzheimer\u2019s disease in APP\/PS1 mice via integrating proteomic and metabolomic approaches","volume":"16","author":"Wu","year":"2024","journal-title":"Alzheimer\u2019s Res. Ther."},{"key":"10.1016\/j.ijbiomac.2026.155016_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.157375","article-title":"Zexieyin formula attenuates Alzheimer\u2019s disease via suppressing A1 astrocyte activation: a serum pharmacochemistry and network pharmacology study","volume":"148","author":"Zhou","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.ijbiomac.2026.155016_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.tifs.2024.104677","article-title":"The multiple benefits of bioactive polysaccharides: from the gut to overall health","volume":"152","author":"Huang","year":"2024","journal-title":"Trends Food Sci. Technol."},{"key":"10.1016\/j.ijbiomac.2026.155016_bb0065","doi-asserted-by":"crossref","first-page":"2683","DOI":"10.1016\/j.ijbiomac.2020.10.173","article-title":"Recent advances in plant polysaccharide-mediated nano drug delivery systems","volume":"165","author":"Zheng","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2026.155016_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.tifs.2024.104678","article-title":"Advances in natural polysaccharides in Alzheimer\u2019s disease and Parkinson\u2019s disease: insights from the brain-gut axis","volume":"153","author":"Feng","year":"2024","journal-title":"Trends Food Sci. Technol."},{"key":"10.1016\/j.ijbiomac.2026.155016_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.147375","article-title":"Transcriptomics and metabolomics revealed the effects of Polygonatum Rhizoma polysaccharide on delaying C. elegans senescence and ameliorating Alzheimer\u2019s disease","volume":"327","author":"Liu","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2026.155016_bb0080","doi-asserted-by":"crossref","DOI":"10.1002\/fsn3.71623","article-title":"Astragalus polysaccharides can effectively alleviate cognitive impairment in mice with Alzheimer's disease by regulating the gut microbiota","volume":"14","author":"Wang","year":"2026","journal-title":"Food Sci. Nutr."},{"key":"10.1016\/j.ijbiomac.2026.155016_bb0085","doi-asserted-by":"crossref","first-page":"10316","DOI":"10.1021\/acs.jafc.5c01042","article-title":"Poria cocos polysaccharide reshapes gut microbiota to regulate short-chain fatty acids and alleviate neuroinflammation-related cognitive impairment in Alzheimer\u2019s disease","volume":"73","author":"Song","year":"2025","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ijbiomac.2026.155016_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.jare.2025.04.025","article-title":"Reshaping the gut microbiota: a novel opinion of Eucommiae cortex polysaccharide alleviate learning and memory impairments in Alzheimer\u2019s disease","volume":"80","author":"Zhao","year":"2026","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.ijbiomac.2026.155016_bb0095","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s13024-023-00700-w","article-title":"Sodium oligomannate alters gut microbiota, reduces cerebral amyloidosis and reactive microglia in a sex-specific manner","volume":"19","author":"Bosch","year":"2024","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.ijbiomac.2026.155016_bb0100","article-title":"Polysaccharides: potential bioactive macromolecules for Alzheimer's disease","volume":"10","author":"Guo","year":"2023","journal-title":"Front. Nutr."},{"key":"10.1016\/j.ijbiomac.2026.155016_bb0105","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/s41422-019-0216-x","article-title":"Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer\u2019s disease progression","volume":"29","author":"Wang","year":"2019","journal-title":"Cell Res."},{"key":"10.1016\/j.ijbiomac.2026.155016_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.140683","article-title":"Chitooligosaccharide ameliorates cognitive deficits and neuroinflammation in APP\/PS1 mice associated with the regulation of Nrf2\/NF-\u03baB axis","volume":"303","author":"Cai","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2026.155016_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2026.150340","article-title":"Lentinan attenuates tau phosphorylation and memory deficits in hTau-overexpressing mice","volume":"1885","author":"Li","year":"2026","journal-title":"Brain Res."},{"key":"10.1016\/j.ijbiomac.2026.155016_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2026.158585","article-title":"Natural polysaccharides as multi-target therapeutic candidates for Alzheimer\u2019s disease: mechanisms, structure-activity relationships, and translational perspectives","volume":"159","author":"Luo","year":"2026","journal-title":"Phytomedicine"},{"key":"10.1016\/j.ijbiomac.2026.155016_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.131425","article-title":"Chondroitin sulphate modified MoS2 nanoenzyme with multifunctional activities for treatment of Alzheimer's disease","volume":"266","author":"Tian","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2026.155016_bb0130","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1229963","article-title":"Sources, morphology, phytochemistry, pharmacology of Curcumae Longae Rhizoma, Curcumae Radix, and Curcumae Rhizoma: a review of the literature","volume":"14","author":"Zhu","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ijbiomac.2026.155016_bb0135","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1093\/jpp\/rgab126","article-title":"Curcumae Radix: a review of its botany, traditional uses, phytochemistry, pharmacology and toxicology","volume":"74","author":"Ao","year":"2022","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.ijbiomac.2026.155016_bb0140","doi-asserted-by":"crossref","first-page":"2933","DOI":"10.1007\/s11357-024-01092-5","article-title":"Longevity and anti-aging effects of curcumin supplementation","volume":"46","author":"Izadi","year":"2024","journal-title":"Geroscience"},{"key":"10.1016\/j.ijbiomac.2026.155016_bb0145","doi-asserted-by":"crossref","DOI":"10.1002\/bmc.5514","article-title":"A highly sensitive method (supercritical fluid chromatography coupled with ion mobility mass spectrometry) for determination of multiple compounds in radix curcumae","volume":"37","author":"Ye","year":"2023","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.ijbiomac.2026.155016_bb0150","doi-asserted-by":"crossref","DOI":"10.3390\/biom14040387","article-title":"Research progress on sesquiterpenoids of Curcumae Rhizoma and their pharmacological effects","volume":"14","author":"Cui","year":"2024","journal-title":"Biomolecules"},{"key":"10.1016\/j.ijbiomac.2026.155016_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156482","article-title":"Curcuma wenyujin extract alleviates cognitive deficits and restrains pyroptosis through PINK1\/Parkin mediated autophagy in Alzheimer\u2019s disease","volume":"139","author":"Qi","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.ijbiomac.2026.155016_bb0160","first-page":"4166","article-title":"Structural characterization and in vitro antioxidant activity of polysaccharides from Curcuma kwangsiensis","volume":"45","author":"Guan","year":"2023","journal-title":"Chin. Tradit. Pat. Med."},{"key":"10.1016\/j.ijbiomac.2026.155016_bb0165","series-title":"Anticoagulant effect and mechanism of polysaccharides from Curcuma kwangsiensis","author":"Yu","year":"2018"},{"key":"10.1016\/j.ijbiomac.2026.155016_bb0170","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.carbpol.2019.05.020","article-title":"Physicochemical properties and functional bioactivities of different bonding state polysaccharides extracted from tomato fruit","volume":"219","author":"Li","year":"2019","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2026.155016_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.147223","article-title":"Physicochemical, functional and antioxidant properties of four polysaccharides sequentially extracted from jute (Corchorus olitorius L.) leaves","volume":"323","author":"Tang","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2026.155016_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.147979","article-title":"Comparative analysis of simulated in vitro digestion, fermentation characteristics, and antioxidant capacity of bitter melon polysaccharides extracted by hot water and alkaline methods","volume":"330","author":"Zhu","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2026.155016_bb0185","first-page":"1125","article-title":"Optimization of extraction and purification technology of polysaccharides having fibrinolytic activities from Curcuma kwangsiensis","volume":"25","author":"Pan","year":"2014","journal-title":"Lishizhen. Med. Mater. Med. Res."},{"key":"10.1016\/j.ijbiomac.2026.155016_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodhyd.2021.107462","article-title":"Structure and fermentation characteristics of five polysaccharides sequentially extracted from sugar beet pulp by different methods","volume":"126","author":"Yu","year":"2022","journal-title":"Food Hydrocoll."},{"key":"10.1016\/j.ijbiomac.2026.155016_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.130459","article-title":"A comparison study on polysaccharides extracted from banana flower using different methods: physicochemical characterization, and antioxidant and antihyperglycemic activities","volume":"264","author":"Tang","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2026.155016_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2024.140493","article-title":"A novel polysaccharide from blueberry leaves: extraction, structural characterization, hypolipidemic and hypoglycaemic potentials","volume":"460","author":"Hu","year":"2024","journal-title":"Food Chem."},{"key":"10.1016\/j.ijbiomac.2026.155016_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2019.115077","article-title":"Structural elucidation of a novel pectin-polysaccharide from the petal of Saussurea laniceps and the mechanism of its anti-HBV activity","volume":"223","author":"Chen","year":"2019","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2026.155016_bb0210","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2022.901953","article-title":"Eucommia ulmoides olive male flower extracts ameliorate Alzheimer\u2019s disease-like pathology in zebrafish via regulating autophagy, acetylcholinesterase, and the dopamine transporter","volume":"15","author":"Sun","year":"2022","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.ijbiomac.2026.155016_bb0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105754","article-title":"Aducanumab for Alzheimer\u2019s disease: a regulatory perspective","volume":"171","author":"Nistic\u00f2","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ijbiomac.2026.155016_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.fochx.2023.100621","article-title":"Sequential extraction, structural characterization, and antioxidant activity of polysaccharides from Lycium barbarum brandisii bamboo shoot shell","volume":"17","author":"Peng","year":"2023","journal-title":"Food Chem. X"},{"key":"10.1016\/j.ijbiomac.2026.155016_bb0225","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.foodhyd.2017.10.004","article-title":"Sequential extraction and physicochemical characterization of polysaccharides from chicory (Cichorium intybus) root pulp","volume":"77","author":"Guo","year":"2018","journal-title":"Food Hydrocoll."},{"issue":"Pt 1","key":"10.1016\/j.ijbiomac.2026.155016_bb0230","article-title":"Role of particle size and co-extraction dynamics in the sequential recovery of phenolics, starch, and proteins from potato peel by-products","volume":"221","author":"Milanezzi","year":"2025","journal-title":"Food Res. Int."},{"key":"10.1016\/j.ijbiomac.2026.155016_bb0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.129234","article-title":"Effects of different extraction methods on the physico-chemical characteristics and biological activities of polysaccharides from Clitocybe squamulosa","volume":"259","author":"Geng","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2026.155016_bb0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2023.113006","article-title":"Structural characterization of polysaccharide fractions in areca (Areca catechu L.) inflorescence and study of its immunological enhancement activity in vitro and in vivo","volume":"171","author":"Chen","year":"2023","journal-title":"Food Res. Int."},{"key":"10.1016\/j.ijbiomac.2026.155016_bb0245","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.ijbiomac.2022.02.112","article-title":"Structural changes, and anti-inflammatory, anti-cancer potential of polysaccharides from multiple processing of Rehmannia glutinosa","volume":"206","author":"Lu","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2026.155016_bb0250","doi-asserted-by":"crossref","DOI":"10.1111\/1750-3841.70340","article-title":"Chemical characteristics and bioactivities of chestnut flower polysaccharides: insights into the impact of extraction methods","volume":"90","author":"Sun","year":"2025","journal-title":"J. Food Sci."},{"key":"10.1016\/j.ijbiomac.2026.155016_bb0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2025.123937","article-title":"Zexie Tang polysaccharides (ZXTPs) alleviate high-fat diet-induced NAFL in mice through improving intestinal microbiota imbalance and liver metabolic dysfunction","volume":"367","author":"Zhang","year":"2025","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2026.155016_bb0260","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.carbpol.2014.09.070","article-title":"Effect of extraction methods on property and bioactivity of water-soluble polysaccharides from Amomum villosum","volume":"117","author":"Yan","year":"2025","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2026.155016_bb0265","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.carbpol.2019.01.037","article-title":"Characterization of polysaccharide fractions from fruit of Actinidia arguta and assessment of their antioxidant and antiglycated activities","volume":"210","author":"Zhu","year":"2015","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2026.155016_bb0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2025.116474","article-title":"Differences in structure, antioxidant capacity and gut microbiota modulation of red raspberry pectic polysaccharides extracted by different methods","volume":"211","author":"Luo","year":"2025","journal-title":"Food Res. Int."},{"key":"10.1016\/j.ijbiomac.2026.155016_bb0275","series-title":"Characterization, antioxidant, antineoplastic and immune activities of selenium modified Sagittaria sagittifolia L. polysaccharides","volume":"153","author":"Feng","year":"2022"},{"key":"10.1016\/j.ijbiomac.2026.155016_bb0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2024.121831","article-title":"An arabinose-rich heteropolysaccharide isolated from Belamcanda chinensis (L.) DC treats liver cancer by targeting FAK and activating CD40","volume":"331","author":"Zhao","year":"2024","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2026.155016_bb0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2025.117511","article-title":"Effects of different processing (Paozhi) methods on the structural characteristics and bidirectional immunomodulatory activities of Astragalus polysaccharides","volume":"221","author":"Zhao","year":"2025","journal-title":"Food Res. Int."},{"key":"10.1016\/j.ijbiomac.2026.155016_bb0290","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.foodhyd.2019.06.002","article-title":"The effect of ultrasound irradiation on the physicochemical properties and \u03b1-glucosidase inhibitory effect of blackberry fruit polysaccharide","volume":"96","author":"Dou","year":"2019","journal-title":"Food Hydrocoll."},{"key":"10.1016\/j.ijbiomac.2026.155016_bb0295","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodhyd.2022.108254","article-title":"Mechanism of high-moisture extruded protein fibrous structure formation based on the interactions among pea protein, amylopectin, and stearic acid","volume":"136","author":"Chen","year":"2023","journal-title":"Food Hydrocoll."},{"key":"10.1016\/j.ijbiomac.2026.155016_bb0300","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2021.129608","article-title":"Effects of enzymatic hydrolysis on the structural, rheological, and functional properties of mulberry leaf polysaccharide","volume":"355","author":"Hu","year":"2021","journal-title":"Food Chem."},{"key":"10.1016\/j.ijbiomac.2026.155016_bb0305","doi-asserted-by":"crossref","DOI":"10.1016\/j.lwt.2022.113687","article-title":"Characterization of polysaccharide fractions from Allii macrostemonis bulbus and assessment of their antioxidant","volume":"165","author":"Guo","year":"2022","journal-title":"LWT-Food Sci. Technol."},{"key":"10.1016\/j.ijbiomac.2026.155016_bb0310","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.143969","article-title":"Effect of various extraction methods on the physicochemical properties, antioxidant, and anti-inflammatory activities of mung bean (Vigna radiata L.) skin polysaccharides","volume":"311","author":"Ding","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2026.155016_bb0315","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.157602","article-title":"Yangxue Qingnao Wan ameliorates cognitive impairment in scopolamine-induced AD mice via modulating neuropeptide signaling pathways and suppressing neuroinflammation","volume":"150","author":"Zhang","year":"2026","journal-title":"Phytomedicine"},{"key":"10.1016\/j.ijbiomac.2026.155016_bb0320","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1093\/procel\/pwae026","article-title":"Alzheimer\u2019s disease: insights into pathology, molecular mechanisms, and therapy","volume":"16","author":"Zheng","year":"2025","journal-title":"Protein Cell"},{"key":"10.1016\/j.ijbiomac.2026.155016_bb0325","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.145427","article-title":"Qingke \u03b2-glucan and Lactobacillus mitigate neuroinflammation and enhance cognitive function in an Alzheimer\u2019s disease mouse model","volume":"319","author":"Wu","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2026.155016_bb0330","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.156229","article-title":"Gastrodin reduces a\u03b2 brain levels in an Alzheimer\u2019s disease mouse model by inhibiting P-glycoprotein ubiquitination","volume":"135","author":"Zhu","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.ijbiomac.2026.155016_bb0335","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2025.147461","article-title":"Antioxidant activity and emulsifying properties of Dendrobium officinale polysaccharides with distinct structural characteristics","volume":"501","author":"Zhao","year":"2026","journal-title":"Food Chem."},{"key":"10.1016\/j.ijbiomac.2026.155016_bb0340","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2025.123222","article-title":"Chemical characteristics and bioactivity potential of polysaccharide extracts and purified fractions from Arctic brown macroalgae","volume":"352","author":"Singh","year":"2025","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2026.155016_bb0345","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2024.122171","article-title":"Glucan polysaccharides isolated from Lactarius hatsudake Tanaka mushroom: structural characterization and in vitro bioactivities","volume":"337","author":"Yang","year":"2024","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2026.155016_bb0350","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2025.123319","article-title":"Structural characterization and chondroprotective activity evaluation of four novel polysaccharides purified from Anoectochilus zhejiangensis on transgenic fluorescent zebrafish","volume":"354","author":"Tao","year":"2025","journal-title":"Carbohydr. Polym."}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813026049688?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813026049688?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T12:50:26Z","timestamp":1793969426000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0141813026049688"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":70,"alternative-id":["S0141813026049688"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2026.155016","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Structural characterization and structure-activity relationship of polysaccharides from Curcuma kwangsiensis extracted sequentially: Anti-Alzheimer's activity in an AlCl3-induced zebrafish model","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2026.155016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"155016"}}