{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:17:32Z","timestamp":1787501852950,"version":"build-2736575974"},"reference-count":36,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2005,4,1]],"date-time":"2005-04-01T00:00:00Z","timestamp":1112313600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2005,4]]},"DOI":"10.1016\/j.ijcard.2004.09.002","type":"journal-article","created":{"date-parts":[[2005,2,21]],"date-time":"2005-02-21T07:18:55Z","timestamp":1108970335000},"page":"267-273","source":"Crossref","is-referenced-by-count":98,"title":["Safety and efficacy of Sildenafil therapy in children with pulmonary hypertension"],"prefix":"10.1016","volume":"100","author":[{"given":"Ageliki A.","family":"Karatza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Bush","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan G.","family":"Magee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijcard.2004.09.002_bib1","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1056\/NEJM199805143382001","article-title":"Oral Sildenafil in the treatment of erectile dysfunction","volume":"338","author":"Goldstein","year":"1998","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijcard.2004.09.002_bib2","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/S0140-6736(98)00015-4","article-title":"Acute myocardial infarction associated with Sildenafil","volume":"352","author":"Feenstra","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.ijcard.2004.09.002_bib3","doi-asserted-by":"crossref","first-page":"967","DOI":"10.2165\/00003495-199957060-00015","article-title":"Sildenafil: a review of its use in erectile dysfunction","volume":"57","author":"Langtry","year":"1999","journal-title":"Drugs"},{"key":"10.1016\/j.ijcard.2004.09.002_bib4","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S0149-2918(98)80103-3","article-title":"Safety and efficacy of Sildenafil citrate in the treatment of male erectile dysfunction","volume":"20","author":"Goldenberg","year":"1998","journal-title":"Clin. Ther."},{"key":"10.1016\/j.ijcard.2004.09.002_bib5","first-page":"L536","article-title":"Identification of PDE isoenzymes in human pulmonary artery and the effect of selective PDE inhibitors","volume":"266","author":"Rabe","year":"1994","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ijcard.2004.09.002_bib6","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1165\/ajrcmb.20.2.3140","article-title":"Identification and function of cyclic nucleotide phosphodiesterase isoenzymes in airway epithelial cells","volume":"20","author":"Fuhrmann","year":"1999","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.ijcard.2004.09.002_bib7","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1161\/hc3601.096826","article-title":"Effect of inhaled iloprost plus oral Sildenafil in patients with primary pulmonary hypertension","volume":"104","author":"Wilkens","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2004.09.002_bib8","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1056\/NEJM200011023431814","article-title":"Sildenafil in primary pulmonary hypertension","volume":"343","author":"Prasad","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijcard.2004.09.002_bib9","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1097\/00000542-199907000-00041","article-title":"Sildenafil ameliorates effects of inhaled nitric oxide withdrawal","volume":"91","author":"Atz","year":"1999","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ijcard.2004.09.002_bib10","doi-asserted-by":"crossref","first-page":"e4","DOI":"10.1136\/heart.84.2.e4","article-title":"Sildenafil a selective pulmonary vasodilator in childhood primary pulmonary hypertension","volume":"84","author":"Abrams","year":"2000","journal-title":"Heart"},{"key":"10.1016\/j.ijcard.2004.09.002_bib11","series-title":"Primary pulmonary hypertension: executive summary from the world symposium\u2014primary pulmonary hypertension (Evian, France. September 6\u201310, 1998)","year":"1998"},{"key":"10.1016\/j.ijcard.2004.09.002_bib12","doi-asserted-by":"crossref","first-page":"13C","DOI":"10.1016\/S0002-9149(99)00043-0","article-title":"Effects of Sildenafil citrate on human hemodynamics","volume":"83","author":"Jackson","year":"1999","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.ijcard.2004.09.002_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1378\/chest.116.1.1","article-title":"Noninvasive estimation of right-sided pressures from spectral Doppler recordings of tricuspid and pulmonic regurgitant velocities","volume":"116","author":"Lavine","year":"1999","journal-title":"Chest"},{"key":"10.1016\/j.ijcard.2004.09.002_bib14","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0378-4347(97)00339-3","article-title":"Development of an assay for the simultaneous determination of Sildenafil (Viagra) and its metabolite (UK-103,320) using automated sequential trace enrichment of dialysates and high performance liquid chromatography","volume":"701","author":"Cooper","year":"1997","journal-title":"J. Chromatogr., B, Biomed. Sci. Appl."},{"issue":"Suppl. 1","key":"10.1016\/j.ijcard.2004.09.002_bib15","doi-asserted-by":"crossref","first-page":"5S","DOI":"10.1046\/j.0306-5251.2001.00027.x","article-title":"Pharmacokinetics of Sildenafil after single oral doses in healthy male subjects: absolute bioavailability, food effects and dose proportionality","volume":"53","author":"Nichols","year":"2002","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.ijcard.2004.09.002_bib16","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1136\/hrt.55.4.385","article-title":"Effect of long term oxygen treatment at home in children with pulmonary vascular disease","volume":"55","author":"Bowyer","year":"1986","journal-title":"Br. Heart J."},{"key":"10.1016\/j.ijcard.2004.09.002_bib17","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1056\/NEJM199207093270203","article-title":"The effect of high doses of calcium-channel blockers on survival in primary pulmonary hypertension","volume":"327","author":"Rich","year":"1992","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijcard.2004.09.002_bib18","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1056\/NEJM199602013340504","article-title":"For the primary pulmonary hypertension study group. A comparison of continuous intravenous epoprostenol (Prostacyclin) with conventional therapy for primary pulmonary hypertension","volume":"334","author":"Barst","year":"1996","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijcard.2004.09.002_bib19","doi-asserted-by":"crossref","first-page":"306","DOI":"10.7326\/0003-4819-139-4-200308190-00025","article-title":"Treatment of severe pulmonary hypertension with inhaled iloprost","volume":"139","author":"Leuchte","year":"2003","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.ijcard.2004.09.002_bib20","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1136\/hrt.80.2.151","article-title":"Long-term intravenous prostaglandin (epoprostenol or iloprost) for treatment of severe pulmonary hypertension","volume":"80","author":"Higenbottam","year":"1998","journal-title":"Heart"},{"key":"10.1016\/j.ijcard.2004.09.002_bib21","unstructured":"McLaughlin VV, Gaine SP, Barst RJ, Oudiz RJ, Bourge RC, Frost A, et al. Efficacy and safety of treprostinil: an epoprostenol analog for primary pulmonary hypertension."},{"key":"10.1016\/j.ijcard.2004.09.002_bib22","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1136\/heart.86.6.661","article-title":"Long term treatment of pulmonary arterial hypertension with beraprost, an oral prostacyclin analogue","volume":"86","author":"Vizza","year":"2001","journal-title":"Heart"},{"key":"10.1016\/j.ijcard.2004.09.002_bib23","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1183\/09031936.03.00008003","article-title":"Bosentan treatment in patients with pulmonary hypertension receiving nonparenteral prostanoids","volume":"22","author":"Hoeper","year":"2003","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.ijcard.2004.09.002_bib24","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1164\/rccm.200307-957OC","article-title":"Sitaxsentan therapy for pulmonary arterial hypertension","volume":"169","author":"Barst","year":"2004","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.ijcard.2004.09.002_bib25","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/S0735-1097(97)00155-1","article-title":"Hemodynamic data and survival in children with pulmonary hypertension","volume":"30","author":"Clabby","year":"1997","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcard.2004.09.002_bib26","first-page":"1189","article-title":"The registry of the international society of heart and lung transplantation: first official pediatric report-1997","volume":"16","author":"Boucek","year":"1997","journal-title":"J. Heart Lung Transplant."},{"key":"10.1016\/j.ijcard.2004.09.002_bib27","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/S0022-3476(96)70067-7","article-title":"A six-minute walk test for assessing exercise tolerance in severely ill children","volume":"129","author":"Nixon","year":"1996","journal-title":"J. Pediatr."},{"key":"10.1016\/j.ijcard.2004.09.002_bib28","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1164\/ajrccm.161.2.9906015","article-title":"Clinical correlates and prognostic significance of six-minute walk test in patients with primary pulmonary hypertension","volume":"161","author":"Miyamoto","year":"2000","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.ijcard.2004.09.002_bib29","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1017\/S1047951102001026","article-title":"Reversal of shunting in pulmonary hypertension after treatment with oral Sildenafil","volume":"12","author":"Karatza","year":"2002","journal-title":"Cardiol. Young"},{"key":"10.1016\/j.ijcard.2004.09.002_bib30","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1161\/01.CIR.95.6.1479","article-title":"For the primary pulmonary hypertension study group. Effects of long-term infusion of prostacyclin (epoprostenol) on echocardiographic measures of right ventricular structure and function in primary pulmonary hypertension","volume":"95","author":"Hinderliter","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2004.09.002_bib31","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1136\/hrt.72.4.384","article-title":"Comparison of Doppler derived haemodynamic variables and simultaneous high fidelity pressure measurements in severe pulmonary hypertension","volume":"72","author":"Brecker","year":"1994","journal-title":"Br. Heart J."},{"key":"10.1016\/j.ijcard.2004.09.002_bib32","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0735-1097(87)80384-4","article-title":"Lung biopsy findings in transposition of the great arteries with ventricular septal defect: potentially reversible pulmonary vascular disease is not always synonymous with operability","volume":"9","author":"Haworth","year":"1987","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcard.2004.09.002_bib33","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1136\/hrt.70.5.461","article-title":"Profile of paediatric patients with pulmonary hypertension judged by responsiveness to vasodilators","volume":"70","author":"Houde","year":"1993","journal-title":"Br. Heart J."},{"key":"10.1016\/j.ijcard.2004.09.002_bib34","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1378\/chest.114.1.334","article-title":"Intrapulmonary shunting in primary pulmonary hypertension. An observation in two patients treated with epoprostenol sodium","volume":"114","author":"Castro","year":"1998","journal-title":"Chest"},{"key":"10.1016\/j.ijcard.2004.09.002_bib35","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1056\/NEJM199701093360207","article-title":"Primary pulmonary hypertension","volume":"336","author":"Rubin","year":"1997","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijcard.2004.09.002_bib36","first-page":"47","article-title":"Sildenafil: an orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction","volume":"8","author":"Boolell","year":"1996","journal-title":"Int. J. Impot. Res."}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527305000161?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527305000161?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T08:51:08Z","timestamp":1548665468000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527305000161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,4]]}},"alternative-id":["S0167527305000161"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2004.09.002","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2005,4]]}}}