{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:34:45Z","timestamp":1791214485511,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2005,10,1]],"date-time":"2005-10-01T00:00:00Z","timestamp":1128124800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2005,10]]},"DOI":"10.1016\/j.ijcard.2004.10.059","type":"journal-article","created":{"date-parts":[[2005,3,22]],"date-time":"2005-03-22T12:34:19Z","timestamp":1111494859000},"page":"298-306","source":"Crossref","is-referenced-by-count":48,"title":["Skeletal muscle fibres synthesis in heart failure: Role of PGC-1\u03b1, calcineurin and GH"],"prefix":"10.1016","volume":"104","author":[{"given":"Giorgio","family":"Vescovo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Ravara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerio","family":"Gobbo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Angelini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano","family":"Dalla Libera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijcard.2004.10.059_bib1","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1136\/hrt.72.2_Suppl.S36","article-title":"Symptoms and quality of life in heart failure. The muscle hypothesis","volume":"72","author":"Coats","year":"1994","journal-title":"Br Heart J"},{"key":"10.1016\/j.ijcard.2004.10.059_bib2","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0167-5273(88)90164-7","article-title":"Abnormalities of skeletal muscle in patients with chronic heart failure","volume":"18","author":"Lipkin","year":"1988","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.ijcard.2004.10.059_bib3","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1161\/01.CIR.85.4.1364","article-title":"Contribution of skeletal muscle atrophy to exercise intolerance and altered muscle metabolism in heart failure","volume":"85","author":"Mancini","year":"1992","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2004.10.059_bib4","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1161\/01.CIR.103.17.2195","article-title":"Beneficial effects on skeletal muscle of the Angiotensin II Type 1 receptor blocker Irbesartan in experimental heart failure","volume":"103","author":"Dalla Libera","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2004.10.059_bib5","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1161\/01.CIR.98.17.1742","article-title":"Improved exercise tolerance after losartan and enalapril in heart failure: correlation with changes in skeletal muscle myosin heavy chain composition","volume":"98","author":"Vescovo","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2004.10.059_bib6","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1006\/jmcc.1998.0807","article-title":"Apoptosis of skeletal muscle myofibers and interstitial cells in experimental heart failure","volume":"30","author":"Vescovo","year":"1998","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.ijcard.2004.10.059_bib7","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1136\/heart.84.4.431","article-title":"Apoptosis in the skeletal muscle of patients with heart failure: investigation of clinical and biochemical changes","volume":"84","author":"Vescovo","year":"2000","journal-title":"Heart"},{"key":"10.1016\/j.ijcard.2004.10.059_bib8","doi-asserted-by":"crossref","first-page":"C802","DOI":"10.1152\/ajpcell.00046.2002","article-title":"L-carnitine: a potential treatment for blocking apoptosis and preventing skeletal muscle myopathy in heart failure","volume":"283","author":"Vescovo","year":"2002","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.ijcard.2004.10.059_bib9","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/(SICI)1520-6408(1996)19:2<95::AID-DVG1>3.0.CO;2-V","article-title":"Molecular control of muscle diversity and plasticity","volume":"19","author":"Buonanno","year":"1996","journal-title":"Dev Genet"},{"key":"10.1016\/j.ijcard.2004.10.059_bib10","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/S0092-8674(00)81410-5","article-title":"A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis","volume":"92","author":"Puigserver","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.ijcard.2004.10.059_bib11","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0092-8674(00)80611-X","article-title":"Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1","volume":"98","author":"Wu","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.ijcard.2004.10.059_bib12","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/nature00904","article-title":"Transcriptional co-activator PGC-1a drives the formation of slow-twitch muscle fibres","volume":"418","author":"Lin","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.ijcard.2004.10.059_bib13","doi-asserted-by":"crossref","first-page":"4545","DOI":"10.1074\/jbc.275.7.4545","article-title":"Stimulation of slow skeletal muscle fibre gene expression by calcineurin in vivo","volume":"275","author":"Naya","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ijcard.2004.10.059_bib14","doi-asserted-by":"crossref","first-page":"6414","DOI":"10.1093\/emboj\/20.22.6414","article-title":"Activation of MEF2 by muscle activity is mediated through a calcineurin-dependent pathway","volume":"20","author":"Wu","year":"2001","journal-title":"EMBO J"},{"key":"10.1016\/j.ijcard.2004.10.059_bib15","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S0092-8674(00)80571-1","article-title":"Generic signals and specific outcomes: signalling through Ca2+, calcineurin and NF-AT","volume":"96","author":"Crabtree","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.ijcard.2004.10.059_bib16","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1146\/annurev.immunol.15.1.707","article-title":"Transcription factors of the NFAT family: regulation and function","volume":"15","author":"Rao","year":"1997","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.ijcard.2004.10.059_bib17","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/23054","article-title":"Skeletal muscle hyperthophy is mediated by a Ca2+-dependent calcineurin signalling pathway","volume":"400","author":"Semsariam","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.ijcard.2004.10.059_bib18","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/23060","article-title":"IGF-1 induces skeletal myocyte hypertrophy through calcineurin in association with GATA-2 and NF-Atc1","volume":"400","author":"Musar\u00f2","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.ijcard.2004.10.059_bib19","doi-asserted-by":"crossref","first-page":"C138","DOI":"10.1152\/ajpcell.00114.2003","article-title":"Beneficial effects of Gh\/IGF-1 on skeletal muscle atrophy and function in experimental heart failure","volume":"286","author":"Dalla Libera","year":"2004","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.ijcard.2004.10.059_bib20","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S0735-1097(01)01385-7","article-title":"Acquired growth hormone resistance in patients with chronic heart failure: implications for therapy with growth hormone","volume":"38","author":"Anker","year":"2001","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ijcard.2004.10.059_bib21","doi-asserted-by":"crossref","first-page":"C982","DOI":"10.1152\/ajpcell.1999.277.5.C982","article-title":"Apoptosis and atrophy in rat slow skeletal muscles in chronic heart failure","volume":"277","author":"Dalla Libera","year":"1999","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.ijcard.2004.10.059_bib22","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1006\/dbio.1993.1074","article-title":"Regional differences in troponin I isoform switching durino rat heart development","volume":"156","author":"Gorza","year":"1993","journal-title":"Dev Biol"},{"key":"10.1016\/j.ijcard.2004.10.059_bib23","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1097\/01.mco.0000134374.24181.5b","article-title":"Muscle wastage in chronic heart failure, between apoptosis, catabolism and altered anabolism: a chimaeric view of inflammation?","volume":"7","author":"Dalla Libera","year":"2004","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"10.1016\/j.ijcard.2004.10.059_bib24","doi-asserted-by":"crossref","first-page":"9213","DOI":"10.1073\/pnas.142166599","article-title":"A protein kinase B-dependent and rapamycin sensitive pathway controls skeletal muscle growth but not fiber type specification","volume":"99","author":"Pallafacchina","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ijcard.2004.10.059_bib25","doi-asserted-by":"crossref","first-page":"2968","DOI":"10.1210\/en.142.7.2968","article-title":"The proliferative and antiapoptotic actions of growth hormone and insulin-like growth factor-1 are mediated through distinct signaling pathways in the Pro-B Ba\/F3 cell line","volume":"142","author":"Baixeras","year":"2001","journal-title":"Endocrinology"},{"key":"10.1016\/j.ijcard.2004.10.059_bib26","doi-asserted-by":"crossref","first-page":"19653","DOI":"10.1074\/jbc.M000430200","article-title":"Calcineurin co-regulates contractile and metabolic components of slow muscle phenotype","volume":"275","author":"Bigard","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ijcard.2004.10.059_bib27","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/j.bbrc.2003.09.020","article-title":"Role of calcineurin in striated muscle : development, adaptation, and disease","volume":"311","author":"Bassel-Dubuy","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.ijcard.2004.10.059_bib28","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1161\/01.RES.0000117088.36577.EB","article-title":"Cardiac-specific induction of the transcriptional coactivator peroxisome proliferators-activated receptor \u03b3 coactivator-1 \u03b1 promotes mitochondrial biogenesis and reversible cardiomyopathy in a developmental stage-dependent manner","volume":"94","author":"Russell","year":"2004","journal-title":"Circ Res"},{"key":"10.1016\/j.ijcard.2004.10.059_bib29","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1096\/fj.02-0367com","article-title":"Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1","volume":"16","author":"Baar","year":"2002","journal-title":"FASEB J"},{"key":"10.1016\/j.ijcard.2004.10.059_bib30","doi-asserted-by":"crossref","first-page":"8466","DOI":"10.1073\/pnas.1032913100","article-title":"Coordinated reduction of genes of oxidative metabolism in humans with insulino resistance and diabetes: Potential role of PGC1 and NRF1","volume":"100","author":"Patti","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ijcard.2004.10.059_bib31","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/84839","article-title":"Localized Igf-1 transgene expression sustains hypertrophy and regeneration in senescent skeletal muscle","volume":"27","author":"Musar\u00f2","year":"2001","journal-title":"Nat Genet"},{"key":"10.1016\/j.ijcard.2004.10.059_bib32","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1073\/pnas.0303792101","article-title":"Stem cell-mediated muscle regeneration is enhanced by local isoform of insulin-like growth factor 1","volume":"101","author":"Musar\u00f2","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ijcard.2004.10.059_bib33","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1113\/jphysiol.2003.045104","article-title":"Depressed mitochondrial transcription factors and oxidative capacity in rat failing cardiac and skeletal muscles","volume":"551.2","author":"Garnier","year":"2003","journal-title":"J Physiol"},{"key":"10.1016\/j.ijcard.2004.10.059_bib34","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1210\/er.2002-0012","article-title":"Peroxisome proliferators-activated receptor-\u03b3 coactivator 1\u03b1 (PGC-1\u03b1): transcriptional coactivator and metabolic regulator","volume":"24","author":"Puigserver","year":"2002","journal-title":"Endocr Rev"},{"key":"10.1016\/j.ijcard.2004.10.059_bib35","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/S0735-1097(02)01736-9","article-title":"Reduction of insulin-like growth factor-1 expression in the skeletal muscle of noncachectic patients with chronic heart failure","volume":"39","author":"Hambrecht","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ijcard.2004.10.059_bib36","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1093\/oxfordjournals.eurheartj.a060425","article-title":"Insulin resistance in chronic heart failure","volume":"1994","author":"Swan","year":"1994","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ijcard.2004.10.059_bib37","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1056\/NEJMp038239","article-title":"Causation of type 2 diabetes\u2014the gordian knot unravels","volume":"350","author":"Taylor","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijcard.2004.10.059_bib38","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1056\/NEJMoa031314","article-title":"Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes","volume":"350","author":"Petersen","year":"2004","journal-title":"N Engl J Med"}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527305001816?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527305001816?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,5]],"date-time":"2019-02-05T00:48:45Z","timestamp":1549327725000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527305001816"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,10]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,10]]}},"alternative-id":["S0167527305001816"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2004.10.059","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2005,10]]}}}