{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T05:07:03Z","timestamp":1792732023241,"version":"4.5.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2005,10,1]],"date-time":"2005-10-01T00:00:00Z","timestamp":1128124800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2005,10]]},"DOI":"10.1016\/j.ijcard.2004.12.021","type":"journal-article","created":{"date-parts":[[2005,3,11]],"date-time":"2005-03-11T16:20:28Z","timestamp":1110558028000},"page":"58-66","source":"Crossref","is-referenced-by-count":56,"title":["Close relationship between the vasodilator response to acetylcholine in the brachial and coronary artery in suspected coronary artery disease"],"prefix":"10.1016","volume":"105","author":[{"given":"Bonpei","family":"Takase","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Hamabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimio","family":"Satomura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takasi","family":"Akima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akimi","family":"Uehata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumitaka","family":"Ohsuzu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Ishihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Kurita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijcard.2004.12.021_bib1","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1161\/01.CIR.101.16.1899","article-title":"Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease","volume":"101","author":"Schachinger","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2004.12.021_bib2","doi-asserted-by":"crossref","first-page":"71B","DOI":"10.1016\/0002-9149(95)80017-M","article-title":"Systemic nature of endothelial dysfunction in atherosclerosis","volume":"75","author":"Anderson","year":"1995","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.ijcard.2004.12.021_bib3","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/S0735-1097(98)00667-6","article-title":"Endothelium-dependent relaxation by acetylcholine is impaired in hypertriglyceridemic humans with normal levels of plasma LDL cholesterol","volume":"33","author":"Lewis","year":"1999","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ijcard.2004.12.021_bib4","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0735-1097(98)00584-1","article-title":"Effect of vitamin E on endothelial vasodilator function in patients with hypercholesterolemia, chronic smoking or both","volume":"33","author":"Heitzer","year":"1999","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ijcard.2004.12.021_bib5","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1016\/S0002-9149(98)00702-4","article-title":"Endothelium-dependent flow-mediated vasodilation in coronary and brachial arteries in suspected coronary artery disease","volume":"82","author":"Takase","year":"1998","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.ijcard.2004.12.021_bib6","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/0735-1097(95)00327-4","article-title":"Close relation of endothelial function in the human coronary and peripheral circulation","volume":"26","author":"Anderson","year":"1995","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ijcard.2004.12.021_bib7","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1161\/01.CIR.99.1.90","article-title":"Attenuation of cyclic nucleotide-mediated smooth muscle relaxation in blacks as a cause of racial differences in vasodilator response","volume":"99","author":"Cardillo","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2004.12.021_bib8","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1177\/1358863X9700200203","article-title":"Noninvasive assessment of endothelium-dependent flow-mediated dilation of the brachial artery","volume":"2","author":"Uehata","year":"1997","journal-title":"Vasc Med"},{"key":"10.1016\/j.ijcard.2004.12.021_bib9","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1161\/circ.98.15.1587\/a","article-title":"Acetylcholine and endothelial function","volume":"98","author":"Tousoulis","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2004.12.021_bib10","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1056\/NEJM198610233151702","article-title":"Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries","volume":"315","author":"Ludmer","year":"1986","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijcard.2004.12.021_bib11","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1161\/01.CIR.81.2.491","article-title":"Coronary vasomotor response to acetylcholine relates to risk factors for coronary artery disease","volume":"81","author":"Vita","year":"1990","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2004.12.021_bib12","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/0735-1097(90)90584-C","article-title":"Large coronary arteries in humans are responsive to changing blood flow: an endothelium-dependent mechanism that fails in patients with atherosclerosis","volume":"16","author":"Nabel","year":"1990","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ijcard.2004.12.021_bib13","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1161\/01.RES.68.4.1027","article-title":"Differential impairment of vasodilator responsiveness of peripherial resistance and conduit vessels in humans with atherosclerosis","volume":"68","author":"Liao","year":"1991","journal-title":"Circ Res"},{"key":"10.1016\/j.ijcard.2004.12.021_bib14","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1161\/01.CIR.83.2.391","article-title":"Modulation of coronary vasomotor tone in humans. Progressive endothelial dysfunction with different early stages of coronary atherosclerosis","volume":"83","author":"Zeiher","year":"1991","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2004.12.021_bib15","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1097\/00005344-199909000-00008","article-title":"Improvement of bradykinin endothelium-mediated vasodilation of forearm resistance circulation by quinaprilat in patients with coronary artery disease with or without left ventricular dysfunction","volume":"34","author":"Benacerraf","year":"1999","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.ijcard.2004.12.021_bib16","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1161\/01.CIR.102.9.1000","article-title":"Elevated C-reactive protein levels and impaired endothelial vasoreactivity in patients with coronary artery disease","volume":"102","author":"Fichtlscherer","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2004.12.021_bib17","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/BF02482298","article-title":"Assessment of endothelium-mediated vasodilation of the peripherial circulation by transcutaneous ultrasonography and venous occlusion plethysmography","volume":"14","author":"Wu","year":"1999","journal-title":"Heart Vessels"},{"key":"10.1016\/j.ijcard.2004.12.021_bib18","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0002-9149(96)90586-X","article-title":"Variable response of the peripheral circulation to acetylcholine in patients with coronary artery disease","volume":"77","author":"Testa","year":"1996","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.ijcard.2004.12.021_bib19","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0167-5273(99)00203-X","article-title":"Endothelial dysfunction associated with left ventricular diastolic dysfunction in patients with coronary heart disease","volume":"72","author":"Ma","year":"2000","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.ijcard.2004.12.021_bib20","doi-asserted-by":"crossref","first-page":"293","DOI":"10.3109\/07853890008995931","article-title":"Testing for endothelial dysfunction","volume":"32","author":"Raitakari","year":"2000","journal-title":"Ann Med"},{"key":"10.1016\/j.ijcard.2004.12.021_bib21","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1161\/01.CIR.90.1.35","article-title":"Selective loss of microvascular endothelial function in human hypercholesterolemmia","volume":"90","author":"Gilligan","year":"1994","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2004.12.021_bib22","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1161\/01.CIR.103.13.1752","article-title":"Role of endothelial nitric oxide in shear stress-induced vasodilation of human microvasculature","volume":"103","author":"Paniagua","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2004.12.021_bib23","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1002\/ajmg.1229","article-title":"Relationship between the G894T polymorphism (Glu298Asp variant) in endothelial nitric oxide synthase and nitric oxide-mediated endothelial function in human atherosclerosis","volume":"100","author":"Guzik","year":"2001","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.ijcard.2004.12.021_bib24","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1097\/00004872-200018120-00010","article-title":"Functional gene testing of the Glu298Asp polymorphism of the endothelial NO synthase","volume":"18","author":"Schneider","year":"2000","journal-title":"J Hypertens"},{"key":"10.1016\/j.ijcard.2004.12.021_bib25","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s004390050785","article-title":"A missense Glu298Asp variant in the endothelial nitric oxide synthase gene is associated with coronary spasm in the Japanese","volume":"103","author":"Yoshimura","year":"1998","journal-title":"Hum Genet"},{"key":"10.1016\/j.ijcard.2004.12.021_bib26","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1161\/01.CIR.103.8.1109","article-title":"Peripheral flow response transient arterial forearm occlusion does not reflect myocardial perfusion reserve","volume":"103","author":"Bottcher","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2004.12.021_bib27","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/S0735-1097(96)00474-3","article-title":"Atherosclerosis in the human brachial artery","volume":"29","author":"Sorensen","year":"1997","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ijcard.2004.12.021_bib28","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0002-9149(00)00857-2","article-title":"Late prognostic value of flow-mediated dilation in the brachial artery of patients with chest pain","volume":"86","author":"Neunteufl","year":"2001","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.ijcard.2004.12.021_bib29","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S1071-3581(05)80003-0","article-title":"Safety of dipyridamole testing in 73,806 patients: the Multicenter Dipyridamole Safety Study","volume":"2","author":"Lette","year":"1995","journal-title":"J Nucl Cardiol"},{"key":"10.1016\/j.ijcard.2004.12.021_bib30","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1067\/mnc.2001.116167","article-title":"Tolerance and diagnostic accuracy of an abbreviated adenosine infusion for myocardial scintigraphy: a randomized, prospective study","volume":"8","author":"Treuth","year":"2001","journal-title":"J Nucl Cardiol"},{"issue":"2 Pt 2","key":"10.1016\/j.ijcard.2004.12.021_bib31","first-page":"H541","article-title":"Adenosine potentiates flow-induced dilation of coronary arterioles by activating KATP channels in endothelium","volume":"269","author":"Kuo","year":"1995","journal-title":"Am J Physiol"},{"key":"10.1016\/j.ijcard.2004.12.021_bib32","doi-asserted-by":"crossref","first-page":"H2612","DOI":"10.1152\/ajpheart.2000.279.6.H2612","article-title":"Transmural difference in coronary arteriolar dilation to adenosine: effect of luminal pressure and K(ATP) channels","volume":"279","author":"Zhang","year":"2000","journal-title":"Am J Physiol, Heart Circ Physiol"},{"key":"10.1016\/j.ijcard.2004.12.021_bib33","doi-asserted-by":"crossref","first-page":"H2198","DOI":"10.1152\/ajpheart.00834.2001","article-title":"Nitric oxide production is maintained in exercising swine with chronic left ventricular dysfunction","volume":"282","author":"Haitsma","year":"2002","journal-title":"Am J Physiol, Heart Circ Physiol"}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527305001968?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527305001968?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,3]],"date-time":"2019-02-03T13:57:44Z","timestamp":1549202264000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527305001968"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,10]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,10]]}},"alternative-id":["S0167527305001968"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2004.12.021","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2005,10]]}}}