{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T19:26:32Z","timestamp":1769628392270,"version":"3.49.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","internationaljournalofcardiology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2007,2]]},"DOI":"10.1016\/j.ijcard.2006.03.019","type":"journal-article","created":{"date-parts":[[2006,8,2]],"date-time":"2006-08-02T17:44:58Z","timestamp":1154540698000},"page":"361-365","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":61,"title":["Elevated levels of platelet\u2013monocyte aggregates and related circulating biomarkers in patients with acute coronary syndrome"],"prefix":"10.1016","volume":"115","author":[{"given":"Junhong","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Songzhao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaping","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangming","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijcard.2006.03.019_bib1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1056\/NEJMoa012295","article-title":"Widerspread coronary inflammation in unstable angina","volume":"347","author":"Buffon","year":"2002","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.ijcard.2006.03.019_bib2","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1055\/s-0037-1616219","article-title":"A journey with platelet P-selectin: the molecular basis of granule secretion, signalling and cell adhesion","volume":"86","author":"Furie","year":"2001","journal-title":"Thromb Haemost"},{"issue":"6667","key":"10.1016\/j.ijcard.2006.03.019_bib3","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/35393","article-title":"CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells","volume":"391","author":"Henn","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.ijcard.2006.03.019_bib4","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1161\/01.CIR.0000127128.52679.E4","article-title":"Upregulation of the CD40\/CD40 ligand dyad and platelet\u2013monocyte aggregation in cigarette smokers","volume":"109","author":"Harding","year":"2004","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.ijcard.2006.03.019_bib5","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.ijcard.2004.03.033","article-title":"Platelet\u2013monocyte aggregates predict troponin rise after percutaneous coronary intervention and are inhibited by Abciximab","volume":"101","author":"Ray","year":"2005","journal-title":"Int J Cardiol"},{"issue":"1","key":"10.1016\/j.ijcard.2006.03.019_bib6","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/nm810","article-title":"Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E","volume":"9","author":"Huo","year":"2003","journal-title":"Nat Med"},{"issue":"10","key":"10.1016\/j.ijcard.2006.03.019_bib7","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1093\/ndt\/gfg348","article-title":"Increased platelet\u2013monocyte aggregates and cardiovascular disease in end-stage renal failure patients","volume":"18","author":"Ashman","year":"2003","journal-title":"Nephrol Dial Transplant"},{"issue":"4","key":"10.1016\/j.ijcard.2006.03.019_bib8","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/S0735-1097(01)01485-1","article-title":"Circulating monocyte\u2013platelet aggregates are an early marker of acute myocardial infarction","volume":"38","author":"Furman","year":"2001","journal-title":"J Am Coll Cardiol"},{"issue":"18","key":"10.1016\/j.ijcard.2006.03.019_bib9","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1161\/01.CIR.0000015700.27754.6F","article-title":"Increased platelet binding to circulating monocytes in acute coronary syndromes","volume":"105","author":"Sarma","year":"2002","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.ijcard.2006.03.019_bib10","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.thromres.2003.08.017","article-title":"Platelet\u2013monocyte complex formation: effect of blocking PSGL-1 alone, and in combination with alphaIIbbeta3 and alphaMbeta2, in coronary stenting","volume":"111","author":"Fernandes","year":"2003","journal-title":"Thromb Res"},{"issue":"12","key":"10.1016\/j.ijcard.2006.03.019_bib11","first-page":"1288","article-title":"Efficient measurement of platelet\u2013monocyte aggregates in whole blood by flow cytometry","volume":"28","author":"Wang","year":"2005","journal-title":"J Chin Lab Med"},{"key":"10.1016\/j.ijcard.2006.03.019_bib12","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1161\/01.CIR.0000133317.49796.0E","article-title":"Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines","volume":"110","author":"Grundy","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2006.03.019_bib13","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1161\/01.CIR.90.2.775","article-title":"Macrophage infiltration in acute coronary syndromes; implications for plaque rupture","volume":"90","author":"Moreno","year":"1994","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2006.03.019_bib14","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1006\/jmcc.2000.1179","article-title":"Matrix metalloproteinase-1 expression by interaction between monocytes and vascular endothelial cells","volume":"32","author":"Hojo","year":"2000","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.ijcard.2006.03.019_bib15","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1161\/01.CIR.0000017140.26466.F5","article-title":"Platelet\u2013monocyte aggregates: bridging thrombosis and inflammation","volume":"105","author":"Freedman","year":"2002","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.ijcard.2006.03.019_bib16","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1097\/00002281-200401000-00005","article-title":"Recent advances in vascular inflammation: C-reactive protein and other inflammatory biomarkers","volume":"16","author":"Maksimowicz-McKinnon","year":"2004","journal-title":"Curr Opin Rheumatol"},{"key":"10.1016\/j.ijcard.2006.03.019_bib17","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1161\/hh2101.099270","article-title":"Novel clinical markers of vascular wall inflammation","volume":"89","author":"Blake","year":"2001","journal-title":"Circ Res"},{"key":"10.1016\/j.ijcard.2006.03.019_bib18","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1161\/01.CIR.0000043802.38699.66","article-title":"Interleukin-6-deficient mice resist development of autoimmune myocarditis associated with impaired upregulation of complement C3","volume":"107","author":"Eriksson","year":"2003","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.ijcard.2006.03.019_bib19","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/S0735-1097(02)02047-8","article-title":"Morphologic and angiographic features of coronary plaque rupture detected by intravascular ultrasound","volume":"40","author":"Maehara","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ijcard.2006.03.019_bib20","doi-asserted-by":"crossref","first-page":"8B","DOI":"10.1016\/0002-9149(94)90258-5","article-title":"Platelet activation in stable coronary artery disease","volume":"73","author":"Diodati","year":"1994","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.ijcard.2006.03.019_bib21","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1055\/s-0037-1615952","article-title":"Platelet reactivity in acute coronary syndromes: evidence for differences in platelet behaviour between unstable angina and myocardial infarction","volume":"85","author":"Mathur","year":"2001","journal-title":"Thromb Haemost"},{"issue":"1","key":"10.1016\/j.ijcard.2006.03.019_bib22","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0008-6363(02)00537-0","article-title":"Molecular and cellular interface between behavior and acute coronary syndromes","volume":"56","author":"Gidron","year":"2002","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.ijcard.2006.03.019_bib23","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1161\/01.HYP.0000130484.20501.df","article-title":"C-Reactive protein: risk marker or mediator in atherothrombosis?","volume":"44","author":"Jialal","year":"2004","journal-title":"Hypertension"},{"issue":"3","key":"10.1016\/j.ijcard.2006.03.019_bib24","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.yjmcc.2003.12.005","article-title":"Effect of C-reactive protein on chemokine expression in human aortic endothelial cells","volume":"36","author":"Devaraj","year":"2004","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.ijcard.2006.03.019_bib25","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1016\/j.jacc.2003.10.071","article-title":"Clopidogrel inhibits platelet\u2013leukocyte interactions and thrombin receptor agonist peptide-induced platelet activation in patients with an acute coronary syndrome","volume":"43","author":"Xiao","year":"2004","journal-title":"J Am Coll Cardiol"}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527306004098?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527306004098?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T20:18:38Z","timestamp":1759090718000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527306004098"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["S0167527306004098"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2006.03.019","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2007,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Elevated levels of platelet\u2013monocyte aggregates and related circulating biomarkers in patients with acute coronary syndrome","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2006.03.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}