{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T21:39:01Z","timestamp":1791149941057,"version":"4.1.0"},"reference-count":19,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No.NSFC30240036"],"award-info":[{"award-number":["No.NSFC30240036"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","internationaljournalofcardiology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2009,1]]},"DOI":"10.1016\/j.ijcard.2007.10.044","type":"journal-article","created":{"date-parts":[[2008,1,26]],"date-time":"2008-01-26T20:39:10Z","timestamp":1201379950000},"page":"313-320","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":55,"title":["Short-term withdrawal of simvastatin induces endothelial dysfunction in patients with coronary artery disease: A dose\u2013response effect dependent on endothelial nitric oxide synthase"],"prefix":"10.1016","volume":"131","author":[{"given":"Hong","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Yi","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan-Lei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruo-Jie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijcard.2007.10.044_bib1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ijcard.2005.05.056","article-title":"Effects of statins beyond lipid lowering: potential for clinical benefits","volume":"109","author":"Almuti","year":"2006","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.ijcard.2007.10.044_bib2","doi-asserted-by":"crossref","first-page":"III","DOI":"10.1161\/01.CIR.0000131517.20177.5a","article-title":"Beneficial cardiovascular pleiotropic effects of statins","volume":"109","author":"Davignon","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2007.10.044_bib3","doi-asserted-by":"crossref","first-page":"208","DOI":"10.5694\/j.1326-5377.1996.tb94138.x","article-title":"Apparent discontinuation rates in patients prescribed lipid-lowering drugs","volume":"164","author":"Simons","year":"1996","journal-title":"Med J Aust"},{"key":"10.1016\/j.ijcard.2007.10.044_bib4","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1016\/S0140-6736(05)79893-7","article-title":"Increased thrombotic vascular events after change of statin","volume":"352","author":"Thomas","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.ijcard.2007.10.044_bib5","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1161\/01.CIR.0000012530.68333.C8","article-title":"Platelet Receptor Inhibition in Ischemic Syndrome Management (PRISM) Investigators. Withdrawal of statins increases event rates in patients with acute coronary syndromes","volume":"105","author":"Heeschen","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2007.10.044_bib6","doi-asserted-by":"crossref","DOI":"10.1161\/01.CIR.0000050552.32300.93","article-title":"Withdrawal of statins increases event rates in patients with acute coronary syndromes","volume":"107","author":"Heeschen","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2007.10.044_bib7","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1161\/01.CIR.0000145118.55201.15","article-title":"Treating to New Target (TNT) Study Group. There is no evidence for an increase in acute coronary syndromes after short-term abrupt discontinuation of statins in stable cardiac patients","volume":"110","author":"McGowan","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2007.10.044_bib8","doi-asserted-by":"crossref","first-page":"24F","DOI":"10.1016\/j.amjcard.2005.06.009","article-title":"Effects of statins on 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibition beyond low-density lipoprotein cholesterol","volume":"96","author":"Liao","year":"2005","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.ijcard.2007.10.044_bib9","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1291\/hypres.23.187","article-title":"Direct effects of statins on cells primarily involved in atherosclerosis","volume":"23","author":"Chen","year":"2000","journal-title":"Hypertens Res"},{"key":"10.1016\/j.ijcard.2007.10.044_bib10","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1016\/S0002-9149(01)02095-1","article-title":"Rapid effects on vascular function after initiation and withdrawal of atorvastastin in healthy, normocholesterolemic men","volume":"88","author":"Laufs","year":"2001","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.ijcard.2007.10.044_bib11","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1161\/01.ATV.0000092126.25380.BC","article-title":"Withdrawal of cerivastatin induces monocyte chemoattractant protein 1 and tissue factor expression in cultured vascular smooth muscle cells","volume":"23","author":"Brandes","year":"2003","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.ijcard.2007.10.044_bib12","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0735-1097(01)01746-6","article-title":"International Brachial Artery Reactivity Task Force. Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force","volume":"39","author":"Corretti","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ijcard.2007.10.044_bib13","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1182\/blood.V42.4.499.499","article-title":"Thrombotic thrombocytopenic purpura coagulation parameters in twelve patients","volume":"42","author":"Jaffe","year":"1973","journal-title":"Blood"},{"key":"10.1016\/j.ijcard.2007.10.044_bib14","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1161\/01.HYP.36.6.923","article-title":"Fluvastatin upregulates inducible nitric oxide synthase expression in cytokine-stimulated rat vascular smooth muscle cells","volume":"36","author":"Chen","year":"2000","journal-title":"Hypertension"},{"key":"10.1016\/j.ijcard.2007.10.044_bib20","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1001\/archinte.164.19.2162","article-title":"National Registry of Myocardial Infarction. Early withdrawal of statin therapy in patients with non-ST-segment elevation myocardial infarction: national registry of myocardial infarction","volume":"164","author":"Spencer","year":"2004","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.ijcard.2007.10.044_bib21","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1016\/S0735-1097(02)02593-7","article-title":"Early statin therapy restores endothelial function in children with familial hypercholesterolemia","volume":"40","author":"de Jongh","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ijcard.2007.10.044_bib22","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1161\/01.RES.0000134628.96682.9b","article-title":"Atorvastatin restores endothelial function in normocholesterolemic smokers independent of changes in low-density lipoprotein","volume":"95","author":"Beckman","year":"2004","journal-title":"Circ Res"},{"key":"10.1016\/j.ijcard.2007.10.044_bib23","doi-asserted-by":"crossref","first-page":"3104","DOI":"10.1161\/01.CIR.102.25.3104","article-title":"Suppression of endothelial nitric oxide production after withdrawal of statin treatment is mediated by negative feedback regulation of rho GTPase gene transcription","volume":"102","author":"Laufs","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2007.10.044_bib19","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1161\/01.STR.0000054055.28435.BF","article-title":"Withdrawal of statin treatment abrogates stroke protection in mice","volume":"34","author":"Gertz","year":"2003","journal-title":"Stroke"}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527307019766?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527307019766?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T20:23:27Z","timestamp":1759091007000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527307019766"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,1]]}},"alternative-id":["S0167527307019766"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2007.10.044","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2009,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Short-term withdrawal of simvastatin induces endothelial dysfunction in patients with coronary artery disease: A dose\u2013response effect dependent on endothelial nitric oxide synthase","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2007.10.044","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}