{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T20:40:53Z","timestamp":1759092053273,"version":"3.44.0"},"reference-count":22,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","internationaljournalofcardiology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2009,2]]},"DOI":"10.1016\/j.ijcard.2008.12.074","type":"journal-article","created":{"date-parts":[[2009,1,23]],"date-time":"2009-01-23T05:00:35Z","timestamp":1232686835000},"page":"153-156","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Aspirin resistance: What the cardiologist needs to know?"],"prefix":"10.1016","volume":"132","author":[{"given":"Dimitris","family":"Tousoulis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerasimos","family":"Siasos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christodoulos","family":"Stefanadis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijcard.2008.12.074_bib1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1172\/JCI200113418","article-title":"Cyclooxygenase-selective inhibition of prostanoid formation: transducing biochemical selectivity into clinical read-outs","volume":"108","author":"Patrono","year":"2001","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ijcard.2008.12.074_bib2","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1172\/JCI27291","article-title":"Biological basis for the cardiovascular consequences of COX-2 inhibition: therapeutic challenges and opportunities","volume":"116","author":"Grosser","year":"2006","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ijcard.2008.12.074_bib3","unstructured":"Lordkipanidz\u00e9 M, Diodati J, Turgeon J, Schampaert E, Palisaitis D, Pharand C Platelet count, not oxidative stress, may contribute to inadequate platelet inhibition by aspirin. Int J Cardiol in press."},{"key":"10.1016\/j.ijcard.2008.12.074_bib4","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/0049-3848(91)90085-B","article-title":"Effects of acetylsalicylic acid in stroke patients. Evidence of nonresponders in a subpopulation of treated patients","volume":"63","author":"Grotemeyer","year":"1991","journal-title":"Thromb Res"},{"key":"10.1016\/j.ijcard.2008.12.074_bib5","first-page":"221","article-title":"Individual variation in the effects of ASA on platelet function: implications for the use of ASA clinically","volume":"11","author":"Buchanan","year":"1995","journal-title":"Can J Cardiol"},{"key":"10.1016\/j.ijcard.2008.12.074_bib6","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/S0735-1097(02)03014-0","article-title":"A prospective, blinded determination of the natural history of aspirin resistance among stable patients with cardiovascular disease","volume":"41","author":"Gum","year":"2003","journal-title":"J Am Coll Cardiol"},{"issue":"Suppl 1","key":"10.1016\/j.ijcard.2008.12.074_bib7","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/j.1538-7836.2007.02498.x","article-title":"Resistance to antiplatelet drugs: molecular mechanisms and laboratory detection","volume":"5","author":"Cattaneo","year":"2007","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.ijcard.2008.12.074_bib8","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1046\/j.1538-7836.2003.00284.x","article-title":"Aspirin resistance: definition, mechanisms and clinical read-outs","volume":"1","author":"Patrono","year":"2003","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.ijcard.2008.12.074_bib9","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/S0140-6736(05)79320-X","article-title":"PLA2 polymorphism and efficacy of aspirin","volume":"351","author":"Cooke","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.ijcard.2008.12.074_bib10","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1161\/01.CIR.101.9.1013","article-title":"Platelet GP IIIa Pla polymorphisms display different sensitivities to agonists","volume":"101","author":"Michelson","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2008.12.074_bib11","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1160\/TH08-01-0056","article-title":"Clinical implications of aspirin resistance","volume":"100","author":"Zimmermann","year":"2008","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.ijcard.2008.12.074_bib12","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1161\/01.CIR.0000081770.51929.5A","article-title":"Functional and biochemical evaluation of platelet aspirin resistance after coronary artery bypass surgery","volume":"108","author":"Zimmermann","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2008.12.074_bib13","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0140-6736(97)11475-1","volume":"351","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.ijcard.2008.12.074_bib14","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1016\/j.amjcard.2005.01.049","article-title":"Analysis of risk of bleeding complications after different doses of aspirin in 192,036 patients enrolled in 31 randomized controlled trials","volume":"95","author":"Serebruany","year":"2005","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.ijcard.2008.12.074_bib15","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.ahj.2006.10.040","article-title":"Prevalence of persistent platelet reactivity despite use of aspirin: a systematic review","volume":"153","author":"Hovens","year":"2007","journal-title":"Am Heart J"},{"key":"10.1016\/j.ijcard.2008.12.074_bib16","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1056\/NEJMoa010746","article-title":"Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation","volume":"345","author":"Yusuf","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijcard.2008.12.074_bib17","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1001\/jama.288.19.2411","article-title":"Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: a randomized controlled trial","volume":"288","author":"Steinhubl","year":"2002","journal-title":"J Am Med Assoc"},{"key":"10.1016\/j.ijcard.2008.12.074_bib18","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1161\/01.CIR.0000163561.90680.1C","article-title":"Dual antiplatelet therapy with clopidogrel and aspirin in symptomatic carotid stenosis evaluated using Doppler embolic signal detection: the Clopidogrel and Aspirin for Reduction of Emboli in Symptomatic Carotid Stenosis (CARESS) trial","volume":"111","author":"Markus","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2008.12.074_bib19","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0140-6736(04)16721-4","article-title":"Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): randomised, double-blind, placebo-controlled trial","volume":"364","author":"Diener","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.ijcard.2008.12.074_bib20","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1056\/NEJMoa060989","article-title":"Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events","volume":"354","author":"Bhatt","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijcard.2008.12.074_bib21","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1097\/MBC.0b013e328040c115","article-title":"Clinical relevance of aspirin resistance in patients with stable coronary artery disease: a prospective follow-up study (PROSPECTAR)","volume":"18","author":"Pamukcu","year":"2007","journal-title":"Blood Coagul Fibrinolysis"},{"key":"10.1016\/j.ijcard.2008.12.074_bib22","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.ijcard.2008.11.048","article-title":"Ethical authorship and publishing","volume":"131","author":"Coats","year":"2009","journal-title":"Int J Cardiol"}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527308015131?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527308015131?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T20:22:12Z","timestamp":1759090932000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527308015131"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["S0167527308015131"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2008.12.074","relation":{},"ISSN":["0167-5273"],"issn-type":[{"type":"print","value":"0167-5273"}],"subject":[],"published":{"date-parts":[[2009,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aspirin resistance: What the cardiologist needs to know?","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2008.12.074","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}