{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:09:47Z","timestamp":1759104587206,"version":"3.44.0"},"reference-count":17,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","internationaljournalofcardiology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2010,10]]},"DOI":"10.1016\/j.ijcard.2009.03.044","type":"journal-article","created":{"date-parts":[[2009,3,27]],"date-time":"2009-03-27T04:58:59Z","timestamp":1238129939000},"page":"326-328","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Homocysteine-lowering therapy for preventing atherothrombotic events: Its role in high risk population"],"prefix":"10.1016","volume":"144","author":[{"given":"Sadik","family":"Acikel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Dogan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramazan","family":"Akdemir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijcard.2009.03.044_bib1","article-title":"The effect of folic acid supplementation on carotid intima-media thickness in patients with cardiovascular risk: a randomized, placebo-controlled trial","author":"Ntaios","year":"2009","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.ijcard.2009.03.044_bib2","doi-asserted-by":"crossref","first-page":"143","DOI":"10.3132\/dvdr.2007.033","article-title":"Homocysteine and cardiovascular disease: a review of the evidence","volume":"4","author":"Wierzbicki","year":"2007","journal-title":"Diab Vasc Dis Res"},{"key":"10.1016\/j.ijcard.2009.03.044_bib3","doi-asserted-by":"crossref","first-page":"1563S","DOI":"10.1093\/ajcn\/86.5.1563S","article-title":"Homocysteine, vitamins, and vascular disease prevention","volume":"86","author":"McCully","year":"2007","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.ijcard.2009.03.044_bib4","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/j.jacc.2006.04.086","article-title":"Homocysteine hypothesis for atherothrombotic cardiovascular disease: not validated","volume":"48","author":"Kaul","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ijcard.2009.03.044_bib5","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1093\/eurheartj\/ehn515","article-title":"Homocysteine and coronary atherosclerosis: from folate fortification to the recent clinical trials","volume":"30","author":"Antoniades","year":"2009","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ijcard.2009.03.044_bib6","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s00392-004-0075-3","article-title":"Clinical use and rational management of homocysteine, folic acid, and B vitamins in cardiovascular and thrombotic diseases","volume":"93","author":"Stanger","year":"2004","journal-title":"Z Kardiol"},{"key":"10.1016\/j.ijcard.2009.03.044_bib7","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1001\/jama.299.17.2027","article-title":"Effect of folic acid and B vitamins on risk of cardiovascular events and total mortality among women at high risk for cardiovascular disease: a randomized trial","volume":"299","author":"Albert","year":"2008","journal-title":"JAMA"},{"key":"10.1016\/j.ijcard.2009.03.044_bib8","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1001\/jama.298.10.1163","article-title":"Effect of homocysteine lowering on mortality and vascular disease in advanced chronic kidney disease and end-stage renal disease: a randomized controlled trial","volume":"298","author":"Jamison","year":"2007","journal-title":"JAMA"},{"key":"10.1016\/j.ijcard.2009.03.044_bib9","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1016\/S0735-1097(03)00485-6","article-title":"Secondary prevention with folic acid: effects on clinical outcomes","volume":"41","author":"Liem","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ijcard.2009.03.044_bib10","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.ijcard.2003.02.001","article-title":"Efficacy of folic acid when added to statin therapy in patients with hypercholesterolemia following acute myocardial infarction: a randomised pilot trial","volume":"93","author":"Liem","year":"2004","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.ijcard.2009.03.044_bib11","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1001\/jama.291.5.565","article-title":"Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: the Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trial","volume":"291","author":"Toole","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.ijcard.2009.03.044_bib12","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1056\/NEJMoa055227","article-title":"Homocysteine lowering and cardiovascular events after acute myocardial infarction","volume":"354","author":"B\u00f8naa","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijcard.2009.03.044_bib13","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1056\/NEJMoa060900","article-title":"Homocysteine lowering with folic acid and B vitamins in vascular disease","volume":"354","author":"Lonn","year":"2006","journal-title":"N Engl J Med."},{"key":"10.1016\/j.ijcard.2009.03.044_bib14","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1093\/ndt\/gfm485","article-title":"Homocysteine lowering with folic acid and B vitamins in people with chronic kidney disease\u2014results of the renal Hope-2 study","volume":"23","author":"Mann","year":"2008","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.ijcard.2009.03.044_bib15","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1001\/jama.300.7.795","article-title":"Mortality and cardiovascular events in patients treated with homocysteine-lowering B vitamins after coronary angiography: a randomized controlled trial","volume":"300","author":"Ebbing","year":"2008","journal-title":"JAMA"},{"key":"10.1016\/j.ijcard.2009.03.044_bib16","doi-asserted-by":"crossref","first-page":"2720","DOI":"10.1001\/jama.296.22.2720","article-title":"Effect of folic acid supplementation on risk of cardiovascular diseases: a meta-analysis of randomized controlled trials","volume":"296","author":"Bazzano","year":"2006","journal-title":"JAMA"},{"key":"10.1016\/j.ijcard.2009.03.044_bib17","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.ijcard.2008.11.048","article-title":"Ethical authorship and publishing","volume":"131","author":"Coats","year":"2009","journal-title":"Int J Cardiol"}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527309002873?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527309002873?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T20:25:08Z","timestamp":1759091108000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527309002873"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["S0167527309002873"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2009.03.044","relation":{},"ISSN":["0167-5273"],"issn-type":[{"type":"print","value":"0167-5273"}],"subject":[],"published":{"date-parts":[[2010,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Homocysteine-lowering therapy for preventing atherothrombotic events: Its role in high risk population","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2009.03.044","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}