{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:46:25Z","timestamp":1791351985562,"version":"4.3.1"},"reference-count":13,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","internationaljournalofcardiology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2010,11]]},"DOI":"10.1016\/j.ijcard.2009.04.023","type":"journal-article","created":{"date-parts":[[2009,5,7]],"date-time":"2009-05-07T23:48:20Z","timestamp":1241740100000},"page":"61-64","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["A novel SCN5A mutation associated with the linker between III and IV domains of Nav1.5 in a neonate with fatal long QT syndrome"],"prefix":"10.1016","volume":"145","author":[{"given":"Kenichiro","family":"Yamamura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Muneuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoshi","family":"Uike","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuyuki","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirosuke","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Takahata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichi","family":"Shiokawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukako","family":"Yoshikane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeru","family":"Makiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minoru","family":"Horie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiro","family":"Hara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"24","key":"10.1016\/j.ijcard.2009.04.023_bib1","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1016\/j.jacc.2008.02.068","article-title":"Long QT syndrome","volume":"51","author":"Goldenberg","year":"2008","journal-title":"J Am Coll Cardiol"},{"issue":"3","key":"10.1016\/j.ijcard.2009.04.023_bib2","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.tcm.2008.01.002","article-title":"Cardiac sodium channel overlap syndromes: different faces of SCN5A mutations","volume":"18","author":"Remme","year":"2008","journal-title":"Trends Cardiovasc Med"},{"issue":"12","key":"10.1016\/j.ijcard.2009.04.023_bib3","doi-asserted-by":"crossref","first-page":"e1258","DOI":"10.1371\/journal.pone.0001258","article-title":"A novel and lethal de novo LQT-3 mutation in a newborn with distinct molecular pharmacology and therapeutic response","volume":"2","author":"Bankston","year":"2007","journal-title":"PLoS ONE"},{"issue":"2","key":"10.1016\/j.ijcard.2009.04.023_bib4","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.cardiores.2004.07.007","article-title":"A novel SCN5A mutation manifests as a malignant form of long QT syndrome with perinatal onset of tachycardia\/bradycardia","volume":"64","author":"Chang","year":"2004","journal-title":"Cardiovasc Res"},{"issue":"10","key":"10.1016\/j.ijcard.2009.04.023_bib5","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1161\/hc3501.095361","article-title":"De novo mutation in the SCN5A gene associated with early onset of sudden infant death","volume":"104","author":"Wedekind","year":"2001","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.ijcard.2009.04.023_bib6","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1136\/heart.90.1.13","article-title":"Long QT syndrome and life threatening arrhythmia in a newborn: molecular diagnosis and treatment response","volume":"90","author":"Schulze-Bahr","year":"2004","journal-title":"Heart"},{"issue":"1","key":"10.1016\/j.ijcard.2009.04.023_bib7","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1007\/s00246-002-0169-5","article-title":"Congenital long QT syndrome and 2:1 atrioventricular block with a mutation of the SCN5A gene","volume":"24","author":"Miura","year":"2003","journal-title":"Pediatr Cardiol"},{"issue":"1","key":"10.1016\/j.ijcard.2009.04.023_bib8","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.eupc.2004.09.007","article-title":"Efficacy of an implantable cardioverter\u2013defibrillator in a neonate with LQT3 associated arrhythmias","volume":"7","author":"Ten Harkel","year":"2005","journal-title":"Europace"},{"issue":"24","key":"10.1016\/j.ijcard.2009.04.023_bib9","doi-asserted-by":"crossref","first-page":"3029","DOI":"10.1161\/01.CIR.0000130666.81539.9E","article-title":"Recurrent third-trimester fetal loss and maternal mosaicism for long-QT syndrome","volume":"109","author":"Miller","year":"2004","journal-title":"Circulation"},{"issue":"20","key":"10.1016\/j.ijcard.2009.04.023_bib10","doi-asserted-by":"crossref","first-page":"12025","DOI":"10.1074\/jbc.270.20.12025","article-title":"A critical role for transmembrane segment IVS6 of the sodium channel alpha subunit in fast inactivation","volume":"270","author":"McPhee","year":"1995","journal-title":"J Biol Chem"},{"issue":"1","key":"10.1016\/j.ijcard.2009.04.023_bib11","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0008-6363(97)00114-4","article-title":"Cellular electropharmacology of amiodarone","volume":"35","author":"Kodama","year":"1997","journal-title":"Cardiovasc Res"},{"issue":"10","key":"10.1016\/j.ijcard.2009.04.023_bib12","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1161\/CIRCULATIONAHA.107.707877","article-title":"Gating properties of SCN5A mutations and the response to mexiletine in long-QT syndrome type 3 patients","volume":"116","author":"Ruan","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2009.04.023_bib13","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.ijcard.2008.11.048","article-title":"Ethical authorship and publishing","volume":"131","author":"Coats","year":"2009","journal-title":"Int J Cardiol"}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527309004823?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527309004823?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T20:25:22Z","timestamp":1759091122000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527309004823"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,11]]}},"alternative-id":["S0167527309004823"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2009.04.023","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2010,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A novel SCN5A mutation associated with the linker between III and IV domains of Nav1.5 in a neonate with fatal long QT syndrome","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2009.04.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}