{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T02:52:51Z","timestamp":1780627971872,"version":"3.54.1"},"reference-count":34,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","internationaljournalofcardiology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2012,9]]},"DOI":"10.1016\/j.ijcard.2011.03.005","type":"journal-article","created":{"date-parts":[[2011,3,30]],"date-time":"2011-03-30T06:05:04Z","timestamp":1301465104000},"page":"20-25","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Furosemide induces mortality in a rat model of chronic heart failure"],"prefix":"10.1016","volume":"160","author":[{"given":"Hirofumi","family":"Rokutan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Suckow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"von Haehling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Strassburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Bockmeyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfram","family":"Doehner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"Waller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johann","family":"Bauersachs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karoline","family":"von Websky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berthold","family":"Hocher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan D.","family":"Anker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Springer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijcard.2011.03.005_bb0005","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.1093\/eurheartj\/ehn309","volume":"29","author":"Dickstein","year":"2008","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ijcard.2011.03.005_bb0010","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/ncpcardio1152","article-title":"Are diuretics overused in the treatment of chronic heart failure?","volume":"5","author":"Vaz P\u00e9rez","year":"2008","journal-title":"Nat Clin Pract Cardiovasc Med"},{"key":"10.1016\/j.ijcard.2011.03.005_bb0015","first-page":"e391","volume":"119","author":"Hunt","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2011.03.005_bb0020","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S0735-1097(03)00765-4","article-title":"Diuretic use, progressive heart failure, and death in patients in the Studies Of Left Ventricular Dysfunction (SOLVD)","volume":"42","author":"Domanski","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ijcard.2011.03.005_bb0025","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1016\/j.amjcard.2005.12.072","article-title":"Relation of loop diuretic dose to mortality in advanced heart failure","volume":"97","author":"Eshaghian","year":"2006","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.ijcard.2011.03.005_bb0030","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/j.ejheart.2007.07.011","article-title":"Relation between dose of loop diuretics and outcomes in a heart failure population: results of the ESCAPE trial","volume":"9","author":"Hasselblad","year":"2007","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.ijcard.2011.03.005_bb0035","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.ijcard.2007.05.032","article-title":"A propensity-matched study of the effects of chronic diuretic therapy on mortality and hospitalization in older adults with heart failure","volume":"125","author":"Ahmed","year":"2008","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.ijcard.2011.03.005_bb0040","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1136\/hrt.57.1.17","article-title":"Untreated heart failure: clinical and neuroendocrine effects of introducing diuretics","volume":"57","author":"Bayliss","year":"1987","journal-title":"Br Heart J"},{"key":"10.1016\/j.ijcard.2011.03.005_bb0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7326\/0003-4819-103-1-1","article-title":"Acute vasoconstrictor response to intravenous furosemide in patients with chronic congestive heart failure. Activation of the neurohumoral axis","volume":"103","author":"Francis","year":"1985","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.ijcard.2011.03.005_bb0050","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1161\/01.CIR.82.5.1724","article-title":"Comparison of neuroendocrine activation in patients with left ventricular dysfunction with and without congestive heart failure. A substudy of the Studies of Left Ventricular Dysfunction (SOLVD)","volume":"82","author":"Francis","year":"1990","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.ijcard.2011.03.005_bb0055","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.ijcard.2008.06.094","article-title":"No effects of human ghrelin on cardiac function despite profound effects on body composition in a rat model of heart failure","volume":"137","author":"Akashi","year":"2009","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.ijcard.2011.03.005_bb0060","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.bcp.2007.09.026","article-title":"Comparative effects of torasemide and furosemide in rats with heart failure","volume":"75","author":"Veeraveedu","year":"2008","journal-title":"Biochem Pharmacol"},{"issue":"3","key":"10.1016\/j.ijcard.2011.03.005_bb0065","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.ijcard.2009.01.060","article-title":"The influence of age and sex on disease development in a novel animal model of cardiac cachexia","volume":"133","author":"Palus","year":"2009","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.ijcard.2011.03.005_bb0070","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1161\/01.RES.44.4.503","article-title":"Myocardial infarct size and ventricular function in rats","volume":"44","author":"Pfeffer","year":"1979","journal-title":"Circ Res"},{"key":"10.1016\/j.ijcard.2011.03.005_bb0075","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S0031-9384(03)00017-9","article-title":"Furosemide, sodium appetite, and ingestive behavior","volume":"78","author":"Lundy","year":"2003","journal-title":"Physiol Behav"},{"key":"10.1016\/j.ijcard.2011.03.005_bb0080","first-page":"599","article-title":"Fluid consumption, electrolyte excretion and heart remodeling in rats with myocardial infarct maintained on regular and high sodium intake","volume":"56","author":"Cudnoch-Jedrzejewska","year":"2005","journal-title":"J Physiol Pharmacol"},{"key":"10.1016\/j.ijcard.2011.03.005_bb0085","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.ejheart.2005.10.009","article-title":"Stabilization of hypoxia inducible factor rather than modulation of collagen metabolism improves cardiac function after acute myocardial infarction in rats","volume":"8","author":"Philipp","year":"2006","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.ijcard.2011.03.005_bb0090","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1681\/ASN.2005080833","article-title":"Diabetic endothelin B receptor-deficient rats develop severe hypertension and progressive renal failure","volume":"17","author":"Pfab","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.ijcard.2011.03.005_bb0095","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1097\/CRD.0b013e31818eba68","article-title":"Reappraisal of the role of diuretics in heart failure","volume":"17","author":"Guglin","year":"2009","journal-title":"Cardiol Rev"},{"key":"10.1016\/j.ijcard.2011.03.005_bb0100","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.cardiores.2005.05.023","article-title":"Different effects of long- and short-acting loop diuretics on survival rate in Dahl high-salt heart failure model rats","volume":"68","author":"Yoshida","year":"2005","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.ijcard.2011.03.005_bb0105","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1006\/jmcc.2001.1497","article-title":"Effect of ramipril and furosemide treatment on interstitial remodeling in post-infarction heart failure rat hearts","volume":"34","author":"Seeland","year":"2002","journal-title":"J Mol Cell Cardiol"},{"issue":"3","key":"10.1016\/j.ijcard.2011.03.005_bb0110","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S1388-9842(02)00242-8","article-title":"Effects of diuretic treatment on cardiac and circulating ras in chronic heart failure post-myocardial infarction in rats","volume":"5","author":"Seeland","year":"2003","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.ijcard.2011.03.005_bb0115","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1161\/01.CIR.0000124064.00494.21","article-title":"Brain natriuretic peptide enhances renal actions of furosemide and suppresses furosemide-induced aldosterone activation in experimental heart failure","volume":"109","author":"Cataliotti","year":"2004","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.ijcard.2011.03.005_bb0120","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/j.jacc.2004.04.059","article-title":"Furosemide and the progression of left ventricular dysfunction in experimental heart failure","volume":"44","author":"McCurley","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ijcard.2011.03.005_bb0125","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0735-1097(99)00630-0","article-title":"Cardiac remodeling\u2013concepts and clinical implications: a consensus paper from an international forum on cardiac remodeling. Behalf of an International Forum on Cardiac Remodeling","volume":"35","author":"Cohn","year":"2000","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ijcard.2011.03.005_bb0130","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1161\/01.CIR.100.12.1311","article-title":"Diuretics and risk of arrhythmic death in patients with left ventricular dysfunction","volume":"100","author":"Cooper","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2011.03.005_bb0135","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1006\/jmcc.2002.2088","article-title":"Molecular mechanisms of myocardial remodeling. The role of aldosterone","volume":"34","author":"Delcayre","year":"2002","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.ijcard.2011.03.005_bb0140","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1161\/hc1102.105264","article-title":"BG9719 (CVT-124), an A1 adenosine receptor antagonist, protects against the decline in renal function observed with diuretic therapy","volume":"105","author":"Gottlieb","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2011.03.005_bb0145","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1111\/j.1469-445X.2000.02064.x","article-title":"Differential effect of frusemide on renal medullary and cortical blood flow in the anaesthetised rat","volume":"85","author":"Dobrowolski","year":"2000","journal-title":"Exp Physiol"},{"key":"10.1016\/j.ijcard.2011.03.005_bb0150","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1172\/JCI117251","article-title":"Angiotensin II stimulates extracellular matrix protein synthesis through induction of transforming growth factor-beta expression in rat glomerular mesangial cells","volume":"93","author":"Kagami","year":"1994","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ijcard.2011.03.005_bb0155","article-title":"Calculation of glomerular filtration rate in conscious rats by the use of a bolus injection of iodixanol and a single blood sample","author":"Katayama","year":"2009","journal-title":"J Pharmacol Toxicol Meth"},{"key":"10.1016\/j.ijcard.2011.03.005_bb0160","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/j.1472-8206.2005.00349.x","article-title":"Captopril-furosemide survival study in experimental heart failure","volume":"19","author":"Mougenot","year":"2005","journal-title":"Fundam Clin Pharmacol"},{"key":"10.1016\/j.ijcard.2011.03.005_bb0165","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1136\/bmj.2.6186.360","article-title":"Adverse reactions to frusemide in hospital inpatients","volume":"2","author":"Lowe","year":"1979","journal-title":"Br Med J"},{"key":"10.1016\/j.ijcard.2011.03.005_bb0170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijcard.2010.07.030","article-title":"Ethics in the authorship and publishing of scientific articles","volume":"144","author":"Shewan","year":"2010","journal-title":"Int J Cardiol"}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527311002579?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527311002579?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T20:30:57Z","timestamp":1759091457000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527311002579"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["S0167527311002579"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2011.03.005","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2012,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Furosemide induces mortality in a rat model of chronic heart failure","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2011.03.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}