{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:14:43Z","timestamp":1786990483945,"version":"build-2736575974"},"reference-count":43,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y T\u00e9cnica of Argentina"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2013,6]]},"DOI":"10.1016\/j.ijcard.2011.10.103","type":"journal-article","created":{"date-parts":[[2011,11,11]],"date-time":"2011-11-11T12:56:00Z","timestamp":1321016160000},"page":"173-180","source":"Crossref","is-referenced-by-count":14,"title":["Participation of mitochondrial permeability transition pore in the effects of ischemic preconditioning in hypertrophied hearts: Role of NO and mitoKATP"],"prefix":"10.1016","volume":"166","author":[{"given":"Juliana C.","family":"Fantinelli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio A.","family":"P\u00e9rez N\u00fa\u00f1ez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa F.","family":"Gonz\u00e1lez Arbel\u00e1ez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo R.","family":"Schinella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana M.","family":"Mosca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.ijcard.2011.10.103_bb0005","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1016\/0022-2828(90)90987-D","article-title":"The effects of global ischemia and reperfusion on compensated hypertrophied rat hearts","volume":"22","author":"Snoeckx","year":"1990","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.ijcard.2011.10.103_bb0010","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1093\/cvr\/27.5.874","article-title":"Differences in ischaemia tolerance between hyperthrophied hearts of adult and aged spontaneously hypertensive hearts","volume":"27","author":"Snoeckx","year":"1993","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.ijcard.2011.10.103_bb0015","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0008-6363(97)00322-2","article-title":"Inotropic response of stunned hypertrofied myocardium: responsiveness of hypertrofied and normal postischemic isolated rat hearts to calcium and dopamine stimulation","volume":"38","author":"Hoffmeister","year":"1998","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.ijcard.2011.10.103_bb0020","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1253\/jcj.50.607","article-title":"Functional and metabolic response to ischemia in the perfused heart isolated from normotensive and spontaneously hypertensive rats","volume":"50","author":"Haneda","year":"1986","journal-title":"Jpn Circ J"},{"key":"10.1016\/j.ijcard.2011.10.103_bb0025","first-page":"174","article-title":"Comparative cardioprotective efects of cromakalim and diltiazen in ischemic hypertrophied rat hearts","volume":"270","author":"Grover","year":"1996","journal-title":"Am J Physiol"},{"key":"10.1016\/j.ijcard.2011.10.103_bb0030","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1023\/A:1006879616265","article-title":"Is stunning prevented by ischemic preconditioning?","volume":"186","author":"Mosca","year":"1998","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.ijcard.2011.10.103_bb0035","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1152\/physrev.00009.2003","article-title":"Preconditioning the myocardium: from cellular physiology to clinical cardiology","volume":"83","author":"Yellon","year":"2003","journal-title":"Physiol Rev"},{"issue":"7","key":"10.1016\/j.ijcard.2011.10.103_bb0040","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1093\/cvr\/28.7.1025","article-title":"Ischaemic preconditioning protects hypertrophied myocardium","volume":"28","author":"Speechly-Dick","year":"1994","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.ijcard.2011.10.103_bb0045","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/S0022-3565(25)12166-6","article-title":"Ischaemic preconditioning, adenosine and bethanechol protect spontaneously hypertensive isolated rat hearts","volume":"275","author":"Boutros","year":"1995","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.ijcard.2011.10.103_bb0050","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1007\/BF00788725","article-title":"Ischaemic preconditioning protects against myocardial dysfunction caused by ischaemia in isolated hypertrophied rat hearts","volume":"91","author":"Pantos","year":"1996","journal-title":"Basic Res Cardiol"},{"key":"10.1016\/j.ijcard.2011.10.103_bb0055","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1007\/BF00796215","article-title":"Myocardial strech induced by increased left ventricular diastolic pressure preconditions isolated perfused hearts of normotensive and spontaneously hypertensive rats","volume":"92","author":"Nakagawa","year":"1997","journal-title":"Basic Res Cardiol"},{"issue":"8","key":"10.1016\/j.ijcard.2011.10.103_bb0060","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.exger.2007.04.005","article-title":"Ischemic preconditioning is lost in aging hypertensive rat heart: independent effects of aging and longstanding hypertension","volume":"42","author":"Ebrahim","year":"2007","journal-title":"Exp Gerontol"},{"issue":"1","key":"10.1016\/j.ijcard.2011.10.103_bb0065","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.phrs.2006.10.004","article-title":"Attenuated cardioprotective response to bradykinin, but not classical ischaemic preconditioning, in DOCA-salt hypertensive left ventricular hypertrophy","volume":"55","author":"Ebrahim","year":"2007","journal-title":"Pharmacol Res"},{"issue":"5","key":"10.1016\/j.ijcard.2011.10.103_bb0070","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.exger.2009.02.005","article-title":"Ischemic preconditioning maintains cardioprotection in aging normotensive and spontaneously hypertensive rats","volume":"44","author":"Dai","year":"2009","journal-title":"Exp Gerontol"},{"key":"10.1016\/j.ijcard.2011.10.103_bb0075","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s11010-006-9296-2","article-title":"Comparative effects of ischemic pre and postconditioning on ischemia\u2013reperfusion injury in spontaneously hypertensive rats (SHR)","volume":"296","author":"Fantinelli","year":"2007","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.ijcard.2011.10.103_bb0080","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/S0008-6363(97)00244-7","article-title":"Effect of protein kinase C inhibitors on cardioprotection by ischemic preconditioning depends on the number of preconditioning episodes","volume":"37","author":"Miura","year":"1998","journal-title":"Cardiovasc Res"},{"issue":"1","key":"10.1016\/j.ijcard.2011.10.103_bb0085","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.yjmcc.2005.09.011","article-title":"The ubiquitous role of nitric oxide in cardioprotection","volume":"40","author":"Jones","year":"2006","journal-title":"J Mol Cell Cardiol"},{"issue":"4","key":"10.1016\/j.ijcard.2011.10.103_bb0090","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1023\/A:1020718619155","article-title":"Nitric oxide and cardioprotection during ischemia\u2013reperfusion","volume":"7","author":"Jugdutt","year":"2002","journal-title":"Heart Fail Rev"},{"key":"10.1016\/j.ijcard.2011.10.103_bb0095","doi-asserted-by":"crossref","first-page":"H921","DOI":"10.1152\/ajpheart.00421.2003","article-title":"KATP channels and myocardial preconditioning: an update","volume":"285","author":"Gross","year":"2003","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.ijcard.2011.10.103_bb0100","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1113\/expphysiol.2006.035097","article-title":"Differential regulation of the nitric oxide\u2013cGMP pathway exacerbates postchaemic heart injury in stroke-prone hypertensive rats","volume":"921","author":"Itoh","year":"2007","journal-title":"Exp Physiol"},{"key":"10.1016\/j.ijcard.2011.10.103_bb0105","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1139\/y06-071","article-title":"Probucol promotes endogenous antioxidant reserve and confers protection against reperfusion injury","volume":"85","author":"Singla","year":"2007","journal-title":"Can J Physiol Pharmacol"},{"key":"10.1016\/j.ijcard.2011.10.103_bb0110","doi-asserted-by":"crossref","first-page":"H277","DOI":"10.1152\/ajpheart.00236.2002","article-title":"Role of intracellular antioxidant enzymes after in vivo myocardial ischemia and reperfusion","volume":"284","author":"Jones","year":"2003","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.ijcard.2011.10.103_bb0115","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1042\/0264-6021:3410233","article-title":"The mitochondrial permeability transition pore and its role in cell death","volume":"341","author":"Crompton","year":"1999","journal-title":"Biochem J"},{"key":"10.1016\/j.ijcard.2011.10.103_bb0120","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.bbabio.2007.05.008","article-title":"The role of mitochondria in protection of the heart by preconditioning","volume":"1767","author":"Halestrap","year":"2007","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.ijcard.2011.10.103_bb0125","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.cardiores.2007.04.022","article-title":"Preconditioning and postconditioning: the essential role of the mitochondrial permeability transition pore","volume":"75","author":"Lim","year":"2007","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.ijcard.2011.10.103_bb0130","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1152\/jappl.1973.34.2.279","article-title":"Validation in awake rats of tail cuff method for measuring systolic pressure","volume":"34","author":"Bu\u00f1ag","year":"1973","journal-title":"J Appl Physiol"},{"issue":"3","key":"10.1016\/j.ijcard.2011.10.103_bb0135","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.vascn.2008.08.002","article-title":"Blood pressure measurement with the tail-cuff method in Wistar and spontaneously hypertensive rats: Influence of adrenergic- and nitric oxide-mediated vasomotion","volume":"58","author":"Fritz","year":"2008","journal-title":"J Pharmacol Toxicol Methods"},{"issue":"5","key":"10.1016\/j.ijcard.2011.10.103_bb0140","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/0002-8703(81)90226-X","article-title":"Early phase acute myocardial infarct size quantification: validation of the triphenyl tetrazolium chloride tissue enzyme staining technique","volume":"101","author":"Fishbein","year":"1981","journal-title":"Am Heart J"},{"key":"10.1016\/j.ijcard.2011.10.103_bb0145","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1172\/JCI0214270","article-title":"Role of sarcolemmal KATP channels in cardioprotection against ischemia\/reperfusion injury in mice","volume":"109","author":"Suzuki","year":"2001","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ijcard.2011.10.103_bb0150","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/0003-2697(68)90092-4","article-title":"Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent","volume":"25","author":"Sedlak","year":"1968","journal-title":"Anal Biochem"},{"key":"10.1016\/j.ijcard.2011.10.103_bb0155","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/0003-2697(71)90370-8","article-title":"Superoxide dismutase: improved assays and an assay applicable to acrylamide gels","volume":"44","author":"Beauchamp","year":"1971","journal-title":"Anal Biochem"},{"key":"10.1016\/j.ijcard.2011.10.103_bb0160","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantitites of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal Biochem"},{"key":"10.1016\/j.ijcard.2011.10.103_bb0165","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1172\/JCI115236","article-title":"Oxygen radicals generated at reflow induce peroxidation of membrane lipids in reperfused hearts","volume":"87","author":"Ambrosio","year":"1991","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ijcard.2011.10.103_bb0225","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1016\/S0021-9258(19)57309-4","article-title":"Measurement of superoxide-derived free radicals in the reperfused heart. Evidence for a free radical mechanism of reperfusion injury","volume":"263","author":"Zweier","year":"1988","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ijcard.2011.10.103_bb0175","doi-asserted-by":"crossref","first-page":"2986","DOI":"10.1152\/ajpheart.01144.2004","article-title":"MnSOD in mouse heart: acute responses to ischemic preconditioning and ischemia\u2013reperfusion injury","volume":"288","author":"Jin","year":"2005","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.ijcard.2011.10.103_bb0180","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1161\/ATVBAHA.108.181610","article-title":"NADPH oxidases: functions and pathologies in the vasculature","volume":"30","author":"Lass\u00e8gue","year":"2010","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.ijcard.2011.10.103_bb0185","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/S0008-6363(00)00078-X","article-title":"Status of myocardial antioxidants in ischemia\u2013reperfusion injury","volume":"47","author":"Dhalla","year":"2000","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.ijcard.2011.10.103_bb0190","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1146\/annurev.ph.52.030190.002415","article-title":"Free radicals and their involvement during long-term myocardial ischemia and reperfusion","volume":"52","author":"Downey","year":"1990","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.ijcard.2011.10.103_bb0195","doi-asserted-by":"crossref","first-page":"H2024","DOI":"10.1152\/ajpheart.00683.2005","article-title":"Reactive oxygen species, but not Ca2+ overloading, trigger ph- and mitochondrial permeability transition-dependent death of adult rat myocytes after ischemia\u2013reperfusion","volume":"290","author":"Kim","year":"2006","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"5","key":"10.1016\/j.ijcard.2011.10.103_bb0200","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s00395-003-0423-x","article-title":"The dual effects of nitric oxide synthase inhibitors on ischemia\u2013reperfusion injury in rat hearts","volume":"98","author":"Kobara","year":"2003","journal-title":"Basic Res Cardiol"},{"key":"10.1016\/j.ijcard.2011.10.103_bb0205","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.1161\/01.CIR.91.9.2310","article-title":"Increased activity of constitutive nitric oxide synthase in cardiac endothelium in spontaneous hypertension","volume":"91","author":"Nava","year":"1995","journal-title":"Circulation"},{"issue":"22","key":"10.1016\/j.ijcard.2011.10.103_bb0210","doi-asserted-by":"crossref","first-page":"4255","DOI":"10.1016\/j.febslet.2007.07.071","article-title":"Cardiac mitochondrial ATP-sensitive potassium channel is activated by nitric oxide in vitro","volume":"581","author":"Ljubkovic","year":"2007","journal-title":"FEBS Lett"},{"issue":"12","key":"10.1016\/j.ijcard.2011.10.103_bb0215","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1016\/j.freeradbiomed.2004.09.014","article-title":"Nitric oxide: a signaling molecule against mitochondrial permeability transition- and pH-dependent cell death alter reperfusion","volume":"37","author":"Kim","year":"2004","journal-title":"Free Radic Biol Med"}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527311019772?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527311019772?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T20:32:35Z","timestamp":1741897955000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527311019772"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["S0167527311019772"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2011.10.103","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2013,6]]}}}