{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T22:30:36Z","timestamp":1790289036189,"version":"4.1.0"},"reference-count":15,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2012,3]]},"DOI":"10.1016\/j.ijcard.2011.12.108","type":"journal-article","created":{"date-parts":[[2012,1,20]],"date-time":"2012-01-20T05:45:56Z","timestamp":1327038356000},"page":"504-505","source":"Crossref","is-referenced-by-count":17,"title":["Osteopontin (OPN) improves risk stratification in pulmonary hypertension (PH)"],"prefix":"10.1016","volume":"155","author":[{"given":"Mark","family":"Rosenberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. Joachim","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekkehard","family":"Gruenig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tibor","family":"Schuster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Lutz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Lossnitzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Wipplinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo A.","family":"Katus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Frey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijcard.2011.12.108_bb0005","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1161\/CIRCHEARTFAILURE.107.746172","article-title":"Osteopontin, a new prognostic biomarker in patients with chronic heart failure","volume":"1","author":"Rosenberg","year":"2008","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.ijcard.2011.12.108_bb0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11010-006-9368-3","article-title":"Osteopontin and the cardiovascular system","volume":"300","author":"Okamoto","year":"2007","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.ijcard.2011.12.108_bb0015","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1161\/01.HYP.33.2.663","article-title":"Myocaridal Osteopontin Expression Coincides With the Development of Heart Failure","volume":"33","author":"Singh","year":"1999","journal-title":"Hypertension"},{"key":"10.1016\/j.ijcard.2011.12.108_bb0020","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/sim.2929","article-title":"Evaluating the added predictive ability of a new marker: From area under the ROC curve to reclassification and beyond","volume":"27","author":"Pecina","year":"2008","journal-title":"Stat Med"},{"key":"10.1016\/j.ijcard.2011.12.108_bb0025","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1152\/japplphysiol.00595.2005","article-title":"Dominant negative mutation of the TGF- receptor block pulmonary vascular remodeling","volume":"100","author":"Chen","year":"2006","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.ijcard.2011.12.108_bb0030","doi-asserted-by":"crossref","first-page":"L238","DOI":"10.1152\/ajplung.90591.2008","article-title":"Sustained hypoxia promotes the development of a chronic inflammatory microenvironment","volume":"297","author":"Burke","year":"2009","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.ijcard.2011.12.108_bb0035","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1172\/JCI117718","article-title":"The adhesive and migratory effects of osteopontin are mediated via distinct cell surface integrins. Role of alpha v beta 3 in smooth muscle cell migration to osteopontin in vitro","volume":"95","author":"Liaw","year":"1995","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ijcard.2011.12.108_bb0040","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1161\/01.RES.77.4.665","article-title":"Osteopontin and beta 3 integrin are coordinately expressed in regenerating endothelium in vivo and stimulate Arg-Gly-Asp-dependent endothelial migration in vitro","volume":"77","author":"Liaw","year":"1995","journal-title":"Circ Res"},{"key":"10.1016\/j.ijcard.2011.12.108_bb0045","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1161\/01.ATV.14.10.1648","article-title":"Osteopontin is synthesized by macrophage, smooth muscle, and endothelial cells in primary and restenotic human coronary atherosclerotic plaques","volume":"14","author":"O'Brien","year":"1994","journal-title":"Arterioscler Thromb"},{"key":"10.1016\/j.ijcard.2011.12.108_bb0050","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1161\/01.RES.74.2.214","article-title":"Osteopontin promotes vascular cell adhesion and spreading and is chemotactic for smooth muscle cells in vitro","volume":"74","author":"Liaw","year":"1994","journal-title":"Circ Res"},{"key":"10.1016\/j.ijcard.2011.12.108_bb0055","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1161\/01.RES.0000025268.10302.0C","article-title":"Osteopontin plays an important role in the development of medial thickening and neointimal formation","volume":"91","author":"Isoda","year":"2002","journal-title":"Circ Res"},{"key":"10.1016\/j.ijcard.2011.12.108_bb0060","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1172\/JCI6539","article-title":"Elastase and matrix metalloproteinase inhibitors induce regression, and tenascin-C antisense prevents progression, of vascular disease","volume":"105","author":"Cowan","year":"2000","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ijcard.2011.12.108_bb0065","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1161\/01.HYP.0000148458.03202.48","article-title":"Osteopontin modulates myocardial hypertrophy in response to chronic pressure overload in mice","volume":"44","author":"Xie","year":"2004","journal-title":"Hypertension"},{"key":"10.1016\/j.ijcard.2011.12.108_bb0070","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1093\/cvr\/cvp002","article-title":"Chronic inhibition of phosphodiesterase 5 does not prevent pressure-overload-induced right-ventricular remodeling","volume":"82","author":"Schaefer","year":"2009","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.ijcard.2011.12.108_bb0075","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.cpcardiol.2004.07.002","article-title":"The natriuretic peptides in cardiovascular medicine","volume":"29","author":"Munagala","year":"2004","journal-title":"Curr Probl Cardiol"}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527311023047?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527311023047?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T00:55:31Z","timestamp":1543280131000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527311023047"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["S0167527311023047"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2011.12.108","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2012,3]]}}}