{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T20:12:23Z","timestamp":1793736743428,"version":"4.6.1"},"reference-count":30,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","internationaljournalofcardiology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2013,8]]},"DOI":"10.1016\/j.ijcard.2012.03.047","type":"journal-article","created":{"date-parts":[[2012,3,28]],"date-time":"2012-03-28T02:19:28Z","timestamp":1332901168000},"page":"768-775","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["Homocysteine predicts increased NT-pro-BNP through impaired fatty acid oxidation"],"prefix":"10.1016","volume":"167","author":[{"given":"R.M.","family":"Gu\u00e9ant Rodriguez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Spada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Pooya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Jeannesson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.A.","family":"Moreno Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Anello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Bosco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Elia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Romano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.M.","family":"Alberto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Juilli\u00e8re","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.L.","family":"Gu\u00e9ant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijcard.2012.03.047_bb0005","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1056\/NEJMra021498","article-title":"Heart failure","volume":"348","author":"Jessup","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijcard.2012.03.047_bb0010","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s10545-010-9235-y","article-title":"Homocysteine and vascular disease: review of published results of the homocysteine-lowering trials","volume":"34","author":"Clarke","year":"2011","journal-title":"J Inherit Metab Dis"},{"key":"10.1016\/j.ijcard.2012.03.047_bb0015","doi-asserted-by":"crossref","first-page":"c6273","DOI":"10.1136\/bmj.c6273","article-title":"Effects of B vitamins and omega 3 fatty acids on cardiovascular diseases: a randomised placebo controlled trial","volume":"341","author":"Galan","year":"2010","journal-title":"BMJ"},{"key":"10.1016\/j.ijcard.2012.03.047_bb0020","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1111\/j.1538-7836.2007.02535.x","article-title":"Left ventricular systolic dysfunction is an independent predictor of homocysteine in angiographically documented patients with or without coronary artery lesions","volume":"5","author":"Gueant-Rodriguez","year":"2007","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.ijcard.2012.03.047_bb0025","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1515\/CCLM.2007.360","article-title":"Homocysteine, brain natriuretic peptide and chronic heart failure: a critical review","volume":"45","author":"Herrmann","year":"2007","journal-title":"Clin Chem Lab Med"},{"key":"10.1016\/j.ijcard.2012.03.047_bb0030","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1093\/ajcn\/85.1.117","article-title":"Plasma B vitamins and their relation to the severity of chronic heart failure","volume":"85","author":"Herrmann","year":"2007","journal-title":"Am J Clin Nutr"},{"issue":"Suppl. 2","key":"10.1016\/j.ijcard.2012.03.047_bb0035","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1017\/S0007114509990560","article-title":"How is the adequacy of micronutrient intake assessed across Europe? A systematic literature review","volume":"101","author":"Tabacchi","year":"2009","journal-title":"Br J Nutr"},{"key":"10.1016\/j.ijcard.2012.03.047_bb0040","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1093\/humupd\/dml063","article-title":"Impact of folate and homocysteine metabolism on human reproductive health","volume":"13","author":"Forges","year":"2007","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.ijcard.2012.03.047_bb0045","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0065-2571(98)00029-6","article-title":"Homocysteine metabolism in cardiovascular cells and tissues: implications for hyperhomocysteinemia and cardiovascular disease","volume":"39","author":"Chen","year":"1999","journal-title":"Adv Enzyme Regul"},{"key":"10.1016\/j.ijcard.2012.03.047_bb0050","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1002\/path.2881","article-title":"Methyl donor deficiency induces cardiomyopathy through altered methylation\/acetylation of PGC-1\u03b1 by PRMT1 and SIRT1","volume":"225","author":"Moreno Garcia","year":"2011","journal-title":"J Pathol"},{"key":"10.1016\/j.ijcard.2012.03.047_bb0055","doi-asserted-by":"crossref","first-page":"H2567","DOI":"10.1152\/ajpheart.00475.2002","article-title":"Hyperhomocysteinemia leads to adverse cardiac remodeling in hypertensive rats","volume":"283","author":"Joseph","year":"2002","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.ijcard.2012.03.047_bb0060","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/path.2942","article-title":"Fattening by deprivation: methyl balance and perinatal cardiomyopathy","volume":"225","author":"Joseph","year":"2011","journal-title":"J Pathol"},{"key":"10.1016\/j.ijcard.2012.03.047_bb0065","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.atherosclerosis.2010.11.031","article-title":"Homocysteine is a determinant of ApoA-I and both are associated with ankle brachial index, in an ambulatory elderly population","volume":"214","author":"Gu\u00e9ant-Rodriguez","year":"2011","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.ijcard.2012.03.047_bb0070","doi-asserted-by":"crossref","first-page":"21930","DOI":"10.1073\/pnas.0811794106","article-title":"Vitamin B12 deficiency reduces proliferation and promotes differentiation of neuroblastoma cells and upregulates PP2A, proNGF and TACE","volume":"106","author":"Hsu-Battaglia","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.ijcard.2012.03.047_bb0075","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1136\/jmg.2006.048041","article-title":"Environmental influence on the worldwide prevalence of a 776C\u2192G variant in the transcobalamin gene (TCN2)","volume":"44","author":"Gu\u00e9ant","year":"2007","journal-title":"J Med Genet"},{"key":"10.1016\/j.ijcard.2012.03.047_bb0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0009-8981(02)00135-3","article-title":"Application of tandem mass spectrometry to biochemical genetics and newborn screening","volume":"322","author":"Carpenter","year":"2002","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.ijcard.2012.03.047_bb0085","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1086\/320602","volume":"68","author":"Andresen","year":"2001","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.ijcard.2012.03.047_bb0090","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1023\/A:1015109127986","article-title":"Screening for carnitine palmitoyltransferase II deficiency by tandem mass spectrometry","volume":"25","author":"Gempel","year":"2002","journal-title":"J Inherit Metab Dis"},{"key":"10.1016\/j.ijcard.2012.03.047_bb0095","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1093\/clinchem\/47.10.1763","article-title":"Hepatic carnitine palmitoyltransferase I deficiency: acylcarnitine profiles in blood spots are highly specific","volume":"47","author":"Fingerhut","year":"2001","journal-title":"Clin Chem"},{"key":"10.1016\/j.ijcard.2012.03.047_bb0100","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1515\/CCLM.2006.194","article-title":"The methylenetetrahydrofolate reductase C677T gene mutation is associated with hyperhomocysteinemia, cardiovascular disease and plasma B-type natriuretic peptide levels in Korea","volume":"44","author":"Cho","year":"2006","journal-title":"Clin Chem Lab Med"},{"key":"10.1016\/j.ijcard.2012.03.047_bb0105","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0960-8966(01)00308-X","article-title":"Defects of mitochondrial beta-oxidation: a growing group of disorders","volume":"12","author":"Vockley","year":"2002","journal-title":"Neuromuscul Disord"},{"key":"10.1016\/j.ijcard.2012.03.047_bb0110","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1002\/pd.2218","article-title":"Fetal dilated cardiomyopathy: an unsuspected presentation of methylmalonic aciduria and hyperhomocystinuria, cblC type","volume":"29","author":"De Bie","year":"2009","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.ijcard.2012.03.047_bb0115","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1093\/cvr\/cvn098","article-title":"Transcriptional control of mitochondrial biogenesis: the central role of PGC-1alpha","volume":"79","author":"Ventura-Clapier","year":"2008","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.ijcard.2012.03.047_bb0120","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.nut.2009.09.012","article-title":"Acute and long-term nutrient-led modifications of gene expression: potential role of SIRT1 as a central co-ordinator of short and longer-term programming of tissue function","volume":"26","author":"Holness","year":"2010","journal-title":"Nutrition"},{"key":"10.1016\/j.ijcard.2012.03.047_bb0125","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1042\/bj3610417","article-title":"Carnitine biosynthesis in mammals","volume":"361","author":"Vaz","year":"2002","journal-title":"Biochem J"},{"key":"10.1016\/j.ijcard.2012.03.047_bb0130","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.ymgme.2008.02.002","article-title":"Cardiomyopathy and carnitine deficiency","volume":"94","author":"Amat di San Filippo","year":"2008","journal-title":"Mol Genet Metab"},{"key":"10.1016\/j.ijcard.2012.03.047_bb0135","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jacc.2007.03.038","article-title":"Prognostic value of B-type natriuretic peptides in patients with stable coronary artery disease: the PEACE trial","volume":"50","author":"Omland","year":"2007","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ijcard.2012.03.047_bb0140","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1056\/NEJM199707243370403","article-title":"Plasma homocysteine levels and mortality in patients with coronary artery disease","volume":"337","author":"Nyg\u00e5rd","year":"1997","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijcard.2012.03.047_bb0145","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1056\/NEJMoa055227","article-title":"Homocysteine lowering and cardiovascular events after acute myocardial infarction","volume":"354","author":"B\u00f8naa","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijcard.2012.03.047_bb0150","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1056\/NEJMoa060900","article-title":"Homocysteine lowering with folic acid and B vitamins in vascular disease","volume":"354","author":"Lonn","year":"2006","journal-title":"N Engl J Med"}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527312002525?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527312002525?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T20:33:22Z","timestamp":1759091602000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527312002525"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["S0167527312002525"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2012.03.047","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2013,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Homocysteine predicts increased NT-pro-BNP through impaired fatty acid oxidation","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2012.03.047","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}