{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T11:06:09Z","timestamp":1759230369502},"reference-count":39,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2013,9]]},"DOI":"10.1016\/j.ijcard.2012.07.007","type":"journal-article","created":{"date-parts":[[2012,8,24]],"date-time":"2012-08-24T10:46:24Z","timestamp":1345805184000},"page":"2813-2819","source":"Crossref","is-referenced-by-count":14,"title":["A combination of increased Rho kinase activity and N-terminal pro-B-type natriuretic peptide predicts worse cardiovascular outcome in patients with acute coronary syndrome"],"prefix":"10.1016","volume":"167","author":[{"given":"Ming","family":"Dong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James K.","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bryan","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruijie","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheuk-Man","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijcard.2012.07.007_bb0005","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1161\/01.CIR.98.18.1860","article-title":"Acute coronary syndromes in the GUSTO-IIb trial: prognostic insights and impact of recurrent ischemia","volume":"98","author":"Armstrong","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2012.07.007_bb0010","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0735-1097(98)00553-1","article-title":"Unstable angina and non-Q wave myocardial infarction: does the clinical diagnosis have therapeutic implications?","volume":"33","author":"Zaacks","year":"1999","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ijcard.2012.07.007_bb0015","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ahj.2006.10.004","article-title":"Global Registry of Acute Coronary Events (GRACE) hospital discharge risk score accurately predicts long-term mortality post acute coronary syndrome","volume":"153","author":"Tang","year":"2007","journal-title":"Am Heart J"},{"key":"10.1016\/j.ijcard.2012.07.007_bb0020","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1016\/S0140-6736(07)61904-7","article-title":"AVOREN Trial investigators. Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: a randomised, double-blind phase III trial","volume":"370","author":"Escudier","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.ijcard.2012.07.007_bb0025","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.drudis.2010.06.011","article-title":"Rho-kinase inhibition: a novel therapeutic target for the treatment of cardiovascular diseases","volume":"15","author":"Dong","year":"2010","journal-title":"Drug Discov Today"},{"key":"10.1016\/j.ijcard.2012.07.007_bb0030","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1161\/01.RES.0000099062.55042.9A","article-title":"Rho-associated protein kinase contributes to early atherosclerotic lesion formation in mice","volume":"93","author":"Mallat","year":"2003","journal-title":"Circ Res"},{"key":"10.1016\/j.ijcard.2012.07.007_bb0035","doi-asserted-by":"crossref","first-page":"H2598","DOI":"10.1152\/ajpheart.01393.2006","article-title":"Rho kinase activation plays a major role as a mediator of irreversible injury in reperfused myocardium","volume":"292","author":"Hamid","year":"2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.ijcard.2012.07.007_bb0040","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1254\/jjp.87.34","article-title":"Antiischemic properties of fasudil in experimental models of vasospastic angina","volume":"87","author":"Sato","year":"2001","journal-title":"Jpn J Pharmacol"},{"key":"10.1016\/j.ijcard.2012.07.007_bb0045","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1161\/CIRCULATIONAHA.106.172860","volume":"113","author":"Krumholz","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2012.07.007_bb0050","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1093\/eurheartj\/ehi187","article-title":"TIMI, PURSUIT, and GRACE risk scores: sustained prognostic value and interaction with revascularization in NSTE-ACS","volume":"26","author":"de Araujo","year":"2005","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ijcard.2012.07.007_bb0055","doi-asserted-by":"crossref","first-page":"2630","DOI":"10.1161\/01.ATV.0000189304.32725.bd","article-title":"Smoking, endothelial function, and Rho-kinase in humans","volume":"25","author":"Noma","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.ijcard.2012.07.007_bb0060","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1096\/fj.05-4197fje","article-title":"Rho-kinase as a molecular target for insulin resistance and hypertension","volume":"20","author":"Kanda","year":"2006","journal-title":"FASEB J"},{"key":"10.1016\/j.ijcard.2012.07.007_bb0065","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0076-6879(07)00414-4","article-title":"A method for measuring Rho kinase activity in tissues and cells","volume":"439","author":"Liu","year":"2008","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.ijcard.2012.07.007_bb0070","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.brainres.2008.12.045","article-title":"Increased leukocyte ROCK activity in patients after acute ischemic stroke","volume":"1257","author":"Feske","year":"2009","journal-title":"Brain Res"},{"key":"10.1016\/j.ijcard.2012.07.007_bb0075","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1161\/01.RES.0000162457.56568.7d","article-title":"Functional effects of rho-kinase-dependent phosphorylation of specific sites on cardiac troponin","volume":"96","author":"Vahebi","year":"2005","journal-title":"Circ Res"},{"key":"10.1016\/j.ijcard.2012.07.007_bb0080","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1161\/01.CIR.0000020682.73694.AB","article-title":"Rho-kinase mediates hypoxia-induced downregulation of endothelial nitric oxide synthase","volume":"106","author":"Takemoto","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2012.07.007_bb0085","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1161\/01.HYP.35.1.313","article-title":"Involvement of Rho-kinase in angiotensin II-induced hypertrophy of rat vascular smooth muscle cells","volume":"35","author":"Yamakawa","year":"2000","journal-title":"Hypertension"},{"key":"10.1016\/j.ijcard.2012.07.007_bb0090","doi-asserted-by":"crossref","first-page":"3081","DOI":"10.1161\/01.CIR.0000074202.19612.8C","article-title":"Nitric oxide-induced decrease in calcium sensitivity of resistance arteries is attributable to activation of the myosin light chain phosphatase and antagonized by the RhoA\/Rho kinase pathway","volume":"107","author":"Bolz","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2012.07.007_bb0095","doi-asserted-by":"crossref","first-page":"E127","DOI":"10.1161\/01.ATV.20.12.e127","article-title":"Role of RhoA and Rho kinase in lysophosphatidic acid-induced endothelial barrier dysfunction","volume":"20","author":"van Nieuw Amerongen","year":"2000","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.ijcard.2012.07.007_bb0100","doi-asserted-by":"crossref","first-page":"3561","DOI":"10.1096\/fj.08-108829","article-title":"Deficiency of ROCK1 in bone marrow-derived cells protects against atherosclerosis in LDLR\u2212\/\u2212 mice","volume":"22","author":"Wang","year":"2008","journal-title":"FASEB J"},{"key":"10.1016\/j.ijcard.2012.07.007_bb0105","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1172\/JCI29226","article-title":"ROCK1 mediates leukocyte recruitment and neointima formation following vascular injury","volume":"118","author":"Noma","year":"2008","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ijcard.2012.07.007_bb0110","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1161\/01.ATV.21.4.548","article-title":"Adenovirus-mediated transfer of dominant-negative rho-kinase induces a regression of coronary arteriosclerosis in pigs in vivo","volume":"21","author":"Morishige","year":"2001","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.ijcard.2012.07.007_bb0115","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1161\/01.RES.87.7.526","article-title":"Targeting Rho in cardiovascular disease","volume":"87","author":"Laufs","year":"2000","journal-title":"Circ Res"},{"key":"10.1016\/j.ijcard.2012.07.007_bb0120","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.atherosclerosis.2008.12.023","article-title":"Statins inhibit Rho kinase activity in patients with atherosclerosis","volume":"205","author":"Nohria","year":"2009","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.ijcard.2012.07.007_bb0125","doi-asserted-by":"crossref","first-page":"307","DOI":"10.2119\/molmed.2009.00121","article-title":"ERK-MAPK signaling opposes rho-kinase to reduce cardiomyocyte apoptosis in heart ischemic preconditioning","volume":"16","author":"Zhang","year":"2010","journal-title":"Mol Med"},{"key":"10.1016\/j.ijcard.2012.07.007_bb0130","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/hr.2010.3","article-title":"Increased leukocyte rho kinase (ROCK) activity and endothelial dysfunction in cigarette smokers","volume":"33","author":"Hidaka","year":"2010","journal-title":"Hypertens Res"},{"key":"10.1016\/j.ijcard.2012.07.007_bb0135","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1016\/j.jacc.2006.12.043","article-title":"Increased Rho kinase activity in a Taiwannese population withmetabolic syndrome","volume":"49","author":"Liu","year":"2007","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ijcard.2012.07.007_bb0140","doi-asserted-by":"crossref","first-page":"2234","DOI":"10.1161\/01.CIR.0000127939.16111.58","article-title":"Long-term inhibition of Rho-kinase suppresses left ventricular remodeling after myocardial infarction in mice","volume":"109","author":"Hattori","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2012.07.007_bb0145","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1161\/hh1101.092034","article-title":"Human urotensin II-induced contraction and arterial smooth muscle cell proliferation are mediated by RhoA and Rho-kinase","volume":"88","author":"Sauzeau","year":"2001","journal-title":"Circ Res"},{"key":"10.1016\/j.ijcard.2012.07.007_bb0150","doi-asserted-by":"crossref","first-page":"C1411","DOI":"10.1152\/ajpcell.00098.2002","article-title":"Early activation of p160ROCK by pressure overload in rat heart","volume":"284","author":"Torsoni","year":"2003","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.ijcard.2012.07.007_bb0155","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.1161\/CIRCULATIONAHA.105.584623","article-title":"Decreased perivascular fibrosis but not cardiac hypertrophy in ROCK1+\/\u2212 haploinsufficient mice","volume":"112","author":"Rikitake","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2012.07.007_bb0160","doi-asserted-by":"crossref","first-page":"14495","DOI":"10.1073\/pnas.0601911103","article-title":"Activation of Rho-associated coiled-coil protein kinase 1 (ROCK-1) by caspase-3 cleavage plays an essential role in cardiac myocyte apoptosis","volume":"103","author":"Chang","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ijcard.2012.07.007_bb0165","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.yjmcc.2010.08.008","article-title":"ROCK1 plays an essential role in the transition from cardiac hypertrophy to failure in mice","volume":"49","author":"Shi","year":"2010","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.ijcard.2012.07.007_bb0170","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1056\/NEJMoa040583","article-title":"Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Myocardial Infarction 22 Investigators. Intensive versus moderate lipid lowering with statins after acute coronary syndromes","volume":"350","author":"Cannon","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijcard.2012.07.007_bb0175","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1136\/hrt.2008.160234","article-title":"A comparison between B-type natriuretic peptide, global registry of acute coronary events (GRACE) score and their combination in ACS risk stratification","volume":"95","author":"Ang","year":"2009","journal-title":"Heart"},{"key":"10.1016\/j.ijcard.2012.07.007_bb0180","unstructured":"Koc M, Karaarslan O, Abali G, Batur MK. Variation in high-sensitivity C-reactive protein levels over 24 hours in patients with stable coronary artery disease. Tex Heart Inst J 37:42\u201348."},{"key":"10.1016\/j.ijcard.2012.07.007_bb0185","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1056\/NEJM199811053391902","article-title":"Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels","volume":"339","author":"The Long-term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijcard.2012.07.007_bb0190","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1161\/01.CIR.0000109691.16944.DA","article-title":"Determinants and prognostic impact of heart failure complicating acute coronary syndromes: observations from the Global Registry of Acute Coronary Events (GRACE)","volume":"109","author":"Steg","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2012.07.007_bb0195","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1136\/heart.84.4.421","article-title":"Plasma N terminal pro-brain natriuretic peptide and cardiotrophin 1 are raised in unstable angina","volume":"84","author":"Talwar","year":"2000","journal-title":"Heart"}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016752731200959X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016752731200959X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T03:21:37Z","timestamp":1562124097000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016752731200959X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["S016752731200959X"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2012.07.007","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2013,9]]}}}