{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:04:12Z","timestamp":1787166252060,"version":"build-2736575974"},"reference-count":31,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2013,9]]},"DOI":"10.1016\/j.ijcard.2012.09.074","type":"journal-article","created":{"date-parts":[[2012,10,8]],"date-time":"2012-10-08T19:30:21Z","timestamp":1349724621000},"page":"60-65","source":"Crossref","is-referenced-by-count":32,"title":["The effects of phosphodiesterase 5 inhibition on hemodynamics, functional status and survival in advanced heart failure and pulmonary hypertension: A case\u2013control study"],"prefix":"10.1016","volume":"168","author":[{"given":"Adrian","family":"Reichenbach","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hikmet","family":"Al-Hiti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Malek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Pirk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Goncalvesova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef","family":"Kautzner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vojtech","family":"Melenovsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijcard.2012.09.074_bb0005","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1016\/S0735-1097(99)00408-8","article-title":"Pulmonary hypertension and exercise intolerance in patients with heart failure","volume":"34","author":"Butler","year":"1999","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ijcard.2012.09.074_bb0010","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0735-1097(00)01102-5","article-title":"Independent and additive prognostic value of right ventricular systolic function and pulmonary artery pressure in patients with chronic heart failure","volume":"37","author":"Ghio","year":"2001","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ijcard.2012.09.074_bb0015","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/j.ejheart.2004.10.021","article-title":"Pulmonary vascular remodeling in pulmonary hypertension due to chronic heart failure","volume":"7","author":"Delgado","year":"2005","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.ijcard.2012.09.074_bb0020","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1161\/01.CIR.102.14.1718","article-title":"Secondary pulmonary hypertension in chronic heart failure: the role of the endothelium in pathophysiology and management","volume":"102","author":"Moraes","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2012.09.074_bb0025","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.jacc.2009.05.021","article-title":"Transpulmonary B-type natriuretic peptide uptake and cyclic guanosine monophosphate release in heart failure and pulmonary hypertension: the effects of sildenafil","volume":"54","author":"Melenovsky","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ijcard.2012.09.074_bb0030","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/0735-1097(92)90050-W","article-title":"Influence of preoperative pulmonary artery pressure on mortality after heart transplantation: testing of potential reversibility of pulmonary hypertension with nitroprusside is useful in defining a high risk group","volume":"19","author":"Costard-Jackle","year":"1992","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ijcard.2012.09.074_bb0035","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/j.jacc.2006.08.066","article-title":"Acute phosphodiesterase 5 inhibition mimics hemodynamic effects of B-type natriuretic peptide and potentiates B-type natriuretic peptide effects in failing but not normal canine heart","volume":"49","author":"Forfia","year":"2007","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ijcard.2012.09.074_bb0040","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1161\/CIRCULATIONAHA.107.716373","article-title":"Sildenafil improves exercise capacity and quality of life in patients with systolic heart failure and secondary pulmonary hypertension","volume":"116","author":"Lewis","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2012.09.074_bb0045","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1161\/CIRCULATIONAHA.106.626226","article-title":"Sildenafil improves exercise hemodynamics and oxygen uptake in patients with systolic heart failure","volume":"115","author":"Lewis","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2012.09.074_bb0050","doi-asserted-by":"crossref","first-page":"2856","DOI":"10.1016\/j.transproceed.2007.08.069","article-title":"Effectiveness and safety of treatment with sildenafil for secondary pulmonary hypertension in heart transplant candidates","volume":"39","author":"Zakliczynski","year":"2007","journal-title":"Transplant Proc"},{"key":"10.1016\/j.ijcard.2012.09.074_bb0055","doi-asserted-by":"crossref","first-page":"2850","DOI":"10.1016\/j.transproceed.2007.08.077","article-title":"Use of sildenafil in heart transplant recipients with pulmonary hypertension may prevent right heart failure","volume":"39","author":"Maruszewski","year":"2007","journal-title":"Transplant Proc"},{"key":"10.1016\/j.ijcard.2012.09.074_bb0060","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.ejheart.2007.01.008","article-title":"Chronic sildenafil lowers transpulmonary gradient and improves cardiac output allowing successful heart transplantation","volume":"9","author":"Jabbour","year":"2007","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.ijcard.2012.09.074_bb0065","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.ijcard.2011.10.064","article-title":"Therapeutic potential of sildenafil in patients with heart failure and reactive pulmonary hypertension","volume":"154","author":"Dumitrescu","year":"2012","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.ijcard.2012.09.074_bb0070","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.cjca.2011.09.018","article-title":"Hemodynamic and clinical benefits associated with chronic sildenafil therapy in advanced heart failure: experience of the montreal heart institute","volume":"28","author":"Potter","year":"2012","journal-title":"Can J Cardiol"},{"key":"10.1016\/j.ijcard.2012.09.074_bb0080","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1161\/CIRCULATIONAHA.105.584102","article-title":"The Seattle heart failure model: prediction of survival in heart failure","volume":"113","author":"Levy","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2012.09.074_bb0085","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/S0140-6736(03)12892-9","article-title":"Prognostic importance of weight loss in chronic heart failure and the effect of treatment with angiotensin-converting-enzyme inhibitors: an observational study","volume":"361","author":"Anker","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.ijcard.2012.09.074_bb0090","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1161\/CIRCULATIONAHA.110.983866","article-title":"Pulmonary hypertension in heart failure with preserved ejection fraction: a target of phosphodiesterase-5 inhibition in a 1-year study","volume":"124","author":"Guazzi","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2012.09.074_bb0095","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1161\/CIRCHEARTFAILURE.110.957050","article-title":"Sildenafil preserves lung endothelial function and prevents pulmonary vascular remodeling in a rat model of diastolic heart failure","volume":"4","author":"Yin","year":"2011","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.ijcard.2012.09.074_bb0100","doi-asserted-by":"crossref","first-page":"303","DOI":"10.33549\/physiolres.931951","article-title":"Sildenafil is more selective pulmonary vasodilator than prostaglandin E1 in patients with pulmonary hypertension due to heart failure","volume":"60","author":"Al-Hiti","year":"2011","journal-title":"Physiol Res"},{"key":"10.1016\/j.ijcard.2012.09.074_bb0105","doi-asserted-by":"crossref","first-page":"2780","DOI":"10.1161\/01.CIR.90.6.2780","article-title":"Cardiovascular effects of inhaled nitric oxide in patients with left ventricular dysfunction","volume":"90","author":"Loh","year":"1994","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2012.09.074_bb0110","doi-asserted-by":"crossref","first-page":"2882","DOI":"10.1161\/CIRCULATIONAHA.111.048520","article-title":"Sildenafil and B-type natriuretic peptide acutely phosphorylate titin and improve diastolic distensibility in vivo","volume":"124","author":"Bishu","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2012.09.074_bb0115","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1023\/A:1026555012135","article-title":"Diastolic ventricular interaction and ventricular diastolic filling","volume":"5","author":"Morris-Thurgood","year":"2000","journal-title":"Heart Fail Rev"},{"key":"10.1016\/j.ijcard.2012.09.074_bb0120","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1016\/j.amjcard.2005.06.091","article-title":"Effect of sildenafil on cardiac performance in patients with heart failure","volume":"96","author":"Hirata","year":"2005","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.ijcard.2012.09.074_bb0125","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1161\/CIRCULATIONAHA.106.655266","article-title":"Phosphodiesterase type 5 is highly expressed in the hypertrophied human right ventricle, and acute inhibition of phosphodiesterase type 5 improves contractility","volume":"116","author":"Nagendran","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2012.09.074_bb0130","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.1161\/CIRCULATIONAHA.105.540500","article-title":"Sildenafil inhibits beta-adrenergic-stimulated cardiac contractility in humans","volume":"112","author":"Borlaug","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2012.09.074_bb0135","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1378\/chest.127.5.1647","article-title":"Hemodynamic effects of sildenafil in patients with congestive heart failure and pulmonary hypertension: combined administration with inhaled nitric oxide","volume":"127","author":"Lepore","year":"2005","journal-title":"Chest"},{"key":"10.1016\/j.ijcard.2012.09.074_bb0140","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0167-5273(99)00117-5","article-title":"Anthropometric evaluation of cachexia in chronic congestive heart failure: the role of tricuspid regurgitation","volume":"71","author":"Ajayi","year":"1999","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.ijcard.2012.09.074_bb0145","doi-asserted-by":"crossref","first-page":"E342","DOI":"10.1152\/ajpendo.00691.2010","article-title":"cGMP phosphodiesterase inhibition improves the vascular and metabolic actions of insulin in skeletal muscle","volume":"301","author":"Genders","year":"2011","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.ijcard.2012.09.074_bb0150","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.2337\/db06-0883","article-title":"Chronic treatment with sildenafil improves energy balance and insulin action in high fat-fed conscious mice","volume":"56","author":"Ayala","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.ijcard.2012.09.074_bb0155","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1016\/j.jacc.2004.09.041","article-title":"The effects of phosphodiesterase-5 inhibition with sildenafil on pulmonary hemodynamics and diffusion capacity, exercise ventilatory efficiency, and oxygen uptake kinetics in chronic heart failure","volume":"44","author":"Guazzi","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ijcard.2012.09.074_bb0160","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.cardfail.2007.11.006","article-title":"Effects of 5\u2032-phosphodiesterase four-week long inhibition with sildenafil in patients with chronic heart failure: a double-blind, placebo-controlled clinical trial","volume":"14","author":"Behling","year":"2008","journal-title":"J Card Fail"}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527312011801?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527312011801?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T11:58:00Z","timestamp":1594727880000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527312011801"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["S0167527312011801"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2012.09.074","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2013,9]]}}}