{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:16:54Z","timestamp":1789193814667,"version":"build-2803163510"},"reference-count":25,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Institut de Recherches Internationales SERVIER"},{"name":"IRCCS San Raffaele Pisana (Ricerca Corrente, Ministero della Salute 2009\u20132012)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2013,9]]},"DOI":"10.1016\/j.ijcard.2012.11.001","type":"journal-article","created":{"date-parts":[[2012,11,28]],"date-time":"2012-11-28T21:00:58Z","timestamp":1354136458000},"page":"1078-1081","source":"Crossref","is-referenced-by-count":55,"title":["Efficacy of trimetazidine on functional capacity in symptomatic patients with stable exertional angina \u2014 The VASCO-angina study"],"prefix":"10.1016","volume":"168","author":[{"given":"Cristiana","family":"Vitale","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Spoletini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Malorni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Perrone-Filardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Volterrani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe M.C.","family":"Rosano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijcard.2012.11.001_bb0005","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1046\/j.1472-8206.2003.00154.x","article-title":"Metabolic therapy in the treatment of ischaemic heart disease: the pharmacology of trimetazidine","volume":"17","author":"Stanley","year":"2003","journal-title":"Fundam Clin Pharmacol"},{"key":"10.1016\/j.ijcard.2012.11.001_bb0010","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.2174\/138161208786071317","article-title":"Cardiac metabolism in myocardial ischemia","volume":"14","author":"Rosano","year":"2008","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.ijcard.2012.11.001_bb0015","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1161\/01.RES.86.5.580","article-title":"The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase","volume":"86","author":"Kantor","year":"2000","journal-title":"Circ Res"},{"key":"10.1016\/j.ijcard.2012.11.001_bb0020","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1097\/00019501-200304000-00010","article-title":"Efficacy and tolerability of trimetazidine in stable angina: a meta-analysis of randomized, double-blind, controlled trials","volume":"14","author":"Marzilli","year":"2003","journal-title":"Coron Artery Dis"},{"key":"10.1016\/j.ijcard.2012.11.001_bb0025","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1053\/euhj.2001.2896","article-title":"Combination treatment in stable effort angina using trimetazidine and metoprolol: results of a randomized, double-blind, multicentre study (TRIMPOL II). TRIMetazidine in POLand","volume":"22","author":"Szwed","year":"2001","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ijcard.2012.11.001_bb0030","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.phrs.2011.01.003","article-title":"Trimetazidine improves exercise performance in patients with peripheral arterial disease","volume":"63","author":"Vitale","year":"2011","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.ijcard.2012.11.001_bb0035","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.amjcard.2004.09.028","article-title":"Comparison of trimetazidine plus sildenafil to chronic nitrates in the control of myocardial ischemia during sexual activity in patients with coronary artery disease","volume":"95","author":"Rosano","year":"2005","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.ijcard.2012.11.001_bb0040","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1475-2840-2-16","article-title":"Trimetazidine improves left ventricular function in diabetic patients with coronary artery disease: a double-blind placebo-controlled study","volume":"2","author":"Rosano","year":"2003","journal-title":"Cardiovasc Diabetol"},{"issue":"Suppl. 1","key":"10.1016\/j.ijcard.2012.11.001_bb0045","doi-asserted-by":"crossref","first-page":"S47","DOI":"10.1177\/107424840400900105","article-title":"Efficacy and safety of a metabolic modulator drug in chronic stable angina: review of evidence from clinical trials","volume":"9","author":"Chaitman","year":"2004","journal-title":"J Cardiovasc Pharmacol Ther"},{"issue":"Suppl. 4","key":"10.1016\/j.ijcard.2012.11.001_bb0050","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1007\/BF00051292","article-title":"Comparison of trimetazidine with nifedipine in effort angina: a double-blind, crossover study","volume":"4","author":"Dalla-Volta","year":"1990","journal-title":"Cardiovasc Drugs Ther"},{"key":"10.1016\/j.ijcard.2012.11.001_bb0055","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1111\/j.1365-2125.1994.tb04276.x","article-title":"Trimetazidine: a new concept in the treatment of angina. Comparison with propranolol in patients with stable angina. Trimetazidine European Multicenter Study Group","volume":"37","author":"Detry","year":"1994","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.ijcard.2012.11.001_bb0060","doi-asserted-by":"crossref","first-page":"12B","DOI":"10.1016\/S0002-9149(99)80456-1","article-title":"Combination therapy of trimetazidine with diltiazem in patients with coronary artery disease. Group of South of France Investigators","volume":"76","author":"Levy","year":"1995","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.ijcard.2012.11.001_bb0065","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1136\/hrt.78.4.353","article-title":"Combination treatment with trimetazidine and diltiazem in stable angina pectoris","volume":"78","author":"Manchanda","year":"1997","journal-title":"Heart"},{"key":"10.1016\/j.ijcard.2012.11.001_bb0070","doi-asserted-by":"crossref","first-page":"8","DOI":"10.2165\/00044011-199713010-00002","article-title":"Antianginal efficacy of the combination of trimetazidine\u2013propranolol compared with isosorbide dinitrate\u2013propranolol in patients with stable angina","volume":"13","author":"Michaelides","year":"1997","journal-title":"Clin Drug Investig"},{"key":"10.1016\/j.ijcard.2012.11.001_bb0075","first-page":"1775","article-title":"Effectiveness of trimetazidine in stable effort angina due to chronic coronary insufficiency. A double-blind versus placebo study","volume":"15","author":"Passeron","year":"1986","journal-title":"Presse Med"},{"key":"10.1016\/j.ijcard.2012.11.001_bb0080","doi-asserted-by":"crossref","first-page":"361","DOI":"10.2165\/00129784-200303050-00007","article-title":"Assessment of anti-ischemic and antianginal effect at trough plasma concentration and safety of trimetazidine MR 35mg in patients with stable angina pectoris: a multicenter, double-blind, placebo-controlled study","volume":"3","author":"Sellier","year":"2003","journal-title":"Am J Cardiovasc Drugs"},{"key":"10.1016\/j.ijcard.2012.11.001_bb0085","first-page":"CD007472","article-title":"Pharmacological interventions versus no pharmacological intervention for ischaemia reperfusion injury in liver resection surgery performed under vascular control","author":"Abu-Amara","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.ijcard.2012.11.001_bb0090","first-page":"CD003614","article-title":"Trimetazidine for stable angina","author":"Ciapponi","year":"2005","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.ijcard.2012.11.001_bb0095","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1159\/000332369","article-title":"Efficacy comparison of trimetazidine with therapeutic alternatives in stable angina pectoris: a network meta-analysis","volume":"120","author":"Danchin","year":"2011","journal-title":"Cardiology"},{"key":"10.1016\/j.ijcard.2012.11.001_bb0100","doi-asserted-by":"crossref","first-page":"691","DOI":"10.2307\/2529759","article-title":"On the use of Pocock and Simon's method for balancing treatment number over prognostic factors in the controlled clinical trials","volume":"32","author":"Freedman","year":"1976","journal-title":"Biometrics"},{"key":"10.1016\/j.ijcard.2012.11.001_bb0105","doi-asserted-by":"crossref","first-page":"103","DOI":"10.2307\/2529712","article-title":"Sequential assignment with balancing for prognostic factors in the controlled clinical trials","volume":"31","author":"Pocock","year":"1975","journal-title":"Biometrics"},{"key":"10.1016\/j.ijcard.2012.11.001_bb0115","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/j.jacc.2006.03.060","article-title":"A randomized clinical trial of trimetazidine, a partial free fatty acid oxidation inhibitor, in patients with heart failure","volume":"48","author":"Fragasso","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ijcard.2012.11.001_bb0120","doi-asserted-by":"crossref","first-page":"857","DOI":"10.2174\/138161209787582093","article-title":"Effects of metabolic approach in diabetic patients with coronary artery disease","volume":"15","author":"Fragasso","year":"2009","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.ijcard.2012.11.001_bb0125","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1124\/jpet.109.165175","article-title":"Trimetazidine, administered at the onset of reperfusion, ameliorates myocardial dysfunction and injury by activation of p38 mitogen-activated protein kinase and Akt signaling","volume":"333","author":"Khan","year":"2010","journal-title":"J Pharmacol Exp Ther"},{"issue":"3","key":"10.1016\/j.ijcard.2012.11.001_bb0130","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.ijcard.2012.09.123","article-title":"Effect of partial fatty acid oxidation inhibition with trimetazidine on mortality and morbidity in heart failure: results from an international multicentre retrospective cohort study","volume":"163","author":"Fragasso","year":"2013","journal-title":"Int J Cardiol"}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527312014623?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527312014623?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,20]],"date-time":"2018-10-20T23:31:26Z","timestamp":1540078286000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527312014623"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["S0167527312014623"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2012.11.001","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2013,9]]}}}