{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T20:41:09Z","timestamp":1783024869152,"version":"3.54.6"},"reference-count":50,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Greta and Johan Kocks Foundation"},{"name":"Thur\u00e9us Foundation"}],"content-domain":{"domain":["internationaljournalofcardiology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2013,10]]},"DOI":"10.1016\/j.ijcard.2013.04.153","type":"journal-article","created":{"date-parts":[[2013,5,13]],"date-time":"2013-05-13T16:21:05Z","timestamp":1368462065000},"page":"3370-3380","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Local inhibition of ornithine decarboxylase reduces vascular stenosis in a murine model of carotid injury"],"prefix":"10.1016","volume":"168","author":[{"given":"Amalia","family":"Forte","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Grossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina M.","family":"Turczynska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaj","family":"Svedberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Rinaldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Donniacuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Holm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Baldetorp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariano","family":"Vicchio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisa","family":"De Feo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Sant\u00e8","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umberto","family":"Galderisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liberato","family":"Berrino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Hellstrand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bengt-Olof","family":"Nilsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilena","family":"Cipollaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijcard.2013.04.153_bb0005","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/j.jacc.2011.11.047","article-title":"Randomized trial of optimal treatment strategies for in-stent restenosis after drug-eluting stent implantation","volume":"59","author":"Song","year":"2012","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ijcard.2013.04.153_bb0010","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1007\/PL00000852","article-title":"Polyamines in cell growth and cell death: molecular mechanisms and therapeutic applications","volume":"58","author":"Thomas","year":"2001","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.ijcard.2013.04.153_bb0015","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.biocel.2009.07.009","article-title":"Modulation of cellular function by polyamines","volume":"42","author":"Igarashi","year":"2010","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.ijcard.2013.04.153_bb0020","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1038\/labinvest.2010.65","article-title":"Endocellular polyamine availability modulates epithelial-to-mesenchymal transition and unfolded protein response in MDCK cells","volume":"90","author":"Prunotto","year":"2010","journal-title":"Lab Invest"},{"key":"10.1016\/j.ijcard.2013.04.153_bb0025","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1002\/jcb.21190","article-title":"Temporal evolution of gene expression in rat carotid artery following balloon angioplasty","volume":"101","author":"Li","year":"2007","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.ijcard.2013.04.153_bb0030","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1111\/j.1582-4934.2008.00212.x","article-title":"Expression profiles in surgically-induced carotid stenosis: a combined transcriptomic and proteomic investigation","volume":"12","author":"Forte","year":"2008","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.ijcard.2013.04.153_bb0035","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0021-9150(90)90157-E","article-title":"Arterial injury-induced smooth muscle cell proliferation in rats is accompanied by increase in polyamine synthesis and level","volume":"83","author":"Nishida","year":"1990","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.ijcard.2013.04.153_bb0040","doi-asserted-by":"crossref","first-page":"706","DOI":"10.2174\/157016111797484116","article-title":"The polyamine pathway as a potential target for vascular diseases: focus on restenosis","volume":"9","author":"Forte","year":"2011","journal-title":"Curr Vasc Pharmacol"},{"key":"10.1016\/j.ijcard.2013.04.153_bb0045","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/0022-4804(91)90054-P","article-title":"Intimal hyperplasia is reduced by ornithine decarboxylase inhibition","volume":"50","author":"Endean","year":"1991","journal-title":"J Surg Res"},{"key":"10.1016\/j.ijcard.2013.04.153_bb0050","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1161\/ATVBAHA.108.183392","article-title":"Arginase promotes neointima formation in rat injured carotid arteries","volume":"29","author":"Peyton","year":"2009","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.ijcard.2013.04.153_bb0055","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0378-4347(00)84307-8","article-title":"High-performance liquid chromatographic procedure for the simultaneous determination of the natural polyamines and their monoacetyl derivatives","volume":"221","author":"Seiler","year":"1980","journal-title":"J Chromatogr"},{"key":"10.1016\/j.ijcard.2013.04.153_bb0060","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ijcard.2013.04.153_bb0065","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s00726-008-0060-7","article-title":"Polyamine synthesis inhibition induces S phase cell cycle arrest in vascular smooth muscle cells","volume":"36","author":"Odenlund","year":"2009","journal-title":"Amino Acids"},{"key":"10.1016\/j.ijcard.2013.04.153_bb0070","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/1097-4652(200002)186:2<307::AID-JCP1029>3.0.CO;2-I","article-title":"Molecular analysis of arterial stenosis in rat carotids","volume":"186","author":"Forte","year":"2001","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.ijcard.2013.04.153_bb0075","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1042\/CS20090416","article-title":"DNA damage and repair in a model of rat vascular injury","volume":"118","author":"Forte","year":"2010","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.ijcard.2013.04.153_bb0080","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1254\/jphs.FP0072275","article-title":"Possible involvement of altered arginase activity, arginase type I and type II expressions, and nitric oxide production in occurrence of intimal hyperplasia in premenopausal human uterine arteries","volume":"106","author":"Marinova","year":"2008","journal-title":"J Pharmacol Sci"},{"key":"10.1016\/j.ijcard.2013.04.153_bb0085","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.yjmcc.2004.05.004","article-title":"Arginase pathway in human endothelial cells in pathophysiological conditions","volume":"37","author":"Bachetti","year":"2004","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.ijcard.2013.04.153_bb0090","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1038\/35099020","article-title":"Men and sin: what's the difference?","volume":"2","author":"Bardin","year":"2001","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.ijcard.2013.04.153_bb0095","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/0014-4827(87)90125-X","article-title":"Induction of ornithine decarboxylase activity and putrescine synthesis in arterial smooth muscle cells stimulated with platelet-derived growth factor","volume":"170","author":"Thyberg","year":"1987","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.ijcard.2013.04.153_bb0100","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1161\/01.HYP.0000196735.85398.0e","article-title":"Tetrahydrobiopterin, but not l-arginine, decreases NO synthase uncoupling in cells expressing high levels of endothelial NO synthase","volume":"47","author":"Bevers","year":"2006","journal-title":"Hypertension"},{"key":"10.1016\/j.ijcard.2013.04.153_bb0105","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1159\/000322578","article-title":"The GPER1 agonist G-1 attenuates endothelial cell proliferation by inhibiting DNA synthesis and accumulating cells in the S and G2 phases of the cell cycle","volume":"48","author":"Holm","year":"2011","journal-title":"J Vasc Res"},{"key":"10.1016\/j.ijcard.2013.04.153_bb0110","doi-asserted-by":"crossref","first-page":"2594","DOI":"10.1158\/1078-0432.CCR-08-2710","article-title":"Antivascular actions of microtubule-binding drugs","volume":"15","author":"Schwartz","year":"2009","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.ijcard.2013.04.153_bb0115","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1161\/01.CIR.92.1.88","article-title":"Angiotensin II type 1 receptor blockade inhibits the expression of immediate-early genes and fibronectin in rat injured artery","volume":"92","author":"Kim","year":"1995","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2013.04.153_bb0120","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1042\/bj2340249","article-title":"Recent advances in the biochemistry of polyamines in eukaryotes","volume":"234","author":"Pegg","year":"1986","journal-title":"Biochem J"},{"key":"10.1016\/j.ijcard.2013.04.153_bb0125","doi-asserted-by":"crossref","first-page":"C212","DOI":"10.1152\/ajpcell.1982.243.5.C212","article-title":"Polyamine metabolism and function","volume":"243","author":"Pegg","year":"1982","journal-title":"Am J Physiol"},{"key":"10.1016\/j.ijcard.2013.04.153_bb0130","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/j.1600-0609.2010.01545.x","article-title":"VWF and ADAMTS13 behavior in estradiol-treated HUVEC","volume":"86","author":"Powazniak","year":"2011","journal-title":"Eur J Haematol"},{"issue":"Pt 1","key":"10.1016\/j.ijcard.2013.04.153_bb0135","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1042\/0264-6021:3460185","article-title":"Changes in gene expression in response to polyamine depletion indicates selective stabilization of mRNAs","volume":"346","author":"Veress","year":"2000","journal-title":"Biochem J"},{"key":"10.1016\/j.ijcard.2013.04.153_bb0140","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.mvr.2008.09.007","article-title":"VEGF regulates FGF-2 and TGF-beta1 expression in injury endothelial cells and mediates smooth muscle cells proliferation and migration","volume":"77","author":"Li","year":"2009","journal-title":"Microvasc Res"},{"key":"10.1016\/j.ijcard.2013.04.153_bb0145","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s10557-011-6359-8","article-title":"Stem cell therapy for arterial restenosis: potential parameters contributing to the success of bone marrow-derived mesenchymal stromal cells","volume":"26","author":"Forte","year":"2012","journal-title":"Cardiovasc Drugs Ther"},{"key":"10.1016\/j.ijcard.2013.04.153_bb0150","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.cellimm.2003.09.009","article-title":"Immunomodulatory action of spermine and spermidine on NR8383 macrophage line in various culture conditions","volume":"226","author":"Perez-Cano","year":"2003","journal-title":"Cell Immunol"},{"key":"10.1016\/j.ijcard.2013.04.153_bb0155","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s00726-010-0489-3","article-title":"Metabolic correlations of glucocorticoids and polyamines in inflammation and apoptosis","volume":"39","author":"Bjelakovic","year":"2010","journal-title":"Amino Acids"},{"key":"10.1016\/j.ijcard.2013.04.153_bb0160","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1093\/cvr\/cvq224","article-title":"Role of myofibroblasts in vascular remodelling: focus on restenosis and aneurysm","volume":"88","author":"Forte","year":"2010","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.ijcard.2013.04.153_bb0165","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1007\/s00726-010-0736-7","article-title":"A pro-survival effect of polyamine depletion on norepinephrine-mediated apoptosis in cardiac cells: role of signaling enzymes","volume":"40","author":"Cetrullo","year":"2011","journal-title":"Amino Acids"},{"key":"10.1016\/j.ijcard.2013.04.153_bb0170","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1007\/s10495-005-1891-2","article-title":"Ornithine decarboxylase prevents tumor necrosis factor alpha-induced apoptosis by decreasing intracellular reactive oxygen species","volume":"10","author":"Liu","year":"2005","journal-title":"Apoptosis"},{"key":"10.1016\/j.ijcard.2013.04.153_bb0175","first-page":"2263","article-title":"Effects of alpha-difluoromethylornithine on markers of proliferation, invasion, and apoptosis in breast cancer","volume":"30","author":"Izbicka","year":"2010","journal-title":"Anticancer Res"},{"key":"10.1016\/j.ijcard.2013.04.153_bb0180","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.cellsig.2008.12.003","article-title":"Role of polyamines in p53-dependent apoptosis of intestinal epithelial cells","volume":"21","author":"Bhattacharya","year":"2009","journal-title":"Cell Signal"},{"key":"10.1016\/j.ijcard.2013.04.153_bb0185","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s00726-007-0514-3","article-title":"Polyamine biosynthesis as a target to inhibit apoptosis of non-tumoral cells","volume":"33","author":"Flamigni","year":"2007","journal-title":"Amino Acids"},{"key":"10.1016\/j.ijcard.2013.04.153_bb0190","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1159\/000085379","article-title":"c-Myc antisense oligonucleotides preserve smooth muscle differentiation and reduce negative remodelling following rat carotid arteriotomy","volume":"42","author":"Forte","year":"2005","journal-title":"J Vasc Res"},{"key":"10.1016\/j.ijcard.2013.04.153_bb0195","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.cardiores.2003.08.015","article-title":"Stenosis progression after surgical injury in Milan hypertensive rat carotid arteries","volume":"60","author":"Forte","year":"2003","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.ijcard.2013.04.153_bb0200","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1172\/JCI117036","article-title":"Inhibition of vascular smooth muscle cell proliferation in vitro and in vivo by c-myc antisense oligodeoxynucleotides","volume":"93","author":"Bennett","year":"1994","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ijcard.2013.04.153_bb0205","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1161\/CIRCRESAHA.106.141986","article-title":"MicroRNA expression signature and antisense-mediated depletion reveal an essential role of MicroRNA in vascular neointimal lesion formation","volume":"100","author":"Ji","year":"2007","journal-title":"Circ Res"},{"key":"10.1016\/j.ijcard.2013.04.153_bb0210","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.ejps.2008.09.003","article-title":"Intravascular site-specific delivery of a therapeutic antisense for the inhibition of restenosis","volume":"35","author":"Yang","year":"2008","journal-title":"Eur J Pharm Sci"},{"key":"10.1016\/j.ijcard.2013.04.153_bb0215","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1161\/01.RES.83.2.217","article-title":"Thrombin stimulates vascular smooth muscle cell polyamine synthesis by inducing cationic amino acid transporter and ornithine decarboxylase gene expression","volume":"83","author":"Durante","year":"1998","journal-title":"Circ Res"},{"key":"10.1016\/j.ijcard.2013.04.153_bb0220","doi-asserted-by":"crossref","first-page":"4202","DOI":"10.1073\/pnas.071054698","article-title":"Role of the arginine-nitric oxide pathway in the regulation of vascular smooth muscle cell proliferation","volume":"98","author":"Ignarro","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ijcard.2013.04.153_bb0225","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0378-4347(00)80114-0","article-title":"Assay of alpha-difluoromethylornithine in body fluids and tissues by automatic amino-acid analysis","volume":"223","author":"Grove","year":"1981","journal-title":"J Chromatogr"},{"key":"10.1016\/j.ijcard.2013.04.153_bb0230","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/nrd2243","article-title":"Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases","volume":"6","author":"Casero","year":"2007","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.ijcard.2013.04.153_bb0235","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0065-2571(85)90072-X","article-title":"Ornithine decarboxylase as target of chemotherapy","volume":"24","author":"Heby","year":"1985","journal-title":"Adv Enzyme Regul"},{"key":"10.1016\/j.ijcard.2013.04.153_bb0240","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1006\/bbrc.2000.3942","article-title":"YC-1, a benzyl indazole derivative, stimulates vascular cGMP and inhibits neointima formation","volume":"279","author":"Tulis","year":"2000","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.ijcard.2013.04.153_bb0245","first-page":"1546","article-title":"Evaluation of pluronic F127 as a base for gradual release of anticancer drug","volume":"17","author":"Abe","year":"1990","journal-title":"Gan To Kagaku Ryoho"},{"key":"10.1016\/j.ijcard.2013.04.153_bb0250","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0168-3659(00)00215-7","article-title":"Experimental investigation and mathematical modeling of Pluronic F127 gel dissolution: drug release in stirred systems","volume":"67","author":"Moore","year":"2000","journal-title":"J Control Release"}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527313008024?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527313008024?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T22:47:31Z","timestamp":1645051651000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527313008024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10]]},"references-count":50,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["S0167527313008024"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2013.04.153","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2013,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Local inhibition of ornithine decarboxylase reduces vascular stenosis in a murine model of carotid injury","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2013.04.153","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}