{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T07:55:18Z","timestamp":1790150118768,"version":"4.0.1"},"reference-count":44,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Spanish Ministry of Education and Science","award":["SAF2011-30067-C02-01"],"award-info":[{"award-number":["SAF2011-30067-C02-01"]}]},{"name":"Instituto de Salud Carlos III & European Fund for Regional Development (ERDF)","award":["FIS PI11\/00747"],"award-info":[{"award-number":["FIS PI11\/00747"]}]},{"DOI":"10.13039\/100008666","name":"Fundaci\u00f3 La MARAT\u00d3 de TV3","doi-asserted-by":"crossref","award":["122232"],"award-info":[{"award-number":["122232"]}],"id":[{"id":"10.13039\/100008666","id-type":"DOI","asserted-by":"crossref"}]},{"name":"European Commission 7th Framework Programme","award":["NMP3-SL-2009-229239"],"award-info":[{"award-number":["NMP3-SL-2009-229239"]}]},{"name":"Red de Terapia Celular \u2014 TerCel","award":["RD12\/0019\/0029"],"award-info":[{"award-number":["RD12\/0019\/0029"]}]},{"name":"Red de Investigaci\u00f3n Cardiovascular \u2014 RIC","award":["RD RD12\/0042\/0027"],"award-info":[{"award-number":["RD RD12\/0042\/0027"]}]},{"name":"Red de Investigaci\u00f3n Cardiovascular \u2014 RIC","award":["RD12\/0042\/0047"],"award-info":[{"award-number":["RD12\/0042\/0047"]}]},{"DOI":"10.13039\/501100002809","name":"Generalitat de Catalunya","doi-asserted-by":"publisher","award":["2013 FI_B01008"],"award-info":[{"award-number":["2013 FI_B01008"]}],"id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000008","name":"RD","doi-asserted-by":"publisher","award":["RD12\/0042\/0027"],"award-info":[{"award-number":["RD12\/0042\/0027"]}],"id":[{"id":"10.13039\/100000008","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","internationaljournalofcardiology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1016\/j.ijcard.2014.07.270","type":"journal-article","created":{"date-parts":[[2014,8,6]],"date-time":"2014-08-06T20:15:14Z","timestamp":1407356114000},"page":"805-814","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Inverse relationship between raft LRP1 localization and non-raft ERK1,2\/MMP9 activation in idiopathic dilated cardiomyopathy: Potential impact in ventricular remodeling"],"prefix":"10.1016","volume":"176","author":[{"given":"Santiago","family":"Roura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roi","family":"Cal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"G\u00e1lvez-Mont\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Revuelta-Lopez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Nasarre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Badimon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoni","family":"Bayes-Genis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicenta","family":"Llorente-Cort\u00e9s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijcard.2014.07.270_bb0005","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1161\/CIRCULATIONAHA.106.174287","volume":"113","author":"Maron","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2014.07.270_bb0010","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1038\/nrcardio.2009.130","article-title":"Vascular dysfunction in idiopathic dilated cardiomyopathy","volume":"6","author":"Roura","year":"2009","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.ijcard.2014.07.270_bb0015","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/S0140-6736(09)62023-7","article-title":"Dilated cardiomyopathy","volume":"375","author":"Jefferies","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.ijcard.2014.07.270_bb0020","first-page":"1639","article-title":"Remodeling of human myocardial collagen in idiopathic dilated cardiomyopathy. Role of metalloproteinases and pyridinoline cross-links","volume":"148","author":"Gunja-Smith","year":"1996","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ijcard.2014.07.270_bb0025","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/0735-1097(94)00557-7","article-title":"Dilated cardiomyopathy is associated with an increase in the type I\/type III collagen ratio: a quantitative assessment","volume":"25","author":"Marijianowski","year":"1995","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ijcard.2014.07.270_bb0030","doi-asserted-by":"crossref","first-page":"2750","DOI":"10.1161\/01.CIR.99.21.2750","article-title":"Dilated cardiomyopathy is associated with significant changes in collagen type I\/III ratio","volume":"99","author":"Pauschinger","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2014.07.270_bb0035","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s10741-011-9269-8","article-title":"Role of various proteases in cardiac remodeling and progression of heart failure","volume":"17","author":"M\u00fcller","year":"2012","journal-title":"Heart Fail Rev"},{"key":"10.1016\/j.ijcard.2014.07.270_bb0045","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1093\/cvr\/cvq208","article-title":"Altered degradation of extracellular matrix in myocardial remodelling: the growing role of cathepsins and cystatins","volume":"87","author":"D\u00edez","year":"2010","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.ijcard.2014.07.270_bb0055","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1161\/01.CIR.97.17.1708","article-title":"Increased matrix metalloproteinase activity and selective upregulation in LV myocardium from patients with end-stage dilated cardiomyopathy","volume":"97","author":"Thomas","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2014.07.270_bb0060","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1161\/CIRCULATIONAHA.105.571414","article-title":"Altered expression of disintegrin metalloproteinases and their inhibitor in human dilated cardiomyopathy","volume":"113","author":"Fedak","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2014.07.270_bb0065","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s11010-007-9595-2","article-title":"Upregulation of lysyl oxidase and MMPs during cardiac remodeling in human dilated cardiomyopathy","volume":"307","author":"Sivakumar","year":"2008","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.ijcard.2014.07.270_bb0070","doi-asserted-by":"crossref","first-page":"9817","DOI":"10.1158\/0008-5472.CAN-07-0683","article-title":"The low-density lipoprotein receptor-related protein regulates cancer cell survival and metastasis development","volume":"67","author":"Montel","year":"2007","journal-title":"Cancer Res"},{"key":"10.1016\/j.ijcard.2014.07.270_bb0085","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1158\/0008-5472.CAN-08-3379","article-title":"Low-density lipoprotein receptor-related protein 1 promotes cancer cell migration and invasion by inducing the expression of matrix metalloproteinases 2 and 9","volume":"69","author":"Song","year":"2009","journal-title":"Cancer Res"},{"key":"10.1016\/j.ijcard.2014.07.270_bb0090","doi-asserted-by":"crossref","first-page":"15498","DOI":"10.1074\/jbc.M100121200","article-title":"The low density lipoprotein receptor-related protein modulates levels of matrix metalloproteinase 9 (MMP-9) by mediating its cellular catabolism","volume":"276","author":"Hahn-Dantona","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ijcard.2014.07.270_bb0095","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1161\/01.RES.0000260204.40510.aa","article-title":"Deletion of macrophage LDL receptor-related protein increases atherogenesis in the mouse","volume":"100","author":"Overton","year":"2007","journal-title":"Circ Res"},{"key":"10.1016\/j.ijcard.2014.07.270_bb0100","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1074\/jbc.M504988200","article-title":"Tissue-type plasminogen activator acts as a cytokine that triggers intracellular signal transduction and induces matrix metalloproteinase-9 gene expression","volume":"281","author":"Hu","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ijcard.2014.07.270_bb0105","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1002\/jcb.20596","article-title":"The low-density lipoprotein receptor-related protein-1 associates transiently with lipid rafts","volume":"96","author":"Wu","year":"2005","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.ijcard.2014.07.270_bb0110","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1194\/jlr.R200021-JLR200","article-title":"Lipid rafts: bringing order to chaos","volume":"44","author":"Pike","year":"2003","journal-title":"J Lipid Res"},{"key":"10.1016\/j.ijcard.2014.07.270_bb0115","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/42408","article-title":"Functional rafts in cell membranes","volume":"387","author":"Simons","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.ijcard.2014.07.270_bb0120","doi-asserted-by":"crossref","first-page":"25663","DOI":"10.1074\/jbc.M111.221903","volume":"286","author":"Geetha","year":"2011","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ijcard.2014.07.270_bb0125","doi-asserted-by":"crossref","first-page":"e11584","DOI":"10.1371\/journal.pone.0011584","article-title":"LRP-1 promotes cancer cell invasion by supporting ERK and inhibiting JNK signaling pathways","volume":"5","author":"Langlois","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.ijcard.2014.07.270_bb0130","doi-asserted-by":"crossref","first-page":"14308","DOI":"10.1074\/jbc.M109.046672","article-title":"Low density lipoprotein receptor-related protein 1 (LRP1) forms a signaling complex with platelet-derived growth factor receptor-beta in endosomes and regulates activation of the MAPK pathway","volume":"285","author":"Muratoglu","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ijcard.2014.07.270_bb0135","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1161\/01.CIR.103.5.670","article-title":"Differential activation of signal transduction pathways in human hearts with hypertrophy versus advanced heart failure","volume":"103","author":"Haq","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2014.07.270_bb0140","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1161\/CIRCULATIONAHA.110.970673","article-title":"Mitogen-activated protein kinase inhibitors improve heart function and prevent fibrosis in cardiomyopathy caused by mutation in lamin A\/C gene","volume":"123","author":"Wu","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2014.07.270_bb0145","doi-asserted-by":"crossref","first-page":"215","DOI":"10.3892\/ol.2013.1655","article-title":"Downregulation of ERK signaling impairs U2OS osteosarcoma cell migration in collagen matrix by suppressing MMP9 production","volume":"7","author":"Poudel","year":"2014","journal-title":"Oncol Lett"},{"key":"10.1016\/j.ijcard.2014.07.270_bb0150","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/j.bcp.2013.08.022","article-title":"Adenosine dialdehyde suppresses MMP-9-mediated invasion of cancer cells by blocking the Ras\/Raf-1\/ERK\/AP-1 signaling pathway","volume":"86","author":"Kim","year":"2013","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.ijcard.2014.07.270_bb0155","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1016\/j.cellsig.2013.06.004","article-title":"Interleukin-5 enhances the migration and invasion of bladder cancer cells via ERK1\/2-mediated MMP-9\/NF-\u03baB\/AP-1 pathway: involvement of the p21WAF1 expression","volume":"25","author":"Lee","year":"2013","journal-title":"Cell Signal"},{"key":"10.1016\/j.ijcard.2014.07.270_bb0160","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1093\/nar\/29.9.e45","article-title":"A new mathematical model for relative quantification in real-time RT-PCR","volume":"29","author":"Pfaffl","year":"2001","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.ijcard.2014.07.270_bb0165","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.ijcard.2014.07.270_bb0170","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.atherosclerosis.2013.08.009","article-title":"New insights into lipid raft function regulating myocardial vascularization competency in human idiopathic dilated cardiomyopathy","volume":"230","author":"Roura","year":"2013","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.ijcard.2014.07.270_bb0175","doi-asserted-by":"crossref","first-page":"3104","DOI":"10.1161\/01.CIR.0000041434.28573.0B","article-title":"Low-density lipoprotein upregulates low-density lipoprotein receptor-related protein expression in vascular smooth muscle cells: possible involvement of sterol regulatory element binding protein-2-dependent mechanism","volume":"106","author":"Llorente-Cort\u00e9s","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2014.07.270_bb0180","doi-asserted-by":"crossref","first-page":"H823","DOI":"10.1152\/ajpheart.00986.2003","article-title":"Cardiac physiology at the cellular level: use of cultured HL-1 cardiomyocytes for studies of cardiac muscle cell structure and function","volume":"286","author":"White","year":"2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.ijcard.2014.07.270_bb0185","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1093\/cvr\/cvs136","article-title":"Low-density lipoprotein receptor-related protein 1 mediates hypoxia-induced very low density lipoprotein-cholesteryl ester uptake and accumulation in cardiomyocytes","volume":"94","author":"Cal","year":"2012","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.ijcard.2014.07.270_bb0190","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1002\/jcb.22737","article-title":"Activated \u03b1(2) macroglobulin induces matrix metalloproteinase 9 expression by low-density lipoprotein receptor-related protein 1 through MAPK-ERK1\/2 and NF-\u03baB activation in macrophage-derived cell lines","volume":"111","author":"C\u00e1ceres","year":"2010","journal-title":"J Cell Biochem"},{"issue":"Pt 1","key":"10.1016\/j.ijcard.2014.07.270_bb0195","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1242\/jcs.113.1.123","article-title":"Extracellular signal-regulated kinase functions in the urokinase receptor-dependent pathway by which neutralization of low density lipoprotein receptor-related protein promotes fibrosarcoma cell migration and matrigel invasion","volume":"113","author":"Webb","year":"2000","journal-title":"J Cell Sci"},{"key":"10.1016\/j.ijcard.2014.07.270_bb0200","doi-asserted-by":"crossref","first-page":"3528","DOI":"10.1002\/jcp.24080","article-title":"Low density lipoprotein receptor-related protein 1 modulates the proliferation and migration of human hepatic stellate cells","volume":"227","author":"Llorente-Cortes","year":"2012","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.ijcard.2014.07.270_bb0205","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1083\/jcb.200207070","article-title":"Regulation of Rac1 activation by the low density lipoprotein receptor-related protein","volume":"159","author":"Ma","year":"2002","journal-title":"J Cell Biol"},{"key":"10.1016\/j.ijcard.2014.07.270_bb0210","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1128\/MCB.01359-08","article-title":"Ras subcellular localization defines extracellular signal-regulated kinase 1 and 2 substrate specificity through distinct utilization of scaffold proteins","volume":"29","author":"Casar","year":"2009","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.ijcard.2014.07.270_bb0215","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1161\/01.CIR.102.16.1944","article-title":"A matrix metalloproteinase induction\/activation system exists in the human left ventricular myocardium and is upregulated in heart failure","volume":"102","author":"Spinale","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2014.07.270_bb0220","doi-asserted-by":"crossref","first-page":"5344","DOI":"10.1016\/j.ijcard.2013.08.005","article-title":"Matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1, B+tenascin-C and ED-A+fibronectin in dilated cardiomyopathy: potential impact on disease progression and patients' prognosis","volume":"168","author":"Franz","year":"2013","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.ijcard.2014.07.270_bb0225","doi-asserted-by":"crossref","first-page":"4773","DOI":"10.4049\/jimmunol.0900871","article-title":"Matrix metalloproteinase (MMP)-9, but not MMP-2, is involved in the development and progression of C protein-induced myocarditis and subsequent dilated cardiomyopathy","volume":"183","author":"Matsumoto","year":"2009","journal-title":"J Immunol"},{"key":"10.1016\/j.ijcard.2014.07.270_bb0230","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1136\/heart.88.5.525","article-title":"Cardiac remodelling in end stage heart failure: upregulation of matrix metalloproteinase (MMP) irrespective of the underlying disease, and evidence for a direct inhibitory effect of ACE inhibitors on MMP","volume":"88","author":"Reinhardt","year":"2002","journal-title":"Heart"},{"key":"10.1016\/j.ijcard.2014.07.270_bb0235","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s11010-008-0016-y","article-title":"Lipopolysaccharide upregulates uPA, MMP-2 and MMP-9 via ERK1\/2 signaling in H9c2 cardiomyoblast cells","volume":"325","author":"Cheng","year":"2009","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.ijcard.2014.07.270_bb0240","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jchf.2012.10.002","article-title":"Heart failure","volume":"1","author":"Braunwald","year":"2013","journal-title":"JACC Heart Fail"}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527314014958?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527314014958?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T20:35:37Z","timestamp":1759091737000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527314014958"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["S0167527314014958"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2014.07.270","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inverse relationship between raft LRP1 localization and non-raft ERK1,2\/MMP9 activation in idiopathic dilated cardiomyopathy: Potential impact in ventricular remodeling","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2014.07.270","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}