{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T15:39:46Z","timestamp":1768318786330,"version":"3.49.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","internationaljournalofcardiology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1016\/j.ijcard.2015.03.053","type":"journal-article","created":{"date-parts":[[2015,3,4]],"date-time":"2015-03-04T22:47:37Z","timestamp":1425509257000},"page":"95-100","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Risk of heart failure- and cardiac death gradually increases with more right ventricular pacing"],"prefix":"10.1016","volume":"185","author":[{"given":"Erik O.","family":"Udo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norbert M.","family":"van Hemel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolaas P.A.","family":"Zuithoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pieter A.","family":"Doevendans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karel G.M.","family":"Moons","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijcard.2015.03.053_bb0005","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1016\/S0735-1097(86)80140-1","article-title":"Left ventricular endocardial activation during right ventricular pacing: effect of underlying heart disease","volume":"7","author":"Vassallo","year":"1986","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcard.2015.03.053_bb0010","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/S0735-1097(03)00757-5","article-title":"A randomized comparison of atrial and dual-chamber pacing in 177 consecutive patients with sick sinus syndrome: echocardiographic and clinical outcome","volume":"42","author":"Nielsen","year":"2003","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcard.2015.03.053_bb0015","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/0002-8703(95)90394-1","article-title":"Hemodynamic importance of preserving the normal sequence of ventricular activation in permanent cardiac pacing","volume":"129","author":"Leclercq","year":"1995","journal-title":"Am. Heart J."},{"key":"10.1016\/j.ijcard.2015.03.053_bb0020","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/0002-9149(91)90437-P","article-title":"Relative importance of activation sequence compared to atrioventricular synchrony in left ventricular function","volume":"67","author":"Rosenqvist","year":"1991","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.ijcard.2015.03.053_bb0025","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.hrthm.2007.03.031","article-title":"Eliminating right ventricular pacing may not be best for patients requiring implantable cardioverter\u2013defibrillators","volume":"4","author":"Olshansky","year":"2007","journal-title":"Heart Rhythm."},{"key":"10.1016\/j.ijcard.2015.03.053_bb0030","doi-asserted-by":"crossref","first-page":"3115","DOI":"10.1001\/jama.288.24.3115","article-title":"Dual-chamber pacing or ventricular backup pacing in patients with an implantable defibrillator: the Dual Chamber and VVI Implantable Defibrillator (DAVID) Trial","volume":"288","author":"Wilkoff","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.ijcard.2015.03.053_bb0035","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ancard.2007.09.011","article-title":"Assessment of heart failure and left ventricular systolic dysfunction after cardiac pacing in patients with preserved left ventricular systolic function","volume":"57","author":"Kachboura","year":"2008","journal-title":"Ann. Cardiol. Angeiol. (Paris)"},{"key":"10.1016\/j.ijcard.2015.03.053_bb0040","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.amjcard.2004.10.049","article-title":"Myocardial Infarction Data Acquisition System Study Group (MIDAS 9). Permanent pacing is a risk factor for the development of heart failure","volume":"95","author":"Freudenberger","year":"2005","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.ijcard.2015.03.053_bb0045","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1093\/europace\/eum288","article-title":"Percent ventricular pacing with managed ventricular pacing mode in standard pacemaker population","volume":"10","author":"Milasinovic","year":"2008","journal-title":"Europace"},{"key":"10.1016\/j.ijcard.2015.03.053_bb0050","first-page":"581","article-title":"RIVER: Portuguese registry to monitor unnecessary right ventricular pacing","volume":"29","author":"Sanfins","year":"2010","journal-title":"Rev. Port. Cardiol."},{"key":"10.1016\/j.ijcard.2015.03.053_bb0055","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1111\/j.1540-8159.2006.00422.x","article-title":"Reducing unnecessary right ventricular pacing with the managed ventricular pacing mode in patients with sinus node disease and AV block","volume":"29","author":"Gillis","year":"2006","journal-title":"Pacing Clin. Electrophysiol."},{"key":"10.1016\/j.ijcard.2015.03.053_bb0060","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1540-8159.2006.00329.x","article-title":"Reduction of right ventricular pacing in patients with dual-chamber ICDs","volume":"29","author":"Olshansky","year":"2006","journal-title":"Pacing Clin. Electrophysiol."},{"key":"10.1016\/j.ijcard.2015.03.053_bb0065","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1111\/j.1540-8167.2009.01470.x","article-title":"Upgrading pacemaker patients with right ventricular apical pacing to right ventricular septal pacing improves left ventricular performance and functional capacity","volume":"20","author":"Tse","year":"2009","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"10.1016\/j.ijcard.2015.03.053_bb0070","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1111\/j.1540-8159.2010.02876.x","article-title":"Pacing the right ventricular septum: time to abandon apical pacing","volume":"33","author":"Mond","year":"2010","journal-title":"Pacing Clin. Electrophysiol."},{"key":"10.1016\/j.ijcard.2015.03.053_bb0075","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1016\/S0735-1097(02)02169-1","article-title":"Functional abnormalities in patients with permanent right ventricular pacing: the effect of sites of electrical stimulation","volume":"40","author":"Tse","year":"2002","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcard.2015.03.053_bb0080","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1093\/europace\/eus069","article-title":"Heart failure in patients with sick sinus syndrome treated with single lead atrial or dual-chamber pacing: no association with pacing mode or right ventricular pacing site","volume":"14","author":"Riahi","year":"2012","journal-title":"Europace"},{"key":"10.1016\/j.ijcard.2015.03.053_bb0085","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1476-7120-5-13","article-title":"Mid-term echocardiographic follow up of left ventricular function with permanent right ventricular pacing in pediatric patients with and without structural heart disease","volume":"5","author":"Shalganov","year":"2007","journal-title":"Cardiovasc. Ultrasound"},{"key":"10.1016\/j.ijcard.2015.03.053_bb0090","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1161\/CIRCULATIONAHA.109.866343","article-title":"Effect of long-term right ventricular pacing in young adults with structurally normal heart","volume":"121","author":"Sagar","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2015.03.053_bb0095","doi-asserted-by":"crossref","first-page":"2932","DOI":"10.1161\/01.CIR.0000072769.17295.B1","article-title":"Adverse effect of ventricular pacing on heart failure and atrial fibrillation among patients with normal baseline QRS duration in a clinical trial of pacemaker therapy for sinus node dysfunction","volume":"107","author":"Sweeney","year":"2003","journal-title":"Circulation"},{"issue":"9","key":"10.1016\/j.ijcard.2015.03.053_bb0100","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1093\/europace\/eut041","article-title":"Incidence and predictors of heart failure hospitalization and death in permanent pacemaker patients: a single-centre experience over medium-term follow-up","volume":"15","author":"Mazza","year":"2013","journal-title":"Europace"},{"key":"10.1016\/j.ijcard.2015.03.053_bb0105","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1093\/europace\/eum008","article-title":"Evolution of left ventricular function in paediatric patients with permanent right ventricular pacing for isolated congenital heart block: a medium term follow-up","volume":"9","author":"Vatasescu","year":"2007","journal-title":"Europace"},{"key":"10.1016\/j.ijcard.2015.03.053_bb0110","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.hrthm.2005.05.015","article-title":"Percent right ventricular pacing predicts outcomes in the DAVID trial","volume":"2","author":"Sharma","year":"2005","journal-title":"Heart Rhythm."},{"key":"10.1016\/j.ijcard.2015.03.053_bb0115","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1093\/europace\/euj005","article-title":"FOLLOWPACE study: a prospective study on the cost-effectiveness of routine follow-up visits in patients with a pacemaker","volume":"8","author":"van Eck","year":"2006","journal-title":"Europace"},{"key":"10.1016\/j.ijcard.2015.03.053_bb0120","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1046\/j.1540-8167.2002.01183.x","volume":"13","author":"Gregoratos","year":"2002","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"10.1016\/j.ijcard.2015.03.053_bb0125","series-title":"Regression Modeling Strategies With Applications to Linear Models, Logistic Regression and Survival Analysis","author":"Harrell","year":"2001"},{"key":"10.1016\/j.ijcard.2015.03.053_bb0130","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/(SICI)1097-0258(19960229)15:4<361::AID-SIM168>3.0.CO;2-4","article-title":"Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors","volume":"15","author":"Harrell","year":"1996","journal-title":"Stat. Med."},{"key":"10.1016\/j.ijcard.2015.03.053_bb0135","series-title":"Applied Multivariate Statistics for the Social Sciences","author":"Stevens","year":"1996"},{"key":"10.1016\/j.ijcard.2015.03.053_bb0140","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1093\/eurheartj\/ehm603","article-title":"Heart failure as an endpoint in heart failure and non-heart failure cardiovascular clinical trials: the need for a consensus definition","volume":"29","author":"Zannad","year":"2008","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcard.2015.03.053_bb0145","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.hrthm.2010.10.035","article-title":"Long-term implications of cumulative right ventricular pacing among patients with an implantable cardioverter\u2013defibrillator","volume":"8","author":"Barsheshet","year":"2011","journal-title":"Heart Rhythm."},{"key":"10.1016\/j.ijcard.2015.03.053_bb0150","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1046\/j.1540-8167.2005.50038.x","article-title":"The clinical implications of cumulative right ventricular pacing in the multicenter automatic defibrillator trial II","volume":"16","author":"Steinberg","year":"2005","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"10.1016\/j.ijcard.2015.03.053_bb0155","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1016\/j.jacc.2006.05.071","article-title":"Abnormal conduction increases risk of adverse outcomes from right ventricular pacing","volume":"48","author":"Hayes","year":"2006","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcard.2015.03.053_bb0160","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1016\/j.hrthm.2006.08.006","article-title":"Right ventricular pacing and the risk of heart failure in implantable cardioverter\u2013defibrillator patients","volume":"3","author":"Smit","year":"2006","journal-title":"Heart Rhythm."},{"key":"10.1016\/j.ijcard.2015.03.053_bb0165","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1093\/europace\/eup118","article-title":"Right ventricular pacing is associated with impaired overall survival, but not with an increased incidence of ventricular tachyarrhythmias in routine cardioverter\/defibrillator recipients with reservedly programmed pacing","volume":"11","author":"Stockburger","year":"2009","journal-title":"Europace"},{"key":"10.1016\/j.ijcard.2015.03.053_bb0170","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1093\/eurjhf\/hfs199","article-title":"Paced QRS duration as a predictor for clinical heart failure events during right ventricular apical pacing in patients with idiopathic complete atrioventricular block: results from an observational cohort study (PREDICT-HF)","volume":"15","author":"Chen","year":"2013","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.ijcard.2015.03.053_bb0175","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1111\/j.1540-8159.2011.03192.x","article-title":"The influence of atrial and ventricular pacing on the incidence of atrial fibrillation: a meta-analysis","volume":"34","author":"Elkayam","year":"2011","journal-title":"Pacing Clin. Electrophysiol."},{"key":"10.1016\/j.ijcard.2015.03.053_bb0180","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1056\/NEJMoa013040","article-title":"Ventricular pacing or dual-chamber pacing for sinus-node dysfunction","volume":"346","author":"Lamas","year":"2002","journal-title":"N. Engl. J. Med."}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527315002910?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527315002910?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T20:36:03Z","timestamp":1759091763000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527315002910"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4]]},"references-count":36,"alternative-id":["S0167527315002910"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2015.03.053","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2015,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Risk of heart failure- and cardiac death gradually increases with more right ventricular pacing","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2015.03.053","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}