{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T18:48:05Z","timestamp":1790534885773,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","internationaljournalofcardiology.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1016\/j.ijcard.2015.05.048","type":"journal-article","created":{"date-parts":[[2015,5,9]],"date-time":"2015-05-09T17:24:44Z","timestamp":1431192284000},"page":"314-319","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":74,"special_numbering":"C","title":["Prognostic significance of quantitative assessment of focal myocardial fibrosis in patients with heart failure with preserved ejection fraction"],"prefix":"10.1016","volume":"191","author":[{"given":"Shingo","family":"Kato","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naka","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidekuni","family":"Kirigaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiki","family":"Gyotoku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Iinuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Kusakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohei","family":"Iguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Nakachi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuki","family":"Fukui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaaki","family":"Futaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae","family":"Iwasawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masataka","family":"Taguri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Umemura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijcard.2015.05.048_bb0005","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1056\/NEJMoa051530","article-title":"Outcome of heart failure with preserved ejection fraction in a population-based study","volume":"355","author":"Bhatia","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijcard.2015.05.048_bb0010","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1001\/jama.289.2.194","article-title":"Burden of systolic and diastolic ventricular dysfunction in the community: appreciating the scope of the heart failure epidemic","volume":"289","author":"Redfield","year":"2003","journal-title":"JAMA"},{"key":"10.1016\/j.ijcard.2015.05.048_bb0015","doi-asserted-by":"crossref","first-page":"e540","DOI":"10.1161\/CIRCULATIONAHA.111.071696","article-title":"Heart failure with preserved ejection fraction","volume":"124","author":"Udelson","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2015.05.048_bb0020","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1161\/CIRCULATIONAHA.109.909614","article-title":"Mode of death in patients with heart failure and a preserved ejection fraction: results from the irbesartan in heart failure with preserved ejection fraction study (i-preserve) trial","volume":"121","author":"Zile","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2015.05.048_bb0025","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1378\/chest.10-2837","article-title":"The role of Doppler echocardiography in pulmonary artery hypertension: the importance of proving the obvious","volume":"139","author":"Paterson","year":"2011","journal-title":"Chest"},{"key":"10.1016\/j.ijcard.2015.05.048_bb0030","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1016\/j.jacc.2012.07.036","article-title":"Incremental prognostic significance of peripheral endothelial dysfunction in patients with heart failure with normal left ventricular ejection fraction","volume":"60","author":"Akiyama","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcard.2015.05.048_bb0035","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/ncpcardio1245","article-title":"Diastolic heart failure: mechanisms and controversies","volume":"5","author":"Ouzounian","year":"2008","journal-title":"Nat. Clin. Pract. Cardiovasc. Med."},{"key":"10.1016\/j.ijcard.2015.05.048_bb0040","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1056\/NEJMoa052256","article-title":"Trends in prevalence and outcome of heart failure with preserved ejection fraction","volume":"355","author":"Owan","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijcard.2015.05.048_bb0045","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1161\/01.CIR.100.19.1992","article-title":"Relationship of MRI delayed contrast enhancement to irreversible injury, infarct age, and contractile function","volume":"100","author":"Kim","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2015.05.048_bb0050","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1056\/NEJM200011163432003","article-title":"The use of contrast-enhanced magnetic resonance imaging to identify reversible myocardial dysfunction","volume":"343","author":"Kim","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijcard.2015.05.048_bb0055","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1161\/01.CIR.97.8.765","article-title":"Prognostic significance of microvascular obstruction by magnetic resonance imaging in patients with acute myocardial infarction","volume":"97","author":"Wu","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2015.05.048_bb0060","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1016\/j.jacc.2008.03.018","article-title":"Late gadolinium enhancement by cardiovascular magnetic resonance heralds an adverse prognosis in nonischemic cardiomyopathy","volume":"51","author":"Wu","year":"2008","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcard.2015.05.048_bb0065","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1016\/j.jacc.2006.07.049","article-title":"Cardiovascular magnetic resonance, fibrosis, and prognosis in dilated cardiomyopathy","volume":"48","author":"Assomull","year":"2006","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcard.2015.05.048_bb0070","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.jacc.2010.05.007","article-title":"Myocardial scar visualized by cardiovascular magnetic resonance imaging predicts major adverse events in patients with hypertrophic cardiomyopathy","volume":"56","author":"Bruder","year":"2010","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcard.2015.05.048_bb0075","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.jacc.2010.05.010","article-title":"Prognostic significance of myocardial fibrosis in hypertrophic cardiomyopathy","volume":"56","author":"O'Hanlon","year":"2010","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcard.2015.05.048_bb0080","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.1161\/CIRCULATIONAHA.105.570648","article-title":"Impact of unrecognized myocardial scar detected by cardiac magnetic resonance imaging on event-free survival in patients presenting with signs or symptoms of coronary artery disease","volume":"113","author":"Kwong","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2015.05.048_bb0085","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/S0140-6736(03)12389-6","article-title":"Contrast-enhanced MRI and routine single photon emission computed tomography (SPECT) perfusion imaging for detection of subendocardial myocardial infarcts: an imaging study","volume":"361","author":"Wagner","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.ijcard.2015.05.048_bb0090","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1093\/eurheartj\/ehm037","article-title":"How to diagnose diastolic heart failure: a consensus statement on the diagnosis of heart failure with normal left ventricular ejection fraction by the Heart Failure and Echocardiography Associations of the European Society of Cardiology","volume":"28","author":"Paulus","year":"2007","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcard.2015.05.048_bb0095","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1148\/radiology.174.3.2305059","article-title":"Normal left ventricular dimensions and function: interstudy reproducibility of measurements with cine MR imaging","volume":"174","author":"Semelka","year":"1990","journal-title":"Radiology"},{"key":"10.1016\/j.ijcard.2015.05.048_bb0100","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0140-6736(86)90837-8","article-title":"Statistical methods for assessing agreement between two methods of clinical measurement","volume":"1","author":"Bland","year":"1986","journal-title":"Lancet"},{"key":"10.1016\/j.ijcard.2015.05.048_bb0105","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1056\/NEJMoa0805450","article-title":"Irbesartan in patients with heart failure and preserved ejection fraction","volume":"359","author":"Massie","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijcard.2015.05.048_bb0110","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.jacc.2010.03.077","article-title":"Global cardiovascular reserve dysfunction in heart failure with preserved ejection fraction","volume":"56","author":"Borlaug","year":"2010","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcard.2015.05.048_bb0115","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/0002-9149(85)90408-4","article-title":"Magnetic resonance imaging in pulmonary arterial hypertension","volume":"56","author":"Bouchard","year":"1985","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.ijcard.2015.05.048_bb0120","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.hrthm.2008.02.042","article-title":"Atrial and ventricular fibrosis induced by atrial fibrillation: evidence to support early rhythm control","volume":"5","author":"Avitall","year":"2008","journal-title":"Heart Rhythm."},{"key":"10.1016\/j.ijcard.2015.05.048_bb0125","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.jcmg.2012.08.019","article-title":"Native T1 mapping in differentiation of normal myocardium from diffuse disease in hypertrophic and dilated cardiomyopathy","volume":"6","author":"Puntmann","year":"2013","journal-title":"J. Am. Coll. Cardiol. Img."},{"key":"10.1016\/j.ijcard.2015.05.048_bb0130","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1016\/j.jacc.2003.11.061","article-title":"The distribution of 10-year risk for coronary heart disease among US adults: findings from the National Health and Nutrition Examination Survey III","volume":"43","author":"Ford","year":"2004","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcard.2015.05.048_bb0135","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1161\/CIRCIMAGING.112.000070","article-title":"Identification and assessment of Anderson\u2013Fabry disease by cardiovascular magnetic resonance noncontrast myocardial T1 mapping","volume":"6","author":"Sado","year":"2013","journal-title":"Circ. Cardiovasc. Imaging"},{"key":"10.1016\/j.ijcard.2015.05.048_bb0140","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.jcmg.2013.10.008","article-title":"Native T1 mapping in transthyretin amyloidosis","volume":"7","author":"Fontana","year":"2014","journal-title":"J. Am. Coll. Cardiol. Img."},{"key":"10.1016\/j.ijcard.2015.05.048_bb0145","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1161\/CIRCIMAGING.113.000633","article-title":"Cardiac magnetic resonance postcontrast T1 time is associated with outcome in patients with heart failure and preserved ejection fraction","volume":"6","author":"Mascherbauer","year":"2013","journal-title":"Circ. Cardiovasc. Imaging"},{"key":"10.1016\/j.ijcard.2015.05.048_bb0150","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.jcmg.2014.04.022","article-title":"Cmr-verified diffuse myocardial fibrosis is associated with diastolic dysfunction in HFpEF","volume":"7","author":"Su","year":"2014","journal-title":"J. Am. Coll. Cardiol. Img."},{"key":"10.1016\/j.ijcard.2015.05.048_bb0155","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1161\/01.CIR.0000095029.57483.60","article-title":"Gadolinium cardiovascular magnetic resonance predicts reversible myocardial dysfunction and remodeling in patients with heart failure undergoing beta-blocker therapy","volume":"108","author":"Bello","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2015.05.048_bb9000","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.jacc.2010.10.018","article-title":"Pentraxin 3 is a new inflammatory marker correlated with left ventricular diastolic dysfunction and heart failure with normal ejection fraction","volume":"57","author":"Matsubara","year":"2011","journal-title":"J Am Coll Cardiol."}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527315010852?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527315010852?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,22]],"date-time":"2018-09-22T18:29:38Z","timestamp":1537640978000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527315010852"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":32,"alternative-id":["S0167527315010852"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2015.05.048","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2015,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prognostic significance of quantitative assessment of focal myocardial fibrosis in patients with heart failure with preserved ejection fraction","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2015.05.048","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}