{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T07:14:12Z","timestamp":1773299652368,"version":"3.50.1"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","internationaljournalofcardiology.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1016\/j.ijcard.2015.07.056","type":"journal-article","created":{"date-parts":[[2015,7,23]],"date-time":"2015-07-23T13:07:08Z","timestamp":1437656828000},"page":"326-332","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Role of Non-Transferrin-Bound Iron in the pathogenesis of cardiotoxicity in patients with ST-elevation myocardial infarction assessed by Cardiac Magnetic Resonance Imaging"],"prefix":"10.1016","volume":"199","author":[{"given":"Alberto","family":"Roghi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika","family":"Poggiali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2008-3187","authenticated-orcid":false,"given":"Lorena","family":"Duca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1941-9963","authenticated-orcid":false,"given":"Antonio","family":"Mafrici","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrizia","family":"Pedrotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Paccagnini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Brenna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessio","family":"Galli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dario","family":"Consonni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Domenica","family":"Cappellini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijcard.2015.07.056_bb0005","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1172\/JCI107898","article-title":"The \u201cno-reflow\u201d phenomenon after temporary occlusion in the dog","volume":"54","author":"Kloner","year":"1974","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ijcard.2015.07.056_bb0010","doi-asserted-by":"crossref","first-page":"2734","DOI":"10.1161\/01.CIR.101.23.2734","article-title":"Microvascular obstruction and left ventricular remodelling early after acute myocardial infarction","volume":"101","author":"Gerber","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2015.07.056_bb0015","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1161\/01.CIR.97.8.765","article-title":"The prognostic significance of microvascular obstruction by magnetic resonance imaging in patients with acute myocardial infarction","volume":"97","author":"Wu","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2015.07.056_bb0020","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/1532-429X-15-58","article-title":"The effect of microvascular obstruction and intramyocardial hemorrhage on contractile recovery in reperfused myocardial infarction: insight from cardiovascular magnetic resonance","volume":"15","author":"Kidambi","year":"2013","journal-title":"J. Cardiovasc. Magn. Reson."},{"key":"10.1016\/j.ijcard.2015.07.056_bb0025","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1161\/CIRCIMAGING.111.963421","article-title":"Dynamic changes of edema and late gadolinium enhancement after acute myocardial infarction and their relationship to functional recovery and salvage index","volume":"4","author":"Dall'Armellina","year":"2011","journal-title":"Circ. Cardiovasc. Imaging"},{"key":"10.1016\/j.ijcard.2015.07.056_bb0030","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1136\/heartjnl-2013-305196","article-title":"International differences in acute coronary syndrome patients' baseline characteristics, clinical management and outcomes in Western Europe: the EURHOBOP study","volume":"100","author":"Andr\u00e8","year":"2014","journal-title":"Heart"},{"key":"10.1016\/j.ijcard.2015.07.056_bb0035","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1161\/01.RES.87.8.648","article-title":"Microvascular integrity and the time course of myocardial sodium accumulation after acute infarction","volume":"87","author":"Rochitte","year":"2000","journal-title":"Circ. Res."},{"key":"10.1016\/j.ijcard.2015.07.056_bb0040","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1161\/01.CIR.92.5.1117","article-title":"Regional heterogeneity of human myocardial infarcts demonstrated by contrast-enhanced MRI: potential mechanisms","volume":"92","author":"Lima","year":"1995","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2015.07.056_bb0045","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1161\/CIRCINTERVENTIONS.111.966226","article-title":"Effect of iron chelation on myocardial infarct size and oxidative stress in ST-elevation-myocardial infarction","volume":"5","author":"Chan","year":"2012","journal-title":"Circ. Cardiovasc. Interv."},{"issue":"Suppl.1","key":"10.1016\/j.ijcard.2015.07.056_bb0050","doi-asserted-by":"crossref","first-page":"P20","DOI":"10.1186\/1532-429X-14-S1-P20","article-title":"Role of iron chelation in hemorrhagic myocardial infarction: a quantitative CMR study","volume":"14","author":"Ghugre","year":"2012","journal-title":"J. Cardiovasc. Magn. Reson."},{"key":"10.1016\/j.ijcard.2015.07.056_bb0055","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1172\/JCI117898","article-title":"Lipid-induced changes in intracellular iron homeostasis in vitro and in vivo","volume":"95","author":"Van Lenten","year":"1995","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ijcard.2015.07.056_bb0060","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1161\/01.CIR.76.4.906","article-title":"Improvement of postischemic myocardial function and metabolism induced by administration of deferoxamine at the time of reflow: the role of iron in the pathogenesis of reperfusion injury","volume":"76","author":"Ambrosio","year":"1987","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2015.07.056_bb0065","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1161\/01.CIR.78.2.442","article-title":"Iron-load increases the susceptibility of rat hearts to oxygen reperfusion damage. Protection by the antioxidant (+)-cyanidanol-3 and deferoxamine","volume":"78","author":"van der Kraaij","year":"1988","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2015.07.056_bb0070","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/S0891-5849(02)00772-4","article-title":"Molecular bases of cellular iron toxicity","volume":"32","author":"Eaton","year":"2002","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ijcard.2015.07.056_bb0075","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.freeradbiomed.2010.04.033","article-title":"Mitochondrial dysfunction may explain the cardiomyopathy of chronic iron overload","volume":"49","author":"Gao","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ijcard.2015.07.056_bb0080","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s00109-005-0029-x","article-title":"Role of L-type Ca2+ channels in iron transport and iron overload cardiomyopathy","volume":"84","author":"Oudit","year":"2006","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.ijcard.2015.07.056_bb0085","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0168-8278(00)80240-8","article-title":"Determination of non-transferrin-bound iron in genetic hemochromatosis using a new HPLC-based method","volume":"32","author":"Loreal","year":"2000","journal-title":"J. Hepatol."},{"key":"10.1016\/j.ijcard.2015.07.056_bb0090","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/ajh.21317","article-title":"High nontransferrin bound iron levels and heart disease in thalassemia major","volume":"84","author":"Piga","year":"2009","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.ijcard.2015.07.056_bb0095","doi-asserted-by":"crossref","first-page":"2730","DOI":"10.2337\/diacare.27.11.2730","article-title":"Serum chelatable redox-active iron is an independent predictor of mortality after myocardial infarction in individuals with diabetes","volume":"27","author":"Sulieman","year":"2004","journal-title":"Diabetes Care"},{"key":"10.1016\/j.ijcard.2015.07.056_bb0100","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/sj.thj.6200028","article-title":"Non-transferrin-bound iron in myelodysplastic syndrome: a marker of ineffective erythropoiesis ?","volume":"1","author":"Cortelezzi","year":"2000","journal-title":"Hematol. J."},{"key":"10.1016\/j.ijcard.2015.07.056_bb0105","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1046\/j.1365-2362.2002.0320s1036.x","article-title":"Nontransferrin-bound iron in the plasma of haemodialysis patients after intravenous iron saccharate infusion","volume":"32","author":"Kooistra","year":"2002","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.ijcard.2015.07.056_bb0110","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.3324\/haematol.2010.032862","article-title":"Relationship between labile plasma iron, liver iron concentration and cardiac response in a deferasirox monotherapy trial","volume":"96","author":"Wood","year":"2011","journal-title":"Haematologica"},{"key":"10.1016\/j.ijcard.2015.07.056_bb0115","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1182\/asheducation-2011.1.443","article-title":"Impact of iron assessment by MRI","volume":"1","author":"Wood","year":"2011","journal-title":"Hematology"},{"key":"10.1016\/j.ijcard.2015.07.056_bb0120","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/1532-429X-11-56","article-title":"T2 quantification for improved detection of myocardial edema","volume":"11","author":"Giri","year":"2009","journal-title":"J. Cardiovasc. Magn. Reson."},{"key":"10.1016\/j.ijcard.2015.07.056_bb0125","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1161\/hc0402.102975","article-title":"Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart: a statement for healthcare professionals from the Cardiac Imaging Committee of the Council of Clinical Cardiology of the American Heart Association","volume":"105","author":"Cerqueira","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2015.07.056_bb0130","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.jcmg.2010.12.004","article-title":"Measuring myocardial scar by CMR","volume":"4","author":"Kwong","year":"2011","journal-title":"J. Am. Coll. Cardiol. Cardiovasc. Img."},{"key":"10.1016\/j.ijcard.2015.07.056_bb0135","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0140-6736(00)03567-4","article-title":"Visualisation of presence, location, and transmural extent of healed Q-wave and non-Q wave myocardial infarction","volume":"357","author":"Wu","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.ijcard.2015.07.056_bb0140","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1006\/abio.1999.4216","article-title":"Quantification of non-transferrin-bound iron in the presence of unsaturated transferring","volume":"273","author":"Gosriwatana","year":"1999","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.ijcard.2015.07.056_bb0145","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1532-429X-10-42","article-title":"Improved survival of thalassemia major in the UK and relation to T2* cardiovascular magnetic resonance","volume":"10","author":"Modell","year":"2008","journal-title":"J. Cardiovasc. Magn. Reson."},{"key":"10.1016\/j.ijcard.2015.07.056_bb0150","first-page":"1187","article-title":"Survival and complications in patients with thalassemia major treated with transfusion and deferoxamine","volume":"89","author":"Borgna-Pignatti","year":"2004","journal-title":"Haematologica"},{"key":"10.1016\/j.ijcard.2015.07.056_bb0155","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.ab.2005.03.008","article-title":"Results of an international round robin for the quantification of serum non-transferrin-bound iron: need for defining standardization and a clinically relevant isoform","volume":"341","author":"Jacobs","year":"2005","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.ijcard.2015.07.056_bb0160","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1053\/euhj.2001.2822","article-title":"Cardiovascular T2-star (T2*) magnetic resonance for the early diagnosis of myocardial iron overload","volume":"22","author":"Anderson","year":"2001","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcard.2015.07.056_bb0165","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1182\/blood.V88.2.705.bloodjournal882705","article-title":"Kinetics of removal and reappearance of non-transferrin-bound plasma iron with deferoxamine therapy","volume":"88","author":"Porter","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.ijcard.2015.07.056_bb0170","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1002\/clc.22089","article-title":"Prognostic evaluation of catalytic iron in patients with acute coronary syndromes","volume":"36","author":"Steen","year":"2013","journal-title":"Clin. Cardiol."},{"key":"10.1016\/j.ijcard.2015.07.056_bb0175","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1136\/hrt.2005.086959","article-title":"The pathophysiology of myocardial reperfusion: a pathologist's perspective","volume":"92","author":"Basso","year":"2006","journal-title":"Heart"},{"key":"10.1016\/j.ijcard.2015.07.056_bb0180","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1161\/CIRCIMAGING.112.973222","article-title":"Characterizing myocardial edema and hemorrhage using quantitative T2 and T2* mapping at multiple time intervals post ST-segment elevation myocardial infarction","volume":"5","author":"Zia","year":"2012","journal-title":"Circ. Cardiovasc. Imaging"},{"key":"10.1016\/j.ijcard.2015.07.056_bb0185","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1161\/CIRCIMAGING.110.960500","article-title":"Prognostic value and determinants of a hypointense infarct core in T2-weighted cardiac magnetic resonance in acute reperfused ST-elevation-myocardial infarction","volume":"4","author":"Eitel","year":"2011","journal-title":"Circ. Cardiovasc. Imaging"},{"key":"10.1016\/j.ijcard.2015.07.056_bb0190","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1136\/hrt.2010.202028","article-title":"Reperfusion hemorrhage as determined by cardiovascular MRI is a predictor of adverse left ventricular remodelling and markers of late arrhythmic risk","volume":"97","author":"Mather","year":"2011","journal-title":"Heart"},{"key":"10.1016\/j.ijcard.2015.07.056_bb0195","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1161\/CIRCIMAGING.112.000133","article-title":"Chronic manifestation of postreperfusion intramyocardial hemorrhage as regional iron deposition. A cardiovascular magnetic resonance study with ex vivo validation","volume":"6","author":"Kali","year":"2013","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.ijcard.2015.07.056_bb0200","first-page":"R229","article-title":"Cytokine signalling during myocardial infarction: sequential appearance of IL-1 beta and IL-6","volume":"269","author":"Guillen","year":"1995","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ijcard.2015.07.056_bb0205","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1093\/cvr\/cvq078","article-title":"Antibody against interleukin-6 receptor attenuates left ventricular remodelling after myocardial infarction in mice","volume":"87","author":"Kobara","year":"2010","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ijcard.2015.07.056_bb0210","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1093\/eurheartj\/eht090","article-title":"Myocardial reperfusion injury: looking beyond primary PCI","volume":"34","author":"Froelich","year":"2013","journal-title":"Eur. Heart J."}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527315301777?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167527315301777?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,5]],"date-time":"2020-09-05T20:00:18Z","timestamp":1599336018000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167527315301777"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11]]},"references-count":42,"alternative-id":["S0167527315301777"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2015.07.056","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2015,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of Non-Transferrin-Bound Iron in the pathogenesis of cardiotoxicity in patients with ST-elevation myocardial infarction assessed by Cardiac Magnetic Resonance Imaging","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2015.07.056","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}