{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:44:47Z","timestamp":1793148287438,"version":"4.5.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","internationaljournalofcardiology.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Cardiology"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.ijcard.2015.07.066","type":"journal-article","created":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T12:53:13Z","timestamp":1438433593000},"page":"10-19","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"special_numbering":"C","title":["Cardiac atrial appendage stem cells engraft and differentiate into cardiomyocytes in vivo: A new tool for cardiac repair after MI"],"prefix":"10.1016","volume":"201","author":[{"given":"Yanick","family":"Fanton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Robic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Luc","family":"Rummens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annick","family":"Dani\u00ebls","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Severina","family":"Windmolders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leen","family":"Willems","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Jamaer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasperina","family":"Dubois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Bijnens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nic","family":"Heuts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristof","family":"Notelaers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rik","family":"Paesen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Ameloot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urbain","family":"Mees","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Bito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1244-7729","authenticated-orcid":false,"given":"Jeroen","family":"Declercq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Hensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remco","family":"Koninckx","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Hendrikx","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijcard.2015.07.066_bb0005","doi-asserted-by":"crossref","first-page":"IV14","DOI":"10.1161\/01.CIR.102.suppl_4.IV-14","article-title":"Congestive heart failure: fifty years of progress","volume":"102","author":"Braunwald","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2015.07.066_bb0010","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1038\/clpt.2011.175","article-title":"The stuttering progress of cell therapy for heart disease","volume":"90","author":"Malliaras","year":"2011","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.ijcard.2015.07.066_bb0015","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1161\/CIRCULATIONAHA.111.086074","article-title":"Adult bone marrow cell therapy improves survival and induces long-term improvement in cardiac parameters: a systematic review and meta-analysis","volume":"126","author":"Jeevanantham","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2015.07.066_bb0020","doi-asserted-by":"crossref","first-page":"2884","DOI":"10.1634\/stemcells.2008-0329","article-title":"Bone marrow-derived mesenchymal stromal cells express cardiac-specific markers, retain the stromal phenotype, and do not become functional cardiomyocytes in vitro","volume":"26","author":"Rose","year":"2008","journal-title":"Stem Cells"},{"key":"10.1016\/j.ijcard.2015.07.066_bb0025","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.scr.2008.02.003","article-title":"TGF-beta1 induces efficient differentiation of human cardiomyocyte progenitor cells into functional cardiomyocytes in vitro","volume":"1","author":"Goumans","year":"2007","journal-title":"Stem Cell Res."},{"key":"10.1016\/j.ijcard.2015.07.066_bb0030","doi-asserted-by":"crossref","first-page":"14068","DOI":"10.1073\/pnas.0706760104","article-title":"Human cardiac stem cells","volume":"104","author":"Bearzi","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ijcard.2015.07.066_bb0035","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1089\/scd.2009.0483","article-title":"Islet-1 cells are cardiac progenitors present during the entire lifespan: from the embryonic stage to adulthood","volume":"19","author":"Genead","year":"2010","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.ijcard.2015.07.066_bb0040","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1161\/CIRCULATIONAHA.106.655209","article-title":"Regenerative potential of cardiosphere-derived cells expanded from percutaneous endomyocardial biopsy specimens","volume":"115","author":"Smith","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2015.07.066_bb0045","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jacc.2013.08.724","article-title":"Intracoronary cardiosphere-derived cells after myocardial infarction: evidence of therapeutic regeneration in the final 1-year results of the CADUCEUS trial (CArdiosphere-Derived aUtologous stem CElls to reverse ventricUlar dySfunction)","volume":"63","author":"Malliaras","year":"2014","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcard.2015.07.066_bb0050","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1016\/S0140-6736(11)61590-0","article-title":"Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): initial results of a randomised phase 1 trial","volume":"378","author":"Bolli","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.ijcard.2015.07.066_bb0055","doi-asserted-by":"crossref","first-page":"S54","DOI":"10.1161\/CIRCULATIONAHA.112.092627","article-title":"Administration of cardiac stem cells in patients with ischemic cardiomyopathy: the SCIPIO trial: surgical aspects and interim analysis of myocardial function and viability by magnetic resonance","volume":"126","author":"Chugh","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2015.07.066_bb0060","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.jtcvs.2007.10.024","article-title":"Cardiac stem cells in the real world","volume":"135","author":"Pouly","year":"2008","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"10.1016\/j.ijcard.2015.07.066_bb0065","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature13309","article-title":"c-kit+cells minimally contribute cardiomyocytes to the heart","volume":"509","author":"van Berlo","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.ijcard.2015.07.066_bb0070","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1161\/CIRCRESAHA.111.259507","article-title":"Cardiomyogenesis in the developing heart is regulated by c-kit-positive cardiac stem cells","volume":"110","author":"Ferreira-Martins","year":"2012","journal-title":"Circ. Res."},{"key":"10.1016\/j.ijcard.2015.07.066_bb0075","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1093\/cvr\/cvs427","article-title":"The cardiac atrial appendage stem cell: a new and promising candidate for myocardial repair","volume":"97","author":"Koninckx","year":"2013","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ijcard.2015.07.066_bb0080","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/j.cell.2006.10.029","article-title":"Multipotent embryonic isl1+ progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification","volume":"127","author":"Moretti","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.ijcard.2015.07.066_bb0085","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1161\/hc0402.102975","article-title":"Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart. A statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association","volume":"105","author":"Cerqueira","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2015.07.066_bb0090","doi-asserted-by":"crossref","first-page":"247","DOI":"10.2144\/000112913","article-title":"Real-time PCR to determine transgene copy number and to quantitate the biolocalization of adoptively transferred cells from EGFP-transgenic mice","volume":"45","author":"Joshi","year":"2008","journal-title":"Biotechniques"},{"key":"10.1016\/j.ijcard.2015.07.066_bb0095","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1093\/cvr\/cvp146","article-title":"Human cardiomyocyte progenitor cell transplantation preserves long-term function of the infarcted mouse myocardium","volume":"83","author":"Smits","year":"2009","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ijcard.2015.07.066_bb0100","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1016\/j.actbio.2014.01.011","article-title":"Polarization second harmonic generation by image correlation spectroscopy on collagen type I hydrogels","volume":"10","author":"Paesen","year":"2014","journal-title":"Acta Biomater."},{"key":"10.1016\/j.ijcard.2015.07.066_bb0105","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.bpj.2011.05.065","article-title":"Modeling of supramolecular centrosymmetry effect on sarcomeric SHG intensity pattern of skeletal muscles","volume":"101","author":"Rouede","year":"2011","journal-title":"Biophys. J."},{"key":"10.1016\/j.ijcard.2015.07.066_bb0110","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1161\/CIRCULATIONAHA.108.812693","article-title":"Stem cell therapy for heart failure: are arrhythmias a real safety concern?","volume":"119","author":"Menasche","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2015.07.066_bb0115","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.gendis.2014.07.003","article-title":"The potential and challenges of using stem cells for cardiovascular repair and regeneration","volume":"1","author":"Sun","year":"2014","journal-title":"Genes & Diseases."},{"key":"10.1016\/j.ijcard.2015.07.066_bb0120","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1161\/CIRCRESAHA.109.210682","article-title":"Relative roles of direct regeneration versus paracrine effects of human cardiosphere-derived cells transplanted into infarcted mice","volume":"106","author":"Chimenti","year":"2010","journal-title":"Circ. Res."},{"key":"10.1016\/j.ijcard.2015.07.066_bb0125","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1007\/s00018-010-0560-y","article-title":"Mesenchymal stem cells or cardiac progenitors for cardiac repair? A comparative study","volume":"68","author":"Koninckx","year":"2011","journal-title":"Cell. Mol. Life Sci."},{"issue":"2","key":"10.1016\/j.ijcard.2015.07.066_bb0130","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/cpr.12166","article-title":"Clinical-scale in vitro expansion preserves biological characteristics of cardiac atrial appendage stem cells","volume":"48","author":"Windmolders","year":"2015","journal-title":"Cell Prolif."},{"key":"10.1016\/j.ijcard.2015.07.066_bb0135","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/S0140-6736(04)15695-X","article-title":"Intra-coronary arterial injection of mesenchymal stromal cells and microinfarction in dogs","volume":"363","author":"Vulliet","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.ijcard.2015.07.066_bb0140","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1161\/01.CIR.0000163546.27639.AA","article-title":"Monitoring of bone marrow cell homing into the infarcted human myocardium","volume":"111","author":"Hofmann","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2015.07.066_bb0145","doi-asserted-by":"crossref","first-page":"S42","DOI":"10.1161\/CIRCULATIONAHA.112.000230","article-title":"Comparison of transendocardial and intracoronary CD34+ cell transplantation in patients with nonischemic dilated cardiomyopathy","volume":"128","author":"Vrtovec","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2015.07.066_bb0150","first-page":"229","article-title":"Safety and feasibility of mapping and stem cell delivery in the presence of an implanted left ventricular assist device: a preclinical investigation in sheep","volume":"40","author":"Zheng","year":"2013","journal-title":"Tex. Heart Inst. J."},{"key":"10.1016\/j.ijcard.2015.07.066_bb0155","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.stem.2014.11.009","article-title":"Cardiac repair in a porcine model of acute myocardial infarction with human induced pluripotent stem cell-derived cardiovascular cells","volume":"15","author":"Ye","year":"2014","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.ijcard.2015.07.066_bb0160","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1093\/eurheartj\/ehi818","article-title":"A quantitative, randomized study evaluating three methods of mesenchymal stem cell delivery following myocardial infarction","volume":"27","author":"Freyman","year":"2006","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ijcard.2015.07.066_bb0165","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.yjmcc.2005.11.006","article-title":"Attenuation of acetaldehyde-induced cell injury by overexpression of aldehyde dehydrogenase-2 (ALDH2) transgene in human cardiac myocytes: role of MAP kinase signaling","volume":"40","author":"Li","year":"2006","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ijcard.2015.07.066_bb0170","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1582-4934.2009.00942.x","article-title":"Aldehyde dehydrogenase activity promotes survival of human muscle precursor cells","volume":"15","author":"Jean","year":"2011","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.ijcard.2015.07.066_bb0175","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.jacc.2010.07.049","article-title":"Intramyocardial injection of autologous cardiospheres or cardiosphere-derived cells preserves function and minimizes adverse ventricular remodeling in pigs with heart failure post-myocardial infarction","volume":"57","author":"Lee","year":"2011","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcard.2015.07.066_bb0180","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1002\/stem.72","article-title":"Murine \u201ccardiospheres\u201d are not a source of stem cells with cardiomyogenic potential","volume":"27","author":"Andersen","year":"2009","journal-title":"Stem Cells"},{"key":"10.1016\/j.ijcard.2015.07.066_bb0185","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1002\/emmm.201201737","article-title":"Cardiomyocyte proliferation and progenitor cell recruitment underlie therapeutic regeneration after myocardial infarction in the adult mouse heart","volume":"5","author":"Malliaras","year":"2013","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.ijcard.2015.07.066_bb0190","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1161\/CIRCULATIONAHA.112.001075","article-title":"Intracoronary delivery of autologous cardiac stem cells improves cardiac function in a porcine model of chronic ischemic cardiomyopathy","volume":"128","author":"Bolli","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.ijcard.2015.07.066_bb0195","doi-asserted-by":"crossref","first-page":"730683","DOI":"10.1155\/2015\/730683","article-title":"Sca-1+ cells from fetal heart with high aldehyde dehydrogenase activity exhibit enhanced gene expression for self-renewal, proliferation, and survival","volume":"2015","author":"Dey","year":"2015","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.ijcard.2015.07.066_bb0200","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1016\/j.jacc.2008.06.052","article-title":"Controlled delivery of basic fibroblast growth factor promotes human cardiosphere-derived cell engraftment to enhance cardiac repair for chronic myocardial infarction","volume":"52","author":"Takehara","year":"2008","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijcard.2015.07.066_bb0205","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1161\/CIRCULATIONAHA.107.734103","article-title":"The Myoblast Autologous Grafting in Ischemic Cardiomyopathy (MAGIC) trial: first randomized placebo-controlled study of myoblast transplantation","volume":"117","author":"Menasche","year":"2008","journal-title":"Circulation"}],"container-title":["International Journal of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016752731530187X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016752731530187X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,20]],"date-time":"2018-09-20T09:28:45Z","timestamp":1537435725000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016752731530187X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":41,"alternative-id":["S016752731530187X"],"URL":"https:\/\/doi.org\/10.1016\/j.ijcard.2015.07.066","relation":{},"ISSN":["0167-5273"],"issn-type":[{"value":"0167-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cardiac atrial appendage stem cells engraft and differentiate into cardiomyocytes in vivo: A new tool for cardiac repair after MI","name":"articletitle","label":"Article Title"},{"value":"International Journal of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijcard.2015.07.066","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}